5,443 results match your criteria: "Hôpitaux Universitaires de Strasbourg[Affiliation]"

What is the lower limb length discrepancy after arthroplasty for proximal femoral fracture? A prospective, multicenter observational study of 590 hips.

Orthop Traumatol Surg Res

December 2024

Société Française de Chirurgie Orthopédique et Traumatologique, 56 rue Boissonade, 75014 Paris Cedex, France.

Introduction: Lower limb length discrepancy (LLD) following hip arthroplasty after proximal femoral fracture (PFFA) is little studied. The aim of this work was to answer the following questions: 1) What are the incidence and mean values ​​of LLD after PFFA? 2) What are the clinical consequences (tolerance) of LLD after PFFA? 3) Can we identify risk factors for LLD after PFFA? 4) Is there a significant difference in terms of LLD after PFFA to treat intra- versus extra-capsular fractures?

Hypothesis: LLD after proximal femoral fracture arthroplasty is rare but has good clinical tolerance, given the low functional demands of the patients.

Patients And Methods: This is a multicenter prospective observational cohort study (15 centers), including 590 patients, operated on for hip arthroplasty for proximal femur fracture between May 2022 and June 2023.

View Article and Find Full Text PDF

Background: Periodontitis is an inflammatory disease causing destruction of periodontal tissues. Controlling inflammation is crucial for periodontitis treatment. Prohibitins (PHBs) are emerging targets in the treatment of inflammatory diseases.

View Article and Find Full Text PDF

Ovarian response in preimplantation genetic testing for myotonic dystrophy type 1.

J Assist Reprod Genet

December 2024

Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, Université Paris-Saclay, Assistance Publique Hôpitaux de Paris, F-92140, Clamart, France.

Purpose: To evaluate ovarian stimulation response in couples undergoing preimplantation genetic testing (PGT-M) for myotonic dystrophy type 1 (DM1) METHODS: Retrospective, observational, multicentric study. Parameters of ovarian response and PGT-M outcomes were compared according to the DM1-affected patient (female or male). A total of 229 couples underwent at least one controlled ovarian hyperstimulation cycle for the PGT-M procedure.

View Article and Find Full Text PDF

Background: Spinal muscular atrophy (SMA) patients benefit from pre-mRNA splicing modifiers targeting the SMN2 gene, which aims to increase functional SMN production. The animal toxicity affecting spermatogenesis associated with one such treatment raised questions about male SMA patients' spermatogenesis.

Methods: This descriptive, cross-sectional study was conducted from June 2022 to July 2023.

View Article and Find Full Text PDF

Allogeneic umbilical cord-derived mesenchymal stromal cells as treatment for systemic lupus erythematosus: a single-centre, open-label, dose-escalation, phase 1 study.

Lancet Rheumatol

December 2024

SITI, CHU Rennes, Etablissement Français du Sang Bretagne, Rennes, France; INSERM UMR 1236, Université Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France. Electronic address:

Background: Patients with systemic lupus erythematosus (SLE) with inadequate responses to standard therapies have unmet therapeutic needs. The immunomodulatory, proangiogenic, and antifibrotic properties of mesenchymal stromal cells support their use in treating patients with SLE. We aimed to assess the safety of a single intravenous infusion of allogeneic umbilical cord-derived mesenchymal stromal cells in patients with severe SLE.

View Article and Find Full Text PDF

Objective: This study aims to present and analyze the results of the French cohort in a European Board of Ophthalmology (EBO) survey on cataract surgical training in Europe, highlighting the particularities of French training.

Materials And Methods: A 23-question electronic questionnaire was sent to interns applying for the EBO examination from 2018 to 2022. Responses from French participants were specifically collected and analyzed.

View Article and Find Full Text PDF

Unlabelled: Type 2 diabetes is a public health problem in which general practitioners are in the front line, acting on all fronts, from screening to management.

Methods: Single-centre, quantitative, retrospective and descriptive study aimed at characterising the profile of patients referred to hospital by general practitioners in an internal medicine department in Strasbourg for rebalancing of their type 2 diabetes during the period from 1 January 2020 to 31 December 2022.

Results: 167 files were analysed, resulting in the inclusion of 72 patients with an average age of 61.

View Article and Find Full Text PDF

Purpose: Significant improvements in the prognosis for young patients with Primary Immunodeficiency Diseases (PID) and Autoinflammatory Disorders (AID), which together make up the majority of Inborn Errors of Immunity (IEI), have resulted in the need for optimisation of transition and transfer of care to adult services. Effective transition is crucial to improve health outcomes and treatment compliance among patients. Evaluations of existing transition programmes in European health centres identified the absence of disease-specific transition guidelines for PID and AID, as a challenge to the transition process.

