United Kingdom Continence Society: Certification and Recertification in Urodynamics.

Aims: Patients coming for urodynamics expect those delivering the service to be fully trained, with assurance of competence and quality. This document proposes a single UKCS Certification and Re-certification process for all health care professionals who perform or interpret urodynamics.

Methods: The Working Group of the United Kingdom Continence Society engaged with stakeholders in relevant professional societies and institutions, recirculating drafts until consensus was reached.

Objective Effects and Patient Preferences for Ambulatory Oxygen in Fibrotic Interstitial Lung Disease With Isolated Exertional Hypoxaemia: A Placebo-Controlled 6-Minute Walk Test Study.

Background And Objective: The available evidence on the effects of ambulatory oxygen on exercise impairment in patients with fibrotic interstitial lung diseases (F-ILD) is of limited quality.

Methods: We conducted a randomised, double-blind, placebo-controlled crossover trial with 32 normoxaemic F-ILD patients, desaturating to ≤ 88% during a baseline 6-minute walk test (6MWT) on ambient air. After determining the oxygen flow needed to prevent desaturation, patients completed two double-blind 6MWTs with either oxygen or placebo (compressed medical air) at the same personalised flow.

Protocol for a randomised controlled feasibility trial of an integrated psychosexual intervention for sexual difficulties in people with Multiple Sclerosis: the PIMS trial.

Background: Multiple Sclerosis (MS) is a long-term condition that significantly diminishes quality of life (QoL). Sexual difficulties (SDs) are common, but often overlooked symptom, affecting 50-80% of people with MS (PwMS). The emergence of SDs in MS results from the intricate interplay of disease processes, treatments, and psychosocial factors, contributing to a further decline in QoL and adverse effects on body image, relationships, and psychological well-being.

A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer.

There are no current stratified medicine options for STK11-deficient NSCLC. STK11 loss mediates mTORC activation, GLUT1 up-regulation and increased glycolysis. This metabolic reprogramming might represent a therapeutic vulnerability targetable with mTORC1/2 inhibition.

Videolaryngoscope designs for tracheal intubation in adults: a systematic review with network meta-analysis of randomised controlled trials.

Introduction: Videolaryngoscopy improves tracheal intubation outcomes compared with direct laryngoscopy in various scenarios. However, the range of videolaryngoscope designs makes it challenging to identify the most effective device. We conducted a systematic review and network meta-analysis to compare different laryngoscope designs when used for tracheal intubation of adults under general anaesthesia.

British Society of Gastroenterology practice guidance on the management of acute and chronic gastrointestinal symptoms and complications as a result of treatment for cancer.

Background: Survival rates after a diagnosis of cancer are improving. Poorly managed gastrointestinal (GI) side effects can interfere with delivery of curative cancer treatment. Long-term physical side effects of cancer therapy impinge on quality of life in up to 25% of those treated for cancer, and GI side effects are the most common and troublesome.

Robotic-assisted retroperitoneal lymph node dissection: defining selection parameters-a B-SAFE approach.

The objective of the study is to define selection parameters for RRPLND and evaluate the outcomes from cases selected via this method. Patients undergoing RRPLND from 2017 to 2023 (n = 57) were included. Initial criteria for robotic case selection were defined via 'B-SAFE' parameters.

Thromboprophylaxis and adult congenital heart disease: The latest on indications, risk scoring and therapy.

Advances in medical care have significantly extended the lifespan of patients with congenital heart disease (CHD), allowing most to survive into adulthood. However, they continue to face significant cardiovascular morbidity, particularly atrial arrhythmias (AA), heart failure, and thromboembolic (TE) events. TE events in adult CHD patients arise from various factors, including AA, intracardiac repairs, cyanotic CHD, Fontan palliation, pregnancy, and mechanical heart valves (MHV).

Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.

Adults born very preterm (i.e. at <33 weeks' gestation) are more susceptible to long-lasting structural and functional brain alterations and cognitive and socio-emotional difficulties, compared with full-term controls.

Recommendations for management of infants and young children with achondroplasia: Does clinical practice align?

Background: Achondroplasia is one of the most prevalent forms of skeletal dysplasia. Lifelong follow-up by an experienced multidisciplinary team is required, particularly during the first 2 years. In 2021, international consensus recommendations and guiding principles were published by two groups.

Pregnancy-related issues in rare and low-prevalence diseases: results of ERN transversal working group on pregnancy and family planning survey.

Background: Rare and complex diseases can have a significant impact on family life, and managing the reproductive aspects of patients of childbearing age with rare diseases is often difficult and complex. A European Reference Network (ERN) Transversal Working Group (WG) on Pregnancy and Family Planning was created to join forces to promote and address issues on these topics in rare and low-prevalence diseases.

Objective: To outline the challenges and the good practices related to pregnancy and family planning in rare and complex diseases for healthcare professionals (HCPs).

Pelabresib plus ruxolitinib for JAK inhibitor-naive myelofibrosis: a randomized phase 3 trial.

Janus kinase (JAK) inhibitors provide limited depth and durability of response in myelofibrosis. We evaluated pelabresib-a bromodomain and extraterminal domain (BET) inhibitor-plus ruxolitinib (a JAK inhibitor) compared with placebo plus ruxolitinib as first-line therapy. In this phase 3 study (MANIFEST-2), JAK inhibitor-naive patients with myelofibrosis were randomized 1:1 to pelabresib 125 mg once daily (QD; 50-175 mg QD permitted) for 14 days followed by a 7-day break (21-day cycle), or to placebo in combination with ruxolitinib 10 or 15 mg twice daily (BID; 5 mg QD-25 mg BID permitted).

