2,215 results match your criteria: "Hacettepe University School of Medicine[Affiliation]"

Introduction: This study investigates the short-term effects of prolene gonioscopy-assisted transluminal trabeculotomy (GATT) on anterior segment parameters and corneal endothelium in patients with open-angle glaucoma.

Methods: This retrospective study included 30 eyes from 30 patients who underwent GATT surgery. Demographic data, ophthalmological examination findings, and intraocular pressure (IOP) measurements using a Goldman applanation tonometer were recorded.

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PCOS - the many faces of a disorder in women and men.

J Endocrinol Invest

December 2024

Department of Internal Medicine, Division of Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara, Turkey.

Purpose: Polycystic ovary syndrome (PCOS) is a very common endocrine, metabolic and reproductive disorder. The underlying pathophysiology is not yet fully understood and both genetic and environmental factors contribute to its development. We aimed to explore clinical and genetic aspects of familial clustering in PCOS, shedding light on its reproductive and metabolic consequences in both male and female first-degree relatives of the affected women.

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Introduction: Proper transfer of patients from pediatric to adult chest clinic has critical importance. In this study, we aimed to evaluate the follow-up data of the patients in the first 12 months after transfer.

Methods: Cystic fibrosis (CF) patients previously transferred to adult chest clinics were included.

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Patients with polycystic ovary syndrome (PCOS) often have many questions about nutrition and turn to chatbots such as Chat Generative Pretrained Transformer (ChatGPT) for advice. This study aims to evaluate the reliability, quality, and readability of ChatGPT's responses to nutrition-related questions asked by women with PCOS. Frequently asked nutrition-related questions from women with PCOS were reviewed in both Turkish and English.

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Objective: This study aims to culturally adapt the 'Motivation and Attitudes Towards Changing Health (MATCH)' scale into Turkish and assess its reliability and validity within the Turkish population.

Methods: The Turkish version of the MATCH questionnaire, designed to gauge patient motivation for initiating or sustaining behaviour changes, was created through translation and adaptation. A total of 305 patients diagnosed with chronic illnesses completed the questionnaire and scale to evaluate its validity and reliability.

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Objectives: To evaluate the predictivity of haematologic parameters and HALP score on testicular viability in adults with testicular torsion.

Methods: We retrospectively analyzed the clinical data of 139 men ≥18 years of age who underwent testicular detorsion with fixation (n = 90) or orchiectomy (n = 49) due to testicular torsion in five different tertiary centers between May 2019 and August 2023. Demographic, pre-, peri- and postoperative data were analyzed.

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Context: Artificial intelligence (AI) is increasingly utilized in healthcare, with models like ChatGPT and Google Gemini gaining global popularity. Polycystic ovary syndrome (PCOS) is a prevalent condition that requires both lifestyle modifications and medical treatment, highlighting the critical need for effective patient education. This study compares the responses of ChatGPT-4, ChatGPT-3.

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Polycystic ovary syndrome as a metabolic disease.

Nat Rev Endocrinol

November 2024

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.

Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder affecting up to one in five women. The aetiology remains unclear, but available evidence suggests it is a polygenic disorder with epigenetic, developmental, and environmental components. The diagnostic criteria for PCOS are based on reproductive features, and the syndrome is categorized into several phenotypes that can vary by race and ethnicity.

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Acute pancreatitis (AP) is a clinical condition that arises acutely in the pancreas through various inflammatory pathways due to multiple causes. Turkish Society of Gastroenterology Pancreas Working Group developed comprehensive guidance statements regarding the management of AP that include its epidemiology, etiology, clinical presentation, diagnostic criteria, disease severity, treatment, prognosis, local and systemic complications. The statements were developed through literature review, deliberation, and consensus opinion.

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The twenty-first century has seen a fundamental shift in disease epidemiology with anthropogenic environmental change emerging as the likely dominant factor affecting the distribution and severity of current and future human disease. This is especially true of allergic diseases and asthma with their intimate relationship with the natural environment. Climate change-related variables including increased ambient temperature, heat waves, extreme weather events, air pollution, and rainfall distribution, all can affect asthma in children, but each of these variables also affects asthma via alterations in pollen production and release, outdoor allergen exposure or the microbiome.

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Objective: To analyze how the PD-L1 expression and CD8 + tumor infiltrating lymphocyte (TIL) levels in biopsy samples before neoadjuvant chemotherapy (NACT) can predict chemotherapy response score and survival for advanced high-grade serous ovarian cancer (HGSC).

Methods: We retrospectively analyzed 45 patients with advanced epithelial ovarian cancer between 2010 and 2018, who had received at least three cycles of NACT. PD-L1 expression and CD8 + TIL levels were evaluated by immunohistochemical staining in the pre-NAC tumor samples from which the patients had been diagnosed.

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Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry.

Joint Bone Spine

November 2024

Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy. Electronic address:

Article Synopsis
  • The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
  • A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
  • Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
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Article Synopsis
  • This study investigates whether daily subcutaneous administration of 25 mg progesterone improves the chances of live birth in women with low serum progesterone levels (7-10 ng/mL) before a frozen embryo transfer (FET).
  • A cohort of 192 women was divided into three groups based on their progesterone levels and whether they received the rescue treatment, with the main focus on comparing live birth rates (LBR) among these groups.
  • The results showed that the live birth rates were similar across the groups, indicating that adding the progesterone rescue treatment does not significantly improve outcomes for patients with low serum progesterone levels.
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Nissen fundoplication (NF) is a common surgical procedure to treat gastroesophageal reflux disease; however, a subset of patients may continue to experience symptoms or develop symptom recurrence despite a successful procedure. This study aims to compare laparoscopic and robotic approaches for treating failed NF and evaluate the outcomes after converting to Toupet fundoplication (TF). We conducted a retrospective analysis of patients who underwent robotic or laparoscopic revision to TF for failed NF between 2016 and 2023.

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Leaving the Ductus Open During BTT Shunt: Risk of Ductus-Associated Pulmonary Coarctation?

World J Pediatr Congenit Heart Surg

January 2025

Division of Paediatric Cardiac Surgery, Department of Cardiovascular Surgery, Hacettepe University School of Medicine, Ankara, Turkiye.

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Current practice of screening and antimicrobial prophylaxis to prevent Gram-negative bacterial infection in high-risk haematology patients: results from a pan-European survey.

Ther Adv Infect Dis

October 2024

Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Article Synopsis
  • - The study examines the use of antimicrobial prophylaxis (AMP) in haematological patients, particularly those at high risk for bacterial infections due to prolonged neutropenia after chemotherapy, amidst the rise of multi-drug resistant Gram-negative bacteria (MDR-GNB).
  • - A survey conducted with 120 haematology centers across 28 European countries revealed that most centers (86.7%) routinely screen for MDR-GNB, with a significant number (39.2%) using fluoroquinolones for prophylaxis.
  • - While bloodstream infections (BSI) rates were slightly lower in patients receiving AMP, the overall increase in MDR-GNB infections highlights the need for improved antimicrobial stewardship and tailored prophylactic strategies.
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Objectives: COVID-19 unravelled new ethical issues in the neglected field of infectious diseases ethics (IDE). We investigated IDE involvement among infectious diseases professionals.

Methods: A global survey was disseminated during 2021-2022.

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