The association between vitamin D deficiency and metabolic syndrome in Ukrainian adolescents with overweight and obesity.

Purpose: This work aims to determine the association between vitamin D deficiency and metabolic syndrome in overweight and obese adolescents from Ukraine.

Methods: Anthropometric measurements were taken and general and biochemical examinations were performed on 136 obese and overweight adolescents and 60 adolescents with normal body weight. The vitamin D status was determined using 25-hydroxyvitamin D (25(OH)D) (calcidiol) levels in blood serum.

Chromatographic profiles and antimicrobial activity of the essential oils obtained from some species and cultivars of the tribe (.

The present study was focused on the chemical composition and antimicrobial activity of the essential oils (EsO) obtained from five representatives grown in the south of Ukraine. Among them are L. (cultivar 'Cambridge Scarlet'), (cultivar '2/6-07') (cultivar 'Jalos') and L.

EFFECT OF XENOGRAFTS SATURATED WITH SILVERNANOCRYSTALS ON HISTOLOGICAL STRUCTURE OF THE SKIN IN THE DYNAMICS OF EXPERIMENTAL THERMAL INJURY.

The aim of this study was to establish histological state of the components of the affected area of skin in cases of application of xenograft saturated with silver nanocrystals in the dynamics after experimental thermal injury. The study was performed on 54 adult guinea pigs following the rules of bioethics. Experimental animals were divided into two groups: the 1st - animals with severe thermal injury (27); the 2nd - animals with burn injury (27), in which the wounds were covered with xenograft after early necrectomy of the damaged tissues.

[CLINICAL CHARACTERISTICS OF DISEASES OF THE ORAL MUCOSA IN PATIENTS WHO HAVE UNDERGONE COVID-19 - WHAT DOES A DENTIST NEED TO KNOW IN A PANDEMIC?].

ization and unification of diseases of the oral mucosa in patients who underwent Covid-19, in order to increase the effectiveness of qualified dental care for this group of people in a pandemic and create conditions for continuous professional development of dentists. 42 patients were attended, who came through Covid-19, aged 36 to 70 years, who applied independently or were referred by doctors of private clinics in the city of Ternopil. The gender distribution of patients was 19 males and 23 females.

COMPARATIVE EVALUATION OF HISTOTOXICITY INDICATORS OF METAL ALLOYS FOR THE MANUFACTURE OF METAL CERAMIC DENTAL CONSTRUCTIONS.

Objective: The aim: To carry out a comparative assessment of metal alloys for the manufacture of metal-ceramic constructions of dentures by determining the indicator of their histotoxicity.

Patients And Methods: Materials and methods: To identify the effect of metal alloys on cobalt and nickel bases on the tissue of organism, we carried out an experimental-morphological study of standard samples of metal alloys "Shot-alloy", "Remanium-2000", "Cerium", "Dent-NCB", "Cellite-N".

Results: Results: A careful histological analysis of the capsules formed around the metal alloy samples during two periods of the experiment showed that the healing time of the subcutaneous tissue was not the same.

AWARENESS OF FOLIC ACID USE AND ITS EFFECTS AMONG MEDICAL STUDENTS IN UKRAINE.

Objective: The aim: To evaluate the awareness of folic acid, its use and effects, general knowledge about neural tube defects among medical students in Ukraine.

Patients And Methods: Materials and methods: This cross-sectional survey was conducted by questioning 114 fourth and fifth years' students of the Faculty of Medicine. The questionnaire contained questions about folic acid, its dietary sources, effects and periconceptional uses; spina bifida and its main symptoms.

Diagnosis and management of pharyngitis in children: a survey study in Ukraine.

Introduction: The purpose of our study was to evaluate the knowledge of pediatricians in diagnosis and management of sore throat in children and to identify further ways to raise their awareness.

Methods: We conducted a survey among pediatricians on evaluation of diagnosis and management of pharyngitis in children. The study involved pediatricians of Ternopil region, Ukraine.

Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential.

The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious challenge for medicine and science. Analysis of the molecular mechanisms associated with the clinical manifestations and severity of COVID-19 has identified several key points of immune dysregulation observed in SARS-CoV-2 infection. For diabetic patients, factors including higher binding affinity and virus penetration, decreased virus clearance and decreased T cell function, increased susceptibility to hyperinflammation, and cytokine storm may make these patients susceptible to a more severe course of COVID-19 disease.

