1,289 results match your criteria: "Gynecologic Care of Women Infected With HIV"
Correlation between HPV-16 integration status and cervical intraepithelial neoplasia and cervical cancer in patients infected with HIV.
Bull Cancer
December 2024
Department of Intensive Care Unit, Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, 510030 Guangzhou, China. Electronic address:
Background: This study aimed to explore the mechanism by which HIV infection promotes cervical cancer and precancerous lesions.
Methods: This was a retrospective observational study including 96 patients with high-risk HPV-16 infection who underwent cervical biopsy, cervical conization, or hysterectomy. Among them, 43 patients were diagnosed with both HIV and cervical cancer or precancerous lesions.
Piloting of a Screen‑Triage‑Treat Surgical Approach Model for Management of Anal Cancer in Liberia.
Ann Glob Health
December 2024
Director of Global Women's Health, Mount Sinai Health System, New York, NY, USA.
While cancer is a leading cause of death worldwide, significant disparities exist in care access in low‑ and middle‑income countries (LMICs). In Liberia, screening and treatment for anal cancers remain limited, and are exacerbated among vulnerable groups, including men who have sex with men (MSM). Screen‑triage‑treat models for cancerous lesions have been successful in reducing cervical cancer mortality, but the feasibility of this approach has not been studied for anal cancers in a low‑resource context.
View Article and Find Full Text PDFHigh Risk of HPV Related Preneoplastic and Neoplastic Vulvar Lesions in Women Living With HIV.
J Low Genit Tract Dis
December 2024
Neurosurgical Intensive Care Unit, Department of Neuroscience, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.
Objective: We aimed to investigate the epidemiology of human papilloma virus (HPV)-related preneoplastic and neoplastic vulvar lesions in a large cohort of women living with HIV (WLWH).
Materials And Methods: We retrospectively selected 1,796 WLWH who had a gynecological examination, cervical cytology, high-risk (HR-) HPV test, vulvoscopy, and colposcopy with targeted biopsies when necessary between 1987 and 2020 at 2 Italian institutions. Univariable and multivariable regression analyses were carried out to test the association of the anamnestic and clinical data with the development of precancerous and cancerous lesions.
Awareness, attendance, and attitudes toward cervical cancer screening among HIV-positive Chinese women in Yunnan province: a cross-sectional study.
BMC Womens Health
December 2024
Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, P.O. Box 2258, 17 South Panjiayuan Lane, Beijing, China.
Article Synopsis
Knowledge, Attitudes, and Perspectives of Women Who Have Migrated from Sub-Saharan Africa to France Toward HIV Pre-Exposure Prophylaxis in a Family Planning Center.
AIDS Patient Care STDS
November 2024
The Potocsnak Family Division of Adolescent and Young Adult Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois, USA.
Article Synopsis
- * Focus groups conducted with 19 women revealed that many had never heard of PrEP but showed a strong desire to learn more, highlighting barriers such as partner negotiation, adherence, and misconceptions about HIV.
- * Participants expressed high trust in family planning center providers and suggested that community outreach and tailored strategies are essential for improving PrEP uptake among these women.
Preferences for pre-exposure prophylaxis delivery among HIV-negative pregnant and breastfeeding women in Zambia: evidence from a discrete choice experiment.
Front Reprod Health
October 2024
Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Article Synopsis
- Pregnant and breastfeeding women in sub-Saharan Africa, particularly Zambia, are at high risk for HIV and could greatly benefit from pre-exposure prophylaxis (PrEP) to reduce this risk.
- A study involving 389 women assessed their preferences for various aspects of PrEP service delivery, including waiting times and provider attitudes, using a discrete choice experiment.
- The findings indicated that women prioritize shorter waiting times and a 3-month supply of PrEP, even if it means enduring longer travel and less-than-friendly care, highlighting the importance of patient-centered service design.
Strategies and implementation outcomes of HPV-based cervical screening studies to prevent cervical cancer in India: A systematic review.
J Cancer Policy
December 2024
Melbourne School of Population and Global Health, Level 4, 207-221 Bouverie St, 3010, The University of Melbourne, Melbourne, Victoria, Australia.
Article Synopsis
- - The study reviews prior research to guide the implementation of HPV testing for cervical screening in India, focusing on methods of invitation, education, and follow-up within community-based programs and among women living with HIV.
