1,539 results match your criteria: "HIV-1 Encephalopathy and AIDS Dementia Complex"
Metab Brain Dis
November 2024
Department of Virology and Biotechnology, ICMR-National Institute for Research in Tuberculosis, Chennai, 600031, India.
Life Sci Alliance
February 2025
https://ror.org/00y4zzh67 School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA
Results Probl Cell Differ
October 2024
Department of Neurobiology, The University of Texas Medical Branch (UTMB), Galveston, TX, USA.
PLoS Pathog
September 2024
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ageing Res Rev
December 2024
Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:
J Acquir Immune Defic Syndr
October 2024
Department of Medical Sciences, Unit of Infectious Diseases, University of Turin, Turin, Italy.
Adv Neurobiol
August 2024
Center for Neurotherapeutics Discovery, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
J Pharmacol Exp Ther
September 2024
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota (A.N.E., A.P., S.M.G., S.A.T.); and Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota (S.D.H., C.K.-M., E.K.-M.)
J Neurovirol
June 2024
Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
J Neurovirol
June 2024
Medical Research Center, Affiliated Hospital 2 of Nantong University, No. 666, Shengli Road, Nantong, 226001, Jiangsu, People's Republic of China.
Front Immunol
June 2024
Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Background: Human immunodeficiency virus (HIV) affects nearly 40 million people globally, with roughly 80% of all people living with HIV receiving antiretroviral therapy. Antiretroviral treatment suppresses viral load in peripheral tissues but does not effectively penetrate the blood-brain barrier. Thus, viral reservoirs persist in the central nervous system and continue to produce low levels of inflammatory factors and early viral proteins, including the transactivator of transcription (Tat).
View Article and Find Full Text PDFInt J Mol Sci
April 2024
Department of Life Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA.
J Extracell Vesicles
April 2024
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
J Neurovirol
August 2024
Department of Microbiology, Immunology and Inflammation, Center for Neurovirology and Gene Editing, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Rev Med Virol
May 2024
Host-Pathogen Interactions Unit, Research Institute for Medicines, iMed-ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.
Int J Mol Sci
September 2023
NeuroEpigenetics Lab, Health Research Institute of Santiago de Compostela (IDIS), Santiago University Hospital Complex, 15706 Santiago de Compostela, Spain.
J Assoc Physicians India
June 2023
Professor, Department of Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, India.
Unlabelled: Human immunodeficiency viruses (HIV) associated neurocognitive disorders (HAND) encompasses a group of syndromes of various degrees of impairment in cognition and daily functioning of HIV positive individuals. Although the widespread use of highly active antiretroviral therapy (HAART) has drastically reduced the prevalence of severe form of HAND, like HIV associated dementia (HAD), the prevalence of HAND and associated morbidity remains high.
Objectives: (1) To know the prevalence of HAND in HIV-infected patients of a multi-ethnic population.
Sci Rep
February 2023
Department of Health and Biomedical Sciences, University of Texas Rio Grande Valley, One West University Blvd, Brownsville, TX, 78520, USA.
The United Nations projects that one in every six people will be over the age of 65 by the year 2050. With a rapidly aging population, the risk of Alzheimer's disease (AD) becomes a major concern. AD is a multifactorial disease that involves neurodegeneration in the brain with mild dementia and deficits in memory and other cognitive domains.
View Article and Find Full Text PDFViruses
December 2022
Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 410013, China.
Human immunodeficiency virus-1 (HIV-1)-associated neurodegenerative disorder (HAND) is frequently reported in HIV-infected individuals. The gp120 envelope viral protein has been implicated in the pathogenesis of HAND in HIV-1-infected patients; however, its pathogenic mechanism remains unclear. In this study, we first overexpressed gp120 proteins in pc12 cells and used PI staining, a CCK8 assay, a TUNEL assay, and caspase-9/caspase-3-induced apoptosis to ascertain the mediated cell death.
View Article and Find Full Text PDFJ Acquir Immune Defic Syndr
May 2022
HIV Neurobehavioral Research Center, University of California, San Diego, CA.
Background: We hypothesized that the induction of monocyte activation biomarkers, especially soluble urokinase-type plasminogen activator receptor (suPAR) and interferon γ-inducible protein 10 (IP-10), is lower in HIV-1C than HIV-1B, owing to a defective Tat cysteine dimotif (C30S).
Methods: A total of 68 paired cerebrospinal fluid (CSF) and blood samples from people with HIV (PWH), free of CNS opportunistic infections, from a Southern Brazil outpatient HIV clinic were evaluated such as HIV-1B subtype (n = 27), HIV-1C (n = 26), other (n = 15), and 19 HIV-negative controls. The levels of suPAR, IP-10, neopterin, and β2 microglobulin (β2m) in the CSF and serum were quantified using different immunoassays.
BMC Neurol
December 2021
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE-415 50, Gothenburg, Sweden.
Pharmacol Ther
June 2022
Oklahoma State University Center for Health Sciences, School of Biomedical Science, 1111 West 17(th) Street, Tulsa, OK 74107-1898, USA. Electronic address:
As our understanding of changes to the neurological system has improved, it has become clear that patients who have contracted human immunodeficiency virus type 1 (HIV-1) can potentially suffer from a cascade of neurological issues, including neuropathy, dementia, and declining cognitive function. The progression from mild to severe symptoms tends to affect motor function, followed by cognitive changes. Central nervous system deficits that are observed as the disease progresses have been reported as most severe in later-stage HIV infection.
View Article and Find Full Text PDFJ Neurosci
December 2021
Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202-9037
Neurotoxic HIV-1 viral proteins contribute to the development of HIV-associated neurocognitive disorder (HAND), the prevalence of which remains high (30-50%) with no effective treatment available. Estrogen is a known neuroprotective agent; however, the diverse mechanisms of estrogen action on the different types of estrogen receptors is not completely understood. In this study, we determined the extent to which and mechanisms by which 17α-estradiol (17αE2), a natural less-feminizing estrogen, offers neuroprotection against HIV-1 gp120-induced neuronal injury.
View Article and Find Full Text PDFClin Infect Dis
August 2022
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Background: The aim of this large multicenter study was to determine variations in cerebrospinal fluid (CSF) HIV-RNA in different phases of untreated human immunodeficiency virus type 1 (HIV-1) infection and its associations with plasma HIV-RNA and other biomarkers.
Methods: Treatment naive adults with available CSF HIV-RNA quantification were included and divided into groups representing significant disease phases. Plasma HIV-RNA, CSF white blood cell count (WBC), neopterin, and albumin ratio were included when available.