5 results match your criteria: "Gunma Paz University Graduate School of Health Science[Affiliation]"
Abstract: During the 2014 to 2018 seasons, we conducted a longitudinal study involving enteric virus surveillance in bivalves, including natural oysters and clams harvested in Ibaraki Prefecture, Japan. Some norovirus (NoV) contaminations were detected in natural oysters, whereas no enteric virus was found in clams. NoVs detected in oysters were of the genotypes GII.
View Article and Find Full Text PDFMolecular evolution of the hemagglutinin-neuraminidase (HN) gene in human respirovirus 3.
Virus Res
February 2020
Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Article Synopsis
- Human respirovirus 3 (HRV3) causes acute respiratory infections and can lead to recurrent infections, though the reasons are unclear.
- A study analyzed the hemagglutinin-neuraminidase (HN) gene of HRV3 across multiple countries, revealing a common ancestor with bovine respirovirus 3 dating back to around 1815 and noted the evolutionary rate of the gene.
- The research identified various selection pressures on the HN protein and found that predicted B cell epitopes were mostly not aligned with neutralization sites, potentially explaining the virus's ability to reinfect humans.
NMR characterization of the interaction between Bcl-x and the BH3-like motif of hepatitis B virus X protein.
Biochem Biophys Res Commun
October 2019
Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo, 208-0011, Japan. Electronic address:
Hepatitis B virus X protein (HBx) possesses a BH3-like motif that directly interacts with the anti-apoptotic proteins, Bcl-2 and Bcl-x. Here we report the interaction between the HBx BH3-like motif and Bcl-x, as revealed by nuclear magnetic resonance spectroscopy. Our results showed that this motif binds to the common BH3-binding hydrophobic groove on the surface of Bcl-x, with a binding affinity of 89 μM.
View Article and Find Full Text PDFArticle Synopsis
- Human norovirus (HuNoV) is a leading cause of viral gastroenteritis, with GII.4 being the most common strain, though other genotypes like GII.2, GII.6, and GII.17 are also noteworthy.
- An epidemiological study in Ibaraki Prefecture, Japan, from September 2012 to August 2018 revealed that each GII genotype had distinct outbreak patterns and patient demographics, with GII.4 showing a resurgence after a decline.
- The research highlighted that different genotypes were linked to various outbreak locations, like childcare facilities and nursing homes, indicating a complex interplay between these viruses and their environments.
Detection of the Onset of the Epidemic Period of Respiratory Syncytial Virus Infection in Japan.
Front Public Health
March 2019
Department of Pediatrics, Faculty of Medicine, Kyorin University, Tokyo, Japan.
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection in young children worldwide. An annual epidemic of RSV infection generally begins around autumn, reaching a peak at the end of year in Japan, but in 2017 it started in early July and peaked in September. As the onset timing of RSV season varies, it is important to detect the beginning of an epidemic, to enable the implementation of preventive measures.
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