40 results match your criteria: "Guy's and St.Thomas Hospital NHS Foundation Trust[Affiliation]"

Objectives: Systemic sclerosis (SSc)-interstitial lung disease (ILD) is one of the leading causes of mortality in SSc. Data from randomised controlled trials (RCTs) supports rituximab and tocilizumab monotherapy but there is limited data regarding their use for those who fail standard immunomodulatory therapies.

Methods: SSc patients treated with rituximab or tocilizumab were retrospectively identified in a single centre cohort.

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Nogo-B Promotes Endoplasmic Reticulum Stress-Mediated Autophagy in Endothelial Cells of Diabetic Nephropathy.

Antioxid Redox Signal

October 2024

Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Endothelial cells are the critical targets of injury in diabetic nephropathy (DN), and endothelial cell lesions contribute to the disease progression. Neurite outgrowth inhibitor B (Nogo-B), an endoplasmic reticulum (ER)-resident protein, plays a pivotal role in vascular remodeling after injury, and maintains the structure and function of the ER. Yet, the role of Nogo-B in the regulation of ER stress and endothelial cell injury remains largely unknown.

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Article Synopsis
  • Researchers wanted to see how willing people with HIV are to join studies that temporarily stop their medication to test cures.
  • They asked 75 people about their thoughts and worries regarding these studies, finding that many wanted to help science but were most concerned about the risk of passing on HIV to others.
  • Most participants preferred to have regular check-ups and wanted to talk to their doctor before joining any study that involved taking a break from their treatment.
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Background: Neck pain, with or without radiculopathy, can have significant negative effects on physical and mental wellbeing. Mental health symptoms are known to worsen prognosis across a range of musculoskeletal conditions. Understanding the association between mental health symptoms and health outcomes in this population has not been established.

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Article Synopsis
  • - ExteNET, a phase 3 clinical trial, studied the effects of neratinib, a drug used after trastuzumab therapy, on improving invasive disease-free survival in women with early-stage HER2-positive breast cancer.
  • - The trial randomly assigned 2,840 eligible women to receive either neratinib or a placebo for one year and analyzed overall survival after a median follow-up of 8.1 years.
  • - Results showed that the overall survival rates were similar between the neratinib group (90.1%) and placebo group (90.2%), indicating that neratinib did not significantly improve survival over placebo.
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The distinguishing pathogenic features of neurodegenerative diseases include mitochondrial dysfunction and derived reactive oxygen species generation. The neural tissue is highly sensitive to oxidative stress and this is a prominent factor in both chronic and acute neurodegeneration. Based on this, therapeutic strategies using antioxidant molecules towards redox equilibrium have been widely used for the treatment of several brain pathologies.

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COVID-19-Associated Pulmonary Mucormycosis.

J Fungi (Basel)

July 2022

Departments of Respiratory Medicine and Intensive Care, Royal Brompton and Harefield Hospital, Guy's and St. Thomas Hospital NHS Foundation Trust, London UB9 6JH, UK.

Article Synopsis
  • COVID-19-associated mucormycosis (CAM) became a significant health issue during the pandemic, particularly with pulmonary infections often being under-identified.
  • High mortality rates of up to 80% highlight the importance of early detection and treatment for COVID-19-associated pulmonary mucormycosis (CAPM).
  • Improved diagnostic methods, combined medical and surgical treatment approaches, and maintaining good glycemic control are crucial in managing this serious condition, alongside the urgent need for better diagnostic tools.
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Article Synopsis
  • Antiretroviral therapy (ART) significantly improves survival rates for people with HIV, but it does not provide a cure or allow control of the virus without medication, making the search for new treatments crucial.
  • The RIO trial is a phase II study that tests two long-acting broadly neutralising antibodies (bNAbs) on participants who started ART early, comparing their effectiveness against a placebo in managing HIV after stopping treatment.
  • Participants will be monitored for viral rebound after treatment and evaluated for various health markers, with the aim of finding potentially lasting remission options for those with HIV.
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Purpose: To provide expert opinion and consensus on salvage carbon dioxide transoral laser microsurgery (CO TOLMS) for recurrent laryngeal squamous cell carcinoma (LSCC) after (chemo)radiotherapy [(C)RT].

Methods: Expert members of the European Laryngological Society (ELS) Cancer and Dysplasia Committee were selected to create a dedicated panel on salvage CO TOLMS for LSCC. A series of statements regarding the critical aspects of decision-making were drafted, circulated, and modified or excluded in accordance with the Delphi process.

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Among the secondary fungal infections in Coronavirus-19 (COVID-19) infection, Aspergillosis has been reported more often than Mucormycosis. Disseminated mucormycosis is almost always a disease of severely immunosuppressed hosts. We report a young obese Asian male who was admitted with an acute anterior cerebral artery (ACA) territory infarct and severe COVID-19 pneumonitis to the intensive care unit (ICU).

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Introduction: Cervical spine pain with or without radiculopathy (CSp ± R) has significant negative impacts to a person's quality of life. Psychosocial factors and/or mental health symptoms are associated with spinal pain with or without radiculopathy and negatively impact health outcomes. This area of research is not yet established for CSp ± R.

