The study on the effect of mercury pollution on soil microorganisms around mercury mining area.

In order to further explore the effects of soil mercury pollution on soil microbial diversity and community structure, soil samples were randomly collected from 2 m, 20 m, 30 m, 500 m and 650 m periphery of Wanshan mining area, as 5 different treatments. Each treatment had 4 replicates. Soil microbial DNA was extracted from 20 soil samples, and then high-throughput sequencing technology was used to analyse the structure and distribution of bacterial and fungal communities.

HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells.

Purinostat Mesylate (PM) is a novel highly selective and active HDAC I/IIb inhibitor, and the injectable formulation of PM (PMF) based on the compound prescription containing cyclodextrin completely can overcome PM's poor solubility and improves its stability and pharmacokinetic properties. Here, we showed that PM effectively repressed the survival of Ph leukemia cells and CD34 leukemia cells from CML patients . studies demonstrated that PMF significantly prevented BCR-ABL(T315I) induced CML progression by restraining leukemia stem cells (LSCs), which are insensitive to chemotherapy and responsible for CML relapse.

Extraction of Music Main Melody and Multi-Pitch Estimation Method Based on Support Vector Machine in Big Data Environment.

Main melody extraction and multi-pitch estimation are two important research topics in the MIR field. In this article, the SVM algorithm is used to analyze and discuss music melody extraction and multi-pitch estimation. In the part of multi-fundamental frequency extraction, this article first filters the song signal with equal loudness and weakens the energy of the high-frequency and low-frequency parts of the song signal.

A prediction method based on fractional order displacement for dynamic multiobjective optimization.

Prediction-based methods have become more popular for solving dynamic multiobjective optimization problems. However, most of these proposed methods only use the optimal solutions in the previous two or three environments to predict the new optimal solutions after a change. Doing so neglects information from earlier in the history, which may reduce the accuracy of the prediction method.

Genome-wide identification and genetic characterization of the CaMYB family and its response to five types of heavy metal stress in hot pepper (Capsicum annuum cv. CM334).

MYB proteins play a crucial role in plant growth and development and stress responses. In this study, 160 members of the MYB gene family from the pepper genome database were used to analyze gene structures, chromosome localization, collinearity, genetic affinity and expression in response to heavy metals. The results identified R2R3-MYB members and further phylogenetically classified them into 35 subgroups based on highly conserved gene structures and motifs.

Coupling analysis on ecological environment fragility and poverty in South China Karst.

Ecological environment and poverty have a strong spatial coupling. It is of great significance to study the interaction mechanism between them for ecological restoration and targeted poverty alleviation in ecologically fragile areas. Taking Guizhou Plateau, the center of South China Karst, as a research object, this study constructs a multi-dimensional poverty and ecological vulnerability coupling index system and analyses the coupling relationship between ecological environment and poverty from a village scale, using the comprehensive coupling coordination degree model and hot spot analysis method, followed by classifying the types of poverty villages.

Hydration and Strength Development of Cementitious Materials Prepared with Phosphorous-Bearing Clinkers.

To rationally use low-grade phosphorous limestone as the raw materials for cement production, the influence of phosphorous introduced by fluorapatite during the clinker calcination process on the mechanical properties of cementitious materials is investigated. Hydration kinetics, phase evolutions, and microstructure of cement pastes have been studied by using calorimetry, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The results indicate that the mechanical properties of cementitious materials can be slightly improved due to the mineralization effect of the small amount of phosphorous in the clinker and significantly decreased with an increase of phosphorous.

Environment dependent microbial co-occurrences across a cyanobacterial bloom in a freshwater lake.

Microbial taxon-taxon co-occurrences may directly or indirectly reflect the potential relationships between the members within a microbial community. However, to what extent and the specificity by which these co-occurrences are influenced by environmental factors remains unclear. In this report, we evaluated how the dynamics of microbial taxon-taxon co-occurrence is associated with the changes of environmental factors in Nan Lake at Wuhan city, China with a Modified Liquid Association method.

