Utilisation of Cryopreserved Gametes in Cancer Patients who Underwent Fertility Preservation.

Background: Cancer treatments such as chemotherapy and radiotherapy often compromise fertility by damaging gonadal function, creating a critical need for fertility preservation options. Despite advancements in fertility preservation techniques, there is a significant lack of research focused on their application in Asian cancer patients and their utilisation remains underexplored in this population.

Aim: This study aims to evaluate the utilisation rates and outcomes of cryopreserved gametes in cancer patients who underwent fertility preservation before their cancer treatment.

HLA allele frequency of HLA-A, -B, -C, -DRB1 and -DQB1 in Indian recurrent implantation failure and recurrent pregnancy loss couples - A retrospective study.

The maternal-fetal interaction has been hypothesized to involve the human leucocyte antigen (HLA). It has been suggested that excessive HLA antigen sharing between spouses is a mechanism causing maternal hyporesponsiveness to paternal antigens encountered during pregnancy and thus leading to a miscarriage. Participants in this retrospective study are RIF and RPL couples who visited Gunasheela Surgical and Maternity Hospital, Bangalore, India from November 2019 to September 2022.

Preimplantation Genetic Testing for Couples with Balanced Chromosomal Rearrangements.

Background: Chromosomal rearrangements play an important role in infertility. Carriers of chromosomal rearrangements have a lower chance of producing normal or balanced gametes due to abnormal segregation of chromosomes at meiosis, which leads to recurrent spontaneous abortions and infertility. Preimplantation genetic testing for structural chromosome rearrangements (PGT-SR) is offered to couples who have balanced chromosomal rearrangements in order to select embryos with a balanced karyotype prior to implantation, thereby increasing the chances of pregnancy.

Cumulative Live Birth Rate per Oocyte Aspiration in Artificial Reproduction Technology: A Retrospective Observational Study of the Association between Maternal Age and the Number of Oocytes Retrieved in an Indian Population.

Background: The association between cumulative live birth rate (CLBR) and oocyte aspiration in the context of maternal age is not well understood in the Indian population.

Aims: To find the relationship between CLBR and a single oocyte aspiration.

Settings And Design: This is a retrospective study analysing the data of 1989 women who underwent fertilisation (IVF) between January 2015 and December 2019, at Gunasheela Surgical and Maternity Hospital, India.

Rupture of Bilateral Theca Lutein Cysts During Pregnancy: A Case Report.

Hyperreactio luteinalis is a rare condition characterized by the presence of bilateral theca lutein cysts, which occur rarely in a singleton normal pregnancy. Bilateral multicystic ovarian enlargement occurs due to elevated beta-human chorionic gonadotropin. We present a rare case of a 23-year-old primigravida in her tenth week of gestation, presenting with an acute abdomen, with increasing abdominal girth, diagnosed with a rupture of theca lutein cyst, and posted for laparotomy.

The Use of Integrative Medical Services to Address Psychological Concerns around Infertility in an Indian Academic Medical Centre.

Background: Alternative and complementary therapies have been gaining popularity as ways to reduce anxiety in patients.

Aim: This study aimed to assess whether yoga and meditation could decrease the severity of anxiety in Indian women diagnosed with infertility Study.

Study Setting And Design: This was a retrospective data analysis of anxiety score of 354 women undergoing treatment at a tertiary infertility hospital between January 2016 and December 2018.

A Study to Find Optimal Intra-cytoplasmic Sperm Injection Timing of Oocytes Matured from Germinal Vesicle in Maturation Cycles Using a Time Lapse System.

Background: The use of maturation (IVM) has allowed patients with polycystic ovary syndrome (PCOS) to have a positive fertility outcome, as it allows utilisation of immature oocytes to mature .

Aim: The aim of the study is to establish an optimum intra-cytoplasmic sperm injection (ICSI) timing for IVM oocytes (germinal vesicles [GV] →, metaphase I [MI]→ and metaphase II [MII]) using time lapse system (TLS) for patients with PCOS.

Setting And Design: Patients included in this study were diagnosed with PCOS, ≤35 years of age, anti-Müllerian hormone levels >6 ng/ml and antral follicle counts <40.

Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women.

Background: Ovarian reserve declines with age. However, there are considerable ethnic differences in the decline of ovarian reserve between individuals.

Aim: This study aimed to make age-specific percentile charts of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in Indian infertile women and to find the proportion of young women with low ovarian reserve.

Automated Follicular Assessment Using a Novel Two-dimensional Ultrasound-based Solution.

Background: High intra- and interobserver variability in the follicular assessment using two-dimensional (2D) ultrasound (US) is still a concern. To solve this issue, we have developed a novel software solution, which automatically provides follicles' count and their diameters using 2D US images obtained by a manual sweep of an ovary. The primary objective of this study was to compare the result of the automated solution with a manual 2D US-based assessment.

Preimplantation genetic testing for aneuploidy (PGT-A)-a single-center experience.

Purpose: The aim of this study was to determine the prevalence and nature of human embryonic aneuploidy based on the preimplantation genetic testing for aneuploidy (PGT-A), the distribution of aneuploidy across the individual chromosomes, and their relationship to maternal age.