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Article Synopsis
  • The study looked at how well certain medicines help people with burning mouth syndrome (BMS) compared to a fake treatment (placebo).
  • After reviewing 14 studies with 734 participants, they found that some medications showed different levels of effectiveness in reducing pain.
  • The researchers suggest using consistent ways to measure results in future studies to improve understanding of how these treatments work.
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Eosinophilic sialodochitis: An emerging atopic condition.

Oral Dis

April 2022

Department of Adult Allergy, Guy's and St. Thomas's NHS Foundation Trust, London, UK.

Article Synopsis
  • This text talks about a study of 37 patients with a condition called eosinophilic sialodochitis, which affects the glands that produce saliva.
  • Most patients have had symptoms for a long time and report swelling and discomfort in their salivary glands.
  • The study suggests that this condition might be related to allergies and more research is needed to find better treatments.
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Final Efficacy Results of Neratinib in HER2-positive Hormone Receptor-positive Early-stage Breast Cancer From the Phase III ExteNET Trial.

Clin Breast Cancer

February 2021

Medical Oncology Service, Instituto de Investigación Sanitaria Gregorio Marañón, CIBERONC, GEICAM, Universidad Complutense, Madrid, Spain.

Background: The ExteNET trial demonstrated improved invasive disease-free survival (iDFS) with neratinib, an irreversible pan-HER tyrosine kinase inhibitor, versus placebo in patients with human epidermal growth factor receptor 2-positive (HER2)/hormone receptor-positive (HR) early-stage breast cancer (eBC).

Patients And Methods: ExteNET was a multicenter, randomized, double-blind, phase III trial of 2840 patients with HER2 eBC after neoadjuvant/adjuvant trastuzumab-based therapy. Patients were stratified by HR status and randomly assigned 1-year oral neratinib 240 mg/day or placebo.

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Background: A core outcome set (COS) represents the agreed minimum set of domains and measurement instruments that should be measured and reported in any clinical trial for a given condition. In BMS randomized controlled trials (RCTs), the outcomes identified in the existing literature regarding the efficacy of therapeutic interventions are numerous and diverse. Although the standardized IMMPACT core outcome domains has been developed for measurement of outcomes in chronic pain RCTs, no BMS-specific COS have been adopted and validated.

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Cervical spine radiculopathy epidemiology: A systematic review.

Musculoskeletal Care

December 2020

School of Health and Social Care, Department of Allied Health Sciences. Pain Research Cluster; Ageing, Acute and Long Term Conditions Research Group., London South Bank University, London, UK.

Background And Objective: Cervical spine radiculopathy (CSR) is a disabling condition that has significant negative impacts on a person's mental health, physical functioning and social participation. Research has reported variable CSR incidence and prevalence among different populations. To date, no systematic review has been completed investigating the prevalence or incidence of CSR; therefore, our objective was to determine the incidence and/or prevalence of CSR in adults.

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Article Synopsis
  • - Traditional practices for early tracheostomy in critically ill patients need to be reevaluated due to the heightened risks of COVID-19 for both patients and healthcare workers, prompting the development of revised safety guidelines.
  • - This narrative review draws on the experience of over 120 patients with tracheostomy, analyzing current evidence to establish safer procedures, particularly aimed at reducing aerosol transmission risks during care.
  • - The study emphasizes the importance of a multidisciplinary approach in tracheostomy care, advocating for improved infection control strategies and individualized protocols to ensure the safety of both patients and medical staff during the pandemic.
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Late HIV diagnosis is associated with significant mortality in people living with HIV (PLWH) and high numbers of missed opportunities (MO) for earlier testing have been identified. A pilot of a national late diagnosis review process (LDRP) was undertaken in 15 HIV services evaluating the feasibility of LDRP implementation, as a patient safety initiative. All newly diagnosed PLWH with CD4 counts <200 cells/mm were included, and healthcare episodes within 5 years of presentation reviewed.

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To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequencing were collected at three time-points. Two showed resistance-associated mutations (RAMs) in the protease gene, while 95-100% had RAMs in the gag gene, which evolved in approximately a quarter of subjects, suggesting a potential clinical role of these kind of mutations.

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Breast reconstruction with Superior Gluteal Artery Perforator free flap: 8 years of experience.

J Plast Reconstr Aesthet Surg

October 2019

Plastic and Reconstructive Surgery Department, Guy's and St. Thomas Hospital NHS Foundation Trust, Westminster Bridge Rd, SE1 7EH, London, UK; University of Basel, Basel, CH, Switzerland.

Introduction: The SGAP flap represents an alternative for autologous breast reconstruction when DIEP is not available. In this article, we report eight years of experience in breast reconstruction using SGAP free flap and discuss our results, how our procedures have evolved, the outcomes and complications rates and how to perform this procedure efficiently while managing the challenges inherent to this type of flap.

Materials And Methods: A retrospective study was conducted from June 2009 and June 2017.

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