7,662 results match your criteria: "Hadassah - Hebrew University[Affiliation]"
Association of Concave Deformity of the Anterior Scalene on Magnetic Resonance Imaging with Vascular Variant of Neurogenic Thoracic Outlet Syndrome.
Plast Reconstr Surg Glob Open
October 2024
Department of Radiology, Interventional Radiology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Article Synopsis
- Neurogenic thoracic outlet syndrome (NTOS) is caused by dynamic compression of the brachial plexus, with this study examining the link between a specific muscle deformity (CDAS) seen in MRI and vascular compression found during surgery.
- The study analyzed 44 patients who underwent surgery after failed rehabilitation, identifying two main types of NTOS: pure neurogenic (type A) and mixed neurogenic-vascular (type B), with type B further divided into three subtypes based on the nature of vascular compression.
- Findings showed that CDAS was more frequently associated with mixed types (especially type B1) and that patients with vascular variants exhibited more significant symptoms related to nerve compression compared to those with pure neurogenic NT
Processing of social closeness in the human brain.
Commun Biol
October 2024
Computational Neuropsychiatry Lab, Department of Medical Neurosciences, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Healthy social life requires relationships in different levels of personal closeness. Based on ethological, sociological, and psychological evidence, social networks have been divided into five layers, gradually increasing in size and decreasing in personal closeness. Is this division also reflected in brain processing of social networks? During functional MRI, 21 participants compared their personal closeness to different individuals.
View Article and Find Full Text PDFFactors associated with failure of intraosseous access in prehospital trauma treatment by military medical personnel.
BMJ Mil Health
October 2024
Israeli Defense Forces Medical Corps, Tel Hashomer, Ramat Gan, Israel.
Article Synopsis
- Intraosseous devices are being explored as an alternative to traditional IV methods in prehospital military care, but real-world data on their effectiveness is lacking.
- The study analyzed data from 172 trauma patients in the Israel Defense Forces from 2010 to 2023, finding a first pass success rate of 67.4% and an overall success rate of 80.8% after multiple attempts.
- The type of intraosseous device used impacted success rates, with the NIO Adult showing the best results; however, increased attempts at peripheral IV access negatively influenced the success of intraosseous access.
Myopia and systemic manifestation of tissue hyperlaxity: A population-based cross-sectional study.
Clin Exp Ophthalmol
October 2024
Department of Ophthalmology, Shamir Medical Center (formerly Assaf-Harofeh), Be'er Ya'akov, Israel.
Article Synopsis
- The study explored whether non-syndromic connective tissue hyperlaxity is linked to myopia in adolescents, using conditions like hernias and scoliosis as indicators of tissue hyperlaxity.
- Over 920,000 adolescents were analyzed, with 31.6% diagnosed with myopia; those with myopia exhibited higher rates of hernias (2.76%), pes planus (14.92%), and scoliosis (9.14%) compared to non-myopic peers.
- Findings suggest that myopic adolescents may have a greater tendency toward conditions associated with tissue laxity, indicating a possible systemic link between myopia and hyperlaxity.
Assessment of ovarian cortex follicles in chemotherapy naïve and chemotherapy exposed patients.
Minerva Obstet Gynecol
October 2024
Unit of Infertility and IVF, Department of Obstetrics and Gynecology, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Background: Histological evaluation of ovarian tissue harvested as part of the attempt to preserve fertility might clarify the mechanism by which ovarian failure is caused. The purpose of this study was to compare the histologic appearance of ovarian tissue harvested for ovarian tissue cryopreservation (OTC) in chemotherapy naïve and chemotherapy exposed patients regarding the presence of follicles in different stages of development and to explore ovarian tissue histology in patients exposed to low- and high-cytotoxicity risk chemotherapy.
Methods: A cohort of post-pubertal cancer survivors who underwent OTC between 1997 and 2018 was evaluated.
Corrigendum: Direct oral anticoagulants for the treatment of cerebral venous thrombosis - a protocol of an international phase IV study.
Front Neurol
September 2024
Department of Neurology, Amsterdam UMC, Location University of Amsterdam, Amsterdam, Netherlands.
Article Synopsis
- The article has a Digital Object Identifier (DOI) that allows it to be easily found online.
- The DOI number given is 10.3389/fneur.2023.1251581.
- This correction is important for making sure the information in the article is accurate.
