Evaluation of solubility, photostability and antioxidant activity of ellagic acid cyclodextrin nanosponges fabricated by melt method and microwave-assisted synthesis.

Ellagic acid (EA) is a polyphenolic bioactive with a wide range of pharmacological activities. Regrettably, it possesses poor solubility, stability and permeability (in the gastrointestinal tract); and first-pass metabolism. Therefore, to address these challenges, the present research was aimed to encapsulate EA in cyclodextrin nanosponges (CDNS).

Sonochemical Protocols for Heterocyclic Synthesis: A Representative Review.

In the present era of the industrial revolution, we all are familiar with ever-increasing environmental pollution released from various chemical processes. Chemical production has had a severe impact on the environment and human health. For the betterment of our environment, the chemical community has turned their interest to developing green, harmless and sustainable synthetic processes.

Effectiveness of spinal mobilization and postural correction exercises in the management of cervicogenic headache: A randomized controlled trial.

Objective: The study aims to assess the effect of spinal mobilization and postural correction exercises in patients suffering from cervicogenic headache.

Methods: A randomized controlled trial was conducted with 72 patients. Patients were randomly allocated into three groups: spinal mobilization ( = 24), postural correction exercises ( = 24), and control group ( = 24).

Comparative analysis of magnetic induction based communication techniques for wireless underground sensor networks.

A large range of applications have been identified based upon the communication of underground sensors deeply buried in the soil. The classical electromagnetic wave (EM) approach, which works well for terrestrial communication in air medium, when applied for this underground communication, suffers from significant challenges attributing to signal absorption by rocks, soil, or water contents, highly varying channel condition caused by soil characteristics, and requirement of big antennas. As a strong alternative of EM, various magnetic induction (MI) techniques have been introduced.

The dark side of miracle plant-Aloe vera: a review.

Background: Aloe vera (Aloe barbadensis Miller), commonly known as Ghritkumari/Gwarpatha, is a member of the Liliaceae family, used in the traditional medicine system for ages. Aloe vera has made its importance as a therapeutic agent, acting as a cure for various diseases such as skin problems, lungs, and heart disorders, diabetes, ulcers, various microbial infections, and asthma. Despite its tremendous health benefits, the dark side of the plant is a reason of concern as there are several active compounds present in the plant, raising questions on its safe oral consumption and application.

A comprehensive physico-chemical quality and heavy metal health risk assessment study for phreatic water sources in Narora Atomic Power Station region, Narora, India.

An investigation of water quality and heavy metal distribution in the groundwater samples collected from the vicinity of Narora Atomic Power Station (NAPS), Narora, India, was conducted for the metals including Cu, Zn, Ni, Co, Cd, Pb, and Fe. A total of 16 water quality parameters were measured for all the groundwater samples, and TDS, TH, Mg, Ca, F, and turbidity were found to be on the higher side in comparison to the prescribed limits of Indian standards. Geometrical mean concentrations for these heavy metals were found to be 0.

Evaluation of anti-inflammatory response of berberine-loaded gum nanocomplexes in carrageenan-induced acute paw edema in rats.

Background: Berberine is a natural plant alkaloid and has been reported to possess anti-inflammatory activity. However, berberine's poor bioavailability and low solubility have limited its clinical applicability. Nanoencapsulation of berberine using a suitable carrier can be a promising strategy to improve its efficacy.

Unswerving modeling of hepatotoxicity of cadmium containing quantum dots using amalgamation of quasiSMILES, index of ideality of correlation, and consensus modeling.

Liver toxicity of quantum dots varies with size, concentration, and other structural as well as experimental parameters. For modeling hepatotoxicity, the eclectic data associated with cadmium containing quantum dots have been used in the creation of quasiSMILES for their representation. The core diameter is normalized for wider applicability and the index of the ideality of correlation is applied to construct the better quantitative features toxicity relationship models.

Formulation and development of tacrolimus-gellan gum nanoformulation for treatment of dry eye disease.

