34,529 results match your criteria: "Guy's & St. Thomas' NHS Hospitals Trust[Affiliation]"

Aims: Type 2 diabetes is a chronic condition affecting increasing numbers of women of reproductive age. Recent UK data show more severe adverse offspring outcomes (stillbirth, neonatal death) than in infants of those with Type 1 diabetes. This systematic review aimed to evaluate randomised controlled trials (RCTs) undertaken in the pre-pregnancy, pregnancy and the postpartum periods in women with Type 2 diabetes, to optimise care and health outcomes.

View Article and Find Full Text PDF

Objectives: To examine the relationship between kidney hyperfiltration during adolescence and subsequent changes in estimated glomerular filtration rate (eGFR) and urinary albumin creatinine ratio (UACR) in a young cohort of participants with type 1 diabetes. Additionally, to explore urinary mitochondrial DNA:nuclear DNA ratio (mtDNA:nDNA) as a marker of metabolic stress and its association with early changes in kidney function.

Methods: Eighty adolescents were studied at baseline [mean (SD) age 14.

View Article and Find Full Text PDF

Background: Centralising prostate cancer surgical and radiotherapy services, requires some patients to travel longer to access treatment, but its impact on actual treatment utilisation and outcomes is unknown.

Methods: Using national cancer registry records linked to administrative hospital data, we identified all patients with high risk and locally advanced prostate cancer diagnosed between 1 April 2019 and 31 March 2020 in the English National Health Service (n = 15,971). Estimated travel times from the patient residential areas to the nearest hospital providing surgery or radiotherapy were estimated for journeys by car and by public transport.

View Article and Find Full Text PDF

Editorial: diagnosis of allergic and mast cell-mediated disorders.

Front Allergy

October 2024

Department of Women and Children's Health (Pediatric Allergy), Faculty of Life Sciences and Medicine, School of Life Course Sciences, King's College London, London, United Kingdom.

View Article and Find Full Text PDF

Neuromodulation with Transcranial Magnetic Stimulation in Epilepsia Partialis Continua: Scoping review and clinical experience.

Seizure

December 2024

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, London, United Kingdom; Department of Clinical Neurophysiology, King's College Hospital, London, United Kingdom; Department of Clinical Neurophysiology, Alder Hey Children's Hospital, London, United Kingdom.

Article Synopsis
  • Epilepsia Partialis Continua (EPC) is a complex condition that may respond to repetitive transcranial magnetic stimulation (rTMS), which offers both diagnostic and therapeutic potential.
  • A review of literature involving cases of EPC treated with rTMS, alongside two in-house patient cases, highlights the varying efficacy of rTMS in reducing seizure activity.
  • Results indicate that while some patients experienced no change, low frequency rTMS led to temporary improvements in seizure frequency and motor function in two patients, suggesting its possible role in guiding further treatment.
View Article and Find Full Text PDF

Background: During the COVID-19 pandemic, virtual visiting technologies were rapidly integrated into the care offered by intensive care units (ICUs) in the UK and across the globe. Today, these technologies offer a necessary adjunct to in-person visits for those with ICU access limited by geography, work/caregiving commitments, or frailty. However, few empirical studies explore the ethical issues associated with virtual visiting.

View Article and Find Full Text PDF
Article Synopsis
  • - Food Protein-Induced Enterocolitis (FPIES) is a type of food allergy that occurs primarily in children and is characterized by symptoms such as delayed vomiting, lethargy, and pale skin, typically emerging 1-4 hours after consuming the allergen.
  • - Despite increasing recognition of FPIES, its exact causes remain unknown, and there are no specific tests to diagnose or track the condition's progress.
  • - A recent workshop by the National Institute of Allergy and Infectious Diseases (NIAID) focused on FPIES, discussing current understanding, research gaps, and future priorities for improving diagnosis and management.
View Article and Find Full Text PDF

Objective: Obesity and type 2 diabetes (T2D) are associated with increased rates of mental disorders, particularly depression, anxiety and binge-eating disorder. GLP-1 receptor agonists are a novel class of pharmacological agents for obesity and T2D. We aimed to describe participants' experiences of GLP-1 receptor agonists on their mental health.