The activating receptor NKG2D is an anti-fungal pattern recognition receptor.
Nat Commun
October 2024
The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRIC, Jerusalem, Israel.
NKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8 T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous or virally infected cells. Fungal pathogens are a major threat to human health, infecting more than a billion patients yearly and becoming more common and drug resistant.
View Article and Find Full Text PDFFrom Gut Motility to Chronic Pain: Studies on the Mammalian Peripheral Nervous System.
Bioelectricity
September 2024
Laboratory of Experimental Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Reproductive disorders in homozygote and heterozygote patients with familial Mediterranean fever patients and controls.
Clin Exp Rheumatol
October 2024
Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.
Belantamab Mafodotin in Relapsed/Refractory AL Amyloidosis: Real-World Multi-Center Experience and Review of the Literature.
Acta Haematol
October 2024
Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Introduction: Treatment for relapsed/refractory AL amyloidosis (AL) is an unmet need. The safety and efficacy of belantamab mafodotin (BLM) in multiple myeloma are known, whereas in AL data are limited.
Methods: We report a multi-center cohort of AL patients receiving BLM, and review all previous data on BLM therapy in AL.
Accurate prediction of disease-risk factors from volumetric medical scans by a deep vision model pre-trained with 2D scans.
Nat Biomed Eng
October 2024
Department of Computer Science, University of California, Los Angeles, Los Angeles, CA, USA.
Article Synopsis
- Limited annotated datasets for 3D biomedical imaging make it challenging to train machine learning models for accurate disease prediction.
- The SLIViT model, pre-trained on 2D scans, effectively predicts disease-risk factors by processing 3D scans into 2D images and integrating their features.
- SLIViT outperformed existing models in various learning tasks and matched the accuracy of trained specialists, potentially saving time and costs in clinical settings.
Mitochondrial Dysfunction in Glycogen Storage Disorders (GSDs).
Biomolecules
September 2024
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel.
Article Synopsis
- - Glycogen storage disorders (GSDs) are genetic metabolic conditions caused by enzyme defects that affect glycogen metabolism, leading to mitochondrial dysfunction and issues like oxidative stress and impaired cell metabolism.
- - Specific GSD types, such as Pompe disease and Cori disease, demonstrate how enzyme deficiencies lead to glycogen accumulation, which disrupts normal mitochondrial function, causing issues like muscle weakness and liver enlargement.
- - Addressing mitochondrial dysfunction through treatments like antioxidants, enhancing mitochondrial growth, and gene therapy may offer new ways to alleviate symptoms and complications associated with GSDs, including cardiac and cognitive issues.
Treatment Outcomes and Definition Inconsistencies in High-Risk Unilateral Retinoblastoma.
Am J Ophthalmol
December 2024
From the Sheba Medical Center, The Goldschleger Eye Institute (M.A., I.D.), Sheba Medical Center, Ramat Gan, Israel; Faculty of Medicine, Tel Aviv University (M.A., A.B., I.D.), Tel Aviv, Israel; London School of Hygiene & Tropical Medicine (I.D., M. A.), London, UK. Electronic address:
Purpose: To compare the clinical outcomes of children with unilateral retinoblastoma (Rb) and high-risk histopathology features (HRHF) following upfront enucleation with/without adjuvant chemotherapy, and investigate cases locally considered non-HRHF but converted to a standardized HRHF definition.
Design: Retrospective multinational clinical cohort study.
Methods: Children with Rb who presented to 21 centers from 12 countries between 2011-2020, and underwent primary enucleation were recruited.
Comment on: Impact of spherical aberration on visual quality and depth of focus.
J Cataract Refract Surg
December 2024
From the Anterior Segment and Refractive Surgery Department, Rothschild Foundation Hospital, Paris, France (Stern, Gatinel); Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (Stern).
Validation of behavioral measures of social cognition in individuals diagnosed with schizophrenia.
Front Psychol
September 2024
Psychiatric Division, Tel Aviv Sourasky Medical Center Ichilov, Tel Aviv, Israel.
Schizophrenia, a complex neuropsychiatric disorder, manifests severe impairments in social cognition, notably in Theory of Mind (ToM), empathy, and emotion recognition, which significantly influence social competence and overall functioning. These aspects are crucial for prognosis in individuals diagnosed with schizophrenia (SZ). This study validates a comics strip paradigm for ToM and empathy assessment, the Montreal Affective Voices (MAV) for measuring emotion recognition, and a Go-NoGo task for inhibition control estimation in individuals diagnosed with SZ, comparing their performance with healthy controls.
