3 results match your criteria: "HDSA Center of Excellence at UTHealth[Affiliation]"

Background: Identifying sex-related differences is critical for enhancing our understanding of factors that may impact prognosis and advance treatments in Huntington's disease (HD).

Objectives: To investigate if sex-related differences exist in clinical HD.

Methods: Longitudinal study of the Enroll-HD database.

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Sleep Dysfunction in Huntington's Disease: Perspectives from Patients.

J Huntingtons Dis

November 2021

Huntington's Disease Society of America (HDSA) Center of Excellence at UTHealth & Department of Neurology, McGovern Medical School, UTHealth, Houston, TX, USA.

Background: Despite the abundance of clinical tools, sleep disorders are still not routinely evaluated in patients with Huntington's disease (HD). Sleep disturbances can exacerbate cognitive impairment and mood disorders and seriously affect the life of the patients and their families.

Objective: The current study was designed to investigate sleep quality and its association with clinical symptoms in HD.

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Huntington's disease (HD) is a heritable and fatal neurodegenerative disease characterized by a triad of motor, cognitive and neuropsychiatric symptoms. A common and particularly detrimental neuropsychiatric alteration in HD gene carriers is irritability, which frequently manifests as abrupt and unpredictable outbursts of anger. This symptom increases the burden of HD in multiple ways, such as jeopardizing employment and straining familial or caregiver support.

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