View Article and Find Full Text PDF

Booster vaccination normalizes postvaccination immunity in patients with severe asthma.

J Allergy Clin Immunol

January 2025

NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; Clinical and Experimental Sciences, School of Medicine, University of Southampton, Southampton United Kingdom; Institute for Life Sciences, University of Southampton, Southampton United Kingdom.

View Article and Find Full Text PDF
Article Synopsis
  • Ovarian cancer has the worst prognosis among gynecological cancers, making accurate pre-operative and intraoperative diagnosis crucial for improving patient outcomes.* -
  • A study reviewed 156 cases of ovarian masses, comparing final histological diagnoses with ultrasound, MRI, and frozen section (FS) to determine diagnostic accuracy; FS showed high sensitivity for detecting malignancies.* -
  • While FS is effective for diagnosing ovarian tumors, the study highlights ongoing challenges in accurately diagnosing borderline ovarian tumors using both imaging techniques and FS.*
View Article and Find Full Text PDF

Introduction: Simulation is increasingly becoming more common in dental curricula as an adjunct to clinical skills labs across many higher education institutions. This study seeks to explore whether the current learning objectives constructively align with our current haptics simulation curriculum - in the specific context of how well they are being met by year 1 undergraduate dental students.

Method: The study incorporated a mixed methods approach to evaluate a module already taking place, which was completed from the perspectives of both the investigators and the students themselves through the triangulation of noninterventional classroom observational data, anonymous Likert-scale questionnaire data, and a literature review.

View Article and Find Full Text PDF

Purpose: Anemia is a cardinal feature of myelofibrosis often managed with red blood cell (RBC) transfusions, which may contribute to negative prognostic, quality-of-life, and healthcare-related economic impacts. The Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor momelotinib was approved for the treatment of patients with myelofibrosis and anemia based on clinical trial evidence of anemia, spleen, and symptom benefits illustrated using binomial response/nonresponse endpoints. In the present post hoc, descriptive analyses, the impact of momelotinib on RBC transfusion burden over time was further characterized across JAK inhibitor-naive and -experienced patients.

View Article and Find Full Text PDF

The Challenges of Oral Tolerance Induction in a Diverse Population Advised to Introduce Allergens Early: Insights From the EarlyNuts Study.

J Allergy Clin Immunol Pract

November 2024

Children's Allergy Service, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Department of Women and Children's Health (Paediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom; Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom. Electronic address:

View Article and Find Full Text PDF

A man in his 60s presented to the emergency department with central crushing chest pain on a background of a week's history of flu-like symptoms. An ECG demonstrated ischaemia with blood tests confirming myocardial injury; catheter angiography revealed an obstructed diagonal coronary artery. In addition, blood tests revealed elevated markers of inflammation, blood cultures grew and transthoracic echocardiography demonstrated a mitral valve lesion.

View Article and Find Full Text PDF

Nocturnal enuresis: A call for advocacy.

S Afr Med J

November 2024

Children's Bladder Clinic, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, UK; Department of Paediatrics, Faculty of Health Sciences, University of Cape Town, South Africa.

View Article and Find Full Text PDF

The public health significance of prior homelessness: findings on multimorbidity and mental health from a nationally representative survey.

Epidemiol Psychiatr Sci

November 2024

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Aims: The associations of prior homelessness with current health are unknown. Using nationally representative data collected in private households in England, this study aimed to examine Common Mental Disorders (CMDs), physical health, alcohol/substance dependence, and multimorbidities in people who formerly experienced homelessness compared to people who never experienced homelessness.

Methods: This cross-sectional study utilised data from the 2007 and 2014 Adult Psychiatric Morbidity Surveys.

View Article and Find Full Text PDF

Automated decision making in Barrett's oesophagus: development and deployment of a natural language processing tool.

NPJ Digit Med

November 2024

Gastroenterology Department, Guy's and St. Thomas' NHS Foundation Trust, London, SE1 7EH, UK.