The present study aimed at the development and evaluation of tacrolimus gellan gum nanoparticles (TGNPs) for the effective management of dry eye disease (DED) following topical application. TGNPs were developed by ionotropic gelation between gellan gum and aluminum chloride. Developed TGNPs were nanosized (274.

Etiology and management of Alzheimer's disease: Potential role of gut microbiota modulation with probiotics supplementation.

Alzheimer's disease (AD) is the leading type of dementia in aging people and is a progressive condition that causes neurodegeneration, resulting in confusion, memory loss, and deterioration of mental functions. AD happens because of abnormal twisting of the microtubule tau protein in neurons into a tangled neurofibrillary structure. Different factors responsible for AD pathogenesis include heavy metals, aging, cardiovascular disease, and environmental and genetic factors.

Graphene oxide and fluorescent aptamer based novel biosensor for detection of 25-hydroxyvitamin D.

For maintaining the healthy metabolic status, vitamin D is a beneficial metabolite stored majorly in its pre-activated form, 25-hydroxyvitamin D (25(OH)D). Due to its important role in bone strengthening, the study was planned to quantify 25(OH)D levels in our blood. Quantification techniques for 25(OH)D are costly thus requiring a need for a low cost, and sensitive detection methods.

An ensemble method to forecast 24-h ahead solar irradiance using wavelet decomposition and BiLSTM deep learning network.

In recent years, the penetration of solar power at residential and utility levels has progressed exponentially. However, due to its stochastic nature, the prediction of solar global horizontal irradiance (GHI) with higher accuracy is a challenging task; but, vital for grid management: planning, scheduling & balancing. Therefore, this paper proposes an ensemble model using the extended scope of wavelet transform (WT) and bidirectional long short term memory (BiLSTM) deep learning network to forecast 24-h ahead solar GHI.

O-WCNN: an optimized integration of spatial and spectral feature map for arrhythmia classification.

The regular monitoring and accurate diagnosis of arrhythmia are critically important, leading to a reduction in mortality rate due to cardiovascular diseases (CVD) such as heart stroke or cardiac arrest. This paper proposes a novel convolutional neural network (CNN) model for arrhythmia classification. The proposed model offers the following improvements compared with traditional CNN models.

Utilization of Agricultural Waste from Paddy (Rice) Fields for the Synthesis of Nanocellulose.

Nanotechnology is an interdisciplinary science with multifold applications in various fields. Nanocellulose is an emerging sustainable material possessing marvellous features. It has broad range of prospects in several research areas especially in agriculture sector.

Synthesis and Characterization of Silver Nanoparticles Using Citrus Fruit Juice for Evaluation of Anticancer Activity Against Colo-205 Cell Lines.

The study focused on the medicinal properties of citrus fruits and their ability to synthesize silver nanoparticles. As the resistance against the modern antibiotic agents is on increase, finding new and effective natural antibiotic agents is the need of the modern era. Similarly, bio-synthesis of nanoparticles is also being encouraged for eco-friendly reasons.

Antifungal and Antibacterial Effects of Biosynthesized Zinc Oxide Nanoparticles Against Selected Pathogenic and Non-Pathogenic Strains.

We have developed a simple, robust environment-friendly and efficient method for ZnO nanoparticles biosynthesis using fresh leaf extract. Before using these nanoparticles for antimicrobial assay, a detailed characterization was performed using techniques like Ultraviolet/Visible (UV/Vis) spectroscopy, Particle size analysis (PSA), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), atomic force microscopy (AFM),Transmission electron microscopy (TEM) etc. The average size of biosynthesized ZnO nanoparticles was around 30 nm and they were pure and crystalline by nature.

Assessment of Antibacterial Activity of Biosynthesised ZnO Nanoparticles Against pv. Causing Bacterial Blight in Cotton.

Cotton ( L.), is an important fibre and oilseed crop of the world. India in particular has the largest area under cotton cultivation and around 60% proportion in the raw fibre textile industry is contributed by cotton alone.

