Multifunctional HMoO-MoO/Carbon Composite Particles for Water Remediation.

Solving a scarcity of freshwater resources is an urgent global challenge by a safe and sustainable approach using renewable energy. We demonstrate the multifunctional catalyst of HMoO-MoO/carbon composite particles toward highly efficient water remediation. A one-step mechanochemical reaction successfully upgraded the composites from commercially available MoO-polypropylene (PP) powders without introducing hydrogen gas.

Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome.

Pseudouridine (Ψ) is one of the most abundant modifications in cellular RNA. However, its function remains elusive, mainly due to the lack of highly sensitive and accurate detection methods. Here, we introduced 2-bromoacrylamide-assisted cyclization sequencing (BACS), which enables Ψ-to-C transitions, for quantitative profiling of Ψ at single-base resolution.

Efficacy and safety of GLP-1 analog ecnoglutide in adults with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 2 trial.

Glucagon-like peptide-1 (GLP-1) analogs are important therapeutics for type 2 diabetes and obesity. Ecnoglutide (XW003) is a novel, long-acting GLP-1 analog. We conducted a Phase 2, randomized, double-blind, placebo-controlled study enrolling 145 adults with T2DM.

State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548.

Nav1.8 sodium channels (Nav1.8) are an attractive therapeutic target for pain because they are prominent in primary pain-sensing neurons with little expression in most other kinds of neurons.

Concentration-QTc analysis of soticlestat in healthy adults: An alternative to a thorough QT study.

Aim: This study aimed to examine the cardiac and overall safety and pharmacokinetic (PK) profiles of soticlestat (TAK-935), an oral, first-in-class selective cholesterol 24-hydroxylase inhibitor.

Methods: Data came from a randomised, phase 1 study of soticlestat in 33 healthy Japanese adults (NCT04461483); 24 adults in Part 1 (single-dose soticlestat 200-1200 mg or placebo) and 9 in Part 2 (soticlestat 100-300 mg twice daily or placebo for 21 days). PK sample collection was paired with 12-lead electrocardiogram data from continuous Holter recordings.

SMTRI: A deep learning-based web service for predicting small molecules that target miRNA-mRNA interactions.

Mature microRNAs (miRNAs) are short, single-stranded RNAs that bind to target mRNAs and induce translational repression and gene silencing. Many miRNAs discovered in animals have been implicated in diseases and have recently been pursued as therapeutic targets. However, conventional pharmacological screening for candidate small-molecule drugs can be time-consuming and labor-intensive.

Robust Magnetic-Field-Free Perpendicular Magnetization Switching by Manipulating Spin Polarization Direction in RuO/[Pt/Co/Pt] Heterojunctions.

Perpendicular magnetization switching by a magnetic-field-free, energy-efficient electrical approach has remained a great challenge. Here, we demonstrate the realization of robust magnetic-field-free perpendicular magnetization switching in the (101)RuO/[Pt/Co/Pt] heterojunction by manipulating the spin polarization direction. We proposed that the relative strength of out-of-plane spin currents with out-of-plane spin polarization and in-plane spin polarization can be effectively manipulated by tuning the nominal thickness of [Pt/Co/Pt] multilayers and the direction of applied electric current with respect to the RuO crystal orientation.

Unveiling the role of artificial intelligence in tetracycline antibiotics removal using UV/sulfite/phenol advanced reduction process.

UV/sulfite-based advanced reduction processes (ARP) have attracted increasing attention due to their high capability for removing a wide range of pollutants. Therefore, developing UV/sulfite ARP systems with assisted Artificial Intelligence (AI) models is considered an efficient strategy for sustainable pollutant removal. The present study delves into modeling and optimizing photodegradation of tetracycline (TC) antibiotics under UV/sulfite/рhenol reԁuсtion рroсess (UV/SPAP) using integrаteԁ Artifiсiаl Neurаl Networks (ANN), Suррort Veсtor Regression (SVR), аnԁ Genetiс Algorithm (GA).

Delta Radiomics Based on MRI for Predicting Axillary Lymph Node Pathologic Complete Response After Neoadjuvant Chemotherapy in Breast Cancer Patients.

Purpose: To develop and test a radiomics nomogram based on magnetic resonance imaging (MRI) and clinicopathological factors for predicting the axillary pathologic complete response (apCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients with axillary lymph node (ALN) metastases.

Materials And Methods: A total of 319 patients who underwent MRI examination and received NAC treatment were enrolled from two centers, and the presence of ALN metastasis was confirmed by biopsy pathology before NAC. The radiomics features were extracted from regions of interest of ALNs before (pre-radiomics) and after (post-radiomics) NAC.