Manual decisions regarding the timing of surveillance endoscopy for premalignant Barrett's oesophagus (BO) is error-prone. This leads to inefficient resource usage and safety risks. To automate decision-making, we fine-tuned Bidirectional Encoder Representations from Transformers (BERT) models to categorize BO length (EndoBERT) and worst histopathological grade (PathBERT) on 4,831 endoscopy and 4,581 pathology reports from Guy's and St Thomas' Hospital (GSTT).

View Article and Find Full Text PDF

Background: Children and young people with cystic fibrosis (CYPwCF) are encouraged to do an average of 60 min of moderate-to-vigorous physical activity (MVPA) daily. However, there are no agreed heart rate (HR) thresholds for defining MVPA, so it is difficult to ascertain whether these targets are actually achieved. Wearable activity trackers enable continuous monitoring of fitness-related measures such as HR and could be used to measure duration and intensity of habitual MVPA.

View Article and Find Full Text PDF
Article Synopsis
  • Dizziness often leads to complicated diagnosis processes, requiring patients to see multiple specialists and imposing challenges on health services; early and accurate diagnosis could help alleviate these issues.
  • The CAVA trial is a multicentre study aiming to assess a new diagnostic device that distinguishes between three common inner-ear causes of dizziness: Ménière's disease, vestibular migraine, and benign paroxysmal positional vertigo, involving 255 participants in the UK.
  • The CAVA device collects eye movement data using specialized sensor arrays, with goals to create a reliable algorithm for diagnosis, evaluate financial and health benefits for the NHS, and facilitate the device's deployment in the healthcare system.
View Article and Find Full Text PDF

Environmentally sustainable surgical systems.

BMJ Glob Health

November 2024

NIHR Global Health Research Unit on Global Surgery, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Surgeons, anaesthetists, wider surgical teams and hospital managers are a large global group that has the capacity and power to play a leadership role to contribute to change. Hospitals are a good target for improvement since they are centres of communities, linking together surrounding healthcare facilities and influencing wider determinants of the environment. District and rural hospitals are good sites to start since they serve large populations, have the least sustained energy and clean water supplies and will benefit most from quality improvement.

View Article and Find Full Text PDF
Article Synopsis
  • - The development of the CompOsite iNdexes For Response in asthMa (CONFiRM) aimed to create patient-centered tools that measure responses to biologics for severe asthma in both adults and children, integrating clinical data and quality of life (QoL) indicators.
  • - Experts and patients collaborated to identify significant outcome changes and devised CONFiRM scores, which demonstrated high levels of agreement on key factors, with patients emphasizing the importance of quality of life more than healthcare professionals did.
  • - The CONFiRM scores effectively measure treatment response, with strong validity metrics indicating their reliability, and they facilitate a comprehensive assessment of biologics’ effectiveness; further studies are required for prospective validation.
View Article and Find Full Text PDF

GALEN ANACARE consensus statement: Potential of omalizumab in food allergy management.

Clin Transl Allergy

November 2024

Division of Allergy and Immunology, Department of Dermatology, Allergy and Venerology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Article Synopsis
  • IgE-mediated food allergies are the most common type, causing quick and serious reactions that affect patients' and caregivers' lives.
  • Omalizumab is a humanized monoclonal antibody that binds to IgE, reducing allergic reactions, and has been approved by the FDA for treating these food allergies.
  • The GALEN ANACARE Consensus Statement supports omalizumab's use based on a systematic review and expert agreement, noting it is currently the only drug that can significantly reduce IgE-mediated food allergic reactions, although more evidence is needed for stronger guideline recommendations.
View Article and Find Full Text PDF

Aims: Patients with endometrial cancer who progress following first line therapy have improved survival outcomes with pembrolizumab and lenvatinib (pem/len) compared with standard of care chemotherapy, as demonstrated in KEYNOTE-775. This was in a group of trial patients with good performance status and excluded those with carcinosarcoma histology. In KEYNOTE-775 pem/len was associated with significant toxicity, leading to dose reductions, treatment cessation, and patient morbidity.

View Article and Find Full Text PDF