25-OH Vitamin D blood serum linkage with VDR gene polymorphism (rs2228570) in thyroid pathology patients in the West-Ukrainian population.

Vitamin D is known to alter immune regulation. It binds to the vitamin D receptors (VDR) expressed on T lymphocytes and macrophages. In individuals with Hashimoto's thyroiditis, serum vitamin D levels were found to be lower compared to healthy controls.

Chitosan self-assembled polymeric nanoparticles for percutaneous delivery of betamethasone in contact dermatitis.

Objective: The study was performed with an aim to investigate the efficiency of two treatment options in experimental nickel-induced contact dermatitis (CT), with either betamethasone or chitosan cross-linked nano-encapsulated betamethasone lanoline solutions (nano-betamethasone).

Methods: Male Wistar rats were used. The differences were compared based on lesion visual appearance, skinfold thickness, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), blood serum prooxidant-antioxidant balance (thiobarbituric acid reactive substances, TBARS; supersoxide dismutase, SOD; catalase, KAT), blood cytokine profile (TNF-α, IL-1β, IL-10, and IL-4), and histological examination of affected skin.

Interplay between reactive oxygen and nitrogen species in living organisms.

In living organisms most oxygen consumed is reduced to water via four-electron reduction. However, few percentages of oxygen are reduced by consecutive one electron mechanisms giving rise to superoxide anion radical, (O), hydrogen peroxide (HO) and hydroxyl radical (HO) and their derivatives collectively called reactive oxygen species (ROS). Nitric oxide (NO) is produced at oxidation of arginine by nitric oxide synthase (NOS) or at reduction of nitrites by diverse reductases.

Chamomile as a potential remedy for obesity and metabolic syndrome.

Obesity is an increasing health concern related to many metabolic disorders, including metabolic syndrome, diabetes type 2 and cardiovascular diseases. Many studies suggest that herbal products can be useful dietary supplements for weight management due to the presence of numerous biologically active compounds, including antioxidant polyphenols that can counteract obesity-related oxidative stress. In this review we focus on , commonly known as chamomile, and one of the most popular medicinal plants in the world.

Environmental concentrations of Roundup in combination with chlorpromazine or heating causes biochemical disturbances in the bivalve mollusc Unio tumidus.

Bivalve molluscs represent the most recognized bioindicators of freshwater pollution. However, their ability to indicate specific xenobiotics in complex exposures is unclear. In this study, we aimed to track the particular effects of the pesticide Roundup (Rnd) and the antipsychotic drug chlorpromazine (Cpz) on the mussel Unio tumidus at the simpler environmentally relevant models.

Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases.

Due to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology applications used to enhance CUR bioavailability and its targeted delivery in specific pathological conditions are collected and discussed.

COVID-19 in patients with juvenile idiopathic arthritis: frequency and severity.

The aim of the study was to determine the frequency and the course of COVID-19 infection in children with juvenile idiopathic arthritis (JIA). The study involved 51 patients with JIA aged 2 to 18 years. Evidence of COVID-19 was found in 10 (19.

THE RESULTS OF THE STUDY OF THE EPIDEMIOLOGICAL STATUS AND SPREAD OF DERMACENTOR RETICULATUS TICKS IN UKRAINE OVER THE LAST 10 YEARS.

Objective: The aim: To analyze the study of the D. reticulatus ticks epidemiology and to carry out their own examinations of ticks for their infection with pathogens of infectious diseases.

Patients And Methods: Materials and methods: Identification of ticks was performed by an optoelectronic SEO system - IMAGLAB.

EVALUATION OF EFFICACY OF EXTRACORPOREAL SHOCK WAVE THERAPY IN COMPLEX TREATMENT OF PATIENTS WITH CHRONIC NON-BACTERIAL PROSTATITIS / CHRONIC PELVIC PAIN SYNDROME.

Objective: The aim: Study of hemodynamics of the prostate and evaluation of the ef f ectiveness of extracorporeal shock wave therapy (ESWT) in the complex treatment of patients with chronic prostatitis with non-inf l ammatory chronic pelvic pain syndrome (NCPPS), (NIH III B).

