40 results match your criteria: "Guy's and St.Thomas Hospital NHS Foundation Trust[Affiliation]"
Rheumatology (Oxford)
January 2025
Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom.
Objectives: Systemic sclerosis (SSc)-interstitial lung disease (ILD) is one of the leading causes of mortality in SSc. Data from randomised controlled trials (RCTs) supports rituximab and tocilizumab monotherapy but there is limited data regarding their use for those who fail standard immunomodulatory therapies.
Methods: SSc patients treated with rituximab or tocilizumab were retrospectively identified in a single centre cohort.
Antioxid Redox Signal
October 2024
Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Endothelial cells are the critical targets of injury in diabetic nephropathy (DN), and endothelial cell lesions contribute to the disease progression. Neurite outgrowth inhibitor B (Nogo-B), an endoplasmic reticulum (ER)-resident protein, plays a pivotal role in vascular remodeling after injury, and maintains the structure and function of the ER. Yet, the role of Nogo-B in the regulation of ER stress and endothelial cell injury remains largely unknown.
View Article and Find Full Text PDFJ Virus Erad
December 2023
Harrison Wing, Department of HIV, Guy's and St Thomas Hospital NHS Foundation Trust, UK.
Metabolism
February 2024
Beth Israel Deaconess Medical Center and Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA. Electronic address:
BMC Musculoskelet Disord
March 2023
Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
Background: Neck pain, with or without radiculopathy, can have significant negative effects on physical and mental wellbeing. Mental health symptoms are known to worsen prognosis across a range of musculoskeletal conditions. Understanding the association between mental health symptoms and health outcomes in this population has not been established.
View Article and Find Full Text PDFInt J Mol Sci
August 2022
Neurotrauma and Neurovascular Surgery, Royal London Hospital, London E1 1FR, UK.
The distinguishing pathogenic features of neurodegenerative diseases include mitochondrial dysfunction and derived reactive oxygen species generation. The neural tissue is highly sensitive to oxidative stress and this is a prominent factor in both chronic and acute neurodegeneration. Based on this, therapeutic strategies using antioxidant molecules towards redox equilibrium have been widely used for the treatment of several brain pathologies.
View Article and Find Full Text PDFJ Fungi (Basel)
July 2022
Departments of Respiratory Medicine and Intensive Care, Royal Brompton and Harefield Hospital, Guy's and St. Thomas Hospital NHS Foundation Trust, London UB9 6JH, UK.
Trials
April 2022
Department of Infectious Disease, Imperial College London, London, UK.
JTCVS Tech
February 2022
Cardio Thoracic Surgery Department, Royal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Br J Oral Maxillofac Surg
January 2022
Guy's Hospital, Guy's and St. Thomas Hospital NHS Foundation trust, United Kingdom. Electronic address:
Eur Arch Otorhinolaryngol
November 2021
Department of Otorhinolaryngology-Head and Neck Surgery, Head, Neck and Thyroid Cancer Unit, Guy's and St Thomas Hospital NHS Foundation Trust, London, UK.
Purpose: To provide expert opinion and consensus on salvage carbon dioxide transoral laser microsurgery (CO TOLMS) for recurrent laryngeal squamous cell carcinoma (LSCC) after (chemo)radiotherapy [(C)RT].
Methods: Expert members of the European Laryngological Society (ELS) Cancer and Dysplasia Committee were selected to create a dedicated panel on salvage CO TOLMS for LSCC. A series of statements regarding the critical aspects of decision-making were drafted, circulated, and modified or excluded in accordance with the Delphi process.
IDCases
May 2021
Department of Respiratory Medicine, Royal Brompton and Harefield Hospital, Guy's and St.Thomas Hospital NHS Foundation Trust, London, United Kingdom.
Among the secondary fungal infections in Coronavirus-19 (COVID-19) infection, Aspergillosis has been reported more often than Mucormycosis. Disseminated mucormycosis is almost always a disease of severely immunosuppressed hosts. We report a young obese Asian male who was admitted with an acute anterior cerebral artery (ACA) territory infarct and severe COVID-19 pneumonitis to the intensive care unit (ICU).
View Article and Find Full Text PDFPain Rep
February 2021
School of Health and Social Care, Division of Allied Health Sciences, London South Bank University, London, United Kingdom.
