482 results match your criteria: "Ha'Emek Medical Center[Affiliation]"

Objective: The present conflict in Israel has led to a surge in cases of acute stress disorder (ASD). The study examined a training program for integrative medicine (IM) providers working in supportive and palliative care settings, teaching clinical skills for treating ASD.

Methods: A 10-h online training program, designed by supportive care trained IM and mental health professionals was attended by a group of 32 IM providers.

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Study Objective: The study examined a training program for integrative medicine (IM) providers, teaching clinical skills for treating acute stress disorder (ASD).

Methods: A 10-h online training program, designed by IM and mental health professionals, was attended by a group of 32 IM providers working in supportive and palliative oncology care. Pre- and post-course questionnaires assessed self-perceived levels of IM and mental health ASD-related skills (from 1, very low; to 7, very high).

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The natural course of newborns with transient congenital hypothyroidism.

Endocr Connect

December 2024

The Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Objectives: The incidence of congenital hypothyroidism (CH) has increased worldwide over the last decades, mainly due to the lowering of screening thresholds, resulting in the increased identification of newborns with transient CH. Several studies have reported the prevalence and the predictive parameters of transient CH, but reports on the long-term outcome are rare. This study aimed to assess the long-term course of neonates with transient CH.

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  • The study investigates the role of Aeromonas spp. in gastroenteritis, noting its controversial status due to differing symptoms and prevalence in symptomatic versus asymptomatic patients.
  • Conducted in Northern Israel, it found that 4.24%-4.81% of patients with Aeromonas-associated gastroenteritis (AAG) and 4.9% of asymptomatic individuals had Aeromonas in their stools, raising questions about its pathogenicity.
  • Compared to Campylobacter-associated gastroenteritis (CAG) patients, AAG patients experienced significantly less severe symptoms, and certain factors like recent dining out and longer diarrhea were identified as predictors for AAG.
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  • * A study analyzing 2,779 cervical spines from individuals who died between 1912-1938 found a 5% prevalence of OB, more common in women, White Americans, and older adults, particularly affecting C3-C4, C2-C3, and C5-C6 segments.
  • * The findings emphasize the need for more accurate diagnostic criteria considering modern lifestyle factors that may influence spine health, as well as the
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Insights into Central Congenital Hypothyroidism: A Multicenter Retrospective Analysis.

J Clin Endocrinol Metab

July 2024

Consulting Endocrine Unit, Clalit Health Services, Afula, Israel.

Context: Central congenital hypothyroidism (CCH) is a thyroid hormone deficiency at birth caused by inadequate pituitary stimulation of the thyroid gland. Although primary CH has been studied extensively, studies on CCH are sparse.

Objectives: To assess the prevalence of CCH in Israel and describe its clinical features, neonatal screening results, and outcomes.

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Upper gastrointestinal (UGI) symptoms are very common in the general adult population. Dysphagia, heartburn, regurgitation and non-cardiac chest pain are the most common signs. The clinical approach in managing these symptoms starts with upper GI endoscopy in order to exclude inflammatory, neoplastic and fibrotic disorders that involve the esophagus.

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Cancer is a consequence of stochastic (mutations, genetic, and epigenetic instabilities) and deterministic (evolutionary bottlenecks) events. Stochastic events are less amenable to prediction, whereas deterministic events yield more predictable results. The relative contribution of these opposing forces determines cancer predictability, which affects the accuracy of our prognostic predictions and is critical for treatment planning.

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  • The study aimed to determine the best dose of selinexor when combined with pomalidomide and dexamethasone for patients with relapsed/refractory multiple myeloma (RRMM).
  • In trials, two doses (40 mg and 60 mg) were assessed, showing overall response rates of 50% and 65%, respectively, with better long-term responses seen in the lower dose group (SPd-40).
  • The SPd-40 regimen demonstrated a more favorable risk-benefit profile compared to SPd-60, indicating it may be the optimal dose due to its efficacy and tolerability.
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Culprit Lesion Coronary Intervention Before Complete Angiography in ST-Elevation Myocardial Infarction: A Randomized Clinical Trial.

JAMA Netw Open

March 2024

Jesselson Integrated Heart Center, The Eisenberg R&D Authority, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Importance: Rapid reperfusion during primary percutaneous coronary intervention (PCI) is associated with improved outcomes among patients with ST-elevation myocardial infarction (STEMI). Although attempts at reducing the time from STEMI diagnosis to arrival at the catheterization laboratory have been widely investigated, intraprocedural strategies aimed at reducing the time to reperfusion are lacking.

Objective: To evaluate the effect of culprit lesion PCI before complete diagnostic coronary angiography (CAG) vs complete CAG followed by culprit lesion PCI on reperfusion times among patients with STEMI.

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[ACUTE OTITIS MEDIA BACTERIOLOGY IN CHILDREN YOUNGER THAN THREE MONTHS IN THE LAST 16 YEARS].

Harefuah

November 2023

Unit of Otoneurology, Lin and Carmel Medical Centers, Haifa, Israel, Department of Communication Science and Disorders, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Background: Only scant information is available regarding the bacteriology of acute otitis media (AOM) in neonates.

Objectives: To investigate the bacteriology of AOM post the introduction of Pneumococcal Conjugate Vaccine (PCV13) in children younger than 3 months and its relation to the mode of delivery.

Methods: Retrospective bacteriological analysis of middle ear fluids taken from children younger than 60 months suffering from AOM.

