417 results match your criteria: "Habib-Bourguiba hospital[Affiliation]"

Annexin A1 expression in Lupus Nephritis.

Tunis Med

December 2024

Research Laboratory LR18/SP12 "Autoimmunity, Cancer, and Immunogenetics", Habib Bourguiba hospital, Sfax, Tunisia.

Introduction: Lupus nephritis (LN) is an immune complex glomerulonephritis, caused by systemic lupus erythematosus. It is associated with an increase of morbidity and mortality. In LN, the immune responses dysregulation is one of the crucial pathogenic pathways.

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In this paper, an automated feature selection (FS) method is presented to optimize machine learning (ML) models' performances, enhancing early keratoconus screening. A total of 448 parameters were analyzed from a dataset comprising 3162 observations sourced from the swept source optical coherence tomography imaging system developed by the Chinese Academy of Sciences Institute of Automation (SS-1000 CASIA OCT) and electronic health records (EHR). To identify the most relevant features, the analysis of variance (ANOVA) method was used in this study.

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Background: Standard treatment for bone metastases is based on bisphosphonates such as zoledronic acid. The objective of this study was to evaluate the incidence of acute renal failure during treatment with Zoledronate and to analyze its correlated factors.

Materials And Methods: This is a retrospective study carried out at the medical oncology department of Habib Bourguiba University Hospital in Sfax, between January 2022 and March 2022.

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Unlabelled: Polycystic ovary syndrome (PCOS) is a common condition. Its pathophysiology involves an interaction between genetic and environmental factors, resulting in different reproductive and metabolic subtypes. Genetic variation in the angiotensin converting enzyme (ACE) gene has been implicated in the pathophysiology of the syndrome.

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Predictive Factors for Fertility of Daughter Cysts in Hepatic Cystic Echinococcosis and Insights into the Origin of Daughter Cysts.

Surg Infect (Larchmt)

November 2024

Faculty of Medicine, Department of General and Digestive Surgery, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Article Synopsis
  • The study investigates the fertility of daughter cysts (DC) from hepatic echinococcal cysts to understand their origin, amidst ongoing debates about their developmental potential.
  • A total of 248 DC from 27 cysts in 21 patients were analyzed, revealing a fertility rate of 64.5%, with specific factors such as cyst size, DC size, and WHO classification type CE2 significantly influencing fertility.
  • The results indicate most DC were fertile, and the absence of hooks in infertile DC challenges existing theories about their formation.
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The aim of this study was to determine the incidence of the self-use of plants in cancer patients and its impact on overall survival (OS). This was a prospective study including young adult patients collected between January 15, 2018 and January 15, 2019 in the department of medical oncology at the Habib Bourguiba University Hospital. All patients were questioned about the concept of taking herbs.

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Gardner syndrome (GS) is a subtype of familial adenomatous polyposis (FAP) characterized by colorectal polyps, multiple osteomas, soft tissue tumors, and specific oral manifestations, such as jaw osteomas. GS is caused by mutations in the APC gene, resulting in a nonfunctional protein. This study reports a comprehensive clinical evaluation and genetic analysis of a Tunisian family affected by GS.

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Recurrent positional unilateral pulmonary edema following CABG: an uncommon case report.

J Surg Case Rep

October 2024

Cardiology Department, Faculty of Medicine of Sfax, Hedi Chaker Hospital, AL ain Road, Km 0.5, 3000, Sfax, Tunisia.

Article Synopsis
  • A 60-year-old patient was found to have pericardial agenesis during heart surgery, but the condition was not addressed at that time.
  • After surgery, the patient suffered from recurring right pulmonary edema when positioned semi-upright.
  • A second surgery to reconstruct the pericardium was performed 48 hours later, and the patient recovered well afterward.*
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Purpose: To analyze changes in peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness in migraine patients with and without aura compared to healthy controls and to identify factors influencing the occurrence of these anomalies.

Methods: This is a cross-sectional case-control study including migraine patients and control subjects. All patients and controls underwent a complete ophthalmological examination, RNFL and GCC thickness measurements using a spectral domain-OCT device.

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Primary angiosarcoma (PAS) of the breast is an extremely uncommon variant of breast malignancies. Highly aggressiveness and dismal prognosis characterize this endothelial neoplasm. We report here an unusual case of PAS of the breast occurring in a 46-year-old woman associated with concurrent bilateral invasive ductal carcinoma and ovarian metastases.

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Objective: We aimed to evaluate the local and systemic side effects of the COVID-19 vaccine in cancer patients.

Methods: we conducted a cross-sectional study including cancer patients treated at Habib Bourguiba Hospital in Sfax, Tunisia between January and March 2022. Patients should have received at least 1 dose of a COVID-19 vaccine.

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Dysfunction of the autonomic nervous system in gastro-esophageal reflux disease: Consequences for the cardiovascular system.

Neurophysiol Clin

November 2024

Functional Explorations Department, Habib Bourguiba Hospital, Sfax Tunisia; LR19ES15, Medical School, University of Sfax, Tunisia. Electronic address:

Objective: The pathophysiology of gastro esophageal reflux disease (GERD) implicates autonomic dysregulation of the lower esophageal sphincter tone. Our goal is to investigate whether this dysregulation of the autonomic nervous system (ANS) function observed in isolated GERD cases can affect other systems, such as cardiovascular regulation.

Methods: Twenty-five participants were included in the study, 11 patients with isolated GERD and 14 controls.

