The fatal fetal tumor: a geneticist's perspective.

Epignathus is an extremely rare oral teratoma which leads to high mortality in the early neonatal period. Various theories have been put forward for the genesis of such a tumor, though none is completely convincing. A genetic basis is not well established for the tumor.

Influence of total cholesterol levels on long-term mortality in coronary heart disease: a reappraisal.

To examine the prognostic significance of total cholesterol levels at baseline in subjects with stable coronary heart disease, 605 patients with stable coronary heart disease were enrolled; 45 of these did not meet inclusion criteria, 41 were lost to follow-up and 40 opted for coronary bypass surgery. Data of the remaining 479 (389 males, 90 females) were analysed. There were 102 males in group I (cholesterol < 200 mg/dL), 187 in group II (cholesterol 200-239 mg/dL), and 100 in group III (cholesterol > or = 240 mg/dL) and 49 females in group I and 41 in group II.

Prevalence of hypertension and subtypes in an Indian rural population: clinical and electrocardiographic correlates.

The aims of this study were to determine the prevalence of hypertension (systolic > or = 140 and/or diastolic > or = 90 mmHg) and its subtypes such as borderline isolated systolic hypertension (systolic > or = 140, diastolic < 90 mmHg), definite isolated systolic hypertension (systolic > or = 160, diastolic < 90 mmHg), isolated diastolic hypertension (systolic < 160, diastolic > or = 90 mmHg) and definite hypertension (systolic > or = 160 and diastolic > or = 90 mmHg or hypertensives on treatment) in a rural population of a developing country. We have conducted a total community cross-sectional survey in a rural population of western India. 3148 persons (1982 males and 1166 females), aged > or = 20 years were examined in a cluster of three villages in Rajasthan.

Influence of alcohol intake on high density lipoprotein cholesterol levels in middle-aged men.

To study the influence of alcohol (ethanol) intake on high density lipoprotein cholesterol (HDLC) levels, we studied 210 healthy middle-aged men (age 45 +/- 8 years). Other factors influencing HDLC (physical exercise, diet, smoking and body mass index) were also studied. Individuals were classified according to daily ethanol consumption.

An eight year review of diseases in rural Rajasthan.

To study the pattern of various medical diseases seen during specialist medical rural practice, we undertook an analysis of 1362 consecutive cases seen over an eight year period at a rural centre in Rajasthan. Analysis showed that infective diseases e.g.

Prognostic significance of radiographic cardiomegaly in patients with coronary heart disease.

To define the long term prognosis in patients with coronary heart disease (CHD) we have used criteria of radiographic cardiomegaly supplemented by M-mode echocardiography. 74 patients (Group A) with CHD and cardiomegaly were seen from 1980 to 1983 and have been compared to 121 patients (Group B) with normal cardiac size and prior myocardial infarction. Patients in Group A were defined by radiographic cardiomegaly with cardio-thoracic ratio of 0.

Influence of cessation of smoking on long term mortality in patients with coronary heart disease.

Cessation of smoking in patients with coronary artery disease (CAD) has shown variable results. The long term mortality in patients of coronary heart disease (CHD) who quit smoking following diagnosis of their disease has been variable. We have analysed the long term effects of cessation of smoking on mortality in a cohort of 173 patients with CAD and compared the mortality of this group with 299 nonsmokers and 52 current smokers.

Induction of myocardial ischaemia by mental stress in coronary heart disease.

To define the importance of mental stress in the genesis of myocardial ischaemia in patients with coronary heart disease, we studied 50 cases in whom ischaemia was provoked by a variety of mental stress tasks: arithmetic calculations, reading aloud and emotionally arousing speech. The haemodynamic responses were compared to those induced by exercise stress tests in 38 of these patients. Thirty four of the 50 patients tested (68%) developed electrocardiographic evidence of ischaemia during mental stress tasks as compared to 29 to 38 patients (76.

Influence of mild to moderate treated hypertension on 9-11 year mortality in patients with pre-existing coronary heart disease.

Hypertension is a known risk factor in the genesis of coronary artery disease. However, the effect of pre-existing hypertension on the long-term mortality in patients with established coronary heart disease is not clear. The present cohort study analysed the influence of baseline mild to moderate treated hypertension in cases of known coronary heart disease with cardiac mortality as end point.

Long term follow up study of prognostic significance of exercise duration during treadmill stress test in patients with stable coronary heart disease.

Treadmill stress tests provide useful noninvasive prognostic information in patients with coronary heart disease (CHD). The present study has prospectively analysed the long term prognostic value of exercise tolerance as measured by exercise time during treadmill stress test in 335 consecutive patients with stable CHD. 161 had exercise time of 6 minutes or less (mean 4.

Total cholesterol and mortality in patients with pre-existing coronary artery disease.

Background: A positive correlation exists between serum cholesterol levels and cardiovascular mortality. However, the role of serum cholesterol in persons with pre-existing coronary artery disease is not clear.

Methods: A cohort of 524 patients with coronary artery disease was divided into four groups based on the total serum cholesterol values.

Prognostic value of profound ST segment depression during treadmill stress test in coronary heart disease: nine years follow-up study.

To define the prognostic significance of profound ST segment depression (greater than or equal to 3mm) during exercise test, 106 patients of definite coronary heart disease enrolled in a prospective study were followed for up to 9 years. Group A (56 patients) had profound (greater than or equal to 3mm) ST segment depression (3.56 +/- 0.