View Article and Find Full Text PDFNewborn screening algorithm distinguishing potential symptomatic isovaleric acidemia from asymptomatic newborns.
J Inherit Metab Dis
January 2025
National Newborn Screening Program, Ministry of Health, Tel-HaShomer, Ramat-Gan, Israel.
Article Synopsis
- * Out of 412 newborns flagged positive for IVA in a large screening in Israel, 371 were false positives, and only 38 confirmedIVA—with 32% being symptomatic and 68% asymptomatic, many of whom have a specific mild variant.
- * The study introduced a new screening algorithm that better distinguishes between symptomatic and asymptomatic cases, aiming to reduce unnecessary treatment and focus on those at higher risk for severe outcomes.
An Integrative Approach for Endometriosis-Related Pain.
West J Nurs Res
November 2024
Department of Obstetrics and Gynecology, Hadassah-Hebrew University, Jerusalem, Israel.
Background: Pain is a common, severe symptom related to endometriosis. Despite this prominent feature, there is limited literature regarding its description and use of integrative treatment methods.
Objective: We aimed to describe endometriosis-related pain characteristics, severity, and association with an integrative approach encompassing pharmacological and non-pharmacological methods.
Intravenous Thrombolysis in Patients With Cervical Artery Dissection: A Secondary Analysis of the STOP-CAD Study.
Neurology
October 2024
From the Department of Neurology (L.S., F. Akpokiere, D.M.M., K.P., V.D., K.B., T.M.B., N.S.K., F. Khan, C.S., N. Mohammadzadeh, E.D.G., K.F., S. Yaghi), Warren Alpert Medical School of Brown University, Providence, RI; Vancouver Stroke Program (T.S.F., L.Z., P.G.), Division of Neurology, University of British Columbia, Vancouver, Canada; Department of Neurology (C.R.L.G.), Atrium Health, Charlotte, NC; Department of Neurology (J. Muppa, N.H.), University of Massachusetts Chan Medical School, Worcester; Department of Neurology (M. Affan, O.U.H.L.), University of Minnesota, Minneapolis; Department of Neurology (M.R.H., K.A., D.J.S., M. Arnold), Inselspital, University Hospital and University of Bern, Switzerland; Department of Neurology (S.S.O., R. Crandall), University of Colorado, Denver; Department of Neurology (E.L.), Weill Cornell Medicine, New York; ; Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez (D.L.-M., A. Arauz), Mexico City, Mexico; Service de neurologie (A.N., M.B., E.T.), Université Caen Normandie, CHU Caen Normandie, France; Department of Neurology (J.A.S., J.S.-F., V.B.), Coimbra University, ; Department of Internal Medicine (P.C.-C., M.T.B.), São João University Hospital, Porto, Portugal; Department of Neurology (M.K., D.M.), Corewell Health, Grand Rapids, MI; Department of Neurology (M.K.), Mayo Clinic, Rochester, MN; Department of Neurology (A.R., O.K.), University of Pennsylvania, Philadelphia; Neurology and Neurorehabilitation (J.E.K., S.T.E., C.T.), University Department of Geriatric Medicine FELIX PLATTER, Department of Clinical Research, University of Basel, and University Hospital Basel, Switzerland; Stroke Center (D.A.d.S.), Centro Hospitalar Universitário Lisboa Central, and Institute of Anatomy, Faculdade de Medicina da Universidade de Lisboa; Department of Neurology (M.D.S.); Department of Neuroradiology (S.B.R.), Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal; Vancouver Stroke Program (S. Mancini), Division of Neurology, University of British Columbia, Vancouver, Canada; Department of Neurology (I.M., R.R.L.), Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Department of Neurology with Experimental Neurology (R.V.R., C.H.N.), Charite Universitätsmedizin-Berlin and Center for Stroke Research, Berlin, and Berlin Institute of Health, Germany; Department of Neurosciences (R. Choi, J. MacDonald), ChristianaCare, Newark, DE; Department of Neurology (R.B.S.), University of California at San Diego; Department of Neurology (X.G.), Loma Linda University, Loma Linda, CA; Department of Neurology (M. Ghannam, M. Almajali, E.A.S.), University of Iowa, Iowa City; Department of Neurosciences (B.R., F.Z.