221 results match your criteria: "Gynecologic Cryosurgery"
Surgical and Percutaneous Image-Guided Therapies of Abdominal Wall Endometriosis: A Systematic Review of Current Evidence.
J Minim Invasive Gynecol
September 2024
Department of Radiology, Memorial Sloan Kettering Cancer Center (Drs. Bodard and Cornelis), New York, New York; Department of Radiology, Weill Cornell Medical College (Dr. Cornelis), New York, New York.
Article Synopsis
- This review examines various surgical and nonsurgical treatments for abdominal wall endometriosis to clarify optimal care options due to existing clinical uncertainty.* -
- A total of 51 articles were analyzed, involving 2674 patients, showing that surgical methods had the best local tumor control and pain relief, with a median local tumor control rate of 100%.* -
- Minor adverse events occurred in 17.5% of surgical cases and up to 76.4% with high-intensity focused ultrasound (HIFU), while severe adverse events were noted in 25 surgical patients.*
Development of a machine learning-based model for predicting positive margins in high-grade squamous intraepithelial lesion (HSIL) treatment by Cold Knife Conization(CKC): a single-center retrospective study.
BMC Womens Health
June 2024
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Yangtze University, Shashi District, 8 Hangkong Road, Jingzhou, Hubei, China.
Article Synopsis
- The study investigates factors that lead to positive surgical margins after cold knife conization (CKC) for patients with cervical high-grade squamous intraepithelial lesions (HSIL) and aims to create a machine learning model for risk prediction.
- A review of 3,343 patients identified several independent risk factors, including glandular involvement, transformation zone III, HPV16/18 infections, multiple high-risk HPV infections, and extensive lesion coverage, with an overall positive margin rate of 12.9%.
- The logistic regression model proved to have the best prediction accuracy (74.7%) and is useful for clinical decision-making regarding patient management after CKC.
Advancing intrauterine adhesion severity prediction: Integrative machine learning approach with hysteroscopic cold knife system, clinical characteristics and hematological parameters.
Comput Biol Med
July 2024
Department of Obstetrics and Gynecology, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, 325000, China. Electronic address:
Article Synopsis
- * The study introduces a new machine learning model called bTLSMA-SVM-FS, which combines an upgraded slime mould algorithm with support vector machines to predict the severity of IUA based on clinical features.
- * The model was tested on 107 IUA patients, achieving 86.7% accuracy, and identified key factors influencing IUA severity, providing insights that could improve treatment strategies and enhance understanding of IUA's development.
Neoadjuvant in Situ and Systemic Immunotherapy with Lymph Node Cryoablation in Resectable Stage III Melanoma Metastasis: a Proof-of-Concept Study.
Cardiovasc Intervent Radiol
May 2024
Dermatologic Clinic, University Hospital of Strasbourg, Strasbourg, France.
Article Synopsis
- The study investigates a new treatment approach for patients with stage III melanoma that avoids traditional surgery, proposing to combine cryoablation with immunotherapy.
- Fifteen patients underwent a specific treatment protocol that involved administering immunotherapy followed by cryoablation and further injections, all without any procedure failures reported.
- Results indicate that this combination is feasible with manageable side effects, and over half of the patients showed significant positive responses to the treatment.
Percutaneous cryoablation of abdominal wall endometriosis: An analysis of 38 patients.
Diagn Interv Imaging
September 2024
Department of Radiology, CHU Toulouse-Purpan Cedex 9, 31059 Toulouse, France.
Article Synopsis
- This study aimed to assess how effective percutaneous cryoablation is for treating abdominal wall endometriosis nodules in women over a period from May 2020 to July 2023.!* -
- A total of 38 women participated, with significant pain reduction noted at 3, 6, and 12 months post-treatment, as measured by the visual analog scale (VAS), with 82% reporting effective pain relief at six months.!* -
- The procedure resulted in a noticeable decrease in the size and activity of the endometriosis nodules on MRI without any major complications, highlighting its effectiveness as a minimally invasive treatment option.!*
Percutaneous Imaging-guided Cryoablation of Endometriosis Scars of the Anterior Abdominal Wall.
J Minim Invasive Gynecol
November 2023
Department of Interventional Radiology (Drs. Cazzato, Weiss, Garnon, and Gangi), University Hospital of Strasbourg, Strasbourg, France.
Article Synopsis
- - The study aimed to assess the safety and effectiveness of cryoablation, a minimally invasive treatment, for patients with endometriosis located in the anterior abdominal wall, involving 29 patients over 6 months.
