2 results match your criteria: "Gynecology and Reproductive Sciences at the University of California[Affiliation]"

Cdc25A activity is required for the metaphase II arrest in mouse oocytes.

J Cell Sci

March 2013

Center for Reproductive Sciences and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California, San Francisco, CA 94143-0556, USA.

Mammalian oocytes are arrested in metaphase of second meiosis (MII) until fertilization. This arrest is enforced by the cytostatic factor (CSF), which maintains the M-phase promoting factor (MPF) in a highly active state. Although the continuous synthesis and degradation of cyclin B to maintain the CSF-mediated MII arrest is well established, it is unknown whether cyclin-dependent kinase 1 (Cdk1) phosphorylations are involved in this arrest in mouse oocytes.

View Article and Find Full Text PDF