408 results match your criteria: "HUN-REN Research Centre for Natural Sciences; gergely.rona@nyulangone.org.[Affiliation]"
Sci Transl Med
January 2025
Synthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre Szeged, Szeged HU-6726, Hungary.
Several antibiotic candidates are in development against Gram-positive bacterial pathogens, but their long-term utility is unclear. To investigate this issue, we studied the laboratory evolution of resistance to antibiotics that have not yet reached the market. We found that, with the exception of compound SCH79797, antibiotic resistance generally readily evolves in .
View Article and Find Full Text PDFSensors (Basel)
December 2024
Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, H-1083 Budapest, Hungary.
The aim of this work is to incorporate lanthanide-cored upconversion nanoparticles (UCNP) into the surface of microengineered biomedical implants to create a spatially controlled and optically releasable model drug delivery device in an integrated fashion. Our approach enables silicone-based microelectrocorticography (ECoG) implants holding platinum/iridium recording sites to serve as a stable host of UCNPs. Nanoparticles excitable in the near-infrared (lower energy) regime and emitting visible (higher energy) light are utilized in a study.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Proteomics Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Vulnerable atherosclerotic plaques, especially hemorrhaged lesions, are the major cause of mortalities related to vascular pathologies. The early identification of vulnerable plaques helps to stratify patients at risk of developing acute vascular events. In this study, proteomics analyses of human carotid artery samples collected from patients with atheromatous plaques and complicated lesions, respectively, as well as from healthy controls were performed.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Research Group of Organic Synthesis and Catalysis, University of Pannonia, Egyetem u. 10, 8200 Veszprém, Hungary.
In the present study, synthesis, conformational behavior, host-guest complex formation, and electrochemical properties of novel 6-substituted-2-ureido-4-ferrocenylpyrimidines were explored. A comprehensive NMR spectroscopic investigation was carried out to confirm the structure and conformational equilibrium of the ureidopyrimidines through studying the temperature- and concentration dependence of NMR spectra. Low-temperature NMR measurements were used to clarify structural changes inflicted by a 2,6-diaminopyridine guest.
View Article and Find Full Text PDFEntropy (Basel)
December 2024
Institute for Radiation Physics, Helmholtz-Zentrum Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden, Germany.
We present a synchronization transition study of the locally coupled Kuramoto model on extremely large graphs. We compare regular 405 and 1004 lattice results with those of 12,0002 lattice substrates with power-law decaying long links (ll). The latter heterogeneous network exhibits ds>4 spectral dimensions.
View Article and Find Full Text PDFBrain Sci
December 2024
Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter utca 50/a, 1083 Budapest, Hungary.
: Accurately classifying Electroencephalography (EEG) signals is essential for the effective operation of Brain-Computer Interfaces (BCI), which is needed for reliable neurorehabilitation applications. However, many factors in the processing pipeline can influence classification performance. The objective of this study is to assess the effects of different processing steps on classification accuracy in EEG-based BCI systems.
View Article and Find Full Text PDFFront Hum Neurosci
December 2024
Institute of Cognitive Neuroscience and Psychology, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.
[This corrects the article DOI: 10.3389/fnhum.2024.
View Article and Find Full Text PDFACS Omega
December 2024
Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, 1111 Budapest, Hungary.
The complex formation of the cationic stilbene-type photoswitch CP with the anionic macrocycles carboxylato-pillar[5]arene (WP5) and carboxylato-pillar[6]arene (WP6) has been investigated in aqueous solution by optical spectroscopic, NMR and isothermal calorimetric experiments and theoretical calculations. Subsequently, the photoisomerization reactions of the supramolecular complexes formed have been studied. CP consists of a 7-diethylamino-coumarin fluorophore and an -methylpyridinium unit, which are connected via an ethene bridge.
View Article and Find Full Text PDFACS Omega
December 2024
HUN-REN Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Magyar Tudósok Körútja 2, 1117 Budapest, Hungary.