Patients And Methods: Materials and methods: There were 63 patients with NCPPS aged 29 to 45 years, with a disease duration of more than 3 years and low ef f i cacy of treatment against the background of standard therapy. All patients received standard therapy according to the clinical protocol.

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. White male 12-14 weeks old inbred rats (n=48) weighing 180-200 g were employed in the experiment. They were randomly divided into the following groups: Group I - control group, Group II - group with a model of periodontitis, Group III - group with a periodontitis in a setting of hyperthyroidism, and Group IV - group with periodontitis in a setting of hypothyroidism.

Metformin Attenuates Postinfarction Myocardial Fibrosis and Inflammation in Mice.

Diabetes is a major risk factor for the development of cardiovascular disease with a higher incidence of myocardial infarction. This study explores the role of metformin, a first-line antihyperglycemic agent, in postinfarction fibrotic and inflammatory remodeling in mice. Three-month-old C57BI/6J mice were submitted to 30 min cardiac ischemia followed by reperfusion for 14 days.

Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction.

This review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds. Properties and advantages of monolithic silica HPLC columns are also highlighted in comparison to conventional particle-packed, fused-core, and sub-2-µm HPLC columns. Nano-LC capillary monolithic silica columns as well as polymeric-based and hybrid-based monolithic columns are also demonstrated to show good enantioresolution abilities.

Comparative assessment of the state of bone resorption in patients with chronic generalized periodontitis according to orthopantomogram and cone-beam computed tomography.

Aim: The aim of the study was to assess bone resorption in patients with chronic generalized periodontitis according to orthopantomogram (OP) and cone-beam computed tomography (CBCT) and substantiate which of these methods is the most appropriate for use.

Materials And Methods: In order to compare the objectivity of the results of examining the periodontal bone tissue by the above methods (panoramic radiography and computed tomography), we analyzed 26 panoramic radiographs and computed tomograms of the same patients, performed on a PICASSO (3D) computed tomograph by «Vatech».

Results: Comparison of CBCT and OP data in patients with periodontal tissue disease showed a significant difference between the indicators of bone tissue resorption in the mesiodistal direction, and revealed that the volumetric image is significantly objective X-ray picture in periodontal diseases by identifying the state (resorption) of the vestibular and oral cortical plates in any section dentition.

Analysis of patients' rehabilitation results after surgical treatment of diabetes complications.

Unlabelled: The results of treatment of patients with diabetic foot syndrome (DFS) remain unsatisfactory, 34% of patients have another wound defect in the foot within 1 year, and the recurrence rate within 5 years is 70%.

Aim: The aim of the study was to determine the indicators of physical capabilities and self-care of patients after organ-sparing surgery due to DFS.

Materials And Methods: 6-12 months after discharge from the surgical hospital, all patients were sent questionnaires of the functional scale of the lower extremities.

COMPERATIVE STRUCTURE OF MUCOSA COAT OF THE PIG`S AND THE HUMAN`S RECTUM.

Objective: The aim: To determine whether the pig could be used as biomodel for study and reconstruction of rectal pathology for development the new approaches for prevention and treatment of rectal diseases.

Patients And Methods: Materials and methods: For the research the rectum of 8 vietnamese pot-bellied pigs were used. Via macro- and microscopy the structure of mucosa coat of the pig`s and human`s rectum was compared.

, , ASSOСIATION BETWEEN VITAMIN D STATUS AND METABOLIC DISORDERS IN PREMENOPAUSAL WOMEN WITH AUTOIMMUNE HYPOTHYROID DISEASE.

Objective: The aim: Is to establish a relationship between serum vitamin D level with carbohydrate and lipid indexes in women with autoimmune hypothyroid disease.

Patients And Methods: Materials and methods: 146 women with autoimmune hypothyroid disease were examined in the period 2017-2019, who signed the informed consent. The mean age of women was 43.

TREC/KREC levels in children with ataxia-telangiectasia.

The aim of the study was to determine the TREC/KREC levels in the patients diagnosed with ataxia-telangiectasia (AT) and to establish their informative value for early diagnosis of this pathology. TRECs and KREC assay was performed using real-time polymerase chain reaction on the DNA of 25 patients diagnosed with AT aged 3 to 14 years and of 173 healthy individuals of the control group aged 1 to 12 years. Clinical and laboratory characteristics of patients were ascertained using their medical records.