Effects of polymyxin B haemoperfusion on septic shock caused by Gram-positive bacteria.

Polymyxin B haemoperfusion is commonly used to adsorb endotoxins in septic shock caused by Gram-negative bacterial infections. Polymyxin B haemoperfusion has been reported to improve hypotension in Gram-positive bacterial infections; however, its efficacy and mechanism in treating such cases are unclear. We hypothesised that polymyxin B haemoperfusion would be equally effective in improving haemodynamics during Gram-positive bacterial infections as in Gram-negative bacterial infections.

From X- To J-Aggregation: Subtly Managing Intermolecular Interactions for Superior Phototheranostics with Precise 1064 nm Excitation.

The stacking mode in aggregate state results from a delicate balance of supramolecular interactions, which closely affects the optoelectronic properties of organic π-conjugated systems. Then, managing these interactions is crucial for advancing phototheranostics, yet remains challenging. A subtle strategy involving peripheral phenyl groups is debuted herein to transform X-aggregated SQ-H into J-aggregated SQ-Ph, reorienting intermolecular dipole interactions while rationally modulating π-π interactions.

Lead Phosphate Material for Exclusive Detection of Hydrogen Sulfide Gas.

Efficient gas sensors that can accurately detect and identify hydrogen sulfide are essential for various practical applications. Conventional resistive sensors often lack the necessary selectivity, which hampers timely and effective HS detection. This study presents lead phosphate-based gas sensors specifically designed for HS detection, which effectively eliminate interference effects.

Platinum/(Carbon-Nanotube) Electrocatalyst Boosts Hydrogen Evolution Reaction in Acidic, Neutral and Alkaline Solutions.

Widely used catalysts for electrocatalytic hydrogen (H) evolution reaction (HER) have high platinum (Pt) contents and show low efficiencies in neutral and alkaline solutions. Herein, a carbon nanotube (CNT) supported Pt catalyst (Pt/CNT45) with 1 wt.% Pt is fabricated.

The Proximal Protonation Source in Cu-NHx-C Single Atom Catalysts Selectively Boosts CO2 to Methane Electroreduction.

Regulating the coordination environment of active sites has proved powerful for tapping into their catalytic activity and selectivity in homogeneous catalysis, yet the heterogeneous nature of copper single-atom catalysts (SACs) makes it challenging. This work reports a bottom-up approach to construct a SAC (rGO@Cu-N(Hx)-C) by inlaying preformed amine coordinated Cu2+ units into reduced graphene oxide (rGO), permitting molecular level revelation on how the proximal N-site functional groups (N-H or N-CH3) impact on the carbon dioxide reduction reaction (CO2RR). It is demonstrated that the N-H moiety of rGO@Cu-NHx-C can serve as an in-situ protonation agent to accelerate the CO2-to-methane reduction kinetics, delivering a methane current density (163 mA/cm2) 2.

A NiP/NiMoO nanocone electrocatalyst for efficient hydrogen evolution: tip-enhanced local electric field effect.

The sluggish kinetics of the hydrogen evolution reaction (HER) result in a high overpotential in alkaline solutions. A high-curvature metal oxide heterostructure can effectively boost the electrocatalytic HER by leveraging the tip-enhanced local electric field effect. Herein, NiP/NiMoO nanocones were synthesised on a nickel foam (NF) substrate by etching a metal-organic framework template.

CoS/CoTe n-n Type Heterojunction: A Heterogenic Interfacial Integration of CoS and CoTe Phases for Energy-Efficient Hydrazine Oxidation Assisted Hydrogen Production.

Controlled and optimized heterogenic interfacial coupling is the key to enhance the electrochemical performance. Herein, for the first time, telluride-based CoS/CoTe heterostructure is reported as a bifunctional catalyst for energy-efficient H generation. Detailed investigations suggest that the heterogenic interfacial coupling leads to superior bifunctional electrochemical performance of the CoS/CoTe heterostructure.

A Honeycomb-Structured Triboelectric Nanogenerator Based on Polyester Cloth for Smart Running Application.

Self-powered devices for human motion monitoring and energy harvesting have garnered widespread attention in recent research. In this work, we designed a honeycomb-structured triboelectric nanogenerator (H-TENG) using polyester cloth and Teflon tape, with aluminum foil as the conductive electrode. This design leverages the large surface area and flexibility of textiles, resulting in significant performance improvements.

Hollow TiO@TpPa S-Scheme Photocatalyst for Efficient HO Production Through O in Deionized Water Using Phototautomerization.