State of Art Manufacturing and Producing Nanocellulose from Agricultural Waste: A Review.

This review article aims to identify current research areas in nanocellulose production from various agricultural waste materials. In the arena of sustainable materials, nano-sized cellulosic materials have achieved great curiosity from scientists and researchers. Nanocellulose is embellished with some remarkable properties like biodegradability, renewability, low density, low weight, high strength and high stiffness.

Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases.

The human digestive tract is the cottage to trillions of live microorganisms, which regulate health and illness. A healthy Gut Microbiota (GM) is necessary for preventing microbial growth, body growth, obesity, cancer, diabetes, and enhancing immunity. The equilibrium in GM's composition and the presence/absence of critical species enable specific responses to be essential for the host's better health condition.

Natural Antimicrobials as Additives for Edible Food Packaging Applications: A Review.

Edible packaging is a swiftly emerging art of science in which edible biopolymers like lipids, polysaccharides, proteins, resins, etc., and other consumable constituents extracted from various non-conventional sources are used alone or imbibed together. Edible packaging with antimicrobial components had led to the development of the hypothesis of active packaging which safeguards the quality of foods as well as health of consumers.

Urea-thiazole/benzothiazole hybrids with a triazole linker: synthesis, antimicrobial potential, pharmacokinetic profile and in silico mechanistic studies.

Some urea-thiazole/benzothiazole hybrids with a triazole linker were synthesized via Cu(I)-catalysed click reaction. After successfully analysed by various spectral techniques including FTIR, NMR and HRMS, antimicrobial screening of the synthesized hybrids along with their precursors was carried out against two Gram (+) bacteria (Staphylococcus aureus and Bacillus endophyticus), two Gram (-) bacteria (Escherichia coli and Pseudomonas fluorescens) and two fungi (Candida albicans and Rhizopus oryzae). All the synthesized compounds (4a-4l) displayed better biological response than the standard fluconazole against both of the tested fungi.

Determining groundwater quality using indices and multivariate statistical techniques: a study of Tosham block, Haryana, India.

Water is the most important component for human survival and often the most misused one. The present study deals with the assessment of groundwater quality of Tosham block, Bhiwani District, Haryana, India, and its nearby villages. A total of 23 samples were collected from different groundwater sources and were analysed for 16 different physico-chemical parameters.

First principles study of Janus WSeTe monolayer and its application in photocatalytic water splitting.

By employing the state-of-the-art density functional theory method, we demonstrate that Janus WSeTe monolayer exhibits promising photocatalytic properties for solar water splitting. The results show that the monolayer possesses thermodynamic stability, suitable bandgap (∼1.89 eV), low excitons binding energy (∼0.

Exploring biological efficacy of novel benzothiazole linked 2,5-disubstituted-1,3,4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization, inhibition, molecular docking, molecular dynamics and Monte Carlo based QSAR studies.

In an effort to explore a class of novel antidiabetic agents, we have made an effort to synergize the α-amylase inhibitory potential of 1,3-benzothiazole and 1,3,4-oxadiazole scaffolds by combining the two into a single structure via an ether linkage. The structure of synthesized benzothiazole clubbed oxadiazole derivatives are established by different spectral techniques. The synthesized hybrids are evaluated for their in vitro inhibitory potential against α-amylase.

Prediction of power conversion efficiency of phenothiazine-based dye-sensitized solar cells using Monte Carlo method with index of ideality of correlation.

Simplified molecular-input line-entry system (SMILES) notation and inbuilt Monte Carlo algorithm of CORAL software were employed to construct generative and prediction QSPR models for the analysis of the power conversion efficiency (PCE) of 215 phenothiazine derivatives. The dataset was divided into four splits and each split was further divided into four sets. A hybrid descriptor, a combination of SMILES and hydrogen suppressed graph (HSG), was employed to build reliable and robust QSPR models.