-E., A.P.), Université de Montréal, Canada; Department of Neurology (A.C.F., M.F.B., D.C.), Hospital de Santa Maria, Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Portugal; Neurology and Stroke Unit (M. Romoli, G.D.M., M.L.), Department of Neuroscience, Bufalini Hospital, Cesena, Italy; Department of Neurology (Z.K., K.J.G.), Mayo Clinic, Rochester, MN; Department of Neurology (L.K., J.A.F.), NYU Langone Health, New York; Department of Neurology (J.Y.A., J.A.G.), Washington University, Saint Louis, MO; Neurology Unit, Stroke Unit (M. Zedde, I.G.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; Department of Internal Medicine (H.N.), Centro Hospital Universitario do Algarve, Faro, Portugal; Department of Neurology (D.S.L., A.M.), University of California at Los Angeles; Department of Neurology (A.C., B.M.G., R.W.), Duke University, Durham, NC; Department of Neurology (W.K.), University of North Carolina Health Rex, Raleigh; Department of Neurology (S.A.K., M. Anadani), Medical University of South Carolina, Charleston, SC; Department of Neurosurgery (K.P.K.), Medical University of South Carolina, Charleston, SC; Department of Neurology (A.E., L.C., R.C.R., Y.N.A., E.A.M.), University of Cincinnati Medical Center, OH; Department of Neurology (E.B., T.L.T.), University of Alabama at Birmingham; Department of Neurology (M.R.-G., M. Requena), University Hospital Vall d'Hebron, Barcelona, Spain; Department of Neurology (F.G.S.V., J.O.G.), University of Oklahoma; Department of Neurology (V.M.), Einstein-Jefferson Healthcare Network, Philadelphia, PA; Department of Neurology (A.H.), University of Utah, Salt Lake City; Department of Neurology (A.H.); Department of Neurology (S. Sanchez, A.S.Z., Y.K.C., R.S.), Yale New Haven Hospital, New Haven, CT; Department of Neurology (V.Y.V.), All India Institute of Medical Sciences, New Delhi, India; Department of Neurology (S. Yaddanapudi, L.A., A. Browngoehl), Thomas Jefferson University, Philadelphia, PA; Department of Neurology (T.R., R.D., Z.L.), Wake Forest Medical Center, NC; Department of Neurology (M.P., J.E.S.), Cooper University, Camden, NJ; Department of Neurology (S. Mayer, J.Z.W.), Columbia University Medical Center, New York, NY; Department of Neurology (J.P.M., D.K.), Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal; Department of Neurology (P.K., T.N.N.), Boston Medical Center, MA; Department of Neurology (S.D.A., Z.S., A. Balabhadra, S.P.), Hartford Hospital, CT; Department of Neurology (T.S.), Hospital Moinhos de Vento; Department of Neurology (S.C.M., G.P.M.), Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Neurology (Y.D.K.), Yonsei University, Seoul, South Korea; Department of Neurology (B.K., C.E.), University of Tennessee at Memphis; Department of Neurology (S. Lingam, A.Y.Q.), Kansas University Medical Center, Kansas City; Department of Neurology (S.F., A. Alvarado), Western Ontario University, London, Canada; Department of Neurology (F. Khasiyev, G.L.), Saint Louis University, MO; Department of Neurology and Stroke Unit (M.M., V.T.), AOOR Villa Sofia-V. Cervello, Palermo, Italy; First Department of Neurology (A.T., V.T.-P.), National and Kapodistrian University of Athens, Greece; Department of Neurology (M.M.M.-M., V.C.W.), Centro Médico Nacional Siglo XXI IMSS., México City; Department of Neurology (F.I., S.E.E.J.), The Miriam Hospital, Providence, RI; Department of Neurocritical Care (S. Liu, M. Zhou), The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology, Hefei, China; Department of Neurology (M.M.A., F. Ali, M.S.), West Virginia University, WV; Department of Neurology (R.Z.M., T.K.-H.), University of Chicago, IL; Department of Neurology (F.S., J.Z.), Sir Run Run Shaw Hospital of Zhejiang University Medical School, Hangzhou, China; Department of Neurology (D.S., J.S., N. Mongare), Aga Khan University, Nairobi, Kenya; Department of Neurology (A.N.S., R.G., Shayak Sen), Cedars Sinai Medical Center, Los Angeles, CA; Department of Neurology (M. Ghani, M.E.), University of Louisville, KY; and Department of Economics (H.X.), University of California, Santa Barbara.
