Integrated Metabolome, Transcriptome, and Physiological Analysis of the Flavonoid and Phenylethanol Glycosides Accumulation in Wild Roots from Different Habitats.

, a traditional medicinal plant, is commonly found on the Tibetan Plateau at altitudes of 3100-5200 m. Its primary active medicinal compounds, flavonoids and phenylethanol glycosides (PhGs), exhibit various pharmacological effects, including hemostatic, anti-inflammatory, antitumor, immunomodulatory, and antioxidant activities. This study analyzed flavonoid and PhG metabolites in the roots of collected from Henan County (HN), Guoluo County (GL), Yushu County (YS), and Chengduo County (CD) in Qinghai Province.

Self-Normalized Moderate Deviations for Degenerate -Statistics.

In this paper, we study self-normalized moderate deviations for degenerate -statistics of order 2. Let {Xi,i≥1} be i.i.

Catalytic Asymmetric Dehydrogenative Si-H/X-H Coupling toward Si-Stereogenic Silanes.

ConspectusChiral organosilicon compounds bearing a Si-stereogenic center have attracted increasing attention in various scientific communities and appear to be a topic of high current relevance in modern organic chemistry, given their versatile utility as chiral building blocks, chiral reagents, chiral auxiliaries, and chiral catalysts. Historically, access to these non-natural Si-stereogenic silanes mainly relies on resolution, whereas their asymmetric synthetic methods dramatically lagged compared to their carbon counterparts. Over the past two decades, transition-metal-catalyzed desymmetrization of prochiral organosilanes has emerged as an effective tool for the synthesis of enantioenriched Si-stereogenic silanes.

Hydrogen-Bond-Regulated Tb-Centered Emission in a Zn-Tb Heterometallic Compound for Water Sensing in Ethanol and Gasoline.

Luminescent lanthanide compounds stand out for their distinctive characteristics including narrow emission bands, substantial Stokes shifts, high quantum yields, and unique luminescent colors. However, Ln is highly susceptible to vibrational quenching from X-H (X = O/N) high-energy oscillators in the embedded organic antenna, resulting in significant nonradiative energy dissipation of the D excited states of Ln. Herein, we introduce a strategy based on supramolecular interactions to modulate the nonradiative transitions in a new Zn-Tb heterometallic compound, [ZnTb(HL)(NO)Cl]·2CHCN·HO (), based on a phenyl-substituted pyrazolinone-modified salicylamide-imide ligand ().

Influences of the second motion probing gradient -value and T2 relaxation time on magnetic resonance diffusion-derived 'vessel density' (DDVD) calculation: the examples of liver, spleen, and liver simple cyst.

Background: Magnetic resonance (MR) diffusion-derived 'vessel density' (DDVD) is calculated according to: DDVD = Sb0/ROI - S/ROI, where S and S refer to the tissue signal when -value is 0 or 2 s/mm. S and ROI can also be approximated by other low -values diffusion-weighted imaging (DWI). This study investigates the influence of the second motion probing gradient -value and T2 on DDVD calculations of the liver, spleen, and liver simple cyst.

Rhodium(III)-NSi Catalyzed Styrene Hydrosilylation: Evidence of the Hemilabile Character of NSi-type Ligands.

The 18e saturated rhodium(III) species [Rh(H)(X)(κ2-NSitBu2)(bipyMe2)] (NSitBu2 = {4-methylpyridine-2-yloxy}ditertbutylsilyl; bipyMe2 = 4,4´-dimethylbipyridine) (X = Cl, 1; OTf, 2) have been prepared and characterized by NMR spectroscopy and in the case of 2 it has been possible to determine its solid-state structure by X-ray diffraction. Complex 1 has proven to be an effective catalyst precursor for the reaction of styrene derivatives with hydrosilanes in CD2Cl2. However, under catalytic conditions complex 2 decomposes.

Molecular Phosphide Complexes of Zirconium.

Molecular Zr phosphides are extremely rare, with no examples containing a one-coordinated and terminal triple-bonded phosphorus atom. We report here an isolable and relatively stable Zr phosphide complex, [(PN)Zr≡P{μ-Na(OEt)}] (), stemming from a cyclometalated Zr-hydride, [(PN)(PN')Zr(H)] (), and NaPH. Complex is prepared from two- or one-electron reductions of precursors [(PN)ZrCl] () or metastable Zr[(PN)ZrCl], respectively.

A first-in-human study of JNJ-70218902, a bispecific T-cell-redirecting antibody against TMEFF2 in metastatic castration-resistant prostate cancer.

Background: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis, necessitating the investigation of novel treatments and targets. This study evaluated JNJ-70218902 (JNJ-902), a T-cell redirector targeting transmembrane protein with epidermal growth factor-like and 2 follistatin-like domains 2 (TMEFF2) and cluster of differentiation 3, in mCRPC.

Patients And Methods: Patients who had measurable/evaluable mCRPC after at least one novel androgen receptor-targeted therapy or chemotherapy were eligible.

Comparative Diagnostic Performance of Color Doppler Flow Imaging, MicroFlow Imaging and Contrast-enhanced Ultrasound in Solid Renal Tumors.

Rationale And Objectives: Accurate distinguish malignant from benign renal masses remains a challenge for radiologists. The purpose of this study was to evaluate the value of Color Doppler Flow Imaging (CDFI), MicroFlow Imaging (MFI) and Contrast-enhanced Ultrasound (CEUS) in diagnosing solid renal tumors.

Materials And Methods: A total of 291 patients with 300 solid renal tumors pathologically confirmed were retrospectively analyzed between January 2020 and December 2022.

Analysis of radiation oncology integration within general practitioners' daily patient care: a cross-sectional survey in Germany.

