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Frequency of mitochondrial m.1555A > G mutation in Syrian patients with non-syndromic hearing impairment.
BMC Ear Nose Throat Disord
May 2018
University, HNO -universities Klink-Tubingen, Tubingen, Germany.
Article Synopsis
- Mitochondrial mutations causing hearing impairment (HI) are rising in frequency, particularly the m.1555A > G mutation linked to non-syndromic deafness and aminoglycoside-induced HI.
- A study of 337 subjects from 54 Syrian families revealed the m.1555A > G mutation in only 1.85% of families and 4.5% of hereditary deafness patients.
- The findings highlight the mutation's diagnostic importance in Syrian populations and suggest testing before aminoglycoside treatment for at-risk individuals.