How to restore lower complete edentulism with implant-supported overdentures: an evidence-based clinical management.

This clinical report demonstrates how a two-implant mandibular implant-supported overdenture is planned and executed. The following steps feature the dual scan technique as part of implant planning and a radiographic-turned-surgical stent to guide a freehand, two-stage surgical placement of two implant fixtures on the bilateral canine positions of the mandibular arch.

GENCODE 2025: reference gene annotation for human and mouse.

GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as new technologies and methodologies allow us to catalog the genome at ever-increasing granularity. In particular, long-read transcriptome sequencing enables us to identify large numbers of missing transcripts and to substantially improve existing models, and our long non-coding RNA catalogs have undergone a dramatic expansion and reconfiguration as a result.

Endochondral ossification: Insights into the cartilage mineralization processes achieved by an anhydrous freeze substitution protocol.

Growth plate cartilage (GP) serves as a dynamic site of active mineralization and offers a unique opportunity to investigate the cell-regulated matrix mineralization process. Transmission electron microscopy (TEM) provides a means for the direct observation of these mechanisms, offering the necessary resolution and chemical analysis capabilities. However, as mineral crystallinity is prone to artifacts using aqueous fixation protocols, sample preparation techniques are critical to preserve the mineralized tissue in its native form.

The short-term postoperative pain and impact upon quality of life of pulpotomy and root canal treatment, in teeth with symptoms of irreversible pulpitis: A randomized controlled clinical trial.

Background: Few studies focus upon patient-reported outcomes in endodontics.

Aim: To determine whether full pulpotomy offers a less painful, improved health-related quality of life (HRQoL) compared with root canal treatment (RCT) in cases of irreversible pulpitis (IP) in the 7 days after the treatment.

Methodology: One hundred sixty-eight participants presenting with symptoms of IP were randomized to either pulpotomy (n = 86) or RCT (n = 82).

A probability model for estimating age in young individuals relative to key legal thresholds: 15, 18 or 21-year.

Age estimations are relevant for pre-trial detention, sentencing in criminal cases and as part of the evaluation in asylum processes to protect the rights and privileges of minors. No current method can determine an exact chronological age due to individual variations in biological development. This study seeks to develop a validated statistical model for estimating an age relative to key legal thresholds (15, 18, and 21 years) based on a skeletal (CT-clavicle, radiography-hand/wrist or MR-knee) and tooth (radiography-third molar) developmental stages.

Visualisation of dental anatomy in CBCT scans (Part 2).

To the trained eye, every tooth is different. An in-depth understanding of dental anatomy in cross-sectional images is a fundamental basic skill required when interpreting cone beam computed tomography (CBCT) scans. The conventional orthogonal planes of axial, coronal, and sagittal are not always the best planes in which to assess teeth because every tooth is at a slightly different angle to all these planes.

Visualisation of dental anatomy in CBCT scans: Part 1.

To the trained eye, every tooth is different. An in-depth understanding of dental anatomy in cross-sectional images is a fundamental basic skill required when interpreting cone beam computed tomography (CBCT) scans. The conventional orthogonal planes of axial, coronal, and sagittal are not always the best planes in which to assess teeth because every tooth is at a slightly different angle to all these planes.

The influence of 'Golden Age' authors of detective fiction, in particular, D. L. Sayers, on the public opinion of dentists and dentistry.

With her wide readership and sympathetic and intelligent handling of dentists and dentistry in her detective novels and short stories, it is probable that Dorothy Leigh Sayers(1893-1957) influenced the public perception of dentists favourably, as being true professionals, particularly after the 1921 Act made it a fully closed specialty. Her encounter with a dental automaton seen when she was very young is acknowledged by her as a formative influence.

Nuala Mary Brigid Mitzi Macey-Dare (née Coyle) (1934-2022): leading community dentist, forensic odontologist and her family.

For many people, being a parent of five children is more than enough to keep oneself occupied. Mitzi Coyle (Macey-Dare) did that, and gained a top post in the community dental service, with a string of dental and other postgraduate qualifications. Her children are equally talented.

Excitatory and inhibitory synapses show a tight subcellular correlation that weakens over development.

Neurons receive correlated levels of excitation and inhibition, a feature that is important for proper brain function. However, how this relationship between excitatory and inhibitory inputs is established during the dynamic period of circuit wiring remains unexplored. Using multiple techniques, including in utero electroporation, electron microscopy, and electrophysiology, we reveal a tight correlation in the distribution of excitatory and inhibitory synapses along the dendrites of developing CA1 hippocampal neurons.

Hematuria Cancer Risk Score with Ultrasound Informs Cystoscopy Use in Patients with Hematuria.

Background: Hematuria is a cardinal symptom of urinary tract cancer and would require further investigations.

