GlmU inhibitor from the roots of as an anti-tuberculosis agent.

At present, the emerging drug-resistance of () against existing frontline drugs has prompted the development of novel anti-tuberculosis agents based on new targets. Activity of the bifunctional enzyme, glucosamine-1-phosphate acetyltransferase activity and -acetylglucosamine-1-phosphate uridyltransferase (GlmU) is essential for biosynthesis of the mycobacterium cell wall components and has been proposed as a potential drug target for therapeutic interventions. On the basis of the high-throughput screening of the GlmU AT inhibitor, an extract of displayed a significant inhibitory effect among 49 tested herbal medicines.

[Preparation of tanshinone Ⅱ_A-glycyrrhetinic acid solid lipid nanoparticles and its inhibitory effect on acne].

The optimal prescription of tanshinone Ⅱ_A(TSN)-glycyrrhetinic acid(GA) solid lipid nanoparticles(GT-SLNs) was explored and evaluated in vivo and in vitro, and its effect on acne after oral administration was investigated. The preparation processing and prescription were optimized and verified by single factor and response surface methodology. The in vitro release of GA and TSN in GT-SLNs was determined by ultra-performance liquid chromatography(UPLC).

Monosialotetrahexosylganglioside sodium combined with hyperbaric oxygen on nervous system development and brain physiology in children with hypoxic ischemic encephalopathy.

To investigate the short-term and long-term clinical effects of monosialotetrahexosylganglioside sodium (GM1) combined with hyperbaric oxygen in neonatal hypoxic ischemic encephalopathy. A total of 80 children with hypoxic ischemic encephalopathy who were admitted to our hospital from January 2016 to March 2018 were selected and divided into the observation group and control group according to a random alphabet method, with 40 cases in each group. Neuron-specific enolase (NSE) and amplitude-integrated electroencephalogram (aEEG) were monitored after treatment in both groups, and the mental development index (MDI) and the psychomotor development index (PDI) of children were evaluated by the Bayley Scales of Infant Development (BSID) 12 months after discharge.

An integrated metabolomics and 16S rRNA gene sequencing approach exploring the molecular pathways and potential targets behind the effects of Radix Scrophulariae.

To assess the impact of the caecal microbiota on faecal metabolic phenotypes in the presence of Radix Scrophulariae (Chinese name: ), an integrated approach involving 16S rRNA gene sequencing combined with ultrahigh-performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOF-MS)-based faecal metabolomics was applied to Radix Scrophulariae-treated rats. Interestingly, Radix Scrophulariae led to significant gut microbiota changes at the phylum and genus levels in treated rats compared to control rats. Additionally, distinct changes in faecal metabolites, including linoleic acid (LA), guanosine, inosine, hypoxanthine, xanthine, 4-hydroxycinnamic acid, cholic acid, -acetyl-d-glucosamine, l-urobilinogen and uridine, were observed in Radix Scrophulariae-treated rats.