Expert consensus and recommendations on the live attenuated hepatitis A vaccine and immunization practices in India.

While Hepatitis A Virus (HAV) vaccination in global immunization programs has shown a virtual elimination of the disease within few years of the vaccination program, changing epidemiological landscape in India underscores the need for evidence-based, updated guidance on immunization practices. In May 2024, a panel of 15 distinguished opinion leaders and an organizing committee convened for an intensive, face-to-face advisory board meeting on high burden of HAV infection among adults, increased mortality rate in adolescents, symptomatic presentation in children, and evolving landscape globally and within India. Extensive comparable deliberations on long-term follow-up data from India and data from country of origin advocated immunogenicity, tolerability, and long-term protective effects of single-dose live attenuated HAV vaccine in children.

Talimogene laherparepvec (T-VEC) as a treatment for melanoma: A systematic review.

Background And Aims: Melanoma now presents an average risk of 1 in 50 in the Western world. Talimogene laherparepvec (T-VEC), an FDAapproved oncolytic virus derived from Herpes Simplex Virus type 1 (HSV-1), has proven effective in reducing morbidity and mortality from melanoma but causes adverse effects like chills, fever, exhaustion, and injection site discomfort. Research focuses on combining T-VEC with immune checkpoint inhibitors, such as pembrolizumab, to enhance its efficacy and broaden its application.

Therapeutic Innovations in Nanomedicine: Exploring the Potential of Magnetotactic Bacteria and Bacterial Magnetosomes.

Nanotechnology has emerged as a revolutionary domain with diverse applications in medicine, and one of the noteworthy developments is the exploration of bacterial magnetosomes acquired from magnetotactic bacteria (MTB) for therapeutic purposes. The demand for natural nanomaterials in the biomedical field is continuously increasing due to their biocompatibility and eco-friendly nature. MTB produces uniform, well-ordered magnetic nanoparticles inside the magnetosomes, drawing attention due to their unique and remarkable features.

Use of generative large language models for patient education on common surgical conditions: a comparative analysis between ChatGPT and Google Gemini.

There is a growing importance for patients to easily access information regarding their medical conditions to improve their understanding and participation in health care decisions. Artificial Intelligence (AI) has proven as a fast, efficient, and effective tool in educating patients regarding their health care conditions. The aim of the study is to compare the responses provided by AI tools, ChatGPT and Google Gemini, to assess for conciseness and understandability of information provided for the medical conditions Deep vein thrombosis, decubitus ulcers, and hemorrhoids.

Gelatin/PLA-loaded gold nanocomposites synthesis using Syzygium cumini fruit extract and their antioxidant, antibacterial, anti-inflammatory, antidiabetic and anti-Alzheimer's activities.

Nanotechnology has experienced significant advancements, attracting considerable attention in various biomedical applications. This innovative study synthesizes and characterizes Ge/PLA/AuNCs (gelatin/PLA/gold nanocomposites) using Syzygium cumini extract to evaluate their various biomedical applications. The UV-Visible spectroscopy results in an absorption peak at 534 nm were primarily confirmed by Ge/PLA/AuNCs synthesis.

A Review of Emerging Evidence and Clinical Applications of Hyperbaric Oxygen Therapy.

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment that involves administering 100% oxygen at increased atmospheric pressure to enhance oxygen delivery to tissues. Initially developed for decompression sickness, HBOT has since been utilized for a wide range of medical conditions, including severe infections, non-healing wounds, and, more recently, COVID-19. This review explores the historical development of HBOT, its principles, its emerging role in the management of and its outcome as treatment in COVID-19, particularly in mitigating inflammation, hypoxemia, and oxidative stress.

Call to action for Clinicians in the South-East Asian Regions on Primary Prevention of Diabetes in people with Prediabetes- A Consensus statement.

Primary prevention of diabetes still remains as an unmet challenge in a real world setting. While, translational programmes have been successful in the developed nations, the prevailing social and economic inequities in the low and middle income countries, fail to integrate diabetes prevention into their public health systems. The resulting exponential increase in the prevalence of diabetes and the cost of treatment has put primary prevention in the back seat.

