Estetrol/Drospirenone Safety in a Population with Cardiovascular Risk Factors.

Objectives: To evaluate cardiovascular safety outcomes in estetrol 15mg/drospirenone 3mg users with cardiovascular risk factors.

Study Design: We performed a secondary analysis of two open-label contraceptive phase-3 trials that enrolled participants 16 to 50 years to use estetrol/drospirenone for up to 13 cycles. Study exclusion criteria included >35 years and smoking, body mass index (BMI) >35 kg/m, and baseline blood pressure (BP) >140/90 mmHg.

Preferences for thromboprophylaxis in the intensive care unit: An international survey.

Background: Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis is widely applied to lower this risk, but guidelines lack dosing recommendations.

Objective: This survey aims to assess current thromboprophylaxis preferences and willingness to participate in future randomized clinical trials (RCTs) on this topic.

Chronic norovirus infection in immunodeficiency: a UK national case series.

Chronic norovirus infection can lead to significant diarrhoea, malabsorption, and weight loss in immunodeficiency. The clinical and histological picture in these patients is remarkably similar, suggesting that the virus is a main driver for the enteropathy.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.

Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not fully explained by variation at robustly identified risk loci.

Segmental redistribution of myocardial blood flow after coronary sinus reducer implantation demonstrated by quantitative perfusion cardiovascular magnetic resonance.

Background: The coronary sinus reducer (CSR) is a novel percutaneous treatment for patients with refractory angina. Increasing evidence supports its clinical efficacy in patients with advanced epicardial coronary artery disease. However, its mechanism of action and its effects on myocardial perfusion remain undefined.

Obstetric and gynaecological features in females carrying variants in the skeletal muscle ryanodine receptor type 1 (RYR1) gene: a questionnaire study.

Mutations in the ryanodine receptor type 1 (RYR1) gene are amongst the most common causes of early-onset, non-dystrophic neuromuscular disorders. RYR1 mutations have also anecdotally been implicated in non-skeletal muscle symptoms such as an increased bleeding tendency particularly prominent in females, but the prevalence of these features is currently unknown. In this questionnaire-based study, we aimed to evaluate smooth muscle function, bleeding, obstetric, and gynaecological outcomes in RYR1-variant carrying females.

Transition and Life-Long Care for Adults With Cerebral Palsy: A Patient Group 'Too Hard to Impact!' Are We Still Sending Young People 'Off a Cliff'?

Objectives: At Evelina London Children's Hospital, tertiary care is provided for children with Cerebral Palsy (CP) across the South East of England. An increasing number of adults with CP remain under the care of the children's hospital due to a lack of appropriate adult neurodisability services. This quality improvement project as part of a gap analysis regarding transition pathways for young adults with CP, aimed to explore the lived experience of young adults within our service, with respect to transition and care in adulthood.

Barriers and facilitators to accessing sexual and reproductive health services for people with severe mental illness: a systematic review.

Purpose: Despite increased prevalence of sexual and reproductive health problems among people with severe mental illness (SMI), uptake of sexual and reproductive healthcare in this group is poor. The reasons for this are unclear. Therefore, this review aimed to identify the barriers and facilitators to accessing sexual and reproductive health services from a service user perspective.

Comparing Mid-Term Outcomes of Donation After Brain Death and Donation After Circulatory Death Orthotopic Heart Transplant Recipients-A Single-Center Retrospective UK Study.

Introduction: The number of patients on heart transplant waitlists is growing globally, with an insufficient number of organ offers to meet this growing demand. To help improve patient outcomes, in the United Kingdom (UK), orthotopic cardiac transplantation (OCTx) can occur using hearts donated following donor brain death (DBD) or donor circulatory death (DCD). The aim of this paper was to compare outcomes between groups of DBD and DCD OCTx patients at Harefield Hospital.

Ketamine cholangiopathy: clinical features and liver biopsy findings.

Aims: To reveal clinical, imaging and pathological features of ketamine cholangiopathy.

Methods And Results: Eight cases, who had a history of long-term ketamine use, abnormal liver function tests and histological or radiological evidence of cholangiopathy, were retrospectively reviewed. Cases consisted of six men and two women with a median age of 36 years.

Pharmacokinetics and safety of CT‑P39 via auto-injector are comparable to reference omalizumab via pre-filled syringe.

Aims: To demonstrate pharmacokinetic equivalence of CT‑P39 administered via auto-injector (CT‑P39 AI) and European Union-approved reference omalizumab via pre-filled syringe (EU-OMA PFS) in healthy Japanese adults.

Participants & Methods: This open-label, Phase 1 study randomized participants (1:1) to a single 150 mg/mL dose of CT‑P39 AI or EU-OMA PFS. The primary endpoint was pharmacokinetic equivalence per area under the concentration-time curve from time zero to infinity (AUC) and maximum serum concentration (C).