Lithium phosphorus oxynitride (LiPON) is a crucial electrolyte for all-solid-state thin-film batteries due to its sufficient ionic conductivity. Understanding the mechanical behavior of LiPON films is crucial for further technological development. Previous studies noted unexpected ductility and strain recovery in amorphous LiPON during sharp-ended tip indentations revealing pile-up formation and densification as the main deformation mechanisms.
View Article and Find Full Text PDFGlob Chang Biol
January 2025
School of Biological Sciences, The University of Hong Kong, Hong Kong, China.
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e.
View Article and Find Full Text PDFPLoS One
January 2025
Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.
Nat Commun
January 2025
Institute for Medical Physics and Biophysics, Leipzig University, Medical Faculty, Leipzig, Germany.
The GPCR autoproteolysis inducing (GAIN) domain is an ancient protein fold ubiquitous in adhesion G protein-coupled receptors (aGPCR). It contains a tethered agonist necessary and sufficient for receptor activation. The GAIN domain is a hotspot for pathological mutations.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Microelectronics, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, The Netherlands.
Silicon integrated circuits (ICs) are central to the next-generation miniature active neural implants, whether packaged in soft polymers for flexible bioelectronics or implanted as bare die for neural probes. These emerging applications bring the IC closer to the corrosive body environment, raising reliability concerns, particularly for chronic use. Here, we evaluate the inherent hermeticity of bare die ICs, and examine the potential of polydimethylsiloxane (PDMS), a moisture-permeable elastomer, as a standalone encapsulation material.
View Article and Find Full Text PDFLangmuir
January 2025
Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3, 1111 Budapest, Hungary.
During the experimental formation of sol-gel coatings, the colloid dispersions go through a drying process, and the structure of the coatings is formed as a result of complex chemical, colloidal, and capillary interactions. While computer simulations provide guidelines to tune and even design the nanomaterials synthesis, simulations of coating structure formation are hitherto unknown in the literature. Based on real experiments, we establish here a ReaxFF reactive force field-based molecular dynamics simulation protocol in order to investigate and determine the role of the experimental conditions on the pore structure formation in the coatings.
View Article and Find Full Text PDFSci Rep
December 2024
MTA-DE "Momentum" Ecology, Evolution & Developmental Biology Research Group, Dept. of Evolutionary Zoology, University of Debrecen, Debrecen, Hungary.
The objective to study the influence of microbiome on host fitness is frequently constrained by spatial and temporal variability of microbial communities. In particular, the environment serves as a dynamic reservoir of microbes that provides potential colonizers for animal microbiomes. In this study, we analyzed the microbiome of Hydra oligactis and corresponding water samples from 15 Hungarian lakes to reveal the contribution of environmental microbiota on host microbiome.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Ecology, Faculty of Sciences, Institute of Biology, University of Pécs, Ifjúság útja 6, Pécs, 7624, Hungary.
The European pond turtle (Emys orbicularis) is a wide-ranging, long-living freshwater species with low reproductive success, mainly due to high predation pressure. We studied how habitat variables and predator communities in near-natural marshes affect the survival of turtle eggs and hatchlings. We followed the survival of artificial turtle nests placed in marshes along Lake Balaton (Hungary) in May and June as well as hatchlings (dummies) exposed in September.
View Article and Find Full Text PDFACS Appl Energy Mater
December 2024
Department of Chemical and Environmental Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest H-1111, Hungary.
Amphiphilic copolymers of comb-like poly(poly(ethylene glycol) methacrylate) (PPEGMA) with methyl methacrylate (MMA) synthesized by one-pot atom transfer radical polymerization were mixed with lithium bis (trifluoromethanesulfonyl) imide salt to formulate dry solid polymer electrolytes (DSPE) for semisolid-state Li-ion battery applications. The PEO-type side chain length (EO monomer's number) in the PEGMA macromonomer units was varied, and its influence on the mechanical and electrochemical characteristics was investigated. It was found that the copolymers, due to the presence of PMMA segments, possess viscoelastic behavior and less change in mechanical properties than a PEO homopolymer with 100 kDa molecular weight in the investigated temperature range.