Association between the dietary inflammatory index and adverse pregnancy outcomes.

Background: Limited research exists on the association between preconception pro-inflammatory diets and adverse pregnancy outcomes, and this relationship remains poorly understood.

Objective: To investigate the association between preconception dietary inflammatory potential, as measured by the Dietary Inflammatory Index (DII), and adverse pregnancy outcomes in nulliparous individuals.

Methods: This was a secondary analysis of the data from the Nulliparous Outcomes Study: Mothers-to-be (nuMoM2b).

Green Synthesis of Eosin-Y Coated Silver Nanoparticles for Sensitive and Selective Fluorometric Detection of L-Dopa.

This study is to produce biogenic silver nanoparticles (AgNPs) by utilizing aqueous extracts derived from Turnera Sublata (TS) leaves under visible light. Subsequently, these nanoparticles are coated with eosin-yellow (EY) to enhance sensitivity and selectivity in L-3,4-dihydroxyphenylalanine (L-dopa) detection. This method encompasses the deposition of metal onto the Ag NPs, resulting in the formation of EY-AgNPs.

Mid-term Outcomes of Patella Resurfacing During Total Knee Arthroplasty (TKA): Clinical, Functional, and Radiographic Insights.

Aim The primary objective of the study was to evaluate the mid-term implant survivability, rate of revisions, and clinical and functional outcomes following patella resurfacing during total knee arthroplasty (TKA) utilizing posterior stabilized (PS) total knee system (TKS). Methods A prospective, single-arm, multi-center, post-marketing surveillance encompassed patients with end-stage primary knee osteoarthritis (OA) or inflammatory arthritis. The time points of the study included baseline, six weeks, six months, one year, and three years post-operatively.

An epidemiological assessment of health status among a cohort of tuberculosis survivors: prospective research in a western Indian city.

Long-term follow-up of tuberculosis (TB) is important to monitor treatment outcomes, prevent relapse, and improve patient care. The aims of the current study are: i) to assess various epidemiological parameters among TB survivors, like mortality and morbidity, with emphasis on recurrence status during pre-defined long-term follow-up; ii) to assess factors responsible for the recurrence of TB among study participants. A prospective observational study was conducted among cured cases of pulmonary TB registered at the TB unit of Ahmedabad City, India.

In Silico design and molecular dynamics analysis of imidazole derivatives as selective cyclooxygenase-2 inhibitors.

Cyclooxygenase-2 (COX-2), a key enzyme in the inflammatory pathway, is the target for various nonsteroidal anti-inflammatory drugs (NSAIDs) and selective inhibitors known as coxibs. This study focuses on the development of novel imidazole derivatives as COX-2 inhibitors, utilizing a Structure-Activity Relationship (SAR) approach to enhance binding affinity and selectivity. Molecular docking was performed using Autodock Vina, revealing binding energies of -6.

Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery.

The prevalence and death due to cancer have been rising over the past few decades, and eliminating tumour cells without sacrificing healthy cells remains a difficult task. Due to the low specificity and solubility of drug molecules, patients often require high dosages to achieve the desired therapeutic effects. Silica nanoparticles (SiNPs) can effectively deliver therapeutic agents to targeted sites in the body, addressing these challenges.

Assessing the Effectiveness of Histaglobulin in Chronic Idiopathic Urticaria: A Retrospective Analysis at a Tertiary Care Hospital.

Introduction Chronic urticaria is a transient cutaneous disorder that waxes and wanes swiftly but, due to its periodic episodes, declines the quality of life of the affected individuals. It is of two types: chronic spontaneous or idiopathic and chronic-induced urticaria. Urticaria can have many different causes, but one of the most common causes of chronic idiopathic urticaria (CIU) is autoimmune.

Multidrug resistant : A study on its pathogenesis and therapeutics.

The overuse of antibiotics has led to the global dissemination of , an increasingly challenging nosocomial pathogen. This review explores the medical significance along with the diverse resistance ability of . Intensive care units (ICUs) serve as a breeding ground for , as these settings harbour vulnerable patients and facilitate the spread of opportunistic microorganisms.