An HIV-infected patient with coronavirus disease 2019 has a favourable prognosis: a case report.

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly, which now has turned into a pandemic. The new emerging infectious disease has raised many challenges and uncertainties regarding disease management and prognosis in immunocompromised patient populations. The risk of COVID-19 among people living with human immunodeficiency virus (HIV) has different opinions.

Study on the properties of perovskite materials under light and different temperatures and electric fields based on DFT.

The photoelectric conversion efficiency of perovskite solar cells has improved rapidly, but their stability is poor, which is an important factor that restricts their commercial production. This paper studies the physical and chemical stability of perovskite solar cells based on first principles. It is well known that methylamido lead iodide compounds and methylamino lead iodide compounds are easily degraded into NHCH[double bond, length as m-dash]NHI, CHNHI and PbI.

Study on the Property of Electron-Transport Layer in the Doped Formamidinium Lead Iodide Perovskite Based on DFT.

The electron-transport layer in planar perovskite solar cells plays an important role in improving photoelectric conversion efficiency. At present, the main electronic transmission materials in perovskite solar cells include TiO, ZnO, WO, ZrO, SnO, ZnO, etc. This work mainly studies the electron-transport characteristics of six different electron-transport layers in perovskite solar cells.

Targeting glutaminase1 and synergizing with clinical drugs achieved more promising antitumor activity on multiple myeloma.

Multiple myeloma (MM) pathogenesis remains incompletely understood and biomarkers predicting treatment response still remain lacking. Here we describe the rational mechanisms of combining targeting glautaminase1 (GLS1) with other chemo-reagents for MM treatment. Gls1 is highly expressed cMYC/KRAS12V-drived plasmacytoma (PCT) cells.

DC Shifts-fMRI: A Supplement to Event-Related fMRI.

Event-related fMRI have been widely used in locating brain regions which respond to specific tasks. However, activities of brain regions which modulate or indirectly participate in the response to a specific task are not event-related. Event-related fMRI can't locate these regulatory regions, detrimental to the integrity of the result that event-related fMRI revealed.

Single-Trial EEG-fMRI Reveals the Generation Process of the Mismatch Negativity.

Although research on the mismatch negativity (MMN) has been ongoing for 40 years, the generation process of the MMN remains largely unknown. In this study, we used a single-trial electro-encephalography (EEG)-functional magnetic resonance imaging (fMRI) coupling method which can analyze neural activity with both high temporal and high spatial resolution and thus assess the generation process of the MMN. We elicited the MMN with an auditory oddball paradigm while recording simultaneous EEG and fMRI.

Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity.

In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus (TMV). In particular, compounds , and exhibited the best curative activity, protection activity, and inactivation activity against TMV, respectively, which were superior to those of Ningnanmycin.

Precise Control of Local Spin States in an Adsorbed Magnetic Molecule with an STM Tip: Theoretical Insights from First-Principles-Based Simulation.

The precise tuning of local spin states in adsorbed organometallic molecules by a mechanically controlled scanning tunneling microscope (STM) tip has become a focus of recent experiments. However, the underlying mechanisms remain somewhat unclear. We investigate theoretically the STM tip control of local spin states in a single iron(II) porphyrin molecule adsorbed on the Pb(111) substrate.

SOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting Angiogenesis in Human Prostate Cancer.

Background: Our previous studies revealed that the downregulation of Suppressor of cytokine signaling 6 (SOCS6) was correlated with malignant progression of human prostate cancer (PCa).

Aims: In the current study, we aimed to investigate the tumor suppressive roles of SOCS6 and the underlying mechanisms in PCa.

Methods: SOCS6 expression in PCa and non-cancerous prostate tissues was compared by immunohistochemistry.