Objective: To determine the ability of renal bladder ultrasound (RBUS) with the Hematuria Cancer Risk Score (HCRS) to inform cystoscopy use in patients with hematuria.

Design, Setting, And Participants: The development cohort comprised 1984 patients with hematuria from 40 UK hospitals (DETECT 1; ClinicalTrials.

BSP Implementation of prevention and treatment of peri-implant diseases - The EFP S3 level clinical practice guideline.

Objectives: to adapt the supranational European Federation of Periodontology (EFP) Prevention and Treatment of Peri-implant Diseases - The EFP S3 Level Clinical Practice Guideline for UK healthcare environment, taking into account a broad range of views from stakeholders and patients.

Sources: This UK version, based on the supranational EFP guideline [1] published in the Journal of Clinical Periodontology, was developed using S3-level methodology, combining assessment of formal evidence from 13 systematic reviews with a moderated consensus process of a representative group of stakeholders, and accounts for health equality, environmental factors and clinical effectiveness. It encompasses 55 clinical recommendations for the Prevention and Treatment of Peri-implant Diseases, based on the classification for periodontal and peri‑implant diseases and conditions [2].

Effect of a Low-Calorie Dietary Intervention on Liver Health and Body Weight in Adults with Metabolic-Dysfunction Associated Steatotic Liver Disease (MASLD) and Overweight/Obesity: A Systematic Review and Meta-Analysis.

Introduction: Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD) is a common cause of chronic liver disease. This review assessed the efficacy of a Low-Calorie Diet (LCD) on liver health and body weight in people living with MASLD and obesity.

Methods: The study was registered with PROSPERO (CRD42021296501), and a literature search was conducted using multiple databases.

Bernard Geoffrey Norman Smith (1938-2016).

Bernard Smith was one of the most significant specialists in restorative dentistry of his generation. He was an inspiring undergraduate and postgraduate teacher, a noted international lecturer and a house-builder. Bernard was president of the British Society for Restorative Dentistry and first chairman of the Association of Consultants and Specialists in Restorative Dentistry.

Suppression head impulse test in children-experiences in a tertiary paediatric vestibular centre.

The suppression head impulse paradigm (SHIMP) involves suppression of the vestibulo-ocular reflex (VOR) and anticompensatory saccades generated thereof. SHIMP is gaining importance to understand vestibular compensation with its different parameters (VOR gain/peak saccadic velocity PSV/latency of saccades). SHIMP studies are emerging in adults, but pediatric studies have hardly been performed.

Franz Alfred (1880-1962) and Georg Frederich (1921-2010) Kantorowicz.

George Kantorowicz was a senior lecturer/consultant in conservative dentistry at the Royal Dental Hospital who provided ground-breaking treatment for cleft palate children at Great Ormond Street Hospital. His father, Alfred, was a Jewish professor, dean at Bonn Dental School and a world-famous advocate of mobile dental surgeries and prevention for children's dental health, until the Nazis put him in a concentration camp. After important interventions, he became director of Istanbul Dental Institute.

Long term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome.

Advanced stage (IIB-IVB) Mycosis Fungoides (MF) and Sezary Syndrome (SS) have a poor prognosis with median survival <5 years. We report long-term outcomes of a non-myeloablative allogeneic stem cell transplantation regimen consisting of total skin electron beam therapy, total lymphoid irradiation and antithymocyte globulin. Our prospective cohort consisted of 41 patients with a higher proportion of MF (34MF, 7SS).

Real-world data of a digitally enabled, time-restricted eating weight management program in public sector workers living with overweight and obesity in the United Kingdom: A service evaluation of the Roczen program.

Introduction: The health of the United Kingdom workforce is key; approximately 186 million days are lost to sickness each year. Obesity and type 2 diabetes (T2D) remain major global health challenges. The aim of this retrospective service evaluation was to assess the impact of a digitally enabled, time-restricted eating (TRE) intervention (Roczen Program, Reset Health Ltd) on weight and other health-related outcomes.

Role of teledentistry in enabling improved oral care outcomes.

Nowadays, the link between oral health and general health is clearly understood and supported by many global bodies, including the World Health Organisation. Yet, oral diseases remain prevalent worldwide, necessitating a practical approach. This opinion paper seeks to clarify the role of teledentistry as an adjunct for improving oral health when access to oral care services is one of the major concerns.

Sir Terence Ward CBE MBE (Mil) (1906-1991) and maxillofacial surgery at Queen Victoria Hospital.

Terence Ward was a major maxillofacial surgeon in World War II, working with Sir Archibold McIndoe to treat badly injured forces personnel, especially air crew. He was important when the time came to establish his speciality in the post-war NHS. Sir Terence played an important role in the Royal College of Surgeons of England, where he was dean of its Faculty of Dental Surgery and raised a great deal of money for the Department of Dental Science.