238 results match your criteria: "Guy's St Thomas' Hospitals[Affiliation]"
Aesthetic Plast Surg
June 2023
Faculty of Life Sciences and Medicine, King's College London, Guy's Campus, Great Maze Pond, London, SE1 1UL, UK.
Piezosurgery use has become increasingly prevalent in osteotomies. Piezoelectric ultrasound waves can cut bone effectively, and some studies have shown reduced post-operative morbidities compared to conventional osteotomies. Oedema and ecchymosis are common complications of rhinoplasty and can impact patient satisfaction, wound healing, and recovery.
View Article and Find Full Text PDFExpert Opin Pharmacother
August 2022
Metabolic Medicine/Chemical Pathology, Guy's & St Thomas Hospitals, London, UK.
Introduction: Low density Lipoprotein cholesterol)LDL-C) levels show a clear relationship with cardiovascular disease (CVD). Statins are first line agents to reduce LDL-C and CVD risk. However, combination lipid-lowering therapy is often required to achieve large reductions in LDL-C.
View Article and Find Full Text PDFCytopathology
September 2022
Cellular Pathology, Guy's & St Thomas' hospitals NHS Foundation Trust, London, UK.
Spine Surg Relat Res
December 2021
Spinal Surgery Dept, Guy's & St. Thomas' Hospitals, London, United Kingdom.
Background And Objective: Whiplash neck injury was described by Crowe in 1928. Whiplash-associated disorder (WAD) is defined as a cervical spinal injury following an acceleration-deceleration mechanism. It is a constellation of symptoms due to psychological factors and neural adaptations, with significant social costs.
View Article and Find Full Text PDFJ Thromb Haemost
September 2022
Coagulation Laboratory, Ghent University Hospital, Ghent, Belgium.
Background: Diagnosis of antiphospholipid syndrome (APS) requires persistent presence of lupus anticoagulant (LAC), anticardiolipin (aCL) IgG/IgM, or anti-β2 glycoprotein I (aβ2GPI) IgG/IgM antibodies. Other antiphospholipid antibodies (aPL) such as antiphosphatidylserine/prothrombin antibodies (aPS/PT) are promising in assessment of thrombotic APS (TAPS).
Aim: To evaluate the added value of aPS/PT IgG and IgM in TAPS.
Biology (Basel)
April 2022
Cardiology Department, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy.
Background: Infections of cardiac implantable devices (CIEDI) have poor outcomes despite improvement in lead extraction (TLE) procedures. Methods: To explore the influence of CIEDI on the outcomes of TLE and the differences between patients with systemic (Sy) vs. local (Lo) CIEDI, we performed a sub-analysis of the EORP ELECTRa (European Lead Extraction ConTRolled) Registry.
View Article and Find Full Text PDFClin Exp Allergy
April 2022
Department of Paediatric Allergy, Guy's & St Thomas' Hospitals NHS Foundation Trust, London, UK.
J Thromb Haemost
March 2022
Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.
Europace
May 2022
Guy's & St. Thomas' Hospitals, Westminster Bridge Road, London, SE1 7EH, UK.
Aims: To determine whether triventricular (TriV) pacing is feasible and improves CRT response compared to conventional biventricular (BiV) pacing in patients with left bundle branch block (LBBB) and intermediate QRS prolongation (120-150 ms).
Methods And Results: Between October 2015 and November 2019, 99 patients were recruited from 11 UK centres. Ninety-five patients were randomized 1:1 to receive TriV or BiV pacing systems.
Curr Opin Endocrinol Diabetes Obes
April 2022
Department of Metabolic Medicine/Chemical Pathology Guy's & St Thomas' Hospitals, London, UK.
Purpose Of Review: Multiple studies have shown a strong association between lipids and diabetes. These are usually described through the effects of cholesterol content of lipid particles and in particular low-density lipoprotein. However, lipoprotein particles contain other components, such as phospholipids and more complex lipid species, such as ceramides and sphingolipids.
View Article and Find Full Text PDFNutrition
February 2022
Department of Clinical Biochemistry and Metabolic Medicine, Guy's & St Thomas' Hospitals, London, UK. Electronic address:
J Thromb Haemost
February 2022
Coagulation Laboratory, Ghent University Hospital, Ghent, Belgium.
Background: Antiβ2glycoprotein I (aβ2GPI) and anticardiolipin (aCL) IgG/IgM show differences in positive/negative agreement and titers between solid phase platforms. Method-specific semiquantitative categorization of titers could improve and harmonize the interpretation across platforms.
Aim: To evaluate the traditional 40/80-unit thresholds used for aCL and aβ2GPI for categorization into moderate/high positivity with different analytical systems, and to compare with alternative thresholds.
Radiother Oncol
December 2021
University College London, UK. Electronic address:
Introduction: In 'IDEAL-6' patients (N = 78) treated for locally-advanced non-small-cell lung cancer using isotoxically dose-escalated radiotherapy, overall survival (OS) was associated more strongly with V, the left atrial (LA) wall volume receiving 64-73 Gy equivalent dose in 2 Gy fractions (EQD2), than with whole-heart irradiation measures. Here we test this in an independent cohort 'OX-RT' (N = 64) treated routinely.
