[Adherence to the national guidelines regarding referral of patients with knee osteoarthritis to orthopedic consultation].

The aim of the study was to investigate: 1) the proportion of referrals from primary care to orthopedic consultations that included the information requested by the national guidelines for patients with knee osteoarthritis, and 2) the proportion of referrals that specified whether patients had completed first-line treatment. A total of 140 referrals were examined. None of the referrals adhered fully to the national guidelines, and none included information on whether the patient had completed first-line treatment.

Considerations regarding the selection, sampling, extraction, analysis, and modelling of biomarkers in exhaled breath for early lung cancer screening.

Lung cancer (LC) is the deadliest cancer due to the lack of efficient screening methods that detect the disease early. This review, covering the years 2011 - 2025, summarizes state-of-the-art LC screening through analysis of volatile organic compounds (VOCs) in exhaled breath. All fundamental parts of the methodology are covered, i.

Clinical education during a crisis lived experiences of nursing students in Sweden during the COVID-19 pandemic.

Background: Nursing education entails extensive training across varying settings where nursing students can practice their theoretical knowledge and practical skills for their future profession. Skills in evidence-based practice are pivotal competences for nurses and need to evolve from novice to expert skills. During the COVID-19 pandemic, Sweden had a unique approach to restrictions.

Effectiveness and cost-effectiveness of chiropractic and physiotherapy for chronic low back pain: a multicenter RCT in Sweden.

Objective: To evaluate the effectiveness and cost-effectiveness of physiotherapy, chiropractic care, and the combination of physiotherapy and chiropractic care compared with information and advice for the treatment of patients with nonspecific chronic low-back pain (CLBP) in Sweden.

Design: A multicentre pragmatic randomized controlled trial.

Setting: Ten primary care rehabilitation units in Sweden.

Sex differences in the association of Alzheimer's disease biomarkers and cognition in a multicenter memory clinic study.

Background: This study investigated sex differences in the associations between Alzheimer's disease (AD) biomarkers, cognitive performance, and decline in memory clinic settings.

Methods: 249 participants (females/males:123/126), who underwent tau-PET, amyloid-PET, structural MRI, and plasma glial fibrillary acidic protein (GFAP) measurement were included from Geneva and Lausanne Memory Clinics. Mann-Whitney U tests investigated sex differences in clinical and biomarker data.

Dysglycaemia and incident aortic stenosis: a cohort study.

Background: Aortic stenosis is a degenerative condition with high mortality in its severe stages and no preventive treatment. While diabetes is a known risk factor, the role of elevated glucose levels below the diabetic threshold in the development of aortic stenosis remains unclear. This study investigated the association between dysglycaemia, including impaired fasting glucose, and the incidence of aortic stenosis.

[Paths to Swedish medical license for international medical graduates].

There are four paths to a Swedish medical license. A shared agreement exists for those converting from a European license to recognize qualifications granted in the respective countries mutually. Swedish medical graduates and International Medical Graduates (IMGs) trained outside the EU/EES/Schweiz are assessed against the professional qualifications specified in the Higher Education Ordinance (1993:100).

An experimental comparison and user evaluation of three different dried plasma products.

Background And Objectives: Access to blood components in pre-hospital bleeding resuscitation is challenging. Dried plasma is a logistically superior alternative, and new products are emerging. Therefore, we aimed to evaluate laboratory and practical differences in three differently produced dried plasma products.

Plasma Concentrations of Benzylpenicillin and Cloxacillin in Infective Endocarditis-With Special Reference to Delayed Hypersensitivity Reactions.

Background: Current antibiotic regimens for infective endocarditis (IE) are effective but pose a high risk of delayed hypersensitivity reactions (DHR). Dose adjustments guided by therapeutic drug monitoring (TDM) could mitigate these risks while maintaining treatment efficacy. This study aimed to investigate the plasma concentration of benzylpenicillin and cloxacillin in patients with IE and explore associations between antibiotic concentrations and DHR.

[The Scandinavian Obesity Surgery Registry - register for quality and research].

The Scandinavian Obesity Surgery Registry (Soreg) was initiated in 2007 in order to track the quality of bariatric surgery in Sweden during a period of rapid expansion. The main focus of Soreg is quality control and a base for research. All surgical units that perform bariatric surgery in Sweden report to Soreg, and to date about 93 000 patients are included in Soreg.

[Preparing for patient work founded on evidence in medical school - a questionnaire study on final-year medical students].

Several of the requirements for obtaining a medical degree according to the Swedish Higher Education Ordinance illustrate the scientific basis of the profession, and systematic reviews as well as health technology assessments (HTA) constitute cornerstones in evidence-based medicine. In this study, medical students' experience of scientific education related to the profession was explored, and their knowledge achieved was sampled by five multiple-choice questions (MCQ). A total of 433 out of 641 students attending the final semester in six medical schools in Sweden participated (response rate: 68%).

[Glucokinase activators and imeglimin: New drugs against type 2 diabetes].

Type 2 diabetes (T2D) is increasing relentlessly globally, affecting ever younger patients. Many T2D patients do not attain glycemic target levels, indicating a clear need for novel antihyperglycemic drugs. Ideally, these should not only control glycemia, but also halt or slow the progressive loss of beta cells.