Article Synopsis
- Cervical artery dissection (CeAD) is a leading cause of ischemic strokes in young adults, and this study explored the effects of intravenous thrombolysis (IVT) on patients with CeAD and stroke symptoms.
- Analyzed data from the STOP-CAD study, it found that IVT significantly improved functional independence after 90 days in patients without increasing the risk of symptomatic intracranial hemorrhage.
- The results suggest that IVT is a beneficial treatment for eligible patients with CeAD, aligning with current medical guidelines on its use.
The Israeli anesthesiology workforce crisis: a reassessment survey.
Isr J Health Policy Res
September 2024
Faculty of Medicine of the Hebrew University of Jerusalem, Jerusalem, Israel.
Article Synopsis
- Anesthesiologists are important doctors who give patients anesthesia during surgeries, and there's a growing need for them because there are more older people in Israel.
- A study found that many anesthesiologists in Israel are immigrants, and not enough new doctors are being trained as the older ones retire.
- Even though there are more female anesthesiologists now and some additional local graduates, the shortage of anesthesiologists is likely to get worse in the next ten years if the situation doesn't change.
Detection of antibody-drug conjugate-induced interstitial lung disease using circulating cell-free DNA.
ESMO Open
October 2024
Center for Liquid Biopsy at the Department of Pediatric Hemato-Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Article Synopsis
- * Researchers analyzed cell-free DNA (cfDNA) from blood samples of a patient with HER2-positive endometrial cancer who developed ILD, as well as samples from other patients, to detect lung damage through specific methylation markers.
- * The findings suggest that liquid biopsy, an easy and cost-effective method, could effectively monitor ADC-related ILD, potentially offering a better alternative to traditional imaging techniques.
Impact of extent of resection and adjuvant radiation therapy in the progression free survival in patients with spheno-orbital meningioma.
J Clin Neurosci
November 2024
Assuta Hospital, Tel Aviv, Israel. Electronic address:
Background: Spheno-orbital meningiomas (SOM) are known to invaded critical skull base areas. The authors report a series of WHO I SOM, propose a subclassification of this tumor according to its extension to critical positions and analyze the impact of extent of resection and the role of stereotactic radiotherapy in tumor recurrence.
Methods: A prospective maintained university medical center registry was utilized to undertake a retrospective review of patients operated with WHO I SOM.
Travelling beyond time: shared brain system for self-projection in the temporal, political and moral domains.
Philos Trans R Soc Lond B Biol Sci
November 2024
Neuropsychiatry Laboratory, Department of Medical Neurosciences, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel.
Mental time travel (MTT), a cornerstone of human cognition, enables individuals to mentally project themselves into their past or future. It was shown that this self-projection may extend beyond the temporal domain to the spatial and social domains. What about higher cognitive domains? Twenty-eight participants underwent functional magnetic resonance imaging (fMRI) while self-projecting to different political, moral and temporal perspectives.
View Article and Find Full Text PDFObjective: To determine if mild-moderate hypertriglyceridemia (HTG) is associated with increased development of chronic pancreatitis (CP) or pancreatitis-associated complications in children with acute recurrent or CP.
Study Design: Longitudinal data from the INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2) cohort of children with acute recurrent or CP (n = 559) were analyzed. Subjects were divided into normal triglycerides (<150 mg/dL; 1.
Ventricular arrhythmias in acute heart failure: a clinical consensus statement of the Association for Acute CardioVascular Care, the European Heart Rhythm Association, and the Heart Failure Association of the European Society of Cardiology.
Europace
October 2024
Department of Cardiology, Institute of Cardiovascular Diseases Prof. C.C. Iliescu, Bucharest, Romania.
Article Synopsis
- Acute heart failure (AHF) patients exhibit a wide range of symptoms and risks, making them a complex group to manage, with increased chances of dangerous ventricular arrhythmias (VAs) during episodes.
- New VAs during AHF correlate with higher morbidity and mortality in hospitals, but there is ongoing debate about when to perform coronary interventions or implant defibrillators.
- Different European countries have varying emergency medical capabilities for treating AHF and VAs, and while guidelines exist for chronic heart failure, less is known about arrhythmias in AHF, prompting this consensus paper to propose better ways to identify and treat these complications.