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Background: Melanoma is the most malignant skin tumor, with a high metastatic potential. Spitzoid melanoma is a subtype of melanoma requiring rapid management and extensive tumor resection. We have set the goal to recognize anatomical peculiarities and difficulties diagnoses posed by this type of tumor, as well as to recognize the management modalities, especially the surgical one, of malignant spitzoid melanoma.

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Chemotherapy induced alopecia in breast cancer patients: A monocentric prospective study.

Breast Dis

August 2024

Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Introduction: Alopecia is one of the main adverse events of chemotherapy in breast cancer. However, its impact is often ignored and underestimated by clinicians. Our aim was to evaluate the quality of life of breast cancer patients with chemotherapy induced alopecia.

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Key Clinical Message: Presenting a rare case of flexor carpi radialis atrophy secondary to cervical spondylotic amyotrophy.

Abstract: A 52-year-old man with a history of cervicobrachial neuralgia presented with an advanced atrophy of the right flexor carpi radialis muscle with a groove hollowed out on the anterior surface of the right forearm. The spine MRI showed that this rare atrophy was related to a cervical spondylotic amyotrophy.

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Migraine, classified as a neurovascular disease, has been identified as a potential risk factor for ocular vascular complications. Our study aimed to compare retinal vessel density and perfusion density between subjects with migraine and healthy subjects using optical coherence tomography angiography (OCTA). In this cross-sectional case-control study, we enrolled 30 migraine subjects with aura (MWA), 30 migraine subjects without aura (MWOA) and 30 age and gender-matched healthy controls (HC).

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Article Synopsis
  • Hemodynamic restoration is crucial in sepsis management, with initial treatment focusing on achieving a mean arterial pressure (MAP) of over 65 mmHg through volume expansion and norepinephrine (NE) if needed.
  • A multicenter randomized trial is underway to evaluate the effectiveness of low-dose NE in controlling shock within 6 hours in septic patients, comparing it to standard care.
  • The study measures various parameters, including lactate levels and cardiac output, with the primary goal of achieving stable shock control, and aims to include at least 100 patients in each treatment group.
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Exploring the role of vitamin D-VDR pathway in pemphigus foliaceous: a novel perspective on disease pathogenesis.

Arch Dermatol Res

July 2024

Research Laboratory LR18/SP12 Auto-Immunity, Cancer and Immunogenetics, Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Several auto-immune diseases have been linked to vitamin D deficiency as a contributing environmental factor. Its pleiotropic effects on the immune system, especially its essential role in maintaining immune tolerance, make the vitamin D pathway of great interest. In this study, we focused on Pemphigus foliaceous (PF) in Tunisian population.

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Objective: Surgery is the mainstay of hepatic cystic echinococcosis (HCE). The conservative surgery of HCE carries a non-negligible risk of recurrence and significant morbidity, dominated by Deep Surgical Site Infections (DSSI). To address these issues, we have improved and standardized this technique, which could reduce complications and achieve better postoperative outcomes.

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CD4+ T-cell Subsets and Cytokine Signature in Pemphigus Foliaceus Clinical Stratification beyond the th1/Th2 Paradigm.

Curr Mol Med

June 2024

"Autoimmunity, Cancer and Immunogenetics" research laboratory [LR18SP12], Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Background: T helper interplay and cytokines monitoring in auto-immune skin disorders such as Pemphigus Foliaceus [PF] may play a central role in predicting the clinical stratification of the pathology.

Objectives: In order to assess the CD4+ T cell imbalance, [i] this study aims to assess the related immune cells [Th1, Th2, Th17, and Treg cells] as well as the related cytokines [IL-1β, IFNγ, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-17F, IL- 22, TNF-β, and TNFα] in peripheral blood, and [ii] their respective transcription factors in the lesioned skin of PF endemic patients during the clinical course.

Methods: Peripheral blood of 22 PF patients was analyzed by flow cytometry to assess the functional associations of Th cell subpopulations and their characteristic cytokines by multiplex bead assay of 14-plex cytokines.

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Unraveling the role of the vitamin D-VDR pathway in pemphigus vulgaris from Tunisian patients.

Steroids

September 2024

Research Laboratoy LR18/SP12 "Autoimmunity, Cancer And Immunogenetics", Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Vitamin D dysregulation has been recognized as a factor that may cause or aggravate autoimmunity. Vitamin D deficiency was found to be common in pemphigus vulgaris (PV) in different populations. This study aimed to investigate the vitamin D-VDR pathway in PV in the Tunisian population.

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Histology is the most widely used test to detect . PCR is less used but allows the detection of both infection and antibiotics' resistance. We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histology in the detection of infection compared with PCR.

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Bladder metastasis of gastric adenocarcinoma is a rare phenomenon. Hereby, we report a case of a 52-year-old patient who presented with upper gastro-intestinal bleeding and ascites and was diagnosed with gastric signet-ring cell carcinoma. A CT scan revealed peritoneal infiltration and anterior parietal thickening of bladder wall.

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Congenital crico-thyroid dysplasia: a comprehensive description.

Eur Arch Otorhinolaryngol

August 2024

Faculty of Medicine of Sfax, Otolaryngology- Head and Neck Surgery Department and Research Laboratory LR23ES01, Habib Bourguiba Hospital, 3029, Sfax, Tunisia.

Introduction: We describe a first case of human congenital crico-thyroid dysplasia associated to a right sided aortic arch and an aberrant subclavian artery.

Case Presentation: Our patient presented with a two-weeks history of acute dyspnea, and reported hoarseness since his childhood. An urgent tracheotomy was performed, followed by direct laryngoscopy.

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