Six early CPAP-usage behavioural patterns determine peak CPAP adherence and permit tailored intervention, in patients with obstructive sleep apnoea.

Background: High rates of non-adherence to continuous positive airway pressure (CPAP) in obstructive sleep apnoea hamper good clinical outcomes. Current recommendations assumes two behaviours (adherence and non-adherence) and days 7-90 follow-up post-CPAP initiation mitigates against non-adherence.

Objectives: To investigate associations between early CPAP-usage behaviours and (1) CPAP adherence at month 3 of treatment and (2) sleep centres' treatment pathways (the procedures patients undergo that may affect barriers or facilitators of CPAP adherence).

Artificial intelligence-enhanced electrocardiography for the identification of a sex-related cardiovascular risk continuum: a retrospective cohort study.

Background: Females are typically underserved in cardiovascular medicine. The use of sex as a dichotomous variable for risk stratification fails to capture the heterogeneity of risk within each sex. We aimed to develop an artificial intelligence-enhanced electrocardiography (AI-ECG) model to investigate sex-specific cardiovascular risk.

Research recommendations from the 2024 Breakthrough T1D, Diabetes UK and Kidney Research UK, diabetes and kidney disease expert workshop.

Aims: To develop a position statement that identifies research priorities in diabetic kidney disease and provides recommendations to researchers and research funders on how best to address them.

Methods: A one-day research workshop was conducted, bringing together research experts in diabetes and kidney disease, healthcare professionals, and people living with diabetes, to identify and prioritise research recommendations.

Results: The following key areas were identified as needing increased focus: Understanding causal mechanisms in diabetic kidney disease Prevention of diabetic kidney disease Addressing health inequalities Improving diagnosis Improving care Supporting self-management CONCLUSIONS: This position statement outlines recommendations to address the urgent need to tackle diabetic kidney disease and calls on the diabetes and kidney research communities to act upon these recommendations to ensure future research works to eliminate unfair and avoidable disparities in health.

Cutaneous Allodynia and Photophobia in Vestibular Migraine and Other Vestibular Disorders: A Prospective Study in a Tertiary Centre.

Introduction: Photophobia (PP) and cutaneous allodynia (CA) are sensory sensitivity symptoms recognised as features of migraine. The prevalence of PP and CA in vestibular migraine (VM) and other vestibular disorders (OVD) is unknown.

Aim: The aim of this study is to measure the prevalence of PP and CA in VM compared with OVD.

LapEx: A new multimodal dataset for context recognition and practice assessment in laparoscopic surgery.

In Surgical Data Science (SDS), there is an increasing demand for large, realistic annotated datasets to facilitate the development of machine learning techniques. However, in laparoscopic surgery, most publicly available datasets focus on low-granularity procedural annotations (such as phases or steps) and image segmentation of instruments or specific organs, often using animal models that lack clinical realism. Furthermore, annotation variability is seldom evaluated.

In-hospital outcomes and 6-month follow-up results of patients supported with extracorporeal membrane oxygenation for COVID-19 from the second wave to the end of the pandemic (EuroECMO-COVID): a prospective, international, multicentre, observational study.

Background: Extracorporeal membrane oxygenation (ECMO) for COVID-19 was thoroughly assessed during the first pandemic wave, but data on subsequent waves are limited. We aimed to investigate in-hospital and 6-month survival of patients with COVID-19 supported with ECMO from the second pandemic wave (Sept 15, 2020) until the end of the pandemic (March 21, 2023, announced by WHO).

Methods: EuroECMO-COVID is a prospective, observational study including adults (aged ≥16 years) requiring ECMO respiratory support for COVID-19 from 98 centres in 21 countries.

Sympathetic neurons can modify the intrinsic structural and functional properties of human pluripotent stem cell-derived cardiomyocytes.

The sympathetic nervous system densely innervates all cardiac chambers and is a key player in cardiac control, yet this relationship has scarcely been investigated using a stem cell-based model. This study investigates the effects that sympathetic neurons (SNs) have on human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in vitro, and whether they induce any degree of functional or structural maturity in these conventionally immature cells. SNs were isolated from neonatal rat pups, and cocultured with hPSC-CMs for up to 15 days.

Modelling inflammation-induced peripheral sensitization in a dish-more complex than expected?

Peripheral sensitization of nociceptors is believed to be a key driver of chronic pain states. Here, we sought to study the effects of a modified version of inflammatory soup on the excitability of human stem cell-derived sensory neurons. For this, we used a preexisting and a novel stem cell line, modified to stably express the calcium sensor GCamP6f.

Clinical and Deep-Learned Evaluation of MR-Guided Self-Supervised PET Reconstruction.

Reduced dose Positron Emission Tomography (PET) lowers the radiation dose to patients and reduces costs. Lower count data, however, degrades reconstructed image quality. Advanced reconstruction methods help mitigate image quality losses, but it is important to assess the resulting images from a clinical perspective.