Stapokibart (CM310) targets IL-4Rα for the treatment of type 2 inflammation.

Stapokibart (CM310) is a humanized IL-4Rα monoclonal antibody currently undergoing phase 3 trials for type 2 inflammatory diseases. In contrast to dupilumab, which bound exclusively to human IL-4Rα, stapokibart demonstrated cross-species reactivity to IL-4Rα from human, cynomolgus monkey, and rat. Stapokibart exhibited comparable blocking activity to dupilumab.

Non-standard amino acid incorporation into thiol dioxygenases.

Thiol dioxygenases (TDOs) are non‑heme Fe(II)‑dependent enzymes that catalyze the O-dependent oxidation of thiol substrates to their corresponding sulfinic acids. Six classes of TDOs have thus far been identified and two, cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO), are found in eukaryotes. All TDOs belong to the cupin superfamily of enzymes, which share a common β‑barrel fold and two cupin motifs: G(X)HXH(X)E(X)G and G(X)PXG(X)H(X)N.

Blood Pressure-Lowering Medications, Sodium Reduction, and Blood Pressure.

Background: Both blood pressure-lowering medication and sodium reduction are effective in hypertension control, but whether the effect of sodium reduction differ across blood pressure-lowering medications is unclear. This study aims to evaluate the dose-response effect of sodium intake reduction on blood pressure in treated hypertensive individuals and the impact of different classes of blood pressure-lowering drugs.

Methods: We searched multiple databases and reference lists up to July 9, 2024.

Cation-eutaxy-enabled III-V-derived van der Waals crystals as memristive semiconductors.

Novel two-dimensional semiconductor crystals can exhibit diverse physical properties beyond their inherent semiconducting attributes, making their pursuit paramount. Memristive properties, as exemplars of these attributes, are predominantly manifested in wide-bandgap materials. However, simultaneously harnessing semiconductor properties alongside memristive characteristics to produce memtransistors is challenging.

Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cells.

Type I CRISPR-Cas systems are widespread and have exhibited high versatility and efficiency in genome editing and gene regulation in prokaryotes. However, due to the multi-subunit composition and large size, their application in eukaryotes has not been thoroughly investigated. Here, we demonstrate that the type I-F2 Cascade, the most compact among type I systems, with a total gene size smaller than that of SpCas9, can be developed for transcriptional activation in human cells.

Acute Kidney Injury and Its Association With Dementia and Specific Dementia Types: Findings From a Population-Based Study in Sweden.

Background And Objectives: Preclinical studies suggest that acute kidney injury (AKI) results in biochemical and pathologic changes in the brain. We aimed to explore the association between experiencing AKI and subsequent risks of developing dementia.

Methods: We conducted a study involving individuals aged 65 years and older in Stockholm from 2006 to 2019, who were free from dementia diagnosis and had data on kidney function.

Duality and the well-posedness of a martingale problem.

For two Polish state spaces E and E, and an operator G, we obtain existence and uniqueness of a G-martingale problem provided there is a bounded continuous duality function H on E×E together with a dual process Y on E which is the unique solution of a G-martingale problem. For the corresponding solutions [Formula: see text] and [Formula: see text] , duality with respect to a function H in its simplest form means that the relation E[H(X,y)]=E[H(x,Y)] holds for all (x,y)∈E×E and t≥0. While duality is well-known to imply uniqueness of the G-martingale problem, we give here a set of conditions under which duality also implies existence without using approximating sequences of processes of a different kind (e.

Friends not Foes: Exfoliation of Non-van der Waals Materials.

ConspectusTwo-dimensional materials have been a focus of study for decades, resulting in the development of a library of nanosheets made by a variety of methods. However, many of these atomically thin materials are exfoliated from van der Waals (vdW) compounds, which inherently have weaker bonding between layers in the bulk crystal. Even though there are diverse properties and structures within this class of compounds, it would behoove the community to look beyond these compounds toward the exfoliation of non-vdW compounds as well.

Predicting Activation of Small Molecules Including Dinitrogen via a Carbene with a σπ Electronic Configuration.

Although the main group species in the s and p blocks have begun to gain prominence in the field of dinitrogen (N) activation in recent years, reports of carbene-mediated N activation remain particularly rare, especially for carbenes with a σπ electronic configuration. Herein, we demonstrate examples of N activation initiated by a carbene with a σπ electronic configuration and consequent N hydroboration reaction (with a reaction barrier as low as 19.9 kcal/mol) via density functional theory calculations.