- - Out of 71 articles analyzed, most studies targeted the general population rather than specific groups, with a notable acceptance of self-collection methods among women; however, there was limited research on certain populations, like tribal groups.
- - The authors conclude that while community-based HPV testing is feasible in India, further research is necessary to understand its integration into health systems and the effectiveness of different screening and treatment models, especially in underrepresented populations.
Care of Pregnant Women Living with Human Immunodeficiency Virus.
Clin Perinatol
December 2024
Division of Maternal Fetal Medicine, Department of Gynecology & Obstetrics, School of Medicine, Johns Hopkins University, 600 N Wolfe Street, Phipps 228, Baltimore, MD, USA. Electronic address: https://twitter.com/AhizechukwuEke.
Article Synopsis
- Managing HIV during pregnancy involves addressing both medical needs and the psychological aspects of the mother's health.
- Effective care plans aim to maintain low HIV levels and enhance the mother's overall health before conception.
- The article discusses the use of antiretroviral drugs, pregnancy outcomes for mothers with HIV, and the importance of a comprehensive approach to care.
High-grade cervical disease and cervical cancer in women aged 50 years and older compared with younger women: examining prevalence by HIV status in two large prospective cohorts in Botswana.
BMJ Open
October 2024
Botswana UPenn Partnership, Gaborone, Botswana.
Article Synopsis
- International guidelines suggest stopping cervical screenings at age 50 if two consecutive tests are negative, but many women over 50 in LMICs, like Botswana, haven't had the chance to screen.
- The study analyzed data from two separate cohorts—one for screening with 2,570 women aged 30+ and another with 1,520 cervical cancer patients—to understand the prevalence of cervical dysplasia and cancer stages by age and HIV status.
- Results showed similar prevalence rates of cervical intraepithelial neoplasia (CIN) between women aged 30-49 and 50+, regardless of HIV status, indicating no significant differences in disease prevalence across these age groups.
High prevalence of human papillomavirus (HPV) in unvaccinated adolescent girls in South Africa, particularly those living with HIV.
Vaccine
December 2024
Wits RHI, University of the Witwatersrand, Johannesburg, Gauteng, South Africa. Electronic address:
Article Synopsis
- In 2014, South Africa launched an HPV vaccination program for girls aged 9 and older, but this study focused on 17-18 year old girls who weren't vaccinated, assessing HPV prevalence and related risk factors.
- From June to December 2019, the study surveyed adolescents at primary care clinics and collected data on HPV testing, HIV status, and sexual history from 900 participants, with a focus on understanding the link between these factors and HPV detection.
- Results showed that 56.5% had high-risk HPV, with a higher prevalence in those living with HIV, underscoring the need for increased HPV vaccination efforts in populations with high HIV rates.
Substance use and menopausal symptoms among people with and without HIV in the US, 2008-2020.
Menopause
October 2024
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
Article Synopsis
- The study investigates how substance use impacts menopausal symptoms in people living with and without HIV in the US over a 12-year period.
- Data from the Women’s Interagency HIV Study involved self-reported information on menopausal symptoms, substance use, and demographic data analyzed using logistic regression.
- Findings reveal that current heavy alcohol, cumulative tobacco, and marijuana use are linked to increased frequency of vasomotor symptoms, while heavy alcohol and opioid use are associated with mood symptoms, highlighting the need for targeted interventions during menopause.
Performance of visual inspection, partial genotyping, and their combination for the triage of women living with HIV who are screen positive for human papillomavirus: Results from the AIMA-CC ANRS 12375 multicentric screening study.
Int J Cancer
February 2025
Gynaecologic Department, Yopougon University Teaching Hospital, Felix Houphouët Boigny University, Abidjan, Côte d'Ivoire.
Article Synopsis
- - The WHO recommends HPV testing for cervical cancer screening due to its high sensitivity, but further triage is needed to identify women with high-grade lesions (CIN2+) who need treatment.
- - The ANRS-12375 study evaluated various triage methods like visual inspection (VIA) and different genotyping options in Côte d'Ivoire, Burkina Faso, and Cambodia to detect CIN2+ lesions among women living with HIV.
- - Results showed that VIA and extended genotyping had high sensitivity (89%), with VIA also exhibiting the best specificity among the tests, making them effective options for identifying women who require treatment for CIN2+.
Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV).
BMJ Open
September 2024
Cantonal Hospital St. Gallen, Department of Infectious Diseases, Infection Prevention and Travel Medicine, St Gallen, Switzerland
Purpose: Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.