View Article and Find Full Text PDF

Introduction: Lung transplant (LT) recipients are at greater risk of complications from COVID-19. Treatment options are limited partly due to interactions with immunosuppressive agents. Convalescent plasma (CP) is a potential treatment option, but it has not been extensively studied in LT patients.

View Article and Find Full Text PDF

Sex Disparities in Bladder Cancer Diagnosis and Treatment.

Cancers (Basel)

December 2024

Medical Oncology Unit, Centre Antoine Lacassagne, Université Côte d'Azur, 06000 Nice, France.

Gender differences in prevalence, tumor invasiveness, response to treatment, and clinical outcomes exist in different types of cancer. The aim of this article is to summarize the sex disparities in bladder cancer diagnosis and treatment and try to suggest areas for improvement. Although men are at a higher risk of developing bladder tumors, women tend to be diagnosed with more advanced stages at diagnosis and are more likely to present with upfront muscle-invasive disease.

View Article and Find Full Text PDF

Real-world multicentre study of cefiderocol treatment of immunocompromised patients with infections caused by multidrug-resistant Gram-negative bacteria: CEFI-ID.

J Infect

December 2024

Département des Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, F-69004 Lyon, France; Centre International de Recherche en Infectiologie (CIRI), Inserm 1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, F-69007, France.

Introduction: The increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria.

Methods: This retrospective multicentre study investigated the real-world use of FDC in 114 immunocompromised adults treated for MDR infections in 12 French hospitals (June 2020-November 2023).

View Article and Find Full Text PDF

Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study.

Clin Kidney J

December 2024

Public Health Department, Epidémiologie - Maison régionale de la recherche clinique, CHU Lille, Lille, France.

Background And Hypothesis: Cardiovascular diseases are a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Acute kidney injury (AKI) has been increasingly recognized as a potential exacerbating factor for cardiovascular events in these patients. The CKD-REIN study aims to explore the relationship between AKI and the risk of major adverse cardiovascular events (MACE) in a cohort of CKD patients.

View Article and Find Full Text PDF

Impact of inspiration level on lung nodule volumetry.

Res Diagn Interv Imaging

March 2024

Diagnostic Imagery Department, Nouvel Hôpital Civil (NHC), Hôpitaux Universitaires de Strasbourg, 17, rue de la Porte-de-l'Hôpital, 67000 Strasbourg, France.

View Article and Find Full Text PDF

Purposes: This research highlights the need for affordable phantoms for MRI education. Current options are either expensive or limited. A phantom, easy to manufacture and distribute, is proposed to demonstrate various pedagogical concepts, aiding students in understanding MRI image quality concepts.

View Article and Find Full Text PDF

Distal Pancreatectomy with Celiac Axis and Venous Resection with Hepatic Artery and Venous Reconstruction (DP-CARV) for Locally Advanced Pancreatic Adenocarcinoma.

Ann Surg Oncol

December 2024

Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pôle des Pathologies Hépatiques et Digestives, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.

Background: Surgery has recently been introduced into the multimodal management of patients with locally advanced pancreatic adenocarcinomas (LAPCs) thanks to the major pathological response seen with the advent of the multiagent regimen FOLFIRINOX. Distal pancreatectomy with celiac axis resection (DP-CAR) may be complicated by ischemic liver and gastric events. Common hepatic artery reconstruction may prevent the occurrence of ischemic complications and can be an alternative to preoperative embolization of the celiac trunk.

View Article and Find Full Text PDF

First example of airway restoration using cryopreserved aortic allograft after total laryngectomy: CARE case report.

Eur Ann Otorhinolaryngol Head Neck Dis

December 2024

Service d'ORL et chirurgie cervico-faciale, hôpitaux universitaires de Strasbourg, Strasbourg, France; Inserm (Institut national de la santé et de la recherche médicale) unité 1121, biomatériaux et bioingénierie, université de Strasbourg, Strasbourg, France. Electronic address:

Case Description: A 70 year-old woman presenting T4aN2cM0 laryngeal carcinoma first underwent total laryngectomy with airway reconstruction by cryopreserved aortic allograft. Six months after chemoradiotherapy, she underwent endoscopic surgery to create a neo-laryngopharynx.