Methods: This is a retrospective cohort study conducted at a single center. The study includes subjects who opted for PGT-A in their in vitro fertilization (IVF) cycle from 2016 to 2020.

Association of Follicular Fluid Advanced Glycation End-Products with Oocyte Response and Clinical Pregnancy in Assisted Reproduction Cycles.

Context: Advanced glycation end-products (AGEs) are toxic metabolic end-products of lipids, nucleic acids, and proteins. Their accumulation in the ovaries can alter the follicular microenvironment and affect stimulation response.

Aims: We aimed to study the association of AGEs in follicular fluid (FF AGE) with oocyte response and clinical pregnancy in ART-Assisted Reproductive Technology cycles.

A Descriptive Study Exploring Semen Quality Among Indian Cancer Patients.

To descriptively explore semen quality among Indian men with various types of malignancies. We evaluated semen parameters of male patients referred to our hospital before commencing their cancer treatment. Four hundred sixty-one male patients who were within the age range of 15-50 years were recruited with diagnosed malignancies.

A Study on Diagnostic Evaluation of Two Different Rapid DNA Polymerase Chain Reaction Techniques Namely Gene Xpert Mycobacterium Tuberculosis/Rifampin (MTB/RIF) and Mycoreal Polymerase Chain Reaction in the Diagnosis of Endometrial Tuberculosis Considering Culture as Gold Standard.

Context: The study involves the evaluation of two polymerase chain reaction (PCR) techniques one of which has been endorsed by the WHO for their diagnostic capabilities.

Aims: The aim of this study is to evaluate the diagnostic accuracy of GeneXpert mycobacterium tuberculosis/Rifampin (MTB/RIF) and mycoreal PCR techniques in the diagnosis of endometrial tuberculosis (TB) considering culture as the gold standard.

Settings And Design: A retrospective study conducted at Gunasheela surgical and maternity hospital.

The Development of an International Oncofertility Competency Framework: A Model to Increase Oncofertility Implementation.

Background: Despite international evidence about fertility preservation (FP), several barriers still prevent the implementation of equitable FP practice. Currently, oncofertility competencies do not exist. The aim of this study was to develop an oncofertility competency framework that defines the key components of oncofertility care, develops a model for prioritizing service development, and defines the roles that health care professionals (HCPs) play.

How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care.

Background: Fertility preservation (FP) is an important quality of life issue for cancer survivors of reproductive age. Despite the existence of broad international guidelines, the delivery of oncofertility care, particularly amongst paediatric, adolescent and young adult patients, remains a challenge for healthcare professionals (HCPs). The quality of oncofertility care is variable and the uptake and utilization of FP remains low.

Effects of yoga on utero-fetal-placental circulation in high-risk pregnancy: a randomized controlled trial.

Introduction. Impaired placentation and inadequate trophoblast invasion have been associated with the etiology of many pregnancy complications and have been correlated with the first trimester uterine artery resistance. Previous studies have shown the benefits of yoga in improving pregnancy outcomes and those of yogic visualization in revitalizing the human tissues.

The effects of yoga in prevention of pregnancy complications in high-risk pregnancies: a randomized controlled trial.

Objective: While previous studies have shown the potential effects of yoga in normal pregnancies, this randomized controlled trial investigated the effects of yoga in prevention of pregnancy complications in high-risk pregnancies for the first time.

Methods: 68 high-risk pregnant women were recruited from two maternity hospitals in Bengaluru, India and were randomized into yoga and control groups. The yoga group (n=30) received standard care plus one-hour yoga sessions, three times a week, from the 12th to the 28th week of gestation.

Efficacy of yoga in pregnant women with abnormal Doppler study of umbilical and uterine arteries.

To study the efficacy of yoga on the outcome of complicated pregnancy, 121 women attending antenatal clinic at Gunasheela Surgical and Maternity Hospital (GSMH) in Bangalore, India, were enrolled between 18-20 weeks of pregnancy in a prospective, matched, observational study. Sixty-eight women were in the yoga group and 53 women in the control group. Women were matched for age, gravida and Doppler velocimetry scores of umbilical and uterine arteries.

Efficacy of yoga on pregnancy outcome.

Objective: To study the efficacy of yoga on pregnancy outcomes.

Design And Setting: Three hundred thirty five (335) women attending the antenatal clinic at Gunasheela Surgical and Maternity Hospital in Bangalore, India, were enrolled between 18 and 20 weeks of pregnancy in a prospective, matched, observational study; 169 women in the yoga group and 166 women in the control group.

Methods: Women were matched for age, parity, body weight, and Doppler velocimetry scores of umbilical and uterine arteries.

Management of endometriosis and its impact on infertility.

Endometriosis is defined as the presence of tissue, histologically similar to endometrium, in any other site but that of uterine cavity. Transplantation of endometrial tissue that comes as a retrograde menstrual flow is the most accepted possible theory. Endometriosis is associated with marked subfertility, but the mechanism of causation of infertility is poorly understood unless it has caused very definite anatomical distortion of internal genitalia.