Predictive value of scoring systems for stone free status and complications before percutaneous nephrolithotomy in children.

PCNL, a minimally invasive surgical technique for kidney stone removal, relies on achieving stone-free status, which various scoring systems aim to predict. This study assesses the predictive accuracy of the Clinical Research Office of the Endourological Society (CROES) and Guy's Stone Score (GSS) systems in determining stone-free rates following percutaneous nephrolithotomy (PCNL) in pediatric patients. A retrospective analysis was conducted on 580 pediatric patients who underwent PCNL at Çukurova University Urology Clinic between January 2007 and March 2024.

Diagnostic, research, and real-life effect of the 2023 EULAR-ACR classification criteria for antiphospholipid syndrome.

The role of classification criteria is particularly important in rheumatic diseases compared with other medical disorders, as the complexity and overlapping symptoms of these conditions make diagnosis challenging. Moreover, the absence of established diagnostic criteria further complicates diagnosing patients. Classification criteria can assist health-care professionals and patients as a diagnostic aid.

Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain.

Pain independent of disease activity is frequently reported by rheumatoid arthritis patients and remains undertreated. Preclinical evidence suggests that imbalance of neuroimmune proresolving interactions within dorsal root ganglia (DRG) rather than at the site of inflammation plays mechanistic roles in persistent arthritis pain. Here, we inhibited production of proresolving lipid mediators by silencing 12/15-lipoxygenase expression in CX3CR1 monocyte/macrophages conditional knockout (cKO) mice.

Artificial intelligence (AI) in radiological paediatric fracture assessment: an updated systematic review.

Background: Recognising bone injuries in children is a critical part of children's imaging, and, recently, several AI algorithms have been developed for this purpose, both in research and commercial settings. We present an updated systematic review of the literature, including the latest developments.

Methods/materials: Scopus, Web of Science, Pubmed, Embase, and Cochrane Library databases were queried for studies published between 1 January 2011 and 6 September 2024 matching search terms 'child', 'AI', 'fracture,' and 'imaging'.

Clinical, genetic, radiological characteristics and management of mediastinal paragangliomas: a literature review and case series.

Paragangliomas (PGLs) are neuroendocrine tumours (NETs) that arise from neural crest derived cells. Up to 40% of cases occur due to the presence of a pathogenic germline variant (PGV) in a known gene. Mediastinal PGLs are rare but are being diagnosed with increasing frequency.

Neuropathological links between T2DM and LOAD: systematic review and meta-analysis.

Recent decades have described in-parallel neuropathological mechanisms, increasing the risk for developing late-onset Alzheimer's dementia (LOAD) in type 2 diabetes mellitus (T2DM), however, still little is known of the role of diabetic encephalopathy and brain atrophy in LOAD. The aim of this systematic review is to provide a comprehensive view on diabetic encephalopathy/cerebral atrophy, taking into account neuroimaging data, neuropathology, metabolic and endocrine mechanisms, amyloid formation, brain perfusion impairments, neuroimmunology and inflammasome activation. Identified were key switches, to further meta-analyse genomic candidate loci and epigenetic modifications.

Comparing ECG Lead Subsets for Heart Arrhythmia/ECG Pattern Classification: Convolutional Neural Networks and Random Forest.

Background: Despite the growth in popularity of deep learning (DL), limited research has compared the performance of DL and conventional machine learning (CML) methods in heart arrhythmia/electrocardiography (ECG) pattern classification. In addition, the classification of heart arrhythmias/ECG patterns is often dependent on specific ECG leads for accurate classification, and it remains unknown how DL and CML methods perform on reduced subsets of ECG leads. In this study, we sought to assess the accuracy of convolutional neural network (CNN) and random forest (RF) models for classifying arrhythmias/ECG patterns using reduced ECG lead subsets representing DL and CML methods.

Vaccination perspectives: the Qdenga® dilemma.

The introduction of the Qdenga® dengue vaccine presents both opportunities and challenges. Debate regarding efficacy, safety, and potential risks for dengue-naïve individuals continues. With varying international guidelines and evolving evidence, advising travellers requires detailed risk assessment, up-to-date evidence based decisions, and clear communication.

Dilatation of the main pulmonary artery in patients with isolated pulmonary stenosis: Arteriopathy or hemodynamic consequence?

Background: Main pulmonary artery (mPA) dilatation has been reported in patients with isolated pulmonary valve (PV) stenosis. The aim of our study was to detect the incidence of mPA dilatation and aneurysm in patients with isolated PV stenosis and the association with PV function.

Methods: In this single-centre retrospective observational study all patients with a diagnosis of isolated PV stenosis referred to our centre were enrolled.

Discrepancy between parallel anti-Xa and APTT is related to mortality in patients with Impella™ supported cardiogenic shock.

Background: Managing unfractionated heparin (UFH) during percutaneous mechanical circulatory support (PMCS) for cardiogenic shock (CS) is challenging due potential discrepancies between coagulation tests.

Objectives: To study the causes and consequences of discrepancies between anti-Xa and activated partial thromboplastin time (APTT) for UFH-monitoring during micro-axial flow pump support (Impella™) for CS.

Patients/methods: We assessed patients in CS supported with Impella™ in two tertiary care centres over 62 months.