Neutrophil-to-lymphocyte ratio as a novel predictor of sarcopenia in maintenance hemodialysis patients: a cross-sectional study exploring associations across body composition categories.

Background: Sarcopenia is prevalent among hemodialysis patients and is associated with poor outcomes. The neutrophil-to-lymphocyte ratio (NLR), an easily obtainable marker of inflammation, may predict sarcopenia risk. This study aimed to investigate the association between NLR and sarcopenia risk in maintenance hemodialysis patients, examining this association in the context of obesity.

A quasi affine transformation evolution algorithm with evolution matrix selection operation for parameter estimation of proton exchange membrane fuel cells.

Electrochemical energy conversion technologies include proton exchange membrane fuel cells (PEMFCs) where proton interchange is an alternative to diesel distributed generation, and PEMFCs are considered as a promising backup power source and a tool to regulate power consumption. Some of the major benefits of these PEMFCs especially in power system applications include low emission of carbon, fast load following capability, no noise and high start-up reliability. It is challenging to find the best PEMFC parameters because the model is complex and the problem is nonlinear; not all optimization algorithms can solve this problem.

Paediatric falls: An analysis of patterns of injury and associated mortality in urban India.

Background: Falls are some of the most common childhood injuries. However, for vulnerable children in low- and middle-income countries (LMICs) such as India, mortality from a fall is nearly three times that of high-income countries. Despite fall being a leading cause of paediatric injury, detailed data from LMICs remain sparse.

Assessment of the Peri-implant Bone Density Following Bicortical Anchored Corticobasal Implants Placement in the Maxillary Arch: A Cross-sectional Prospective Study.

Aim: The aim of this cross-sectional prospective study was to evaluate the bone density changes around the bicortical corticobasal implant placed in the maxilla over 18 months of follow-up using cone-beam computed tomography (CBCT), focusing on the comparison between the anterior and posterior teeth and regions.

Materials And Methods: Thirty-five subjects (20, 53.26%, were males, and 15, 46.

Postpartum depression in Gujarat, India: Associations with social support, breastfeeding attitudes, and self-efficacy.

Background: Postpartum depression (PPD) is a significant public health concern with detrimental effects on maternal and child well-being. Social support, breastfeeding attitudes, and self-efficacy have been identified as potential protective or risk factors for PPD. This study aimed to investigate the associations between PPD, social support, breastfeeding attitudes, and self-efficacy among postpartum women in Gujarat, India.

Factors influencing adherence to dietary recommendations for type 2 diabetes mellitus and their impact on disease control: A cross-sectional study.

Background And Objectives: Diabetes is a chronic metabolic disease, with current estimates by the IDF (International Diabetes Federation) suggesting nationwide prevalence rates of 9.2% among Indians aged 20-79 years. An appropriate dietary pattern is widely accepted as a cornerstone of treatment among diabetes patients.

Prevalence of traditional cardiovascular risk factors in high-risk Kyrgyzstan population as compared to Indians - An Indo-Kyrgyz cardiometabolic study.

Background: Cardiovascular diseases (CVDs) are one of the most prevalent causes of mortality worldwide, especially significant in low- and middle-income countries. Kyrgyzstan and India represent such nations that face a huge burden of CVD-related deaths globally. Understanding the prevalence of traditional cardiovascular risk factors (CVRFs) in these populations is critical for effective prevention and management strategies.

Undergraduate psychiatry CBME curriculum revision: The process and the way ahead.

Nationa Medical Commission (NMC) had recently undertook the revision of Undergraduate CBME curriculum. the Authors were involved in Psychiatry curriculum revision. In this paper, authors explain the process of revision, the rationale behind the changes made and make specific suggestions for the better implementation of the revised curriculum.

A comparison of demographic profiles, clinical profile, course, and outcome of Bipolar I Disorder and Bipolar II Disorder: Findings from the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study).

Background: There is lack of data on bipolar disorder (BD) type II from India.

Aim: To compare the demographic and clinical characteristics of patients with BD-I and BD-II using the data of the Bipolar Disorder Course and Outcome study from India (BiD-CoIN study).

Methodology: Using the data of the BiD-CoIN study, patients with BD-I and BD-II were compared for demographic and clinical variables.