DIDACTIC CULTURE OF MEDICAL UNIVERSITY TEACHERS AND STUDENTS IN THE CONDITIONS OF WAR.

Objective: The aim: To analyse the essence of the concept of "didactic culture", to outline its structure, to describe the peculiarities of the development of the didactic culture of teachers and students in the conditions of war, to characterize the role of information technologies in its formation.

Patients And Methods: Materials and methods: A number of scientific methods were used in the research: a comparative-historical method to consider retrospectively the concept of didactic culture; bibliographic method to identify the existing source base; content analysis for analytical processing of literature; chronological method to analyse the study of didactic culture in a time sequence; structural and systemic analysis to clarify its specifics at different levels; comparative analysis to establish common and specific features in the system of didactic culture development in different countries; a questionnaire method for studying students' opinions about the structure of speech culture as a component of didactic culture; a method of generalization and specification that contributes to the formulation of conclusions and recommendations on the didactic culture development.

Conclusion: Conclusions: The didactic culture is considered as a socio-pedagogical phenomenon and an important component of professional and pedagogical culture.

CURRENT PROBLEMS IN COMMUNICATIVE DEVELOPMENT OF CHILDREN WITH SPECIAL EDUCATIONAL NEEDS: UKRAINIAN AND EUROPEAN SCIENTIFIC CONTEXTS.

Objective: The aim is to analyze the current problems in communicative development of children with special educational needs.

Patients And Methods: Materials and methods: The research used a number of scientific methods: general scientific (analysis, synthesis, generalization), historical, specific research, comparative-historical, and others, which ensured the selection and analysis of the source base, made it possible to determine the general trends in the study of the problem of the communicative development of the child, the achievements of Ukrainian and foreign scientists in the field of research on the language of children with special educational needs, to distinguish the common and the different in the scientific research of scientists.

Conclusion: Conclusions: Updated studies of scientists from Ukraine, Poland, Sweden, Britain and other countries testify that communication skills are key in the language development of a preschool child, they form the basis without which the child's further education, socialization, etc.

Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population.

Over the past four decades, the prevalence of obesity has tripled and limited genetic studies with specific SNPs have been conducted, but no investigations using ghrelin and obestatin prepropeptide (GHRL) gene have been reported in the Ukrainians population. The aim of this study was to evaluate changes in the level of metabolic hormones in the blood of obese patients in relation to the GHRL (rs696217) polymorphism. The study involved 53 obesity cases and 48 non-obesity subjects (controls).

Effects of metformin on the gut microbiota: A systematic review.

Background: The gut microbiota is increasingly recognized as a crucial factor in human health and disease. Metformin, a commonly prescribed medication for type 2 diabetes, has been studied for its potential impact on the gut microbiota in preclinical models. However, the effects of metformin on the gut microbiota in humans remain uncertain.

Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis.

Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated with MAFLD, previously recognized as non-alcoholic fatty liver disease (NAFLD), and their potential influence on COVID-19 outcomes. Various genetic polymorphisms, including PNPLA3 (rs738409), GCKR (rs780094), TM6SF2 (rs58542926), and LYPLAL1 (rs12137855), have been investigated in relation to MAFLD susceptibility and progression.

The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues.

An important feature of the functioning of the organs and tissues of the oral cavity is the fact that all processes that take place in it are carried out in the constant presence of various microorganisms that cause the development of pathological processes in the body or are associated with them. In the pathogenesis of chronic generalized periodontitis, dental plaque penetrates the bottom of the gingival sulcus, penetrating under the epithelium into the stroma of the connective tissue, causing its inflammation. Bacteria produce a number of toxic substances that have a toxic effect on surrounding tissues.

RATIONALE FOR THE APPLICATION OF CALCITONIN LEVEL IN THE EARLY POSTOPERATIVE PERIOD TO EVALUATE THE EFFECTIVENESS OF SURGICAL TREATMENT OF MEDULLARY THYROID CANCER.

Purpose: To determine the effectiveness of the basal calcitonin (CTb) determination in the early postoperative period to predict the possible recurrence (persistence) of medullary thyroid cancer (MTC).