First out-of-bed mobilisation in adults with severe acquired brain injury in Scandinavian neurointensive care units: A survey of current clinical practice (FOOBScan).

Background: The harm-benefit balance for early out-of-bed mobilisation of patients with severe acquired brain injury (ABI) in neurointensive care units (neuro-ICUs) is unclear, and there are no clinical guidelines. This study aimed to survey the current clinical practice and perceptions among clinicians involved in first out-of-bed mobilisation in Scandinavian neuro-ICUs.

Methods: This was a cross-sectional, anonymous, web-based survey; the reporting follows the recommended CROSS checklist.

[The role of anaesthesia in global health].

The article explores the role of anaesthesia in global health and highlights key initiatives such as the Lancet Commission on Global Surgery and the National Surgical, obstetric and Anaesthesia Plans (NSOAP). Recognizing the global disparities in anaesthesia education, the article mentions the varying standards of training for anaesthesia providers worldwide as well as the problem of low status of providers. The article underscores a shift in focus from traditional aid models to capacity-building approaches, risks associated with indiscriminate donations of tools and technology to low and middle-income countries, as well as both positive and negative aspects of investing in education and training programs.

Non-Palpable Breast Cancer: A Targeting Challenge-Comparison of Radio-Guided vs. Wire-Guided Localization Techniques.

The incidence of non-palpable breast cancer is increasing due to widespread screening and neo-adjuvant therapies. Among the available tumor localization techniques, radio-guided occult lesion localization (ROLL) has largely replaced wire-guided localization (WGL). The aim of this study was to compare the ROLL and WGL techniques in terms of the effectiveness of isotopic marking of axillary sentinel lymph nodes and to assess patient perspectives along with surgeon and radiologist preferences.

Patients' experience of suffering a distal radius fracture with long-lasting impairment-a qualitative study.

Background: Every year a large number of people suffer a distal radius fracture and some of them never regain their activity level. The correlation between radiographic features and outcome explains some but not all the disability perceived after fracture healing and rehabilitation. Little is known of the persons reporting persistent upper limb dysfunction.

Technological lifelines: the everyday lived complexities of dependence and care of pediatric long-term tracheostomy.

Purpose: As the group of technology-dependent children with long-term tracheostomy continues to expand, we aimed to explore parents' lived experience of everyday life with a child dependent on long-term tracheostomy.

Materials And Methods: Six parents of four children were interviewed and the transcripts analyzed using Giorgi's descriptive phenomenology.

Results: All aspects of everyday life, parent-child interaction, and interaction with the surrounding outside world were affected by technology dependency.

The Extent of Tumor in the Peritoneum and Liver Influences Outcomes After Surgery for Synchronous Liver and Peritoneal Colorectal Metastases: A Cohort Study.

Purpose: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRSH) or liver resection have led to increased survival in patients with peritoneal or liver metastases of colorectal cancer. Selected patients undergo concomitant CRSH and liver resection. Differences in survival and morbidity between patients who underwent concomitant surgery, CRSH or liver resection for peritoneal and/or liver metastases were compared.

[Glycogenic hepatopathy/hepatic glycogenosis: an underappreciated but benign and reversible diabetic complication].

Almost 100 years ago, the French physician Pierre Mauriac described a syndrome named after him, resulting from poorly controlled type 1 diabetes, with growth retardation, delayed puberty, Cushingoid features and hepatomegaly. With modern diabetes care, this is very rare but does occur; however, despite the condition having important clinical implications and being easily treatable, this diabetes complication remains relatively unknown. We present here an authentic patient case in the form of a young man with glycemically poorly controlled type 1 diabetes who developed hepatomegaly, hyperlactatemia and histopathological changes in the liver consistent with glycogenosis, a state readily reversed by normalization of glycemia.

What CPAP to use in the delivery room? Bench comparison of two methods to provide continuous positive airways pressure in neonates.

Background: Continuous positive airway pressure (CPAP) is a recommended first-line therapy for infants with respiratory distress at birth. Resuscitation devices incorporating CPAP delivery can have significantly different imposed resistances affecting airway pressure stability and work of breathing.

Aim: To compare CPAP performance of two resuscitation devices (Neopuff T-piece resuscitator and rPAP) in a neonatal lung model simulating spontaneous breathing effort at birth.

The Expression of Vitamin D Receptor on Peripheral Blood Mononuclear Cells in Patients with Psoriasis.

Vitamin D plays an important role in psoriasis, but its involvement in pathogenesis remains unclear. This study aimed to evaluate vitamin D receptor (VDR) expression on peripheral blood mononuclear cells (PBMCs) in patients with psoriasis and healthy controls and to study the effects of the Etanercept treatment on VDR expression on PBMCs in patients with psoriasis. Twenty patients with moderate to severe psoriasis received treatment with Etanercept for 24 weeks.

Surgical complications after immediate implant-based breast reconstruction for breast cancer in women over 65 years.

Background: While immediate breast reconstruction rates in breast cancer are increasing, they remain low in women over 65 years old. The aim was to investigate surgical outcomes in women older than 65 years receiving implant-based immediate breast reconstruction.

Method: The population-based Stockholm Breast Reconstruction Database includes all adult women with breast cancer receiving an implant-based immediate breast reconstruction in Stockholm, Sweden, 2005-2015.