Introduction: Cervical spine pain with or without radiculopathy (CSp ± R) has significant negative impacts to a person's quality of life. Psychosocial factors and/or mental health symptoms are associated with spinal pain with or without radiculopathy and negatively impact health outcomes. This area of research is not yet established for CSp ± R.
View Article and Find Full Text PDFTrials
March 2021
Oral Medicine Department, Guy's and St. Thomas Hospital NHS Foundation Trust, King's College London, London, UK.
Oral Dis
March 2023
Department of Diagnostic Sciences, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Oral Dis
April 2022
Department of Adult Allergy, Guy's and St. Thomas's NHS Foundation Trust, London, UK.
Clin Breast Cancer
February 2021
Medical Oncology Service, Instituto de Investigación Sanitaria Gregorio Marañón, CIBERONC, GEICAM, Universidad Complutense, Madrid, Spain.
Background: The ExteNET trial demonstrated improved invasive disease-free survival (iDFS) with neratinib, an irreversible pan-HER tyrosine kinase inhibitor, versus placebo in patients with human epidermal growth factor receptor 2-positive (HER2)/hormone receptor-positive (HR) early-stage breast cancer (eBC).
Patients And Methods: ExteNET was a multicenter, randomized, double-blind, phase III trial of 2840 patients with HER2 eBC after neoadjuvant/adjuvant trastuzumab-based therapy. Patients were stratified by HR status and randomly assigned 1-year oral neratinib 240 mg/day or placebo.
Trials
August 2020
Oral Medicine Department, Guy's and St. Thomas Hospital NHS Foundation Trust, King's College London, London, UK.
Background: A core outcome set (COS) represents the agreed minimum set of domains and measurement instruments that should be measured and reported in any clinical trial for a given condition. In BMS randomized controlled trials (RCTs), the outcomes identified in the existing literature regarding the efficacy of therapeutic interventions are numerous and diverse. Although the standardized IMMPACT core outcome domains has been developed for measurement of outcomes in chronic pain RCTs, no BMS-specific COS have been adopted and validated.
View Article and Find Full Text PDFMusculoskeletal Care
December 2020
School of Health and Social Care, Department of Allied Health Sciences. Pain Research Cluster; Ageing, Acute and Long Term Conditions Research Group., London South Bank University, London, UK.
Background And Objective: Cervical spine radiculopathy (CSR) is a disabling condition that has significant negative impacts on a person's mental health, physical functioning and social participation. Research has reported variable CSR incidence and prevalence among different populations. To date, no systematic review has been completed investigating the prevalence or incidence of CSR; therefore, our objective was to determine the incidence and/or prevalence of CSR in adults.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
February 2021
Department of Otorhinolayngology Head and Neck Surgery, Guy's and St Thomas Hospital NHS Foundation Trust, London, UK.
Clin Med (Lond)
March 2020
South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Late HIV diagnosis is associated with significant mortality in people living with HIV (PLWH) and high numbers of missed opportunities (MO) for earlier testing have been identified. A pilot of a national late diagnosis review process (LDRP) was undertaken in 15 HIV services evaluating the feasibility of LDRP implementation, as a patient safety initiative. All newly diagnosed PLWH with CD4 counts <200 cells/mm were included, and healthcare episodes within 5 years of presentation reviewed.
View Article and Find Full Text PDFHIV Res Clin Pract
May 2020
Department of HIV, Sexual Health, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequencing were collected at three time-points. Two showed resistance-associated mutations (RAMs) in the protease gene, while 95-100% had RAMs in the gag gene, which evolved in approximately a quarter of subjects, suggesting a potential clinical role of these kind of mutations.
View Article and Find Full Text PDFSex Transm Infect
December 2020
Harrison Wing Department, Guy's and St Thomas Hospital NHS Foundation Trust, London, UK.
J Plast Reconstr Aesthet Surg
October 2019
Plastic and Reconstructive Surgery Department, Guy's and St. Thomas Hospital NHS Foundation Trust, Westminster Bridge Rd, SE1 7EH, London, UK; University of Basel, Basel, CH, Switzerland.
Introduction: The SGAP flap represents an alternative for autologous breast reconstruction when DIEP is not available. In this article, we report eight years of experience in breast reconstruction using SGAP free flap and discuss our results, how our procedures have evolved, the outcomes and complications rates and how to perform this procedure efficiently while managing the challenges inherent to this type of flap.
Materials And Methods: A retrospective study was conducted from June 2009 and June 2017.