Participants: Between January 1986 and December 2022, a total of 1446 mother-child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available.
Article Synopsis
- Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
- In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
- There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
Barriers and facilitators of cervical cancer screening literacy among rural women with HIV attending rural public health facilities in East Central Uganda: a qualitative study using the integrated model of health literacy.
BMC Womens Health
September 2024
Department of Obstetrics and Gynecology, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Article Synopsis
- - The study examined the low uptake of cervical cancer screening services (below 50%) among women with HIV in East Central Uganda, identifying significant barriers and facilitators at multiple levels, including health facilities and individual circumstances.
- - Ten Focus Groups were conducted with rural women aged 25-49, analyzing their experiences with cervical cancer screening through thematic analysis based on the Integrated model of health literacy, which includes accessing, understanding, and applying information.
- - Key barriers identified included a lack of communication materials and difficulties in accessing information, while facilitators included effective information access at various levels and women's willingness to engage with the information provided during health education efforts.
Engaging Family Members to Support Exclusive Breastfeeding, Responsive care, and Antiretroviral Therapy Adherence Among Families with Children who are HIV-Exposed and Uninfected.
AIDS Behav
December 2024
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Article Synopsis
- Children who are HIV-exposed and uninfected (CHEU) face greater challenges in growth and health compared to those who are not exposed, highlighting a need for targeted support for their families.
- A study in Lusaka, Zambia, involved postpartum women living with HIV (WLWH) and their home supporters to enhance exclusive breastfeeding (EBF), ART adherence, and responsive caregiving through tailored counseling sessions.
- After the intervention, WLWH showed reduced fears about HIV transmission through breastfeeding and improved practices, while home supporters felt more engaged and supportive in the caregiving process, emphasizing the effectiveness of family involvement in addressing the needs of CHEU.
The relationship between selected sexually transmitted pathogens, HPV and HIV infection status in women presenting with gynaecological symptoms in Maputo City, Mozambique.
PLoS One
September 2024
Department of Pathology, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Article Synopsis
- The study examined the prevalence of sexually transmitted infections (STIs) among 233 non-pregnant women in Maputo, Mozambique, finding a high overall STI prevalence of 89%, with 63% testing positive for HPV and 24% for HIV.* -
- The majority of women reported vaginal discharge (90%), a common symptom, and 56% had co-infections with any STI and HPV, with 45% of these co-infections identified as high-risk HPV genotypes.* -
- The research utilized advanced diagnostic methods, including multiplex STD and HPV Direct Flow Chip Kits and rapid HIV tests, indicating a significant health concern in the region regarding STIs and their effective detection.*
Characterizing HIV drug resistance in cases of vertical transmission in the VESTED randomized antiretroviral treatment trial.
J Acquir Immune Defic Syndr
August 2024
Department of Global Infectious Diseases, Seattle Children's Research Institute, 307 Westlake Ave N, Seattle, 98109, Washington, USA.
Article Synopsis
- - VESTED (NCT03048422) compared the safety and effectiveness of three antiretroviral therapy regimens in pregnant and postpartum women with HIV, finding a low vertical transmission rate of 0.60% among infants.
- - The study analyzed data from 2018 to 2020, enrolling women in early pregnancy and measuring outcomes up to 50 weeks postpartum, focusing on HIV drug resistance in cases of transmission.
- - Results revealed that mothers taking efavirenz-based treatment prior to switching to dolutegravir likely contributed to the transmission of specific HIV drug resistance mutations to their infants, despite prophylactic treatment.
Evaluation of person-centered interventions to eliminate perinatal HIV transmission in Kisumu County, Kenya: A repeated cross-sectional study using aggregated registry data.
PLoS Med
August 2024
Bixby Center for Global Reproductive Health, University of California San Francisco, San Francisco, California, United States of America.
Article Synopsis
- Following a decline in perinatal HIV transmission rates in Kenya from 20% to 8% between 2010 and 2021, the FACES program aimed to further reduce these rates by supporting HIV care for pregnant and postpartum women at 61 facilities in Kisumu County.
- The program implemented three specific interventions in 2019, including high-risk clinics, case management, and a mobile app, to enhance support for women and their infants, while monitoring infant HIV acquisition up to 24 months.