- - Cryoablation was performed under imaging guidance, with nearly half of the procedures done under local anesthesia, resulting in minor complications and significant pain reduction from baseline to 6 months.
- - At the 6-month follow-up, approximately 72% of patients experienced complete symptom relief, although some reported ongoing symptoms or had MRI-confirmed residual disease.
Resolution of Pain after Percutaneous Image-Guided Cryoablation of Extraperitoneal Endometriosis.
J Vasc Interv Radiol
July 2023
Department of Interventional Radiology and Oncology, Tenon Hospital, Sorbonne University, Paris, France; Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:
Article Synopsis
- The study aimed to evaluate the effectiveness of cryoablation in relieving pain caused by symptomatic extraperitoneal endometriosis over a period from 2017 to 2022, involving 42 patients.
- Results showed significant pain reduction, with a median pain score dropping from 8/10 to 0/10 after treatment, and a high pain-free survival rate of 93.8% at 6 months.
- The procedure was determined to be safe, with a low rate of adverse events, and was successful in preventing the need for secondary surgeries in 92.8% of patients.
Percutaneous Image-guided Cryoneurolysis: Applications and Techniques.
Radiographics
October 2022
From the Division of Vascular and Interventional Radiology, Department of Radiology, Duke University Medical Center, 2301 Erwin Road, DUMC Box 3808, Durham, NC 27710 (A.A.S.); Department of Radiology and Imaging Sciences, Division of Interventional Radiology and Image Guided Medicine (R.B., E.B.F., J.D.P.), Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Gynecology and Obstetrics (S.A.), Emory University School of Medicine, Atlanta, Ga; Department of Biological Sciences. Clemson University, Clemson, SC (F.P.); Division of Vascular and Interventional Radiology, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (N.N.); and Experimental Therapeutics Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Md (N.N.).
Article Synopsis
- - The growth of interventional cryoneurolysis has been driven by better imaging technology, deeper insights into nerve responses to cold, and expanding uses beyond just pain relief.
- - Successful application in clinical settings involves carefully evaluating nerve characteristics, confirming with imaging, and understanding different pain causes along with potential complications.
- - Cryoneurolysis is gaining recognition as a viable, non-opioid pain management option, supported by new Medicare coding, and offers interventional radiologists opportunities to integrate procedures that enhance patient care and streamline treatment processes.
Percutaneous cryoablation: a novel treatment option in non-visceral metastases of the abdominal cavity after prior surgery.
Abdom Radiol (NY)
September 2022
Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Article Synopsis
- The study aimed to evaluate the safety and effectiveness of using percutaneous cryoablation on patients with non-visceral abdominal metastases following previous surgery.
- A total of 11 patients with 14 metastases underwent the procedure, achieving technical success in all cases, with most experiencing good local control and no major complications.
- The findings indicate that cryoablation could be a viable minimally invasive treatment for select patients dealing with this type of cancer recurrence in the abdomen.
Feasibility and safety of percutaneous image-guided cryoablation of abdominal wall endometriosis.
Abdom Radiol (NY)
August 2022
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, USA.
Article Synopsis
- The study evaluated the feasibility and safety of percutaneous image-guided cryoablation for treating abdominal wall endometriosis (AWE) in 18 female patients between January 2018 and December 2020.
- All procedures showed technical success, with 94% of lesions showing no signs of residual disease at follow-up, and 93% of patients reported symptom improvement post-treatment.
- The study concluded that cryoablation is a safe and effective treatment for AWE, and more long-term studies are needed to assess the durability of results.
The suture fixation of levonorgestrel-releasing intrauterine device using the hysteroscopic cold-knife surgery system: an original method in treatment of adenomyosis.
Fertil Steril
October 2021
Department of Gynecology, Hangzhou Women's Hospital, Zhejiang, People's Republic of China. Electronic address:
Article Synopsis
- The study explores the use of hysteroscopic cold-knife surgery (HCSS) for securely placing a levonorgestrel-releasing intrauterine device (LNG-IUD) in a patient with adenomyosis.
- The procedure involved detailed video demonstrations, focusing on the technique required for successful suture fixation of the IUD while preserving the patient's fertility.
- The results showed that the HCSS technique was effective, with the patient experiencing significant relief from symptoms and a normal IUD position maintained over a year, with minimal complications.
Evaluation of cervical length and optimal timing for pregnancy after cervical conization in patients with cervical intraepithelial neoplasia: A retrospective study.