Material And Methods: A retrospective study of the treatment results in 194 patients with MTC (148 (76.3%) primary - group 1 and 46 (23.

Variable CD18 expression in a 22-year-old female with leukocyte adhesion deficiency I: Clinical case and literature review.

Key Clinical Message: Partial leukocyte adhesion deficiency type 1 (LAD-1) deficiency is extremely rare condition with milder infectious manifestation and immune system imbalance leads to increased risks of autoinflammatory complications, such as pyoderma gangrenosum, that can be triggered by trauma or pregnancy. In patients with spice-site ITGB2 variants, partial expression can occur due to different β2 integrin isophorms expression.

Abstract: LAD-1, OMIM ID #116920 is a rare, autosomal recessive disorder that results from mutations in the gene that encodes the CD18 β2 integrin subunit.

MAINTAINING COMPETITIVE ACTIVITY IN ELITE SPORTS WITH ACUTE PLANTAR FASCIITIS.

Competition in the modern pentathlon in the new 2024 Olympic program are tense and high intensity. Before reaching the final the athlete must go through 8 types of events in 4 days performs before 5 events in final competitions. It's quit difficult to restore the function of damaged link of the musculoskeletal system during competition in a short time.

CLINICAL SIGNS AND QUALITY OF LIFE ANALYSIS IN THE PATIENTS WITH HYPOTHYREOSIS AND CHRONIC PANCREATITIS.

Objective: Aim: To analyze the clinical condition and evaluate the quality of life of patients with a comorbid course of Ht and CP and patients with isolated CP based on the results of testing according to the GSRS and SF-36 questionnaires.

Patients And Methods: Materials and methods: Were examined 62 patients with comorbid course of Ht and CP. The comparison group consisted of 48 people with isolated CP, the control group consisted of 30 healthy people, comparable in age and sex.

THE ROLE OF ENDOTOXICOSIS AND INFLAMMATION IN DEEPENING THE PANCREATIC FUNCTIONAL INSUFFICIENCY IN CHRONIC PANCREATITIS IN COMBINATION WITH TYPE 2 DIABETES.

Objective: Aim: To analyze the state of parameters of inflammation, endotoxicosis, and their influence on the functional capacity of the pancreas in the comorbid course of chronic pancreatitis and type 2 diabetes mellitus (DM2).

Patients And Methods: Materials and methods: 115 patients with CP in the phase of mild therapeutic exacerbation in combination with DM2 in the stage of subcompensation were examined. To assess the impact of comorbid DM2 on the clinical condition of patients with CP, a comparison group of 25 patients with CP in the exacerbation phase was included in the study.

Medicinal Plant-derived Phytochemicals in Detoxification.

The average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of life in aged patients and an excessive accumulation of various toxic compounds in the human body during life. Today, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body.

Hypothalamic astrocytic-BMAL1 regulates energy homeostasis in a sex-dependent manner.

Here, we demonstrate that hypothalamic astrocytic BMAL1 computes cyclic metabolic information to optimize energetic resources in a sexually dimorphic manner. Knockdown of BMAL1 in female astrocytes leads to negative energy balance and alters basal metabolic cycles without affecting circadian locomotor activity. Thus, astrocytic BMAL1 contributes to the control of energy balance through the modulation of the metabolic rate, hepatic and white adipose tissue lipogenesis, and the activity of brown adipose tissue.

Diagnostic challenge of tuberculosis in systemic lupus erythematosus: a case report and literature review.

Patients with systemic lupus erythematosus (SLE) are at increased risk of tuberculosis (TB) infection due to immune dysfunction and immunosuppressive therapy. We present a case study of a 40-year-old woman with systemic lupus erythematosus (SLE). Initially, she was diagnosed with a lupus flare based on her clinical symptoms and laboratory results.

The Role of Lyophilized Xenodermotransplants in Repairing the Atria's Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment.

The effects of severe burn injuries on the cardiovascular system, specifically the atria and auricles of the heart, were investigated. The potential benefits of using lyophilized xenodermotransplants as a treatment option were also evaluated. The experiments were conducted on adult guinea pigs divided into three groups: intact animals, animals with burns, and animals with burns who underwent early necrectomy followed by wound closure with lyophilized xenodermotransplants.