Results: At 13 months after primary surgery, day- and night-time breathing was effectively restored, with a little persistent salivary false passage, and a whispering but comprehensible voice after tracheostomy closure.

View Article and Find Full Text PDF

Background And Aims: Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.

View Article and Find Full Text PDF

Shaping tomorrow: how the STEP training course pioneered noninvasive brain stimulation training for psychiatry in France.

Front Psychiatry

November 2024

French Society for Biological Psychiatry and Neuropsychopharmacology, STEP Section (Stimulation Transcrânienne En Psychiatrie), Saint-Germain-en-Laye, France.

Over the past three decades, non-invasive brain stimulation (NIBS) techniques have gained worldwide attention and demonstrated therapeutic potential in various medical fields, particularly psychiatry. The emergence of these novel techniques has led to an increased need for robust training programs to provide practitioners, whether clinicians or scientists, with the necessary skills and knowledge. In response, a comprehensive training curriculum for NIBS in psychiatry has been developed in France.

View Article and Find Full Text PDF

[Integrative medicine and nursing: a necessary opening in training and practice].

Soins

December 2024

Université de Nantes, CHU Nord-Laennec, Laboratoire de Thérapeutique EA4391, boulevard Jacques-Monod, 44093 Nantes cedex, France; Collège universitaire des médecines intégrative et complémentaires, service interdisciplinaire douleur, soins palliatifs et de support, éthique et médecine intégrative, CHU Nord-Laennec, boulevard Jacques-Monod, 44093 Nantes cedex 1, France.

The majority of nurses have a favourable opinion of complementary therapies. This makes it easier to identify the therapies used by patients. Being trained in and practising a complementary therapy strengthens the nursing skills and helps to give it new meaning.

View Article and Find Full Text PDF

Introduction: Traditionally, to determine a length on a limb radiograph after total hip arthroplasty (THA), calibration is performed manually with the diameter of a ball or the femoral head. More recently, the development of EOS with automatic calibration has called into question the usefulness of manual calibration to highlight lower limb length inequality (LLLI). However, the validation of EOS with automatic calibration without landmarks to measure length inequalities on large images has not been verified against manual measurements on calibrated radiographs (conventional method), which motivated the present work.

View Article and Find Full Text PDF

MRI management of NMOSD and MOGAD: Proposals from the French Expert Group NOMADMUS.

J Neuroradiol

December 2024

Service de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France; Creatis LRMN, CNRS UMR 5220, Université Claude Bernard Lyon 1, INSERM U630, Lyon, France.

Background: Currently, there are no available recommendations or guidelines on how to perform MRI monitoring in the management of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The issue is to determine a valuable MRI monitoring protocol to be applied in the management of NMOSD and MOGAD, as previously proposed for the monitoring of multiple sclerosis.

Objectives: The objectives of this work are to establish proposals for a standardized and feasible MRI acquisition protocol, and to propose control time points for systematic MRI monitoring in the management of NMOSD and MOGAD.

View Article and Find Full Text PDF

[Treatment of posttraumatic nightmares: the role of imagery rehearsal therapy].

Rev Prat

November 2024

Psychiatre, service de psychiatrie de l'enfant et de l'adolescent, pôle psychiatrie, santé mentale et addictologie, Hôpitaux universitaires de Strasbourg, Strasbourg, France. Centre régional du psychotraumatisme Alsace-Nord, pôle psychiatrie, santé mentale et addictologie, Hôpitaux universitaires de Strasbourg, Strasbourg, France. CNRS UPR 3212, Institut des neurosciences cellulaires et intégratives, Strasbourg, France.

Article Synopsis
  • Post-traumatic stress disorder (PTSD) affects about 30% of adults following a traumatic event, often leading to persistent sleep disturbances and nightmares that cause significant emotional distress.
  • Over 70% of PTSD patients experience post-traumatic nightmares, which are considered one of the earliest symptoms and are not effectively treated by standard PTSD treatments.
  • Imagery rehearsal therapy, a first-line treatment for these nightmares, uses mental imagery and cognitive restructuring techniques, and has been shown to improve the frequency of nightmares, insomnia severity, sleep quality, and overall PTSD symptoms.
View Article and Find Full Text PDF

Objectives: Data on the economic consequences of Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) are scarce in Europe. We aimed to estimate the total direct costs attributable to SLE and LN in France, at the nation-wide level.

Methods: Patients with SLE and LN were identified in the French nation-wide health insurance database (SNDS).

View Article and Find Full Text PDF