Medicine (Baltimore)
December 2020
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine.
Article Synopsis
- The study aimed to evaluate changes in cervical length and optimal timing for pregnancy after cervical conization in patients with cervical intraepithelial neoplasia (CIN), focusing on those under 40 with a desire for fertility.
- It found that cervical length significantly decreased after surgical procedures (LEEP and CKC), with specific measurements indicating a notable decline at 3 and 6 months post-operation compared to pre-operative lengths.
- Recommendations suggested that patients could consider conceiving at 6 months after LEEP and 9 months after CKC, with cervical cerclage shown to help maintain cervical length in those at risk of incompetence.
Feasibility and safety of cryoablation on the porcine ureter using a new balloon cryoprobe.
Cryobiology
October 2020
Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China; Shanghai Municipal Key Clinical Specialty of Gynecologic Oncology, Shanghai, 200030, China; Shanghai Key Laboratory of Embryo Original Diseases Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. Electronic address:
Article Synopsis
- Cryoablation, a technology used for various medical treatments, is being explored for ureteral endometriosis but lacks sufficient research.
- In a study using a balloon cryoprobe on pigs, cryoablation successfully created controlled areas of tissue necrosis with no immediate complications observed.
- The study showed that cryoablation is a feasible, safe, and effective method for targeting ureters, providing valuable insights for potential future clinical applications.
Cryoablation used in fertility-sparing treatment for early endometrial cancer: A pig model experiment using a new designed balloon cryoprobe.
Cryobiology
June 2020
Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China; Shanghai Municipal Key Clinical Specialty of Gynecologic Oncology, Shanghai, 200030, China; Shanghai Key Laboratory of Embryo Original Diseases Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. Electronic address:
Article Synopsis
- * A new surgical method combining hysteroscopic resection with cryoablation was proposed to achieve tumor removal while maintaining uterine integrity.
- * Tests on a pig model showed this cryoablation technique is safe and effective, with potential to freeze a tumor’s surrounding area effectively, paving the way for clinical use in fertility-sparing treatments.
Percutaneous cryoablation of abdominal wall endometriosis: the Mayo Clinic approach.
Abdom Radiol (NY)
June 2020
Department of Obstetrics and Gynecology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA.
Article Synopsis
- - Abdominal wall endometriosis (AWE) is a rare but painful condition that can significantly impact quality of life.
- - There is a lack of a well-defined treatment plan for AWE, making it challenging to manage effectively.
- - This review focuses on the Mayo Clinic's approach to using thermal ablation for treating symptomatic AWE and examines current diagnostic and treatment literature related to the condition.
Development and Implementation of a Culturally Appropriate Education Program to Increase Cervical Cancer Screening among Maasai Women in Rural Tanzania.
Ann Glob Health
October 2019
Department of Obstetrics, Gynecology and Reproductive Sciences at the Robert Larner College of Medicine at the University of Vermont, Burlington, VT, US.
Article Synopsis
- In Tanzania, cervical cancer rates are significantly higher than in the US, especially among Maasai women who face educational, financial, and language barriers affecting their healthcare access.
- A patient education program was developed specifically for Maasai women, utilizing their native language and culturally relevant materials to inform them about cervical cancer and the importance of screenings.
- The intervention led to a substantial increase in understanding of healthcare services among Maasai women, resulting in an 18% rise in their attendance at cervical cancer screening clinics after the education was provided.
Effect of Cryotherapy vs Loop Electrosurgical Excision Procedure on Cervical Disease Recurrence Among Women With HIV and High-Grade Cervical Lesions in Kenya: A Randomized Clinical Trial.
JAMA
October 2019
Department of Global Health, University of Washington, Seattle.
Article Synopsis
- The World Health Organization recommends cryotherapy or LEEP for women with CIN grade 2 or higher, but cryotherapy may be less effective for those living with HIV.
- A study conducted in Kenya evaluated the effectiveness of cryotherapy versus LEEP among 400 women with HIV and high-grade cervical lesions over a 24-month follow-up.
- Results showed that 30% of women treated with cryotherapy experienced disease recurrence compared to 19% in the LEEP group, indicating LEEP may be a more effective treatment option.
Comparative efficacy and complication rates after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE Group.
BMJ Open
August 2019
Department of Surgery and Cancer, Faculty of Medicine, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
Article Synopsis
- - This study aims to conduct a systematic review and network meta-analysis of local treatments for cervical intraepithelial neoplasia (CIN) and microinvasive disease, comparing different excisional and ablative techniques to evaluate their effectiveness and complications.