- Data collected from over 12,000 women and nearly 12,000 mother-infant pairs showed a focus on understanding the impact of these interventions on HIV transmission rates, with a particular emphasis on comparing outcomes
Exploring factors influencing awareness and knowledge of human papillomavirus in Chinese college students: A cross-sectional study.
Hum Vaccin Immunother
December 2024
Department of Gynecology, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, PR China.
Article Synopsis
- - Cervical cancer is a major health issue in China, worsened by low HPV vaccination rates, leading to productivity loss and emotional distress among families.
- - A study conducted with 2,679 college students in Jiangsu Province assessed their HPV knowledge and revealed significant misconceptions, despite high general awareness of HPV transmission and risks.
- - Key factors linked to better HPV knowledge included being older, female, in a medical field, in a relationship, familiar with HPV, and having sexual education; although many students were willing to get vaccinated, actual vaccination rates were still low, highlighting the need for targeted education.
Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews.
AIDS Care
December 2024
Center for Global Health, University of Colorado, Aurora, CO, USA.
Article Synopsis
- Adherence to antiretroviral therapy (ART) is low among pregnant and postpartum women living with HIV in resource-limited settings, with few effective interventions available.
- A study conducted 24 in-depth interviews with women in western Kenya, correlating their self-reported experiences with actual ART drug concentration levels obtained from blood samples.
- Key themes identified included the effects of HIV status disclosure, social support, healthcare interactions, and health beliefs, highlighting a potential for targeted interventions to enhance ART adherence and improve health outcomes for mothers and infants.
Gynaecological cancer-related deaths in a tertiary hospital: A four-year retrospective review.
Afr J Reprod Health
July 2024
Faculty of Health Sciences, School of Clinical Medicine, Department of Obstetrics and Gynaecology, University of the Witwatersrand, Johannesburg, South Africa.
Article Synopsis
- The study investigates the profiles, causes of death, and complications of women who died from gynecological cancers over four years at a tertiary hospital, based on a review of 48 clinical records.
- Key findings show that the average age of deceased women was 52.7, with a majority being South African, black, and unemployed; common comorbidities included hypertension and HIV.
- Cancer types primarily included cervical, ovarian, and endometrial cancers, with most women presenting complications like obstructive uropathy and receiving limited palliative or surgical treatments due to advanced disease stages.
True and false positive HIV point of care test results in a prospective multinational study of at-risk African women: implications for large-scale repeat HIV testing in HIV prevention programs.
J Acquir Immune Defic Syndr
August 2024
Department of Global Health, University of Washington, Seattle, United States.
Article Synopsis
- The study investigated the accuracy of HIV point-of-care testing among African women using various contraceptive methods, focusing on the occurrence of true and false positive results.
- Out of 48,234 visits by 7,730 women, true positive results were found in only 0.9% of cases, while false positives occurred in 0.2%, necessitating additional confirmatory testing.
- The findings emphasize the need for confirmatory tests, as not all HIV infections presented typical laboratory results, particularly in populations with low HIV prevalence and repeat testing.
Barriers and Facilitators to HIV Care Linkage and Retention Among Older Adults Diagnosed With HIV in Malaysia: A Qualitative Study.
Sex Transm Dis
December 2024
Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Article Synopsis
- Older adults diagnosed with HIV in Malaysia face greater health risks and mortality compared to younger patients, prompting a study on their care challenges.
- In-depth interviews with 16 older individuals living with HIV and 7 healthcare providers revealed barriers at individual, interpersonal, and institutional levels impacting their care.
- Key obstacles included misinformation, stigma, high costs, and inadequate support systems, while support from friends or doctors and a reputable healthcare system served as positive facilitators to engagement in care.
"We chose PrEP because I wanted to be sure that this child my wife was going to conceive was indeed mine." Factors influencing the choice of safer conception methods and experiences with its use: a qualitative study among HIV sero-discordant couples in Zimbabwe.
BMC Public Health
July 2024
University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe.
Article Synopsis
- Safer conception services are essential for HIV sero-discordant couples wanting to conceive, yet there is limited research on their experiences and preferences with various methods.
- A study involving 17 couples in Zimbabwe revealed that choices around safer conception were influenced by desires for intimacy and factors like method familiarity, ease of use, and effectiveness in preventing HIV while achieving pregnancy.
- Participants generally had positive experiences and satisfaction, particularly with ART/VL and PrEP, highlighting the importance of finding suitable methods for safe conception.