Purpose: General practitioners (GPs) play a crucial role in providing interdisciplinary care for radiation oncology patients. This study aims to understand the specific needs and challenges faced by general practitioners in Germany when treating oncology patients.

Methods: A comprehensive web-based questionnaire with 24 items was disseminated to GPs in Germany via email using survio.

Arthroscopic Extensor Carpi Radialis Brevis Tenotomy Under Local Anesthesia for Refractory Lateral Epicondylitis.

Refractory lateral epicondylitis poses significant challenges for patients and doctors. Whereas traditional surgical treatments involve open resection and extensor carpi radialis brevis (ECRB) muscle debridement, arthroscopic surgery advancements offer a more refined approach. Numerous surgical methods are used to treat lateral epicondylitis.

Nucleophilic Functionalization of Activated P in [CpFe(CO)-(η-P)][Al(OR)] with Alcohols R-OH.

The bonding situation in [Fp-P][Al(OR)] (1) (Fp = (CO)CpFe, R = C(CF)) gives rise to an Umpolung of the P fragment, which should make it accessible for nucleophiles. To investigate this projected reactivity, the complex was combined with a series of hydroxy-nucleophiles - that all do not react with free P - leading to a variety of P building blocks. With excess of R-OH (R = Me, Et, Ph), the thermodynamically more stable complex salts [Fp-P(H)(OR))][Al(OR)] (x=2,1,0) (2b-2d) are formed and show that the phosphonium type pathway is accessible.

Safety and Efficacy of Remote Ischemic Conditioning in Patients With Intravenous Thrombolysis: The SERIC-IVT Trial.

Background: Approximately half of the patients with acute ischemic stroke who receive intravenous thrombolysis (IVT) do not achieve an excellent outcome. Remote ischemic conditioning (RIC) as a promising neuroprotective treatment may improve clinical outcomes in this population. This study aimed to assess the efficacy and safety of RIC in patients with IVT.

Novel MRI-based Hyper-Fused Radiomics for Predicting Pathologic Complete Response to Neoadjuvant Therapy in Breast Cancer.

Rationale And Objectives: To propose a novel MRI-based hyper-fused radiomic approach to predict pathologic complete response (pCR) to neoadjuvant therapy (NAT) in breast cancer (BC).

Materials And Methods: Pretreatment dynamic contrast-enhanced (DCE) MRI and ultra-multi-b-value (UMB) diffusion-weighted imaging (DWI) data were acquired in BC patients who received NAT followed by surgery at two centers. Hyper-fused radiomic features (RFs) and conventional RFs were extracted from DCE-MRI or UMB-DWI.

High correlation between Ki-67 expression and a novel perfusion MRI biomarker diffusion-derived vessel density (DDVD) in endometrial carcinoma.

Objective: This study aimed to investigate the feasibility of diffusion-derived vessel density (DDVD) in characterizing tumor microvasculature in endometrial carcinoma (EC), and to explore the correlations with Ki-67 proliferation status and histological type based on DDVD values.

Methods: There were in total 81 EC patients. There were 64 cases of non-aggressive histological type, and 17 cases of aggressive histological type.

Highly efficient heteronuclear polarization transfer using dipolar-echo edited R-symmetry sequences in solid-state NMR.

In solid-state NMR, dipolar-based heteronuclear polarization transfer has been extensively used for sensitivity enhancement and multidimensional correlations, but its efficiency often suffers from undesired spin interactions and hardware limitations. Herein, we propose a novel dipolar-echo edited R-symmetry (DEER) sequence, which is further incorporated into the INEPT-type scheme, dubbed DEER-INEPT, for achieving highly efficient heteronuclear polarization transfer. Numerical simulations and NMR experiments demonstrate that DEER-INEPT offers significantly improved robustness, enabling efficient polarization transfer under a wide range of MAS conditions, from slow to ultrafast rates, outperforming existing methods.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Revolutionizing Epithelial Differentiability Analysis in Small Airway-on-a-Chip Models Using Label-Free Imaging and Computational Techniques.

Organ-on-a-chip (OOC) devices mimic human organs, which can be used for many different applications, including drug development, environmental toxicology, disease models, and physiological assessment. Image data acquisition and analysis from these chips are crucial for advancing research in the field. In this study, we propose a label-free morphology imaging platform compatible with the small airway-on-a-chip system.

A Systematic Method to Detect Next-Generation Sequencing-Based Microsatellite Instability in Plasma Cell-Free DNA: plasmaMSI.

Microsatellite instability (MSI) detection using tumor tissue is a well-established prognostic and predictive biomarker for certain types of cancers. However, tumor tissue samples are less convenient to obtain than blood plasma samples. The main challenge facing next-generation sequencing-based MSI detection in blood plasma samples is the ultralow signal/noise ratio in plasma cell-free DNA (cfDNA).

Bio-inspired snapshot polarization-hyperspectral camera.

The mantis shrimp is recognized to have one of the most powerful vision systems in nature, with up to 16 color-perceiving channels and the perception of linear and circular polarization detection. Inspired by its biostructure, we developed a snapshot polarization-hyperspectral camera (pHScam) to detect linear polarization in four directions and spectral signature in 21 bands of incident light, resulting in a 4D polar-spectral hypercube, represented as (,,,→). We introduced two bio-mimetic encoding mechanisms, viz.

Arthroscopic V-Shaped Double-Pulley Suture-Bridge Repair of Massive Rotator Cuff Tear.

At present, suture bridge is a feasible choice in the treatment of massive rotator cuff tears (MRCTs). However, high tension on the repair site and medial tension during suture tightening and after medial knotting are unavoidable problems in MRCT repair with a suture bridge. Arthroscopic V-shaped double-pulley suture-bridge repair is a pragmatic surgical technique for the repair of MRCTs.