The absence of reproductive isolation between non-sister and deeply diverged mitochondrial lineages of the black-throated tit (Aegithalos concinnus) revealed by a multilocus genetic analysis in a contact zone.

Background: A deep divergence of mitochondrial DNA is common in species delimitated by morphological traits. Several hypotheses can explain such variations, such as cryptic species, introgression, allopatric divergence and ancestral lineage. The black-throated tit harbors several deeply divergent mitochondrial lineages.

Highly Active Graphene Oxide-Supported Cobalt Single-Ion Catalyst for Chemiluminescence Reaction.

Graphene- or graphene oxide (GO)-supported metallic nanoparticles and single metal atom as potentially effective catalysts for chemical reactions have recently received extensive research interests. However, metal utilization in nanoparticle catalysts is limited and metal atoms readily drift on the graphene surface and consequently form aggregated large particles, making practical applications limited. Here, we report metal ions directly immobilized on GO as a novel GO-supported single-ion catalyst for chemiluminecence (CL) reactions.

[Studies on effects of water temperature, stocking density and feeding cycle on growth and feeding in Hirudo nipponica].

Effects of different water temperature, stocking density and feeding cycle on growth, feeding and survival of Hirudo nipponica have been studied, six temperature gradients were set: 18, 22, 26, 30, 34 and 38 ℃, five stocking density gradients were set: 30, 60, 120, 180 and 240 leech/L, four feeding cycle gradients were set: 2, 5, 10 and 20 d, respectively. The results showed that there exists a significant regression relationship between water temperature and specific growth rate: y=-0.016 5x²+0.

Protecting quantum Fisher information of N-qubit GHZ state by weak measurement with flips against dissipation.

In this paper we propose a scheme by using weak-measurement-based pre- and post-flips (WMPPF) to protect the average quantum Fisher information (QFI) in the independent amplitude-damping channel (ADC) for N-qubit GHZ state and generalized N-qubit GHZ states. We also discuss the weak measurement and quantum measurement reversal (WMQMR) with the same ADC. Based on the analytical and numerical results we obtain the main result: the WMPPF can reduce the effect of dissipation on the average QFI of the phase or the frequency for GHZ state and some generalized GHZ states, and the WMQMR can reduce the effect of dissipation on the average fidelity for GHZ state and generalized GHZ states in ADC.

Quantitative assessment of the impacts of climate change and human activities on runoff change in a typical karst watershed, SW China.

The Yinjiang River watershed is a typical karst watershed in Southwest China. The present study explored runoff change and its responses to different driving factors in the Yinjiang River watershed over the period of 1984 to 2015. The methods of cumulative anomaly, continuous wavelet analysis, Mann-Kendall rank correlation trend test, and Hurst exponent were applied to analyze the impacts of climate change and human activities on runoff change.

Graphitic carbon nitride supported single-atom catalysts for efficient oxygen evolution reaction.

Based on DFT calculations, we propose a TM@CN hybrid structure, in which the single-atom transition metal (TM = Pt, Pd, Co, Ni, Cu) is supported by graphitic carbon nitride (g-CN), as a promising high-performance OER catalyst. Our work reveals the importance of local TM coordination in catalysts for the OER, which would lead to a new class of low-cost, durable and efficient OER catalysts.

Epitaxial Growth of Single Layer Blue Phosphorus: A New Phase of Two-Dimensional Phosphorus.

Blue phosphorus, a previously unknown phase of phosphorus, has been recently predicted by theoretical calculations and shares its layered structure and high stability with black phosphorus, a rapidly rising two-dimensional material. Here, we report a molecular beam epitaxial growth of single layer blue phosphorus on Au(111) by using black phosphorus as precursor, through the combination of in situ low temperature scanning tunneling microscopy and density functional theory calculation. The structure of the as-grown single layer blue phosphorus on Au(111) is explained with a (4 × 4) blue phosphorus unit cell coinciding with a (5 × 5) Au(111) unit cell, and this is verified by the theoretical calculations.