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Outcomes of Infants Who Are Febrile Aged 29-90 Days Discharged from the Emergency Department.

J Pediatr

December 2023

Pediatric Emergency Department, Ha'Emek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, Technion-Institute of Technology, Haifa, Israel. Electronic address:

Objective: To evaluate the characteristics and outcomes of infants aged 29-90 days who are febrile discharged from the pediatric emergency department (ED).

Study Design: This was a multicenter, retrospective cohort study of infants aged 29-90 days who visited any of the 7 Clalit Health Services pediatric EDs in Israel between January 1, 2019, and March 31, 2022. Infants who were febrile discharged from the ED after having blood and urine cultures taken were included.

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We present a large, multicenter, cohort study that aimed to assess bacterial infection rates among febrile infants up to 90 days old presenting to the pediatric emergency department with severe acute respiratory syndrome coronavirus 2 infection during 2021-2022 throughout successive variant waves. Overall, 417 febrile infants were included. Twenty-six infants (6.

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  • A real-world study assessed the benefit of adjuvant chemotherapy (CT) in early-stage breast cancer patients with a Recurrence Score (RS) of 26-30, using data from 534 patients.
  • The study found that, despite imbalances in risk factors between CT-treated and untreated groups, overall survival (OS) and distant recurrence-free survival (DRFS) were similar for N0 patients regardless of treatment.
  • In N1mi/N1 patients, while OS and DRFS were comparable between treatment groups, a notable difference in breast cancer-specific mortality (BCSM) was observed, indicating a potential benefit of CT for those patients.
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Introduction: Reducing the risk of renal scarring in infants with urinary tract infection (UTI) necessitates timely and effective administration of antimicrobial treatment. The Israeli Medical Association recommends the empirical use of gentamicin and ampicillin for febrile infants younger than 2 months with suspected UTI. We aimed to assess the prevalence of Extended Spectrum Beta-Lactamase (ESBL)-producing and gentamicin-resistant Gram-negative UTI among infants younger than 2 months.

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Introduction: The aim of this study is to identify factors that may predict the response of locally advanced rectal cancer tumors (LARC) to neoadjuvant chemoradiotherapy (CRT) and to evaluate the effect of circulating lymphocytes on pathological tumor response.

Methods: This retrospective study included neoadjuvant CRT-treated, LARC-diagnosed patients at the Rambam Health Care Campus in Haifa, Israel. CHAID analysis, t-test, χ test, and ROC curve analyses were performed to explore the association between pathological complete response (pCR) and several factors including patient demographics, tumor characteristics, type of treatment, and levels of circulating lymphocytes measured on a weekly basis.

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Early unplanned return visits to pediatric emergency departments in Israel during the SARS-CoV-2 pandemic.

Am J Emerg Med

June 2023

Pediatric Emergency Department, Ha'Emek Medical Center, Afula, Israel; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

Introduction: During the SARS-CoV-2 pandemic there was a considerable drop in the number of visits to Pediatric Emergency Departments (PED). Unplanned return visits (URV) might represent inadequate emergency care. We assessed the impact of the pandemic on early URV to PEDs in Israel.

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Urine soluble triggering receptor expressed on myeloid cells-1 is a novel biomarker for active lupus nephritis: a case-control study.

Clin Exp Rheumatol

May 2023

Laboratory of Inflammation Research, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Israel.

Objectives: To determine the value of plasma and urine sTREM-1 levels as a biomarker of lupus nephritis (LN) as well as extra-renal systemic lupus erythematosus (SLE).

Methods: Consecutive adult patients with SLE attending a tertiary lupus clinic in 2016-2018 were prospectively divided into 3 groups according to SLEDAI-2K and renal-SLEDAI scores: active renal lupus (ARL), active non-renal lupus (ANL), and inactive lupus (IL). Blood and spot urine samples from each group and matched healthy subjects were analysed by means of ELISA for plasma and urine sTREM-1 levels.

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  • - The study investigates how achalasia, a condition affecting the esophagus, presents differently between two ethnic groups: Israeli Arabs (IA) and Israeli Jews (IJ), with a focus on demographic, clinical, and medical findings.
  • - Results show that IA patients have more severe symptoms like esophageal dysphagia, chest pain, and a higher integrated relaxation pressure (IRP) on manometry tests, and they are diagnosed at a younger age compared to IJ patients.
  • - The findings suggest that ethnicity influences achalasia presentations and underline the need for further research into how genetic factors might play a role in this condition among diverse populations.
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Among the main metabolic pathways implicated in cancer cell proliferation are those of cholesterol and fatty acid synthesis, both of which are tightly regulated by sterol regulatory element-binding proteins (SREBPs). SREBPs are activated through specific cleavage by membrane-bound transcription factor protease 1 (MBTPS1), a serine protease that cleaves additional substrates (ATF6, BDNF, CREBs and somatostatin), some of which are also implicated in cell proliferation. The goal of this study was to determine whether MBTPS1 may serve as a master regulator in proliferation of colorectal cancer (CRC).

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Background: Few studies describe acute kidney injury (AKI) burden during paediatric cisplatin therapy and post-cisplatin kidney outcomes. We determined risk factors for and rate of (1) AKI during cisplatin therapy, (2) chronic kidney disease (CKD) and hypertension 2-6 months post-cisplatin, and (3) whether AKI is associated with 2-6-month outcomes.

Methods: This prospective cohort study enrolled children (aged < 18 years at cancer diagnosis) treated with cisplatin from twelve Canadian hospitals.

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