Metabolic, Apoptotic and Fibro-Inflammatory Profiles of the Heart Exposed to Environmental Electromagnetic Fields.

Environmental stress can disturb the integrative functioning of the cardiovascular system and trigger a number of adaptive and/or maladaptive cell responses. Concomitant with the expanding use of mobile communication systems, public exposure to electromagnetic fields (EMFs) raises the question of the impact of 900 MHz EMFs on cardiovascular health. Therefore, in this study, we experimentally investigated whether 915 MHz EMF exposure influenced cardiac metabolic, antioxidant, apoptotic, and fibro-inflammatory profiles in a mouse model.

Identifying risk factors and disease severity in leptospirosis: A meta-analysis of clinical predictors.

Leptospirosis is a bacterial zoonosis with a wide spectrum of clinical presentations. In order to identify potential risk factors and predictors of disease severity, a meta-analysis of the clinical features of severe and non-severe leptospirosis patients was conducted. PubMed was searched to collect studies on the difference in clinical characteristics of severe and nonsevere patients, and data were analyzed using Comprehensive Meta-Analysis V3 software.

Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study.

Background: Components of the metabolic syndrome are more common in patients with Turner syndrome (TS) than in the general population. Long-term growth hormone (GH) treatment also affects the parameters of carbohydrate metabolism. Therefore, all these factors should be monitored in girls with TS.

EMOTIONAL INTELLIGENCE AS A FACTOR IN STRENGTHENING THE STUDENTS' MENTAL HEALTH DURING THE COVID-19 PANDEMIC.

Objective: The aim of the article is to reveal the potential of Emotional Intelligence (EI) as a factor in strengthening the students' mental health (MH) during and after the COVID-19 pandemic.

Patients And Methods: Materials and methods: The experimental work was carried out in four stages: 1) preparation - substantiation of its scientific and theoretical principles; 2) ascertaining - development of prognostic tools, conducting an on-line survey of students, an analysis of its results; 3) formative - training with the experimental group participants following the author's methodology; 4) control - survey of experimental group members, determination of experimental results. About 230 students of Ukraine took part in the survey.

Potential Drugs in COVID-19 Management.

The SARS-CoV-2 virus first emerged in China in December 2019 and quickly spread worldwide. Despite the absence of a vaccination or authorized drug specifically developed to combat this infection, certain medications recommended for other diseases have shown potential effectiveness in treating COVID-19, although without definitive confirmation. This review aims to evaluate the existing literature on the efficacy of these medications against COVID-19.

Infectious diseases during the Russian-Ukrainian war - Morbidity in the Transcarpathian region as a marker of epidemic danger on the EU border.

•The Transcarpathian region in Ukraine has received over 350,000 Internally Displaced Persons (IDPs) since the beginning of the invasion, making the region vulnerable to outbreaks of communicable diseases.•The coverage of vital vaccination programs has been substantially harmed since the invasion began, with many children displaced without documentation and their vaccination status unknown.•The conditions in which IDPs in Transcarpathia reside risk local outbreaks of infectious diseases and their transmission into EU countries, making it vital to continue supporting Ukrainian healthcare authorities on the pivotal issue of vaccination.

Spontaneous Recession Repair after Orthodontic Treatment: Case Report with the Use of Digital Approach for Quantification of Soft Tissue Changes.

The article presents a case of spontaneous recession repair in a male patient with Class II malocclusion, division 1, after orthodontic treatment with aligners. The difference in digital recession depth was measured before and at the end of treatment by means of automatic intraoral scans superimposition within adapted software while using "Cross section" and "Measuring" instruments. Digital analysis of intraoral scans obtained before and at the end of treatment has revealed that recessions within the area of teeth 1.

Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment.

The gut microbiota play a crucial role in maintaining host health and have a significant impact on human health and disease. In this study, we investigated the alpha diversity of gut microbiota in COVID-19 patients and analyzed the impact of COVID-19 variants, antibiotic treatment, type 2 diabetes (T2D), and metformin therapy on gut microbiota composition and diversity. We used a culture-based method to analyze the gut microbiota and calculated alpha-diversity using the Shannon H' and Simpson 1/D indices.