Hydrogen peroxide (HO) production through photocatalytic O reduction reaction (ORR) is a mild and cost-efficient alternative to the anthraquinone oxidation strategy. Of note, singlet state oxygen (O) plays a crucial role in ORR. Herein, a hollow TiO@TpPa (TOTP) S-scheme heterojunction by the Schiff base reactions involving 1,3,5-triformylphloroglucinol (Tp) and paraphenylenediamine (Pa) for efficient photocatalytic HO production in deionized water has been developed.

Minimizing Zn Loss Through Dual Regulation for Reversible Zinc Anode Beyond 90% Utilization Ratio.

Large-scale energy storage devices experience explosive development in response to the increasing energy crisis. Zinc ion batteries featuring low cost, high safe, and environment friendly are considered promising candidates for next-generation energy storage devices. However, their practical application suffers from the limited anode lifespan under a high zinc utilization ratio, which can be attributed to aggravated Zn loss caused by zinc conversion reactions and "dead" Zn.

Ultrahigh Exchange Bias Field/Coercive Field Ratio in In Situ Formed Two-Dimensional Magnetic Te-CrO/CrTe Heterostructures.

The exchange bias (EB) effect is a fundamental magnetic phenomenon, in which the exchange bias field/coercive field ratio (|H/H|) can improve the stability of spintronic devices. Two-dimensional (2D) magnetic heterostructures have the potential to construct low-power and high-density spintronic devices, while their typically air unstable and |H/H| lesser, limiting the possibility of applications. Here, 2D CrTe nanosheets have been systematically synthesized with an in situ formed ≈2 nm-thick Te doped CrO layer (Te-CrO) on the upper surface by chemical vapor deposition (CVD) method.

Analysis of Risk Factors for Gastric Cancer and Precancerous Lesions: A Case-Control Study.

Objectives: To investigate the correlation between gastric xanthoma (GX) and precancerous lesions (PCL) and gastric cancer (GC), and to explore other potential risk factors for PCL and GC in northwest China.

Methods: A case-control study was conducted from September 2022 to September 2023 at Xijing Hospital, Air Force Medical University (Xi'an, Shaanxi Province, China). The patients who underwent gastroscopy were enrolled and divided into the chronic gastritis (CG) group (n = 423), PCL group (n = 422), and GC group (n = 415).

Improved therapeutic efficacy of a bifunctional anti-C5 mAb-FH SCR1-5 fusion protein over anti-C5 mAb in an accelerated mouse model of C3 glomerulopathy.

C3 glomerulopathy (C3G), a rare kidney disease caused by dysregulation of alternative pathway complement activation, is characterized by glomerular C3 deposition, proteinuria, crescentic glomerulonephritis, and renal failure. The anti-C5 monoclonal antibody (mAb) drug eculizumab has shown therapeutic effects in some but not all patients with C3G, and no approved therapy is currently available. Here, we developed and used a triple transgenic mouse model of fast progressing lethal C3G (FHm/mP-/-hFDKI/KI) to compare the therapeutic efficacy of a bifunctional anti-C5 mAb fused to a functional factor H (FH) fragment (short consensus repeat 1-5 [SCR1-5]) and the anti-C5 mAb itself.

Size-Controllable High-Entropy Alloys Toward Stable Hydrogen Production at Industrial-Scale Current Densities.

Efficient and stable electrocatalytic hydrogen evolution reaction (HER) at high current densities is highly desirable for industrial-scale hydrogen production, which is yet challenging, because of the electrocatalyst with short lifespans during the acidic HER process. Here, a controllable preparation technique is successfully developed to synthesize PdPtRuRhAu high-entropy alloys (HEAs) of various sizes, within the 3.14 nm particles (HEA-3.

Linkage Microenvironment Modulation in Triazine-Based Covalent Organic Frameworks for Enhanced Photocatalytic Hydrogen Peroxide Production.

Covalent organic frameworks (COFs), known for the precise tunability of molecular structures, hold significant promise for photocatalytic hydrogen peroxide (HO) production. Herein, by systematically altering the quinoline (QN) linkages in triazine (TA)-based COFs via the multi-component reactions, six R-QN-TA-COFs are synthesized with identical skeletons but different substituents. The fine-tuning of the optoelectronic properties and local microenvironment of COFs is allowed, thereby optimizing charge separation and improving interactions with dissolved oxygen.

Digested Ingredients as Substitute for Ileal Digesta in Assessing Protein Fermentation Potential in Growing Pigs.

Understanding protein fermentation in the hindgut of pigs is essential due to its implications for health, and ileal digesta is commonly used to study this process . This study aimed to assess the feasibility of utilizing digested residues as a replacement for ileal digesta in evaluating the protein fermentation potential. residues from cottonseed meal, maize germ meal, peanut meal, rapeseed cake, rapeseed meal, soybean meal and sunflower meal were analysed using a modified gas production (GP) technique and curve fitting model to determine their fermentation dynamics and compare with the use of ileal digesta.