Methods: Using Cox regression analysis we assessed how strongly OS was associated with V, with whole-heart volumes receiving 64-73 Gy EQD2 or doses above 10-to-70 Gy thresholds, and with principal components of whole-heart dose-distributions.
BMJ
September 2021
Department of Metabolic Medicine/Chemical Pathology, Guy's & St Thomas' Hospitals, London, UK.
Laryngoscope Investig Otolaryngol
August 2021
Department of Radiology Guy's & St Thomas' Hospitals NHS Foundation Trust London UK.
Objectives: The primary objective was to determine whether the narrowest dimensions of the labyrinthine facial nerve (LFN) canal on the symptomatic side in patients with unilateral recurrent Bell's palsy (BP) differ from those on the contralateral side or in asymptomatic, age- and gender-matched controls on computed tomography (CT). The secondary objectives were to assess the extent of bony covering at the geniculate ganglion and to record inter-observer reliability of the CT measurements.
Methods: The dimensions of the LFN canal at its narrowest point perpendicular to the long axis and the extent of bony covering at the geniculate ganglion were assessed by two radiologists.
Int J Spine Surg
August 2021
Consultant Spine Surgeon, Guy's & St. Thomas' Hospitals, London, United Kingdom.
Background: The term describes the acceleration-deceleration mechanism of injury to the cervical spine. Whiplash injuries present with a variety of clinical and psychological manifestations, collectively termed as (WADs). Although largely self-limiting, some patients may experience long-lasting symptoms.
View Article and Find Full Text PDFJ Thromb Haemost
December 2021
Coagulation Laboratory, Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
Background: Lupus anticoagulant (LA) assays are compromised in anticoagulated patients, and existing strategies to overcome the interferences have limitations. The prothrombin-activating Taipan snake venom time (TSVT) screening test and ecarin time (ET) confirmatory test are innately insensitive to vitamin K antagonists (VKA) and direct factor Xa inhibitors (DFXaI).
Objectives: Validate standardized TSVT/ET reagents for LA detection, in a multicenter, multiplatform study.
BMJ
June 2021
Department of Metabolic Medicine/Chemical Pathology, Guy's & St Thomas' Hospitals, London, UK
Thorax
February 2022
Guy's and St Thomas' NHS Foundation Trust, London, UK.
Background: COVID-19 has become the most common cause of acute respiratory distress syndrome (ARDS) worldwide. Features of the pathophysiology and clinical presentation partially distinguish it from 'classical' ARDS. A Research and Development (RAND) analysis gauged the opinion of an expert panel about the management of ARDS with and without COVID-19 as the precipitating cause, using recent UK guidelines as a template.
View Article and Find Full Text PDFCurr Opin Cardiol
July 2021
Department of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, UK.
Int J STD AIDS
September 2021
Genitourinary Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
The British Association for Sexual Health and HIV (BASHH) UK guideline for the management of epididymo-orchitis has been updated in 2020. It offers advice on diagnostic tests, treatment and health promotion principles in the effective management of epididymo-orchitis. Empirical treatment should be started in patients with objective swelling and tenderness on testicular examination.
View Article and Find Full Text PDFBreast
August 2021
Department of Plastic & Reconstructive Surgery, Department of Haematology, Guy's & St. Thomas' Hospitals NHS Foundation Trust, London, UK.
Introduction: Venous thromboembolism (VTE) is a serious adverse event associated with tamoxifen use, with a 2 to 3-fold increase incidence in users. We aimed to reduce the incidence of venous thromboembolism in patients undergoing breast related surgery by implementing a risk stratifying algorithm for the perioperative management of tamoxifen.
Methods: A retrospective control cohort was compared to a prospective interventional cohort to validate the algorithm which was created by a multidisciplinary team.
Br J Radiol
June 2021
Department of Interventional Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Objectives: Obtaining informed consent is a mandatory part of modern clinical practice. The aim of this study was to identify how often complications relating to Interventional Radiology (IR) procedures were discussed with the patient prior to the procedure.
Methods: A retrospective analysis of 100 patients who experienced a complication related to an IR procedure was performed.
Curr Opin Cardiol
July 2021
Metabolic Medicine/Chemical Pathology, Guy's & St Thomas Hospitals, London SE1 7EH, UK.
Purpose Of Review: Triglycerides (TGs) are measured as part of routine lipid profiles but their relationship to cardiovascular disease (CVD) risk has been controversial and overshadowed by high-density lipoprotein cholesterol (HDL-C).
Recent Findings: Epidemiological studies show a clear relationship of TG-containing lipoproteins including remnant particles with CVD risk with the effect being most clearly demonstrated through the excess risk captured by non-HDL-C compared with low-density lipoprotein-cholesterol (LDL-C). Mendelian randomisation studies show a consistent relationship of gene variants linked to TG metabolism with rates of CVD.
Clin Endocrinol (Oxf)
August 2021
Department of Cancer Imaging, KCL School of Biomedical Engineering and Imaging Sciences, Guy's & St Thomas' Hospitals NHS Foundation Trust, London, UK.
Unlabelled: Head and neck paragangliomas (HNPGLs) are rare tumours with ~ 30% genetic mutations, mainly in succinate dehydrogenase (SDHx) genes. The utility of FDG PET-CT in HNPGLs is questioned by recent developments in novel radiotracers. We therefore performed a retrospective study in a single tertiary referral centre to address the utility of FDG PET/CT in HNPGLs.
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