- - It will include a comprehensive literature search for randomized controlled trials and cohort studies, focusing on treatment outcomes such as residual disease rates and complications like bleeding or cervical stenosis.
- - The authors will use established tools to assess bias and plan to perform statistical analyses to integrate the data, ultimately providing updated insights into the safety and efficacy of these treatment methods.
A Freezing-Induced Turn-On Imaging Modality for Real-Time Monitoring of Cancer Cells in Cryosurgery.
Angew Chem Int Ed Engl
March 2019
School of Materials Science and Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, China.
Article Synopsis
- Cryosurgery is a promising method for treating tumors, but real-time monitoring of the frozen tissue volume is challenging, reducing its effectiveness in cancer treatment.
- This study introduces a technique using TABD-Py molecules that emit bright fluorescence when they interact with ice crystals, allowing for selective real-time imaging of frozen cancer cells.
- The TABD-Py molecules are highly compatible with cancer cells and have low toxicity, which enhances the effectiveness of cryosurgery in tumor treatment.
Community-based HPV self-collection versus visual inspection with acetic acid in Uganda: a cost-effectiveness analysis of the ASPIRE trial.
BMJ Open
June 2018
Department of Health Policy and Management, Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Article Synopsis
- Cervical cancer is a major health issue for women in Uganda, but screening can help prevent it; a community-based self-collection method for HPV testing was proposed to make screening more accessible.
- The ASPIRE trial compared two screening methods: self-collected HPV testing facilitated by community health workers and clinic-based visual inspection, evaluating their effectiveness and cost.
- The results indicated that the HPV screen-and-treat strategy was the most effective and cost-effective option, significantly reducing cervical cancer risk while costing around $130 per year of life saved.
Management of cervical premalignant lesions.
Curr Probl Cancer
April 2019
Jehangir Clinical Development Centre, Jehangir Hospital Premises and Prayas, Pune, India.
Article Synopsis
Cryoablation of Abdominal Wall Endometriosis: A Minimally Invasive Treatment.
AJR Am J Roentgenol
September 2017
1 Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, 3rd Fl Main Bldg, 593 Eddy St, Providence, RI 02903.
Article Synopsis
- The study aims to explore cryoablation as a less invasive and effective treatment option for abdominal wall endometriosis.
- It details the outpatient application of this technique on three patients experiencing symptoms from the condition.
- The results indicate that cryoablation was successful in treating the endometriosis and led to quick positive clinical outcomes for the patients.
Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis.
PLoS One
August 2017
Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Article Synopsis
- The systematic review aimed to compare the effectiveness and safety of loop electrosurgical excision procedure (LEEP) and cold-knife conization (CKC) for treating cervical adenocarcinoma in situ in women who want to preserve fertility.
- Eighteen studies were analyzed, showing that LEEP had a higher rate of positive margins (44%) compared to CKC (29%), but there were no significant differences in residual or recurrence rates between the two methods.
- The review concluded that both treatments are safe and effective, with LEEP potentially being the preferred option due to fewer complications related to fertility preservation.
High-risk human papillomavirus infection clearance following conization among patients with cervical intraepithelial neoplasm grade 3 aged at least 45 years.
Int J Gynaecol Obstet
January 2017
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- The study aimed to explore the rates of high-risk HPV infection clearance after cold knife conization in patients with cervical intraepithelial neoplasm grade 3 and identify predictors of clearance.
- It involved analyzing data from 156 patients aged 45 and older who underwent the procedure at a hospital in China between 2002 and 2012, with findings indicating significant persistence of HPV infections at various follow-up intervals.
- Results showed that patients aged 55 and older had significantly lower rates of HPV clearance compared to younger patients, highlighting age as a critical factor in infection prognosis post-surgery.
Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment.
Cochrane Database Syst Rev
July 2016
Gynaecological Oncology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge, UK, CB2 0QQ.
Article Synopsis
- Pre-cancerous lesions of the cervix (CIN) are typically treated through outpatient procedures like laser or excisional treatments, and the NHS guidelines recommend pain relief for patients before such treatments.
- The study aims to evaluate whether analgesia effectively reduces pain during and after colposcopy procedures for women with CIN.
- A total of 19 randomized controlled trials involving 1,720 women were analyzed to assess various pain relief methods during outpatient cervical treatments, highlighting the different levels of effectiveness and quality among the studies.