Structural Control of Photoconductivity in a Flexible Titanium-Organic Framework.

The soft nature of Metal-Organic Frameworks (MOFs) sets them apart from other non-synthetic porous materials. Their flexibility allows the framework components to rearrange in response to environmental changes, leading to different states and properties. The work extends this concept to titanium frameworks, demonstrating control over charge transport in porous molecular crystals.

Achieving Near Infrared Photodegradation by the Synergistic Effect of Z-Scheme Heterojunction and Antenna of Rare Earth Single Atoms.

Near-infrared light response catalysts have received great attention in renewable solar energy conversion, energy production, and environmental purification. Here, near-infrared photodegradation is successfully achieved in rare earth single atom anchored NaYF@g-CN heterojunctions by the synergistic effect of Z-scheme heterojunction and antenna of rare earth single atoms. The UV-vis light emitted by Tm can not only be directly absorbed by g-CN to generate electron-hole pairs, realizing efficient energy transfer, but also be absorbed by NaYF substrate, and generating photo-generated electrons at its impurity level, transferring the active charge to the valence band of g-CN, forming a Z-scheme heterojunction and further improving the photocatalytic efficiency.

Characteristics, Motivations, and Preferences of Healthy Volunteers in Phase I Clinical Trials in Sweden.

This study examined the characteristics, experiences, motivations, and preferences of healthy volunteers participating in Phase I clinical trials in Sweden. A descriptive, cross-sectional survey was conducted among 135 healthy volunteers who had participated in at least one Phase I clinical trial from 2021 to 2024. Volunteers considered trial personnel, financial compensation, and regulatory review and approval as highly important factors in their decision to participate.

Molecular Mechanism of Unexpected Metal-Independent Hydroxyl Radical Production by Mercaptotriazole and HO.

It is well known that hydroxyl radical (OH) can be largely produced either through the classic iron-mediated inorganic-Fenton system or our recently discovered haloquinones/HO organic-Fenton-like system, but rarely produced via thiol compounds. Here, unexpectedly, we found that OH can be unequivocally generated by incubation of HO and mercaptotriazole (MTZ), a typical heterocyclic thiol which has been used as an environmentally friendly corrosion inhibitor for mild steel. By the complementary applications of HPLC-MS and oxygen-18 isotope-labeling method, MTZ-derived sulfenic (MTZ-SOH) and sulfinic acids were detected and identified as transient intermediates, and sulfonic acid as final products.

Super-Resolution Mitochondrial Fluorescent Probe for Accurate Monitoring of Drug-Induced Liver Injury.

Drug-induced liver injury (DILI) has emerged as an urgent clinical challenge. It is characterized by mitochondrial dysfunction in liver cells, which leads to abnormal changes in HO levels within the mitochondria. Super-resolution imaging allows for the observation of the fine structure of mitochondria at the nanometer scale, potentially enabling the detection of mitochondrial HO levels during DILI at the subcellular organelle level.

Cation-Vacancy Engineering in Cobalt Selenide Boosts Electrocatalytic Upcycling of Polyester Thermoplastics at Industrial-Level Current Density.

The past decades have witnessed the increasing accumulation of plastics, posing a daunting environmental crisis. Among various solutions, converting plastics into value-added products presents a significant endeavor. Here, an electrocatalytic upcycling route that efficiently converts waste poly(butylene terephthalate) plastics into high-value succinic acid with high Faradaic efficiency of 94.

Generating Beta Zeolite Nanosheets of Intergrown Polymorph B and C Using Polycationic Structure-Directing Agent.

Zeolitic nanosheets possess great potential in catalysis due to their enhanced transport property and accessibility toward bulky molecules compared to conventional micron- meter scale crystals. However, the generation of Beta zeolite nanosheets, which are crucial for industrial catalysis, is still challenging for its intergrowth nature. In this work, aluminosilicate Beta nanosheets of ca.

Development and validation of a nomogram for delirium in the old ischaemic stroke patients.

Aim: To investigate the predictors of post-stroke delirium (PSD) in the old ischaemic stroke patients, and develop a nomogram to predict the risk of PSD.

Methods: A cross-observational study was conducted. The old ischaemic stroke patients in a tertiary hospital in South China were recruited and randomly divided into the train group and test group.

Dynamic Brush Surface Inducing Mobile Crystallization for Sustainable Spray Cooling Using Saline.

Spray cooling, which dissipates heat through droplet evaporation, is an efficient cooling method. Using seawater instead of freshwater in spraying is appealing given the intensifying global water crisis. However, seawater-based cooling suffers from salt accumulation on hot surfaces.