View Article and Find Full Text PDFSci Rep
December 2024
Research Group for Implantable Microsystems, Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter utca 50/a, Budapest, 1083, Hungary.
Infrared neural stimulation has consistently shown that temperature is a critical neuronal state variable. However, a comprehensive understanding of the biophysical background is essential. In this study, using high-density laminar electrode recordings, we investigated the impact of pulsed and continuous-wave infrared illumination on cortical neurons in anesthetized rats ([Formula: see text]).
View Article and Find Full Text PDFChemistryOpen
December 2024
MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Center for Natural Sciences, H-1117, Budapest, Magyar tudósok krt. 2, Hungary.
Novel tetrahydroisoquinoline and piperidine derivatives were selectively synthesized from substituted indenes or cyclopentenes. The process starts with an oxidative cleavage of the ring olefin bond, which gives reactive diformyl intermediates. By a ring-closing step using chiral (R) or (S) α-methylbenzylamine under a reductive amination protocol facilitated ring formation with ring expansion of the corresponding nitrogen-containing heterocycles.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Organocatalysis Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest H-1117, Hungary.
The partial reduction of esters to aldehydes is a fundamentally important transformation for the synthesis of numerous fine chemicals and consumer goods. However, despite the many efforts, limitations have persisted, such as competing overreduction, low reproducibility, use of exigent reaction conditions and hazardous chemicals. Here, we report a novel catalyst family with a unique steric design which promotes the catalytic partial reduction of esters with unprecedented, near-perfect selectivity and efficiency.
View Article and Find Full Text PDFHum Brain Mapp
December 2024
Brain Imaging Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.
Age-related atrophy of the human hippocampus and the enthorinal cortex starts accelerating at around age 60. Due to the contributions of these regions to many cognitive functions seamlessly used in everyday life, this can heavily impact the lives of elderly people. The hippocampus is not a unitary structure, and mechanisms of its age-related decline appear to differentially affect its subfields.
View Article and Find Full Text PDFBMC Bioinformatics
December 2024
Albert Szent-Györgyi Health Centre, University of Szeged, Korányi fasor 14-15, Szeged, H-6725, Csongrád-Csanád, Hungary.
Background: Accurate prediction of copy number variations (CNVs) from targeted capture next-generation sequencing (NGS) data relies on effective normalization of read coverage profiles. The normalization process is particularly challenging due to hidden systemic biases such as GC bias, which can significantly affect the sensitivity and specificity of CNV detection. In many cases, the kit manifests provide only the genome coordinates of the targeted regions, and the exact bait design of the oligo capture baits is not available.
View Article and Find Full Text PDFJ Inorg Biochem
March 2025
Department of Molecular and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7-8, H-6720 Szeged, Hungary. Electronic address:
Schiff bases derived from aminoguanidine are extensively investigated for their structural versatility. The tridentate 2-formylpyridine guanylhydrazones act as analogues of 2-formyl or 2-acetylpyridine thiosemicarbazones, where the thioamide unit is replaced by the guanidyl group. Six derivatives of 2-formylpyridine guanylhydrazone were synthesized and their proton dissociation and complex formation processes with Cu(II), Fe(II) and Fe(III) ions were studied using pH-potentiometry, UV-visible, NMR and electron paramagnetic resonance spectroscopic methods.
View Article and Find Full Text PDFAmbio
December 2024
National Biodiversity Future Centre, Piazza Marina, 61, 90133, Palermo, Italy.
Balancing increasing demand for wood products while also maintaining forest biodiversity is a paramount challenge. Europe's Biodiversity and Forest Strategies for 2030 attempt to address this challenge. Together, they call for strict protection of 10% of land area, including all primary and old growth forests, increasing use of ecological forestry, and less reliance on monocultural plantations.
View Article and Find Full Text PDFSci Adv
December 2024
Institute of Archaeogenomics, HUN-REN Research Centre for the Humanities, Budapest, Hungary.