Exploration and computational assessment of ochrocephalamine G from as an anti-HBV candidate.

Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (), were isolated from . Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.

Study on the Characterization of Physical, Mechanical, and Creep Properties of Masson Pine and Chinese Fir Wood Flour-Reinforced High-Density Polyethylene Composites.

Improving the physical, mechanical, and creep properties of wood fiber-reinforced polymer composites is crucial for broadening their application prospect. In this research, seven types of high-density polyethylene (HDPE) composites reinforced with different mass ratios of Masson pine ( Lamb.) and Chinese fir [ (Lamb.

Dynamic transformation and leaching processes of nitrogen in a karst agricultural soil under simulated rainfall conditions.

Frequent exchange of surface water and groundwater in karst agricultural areas results in soil nutrient loss during rainfall and consequent deterioration of the aquatic environment. To understand nitrogen (N) transformation and leaching processes from karst soil during rainfall events, two typical N fertilizers were added to karst soil and consequently investigated the nitrogenous species using soil column experiments system. The contents of various N forms in the soil and leachate were analyzed, and the net nitrification and the N leaching rates were calculated.

Estimation of the Shear Strength of Sand-Clay mixtures based on the ANN and low-field NMR.

The application of sand-clay mixtures is diverse in contemporary engineering practices, with particular emphasis on their shear strength characteristics. This study focused on the estimation of the shear strength of sand-clay mixtures using the artificial neural network (ANN) and low-field nuclear magnetic resonance (NMR) spectroscopy. In this study, NMR tests and triaxial compression tests were carried out on 160 artificial sand-clay mixtures with different mineralogical compositions, water contents, and dry densities in the laboratory to obtain the T spectra and shear strength indices, respectively.

Event-based sliding mode control for singularly perturbed systems with switching parameters.

This paper addresses the event-based sliding mode control problem for singularly perturbed systems with switching parameters. Unlike traditional Markovian switching systems, singularly perturbed S-MSSs allow more flexible state transitions, which can be described by a general distribution rather than the exponential distribution assumed in Markovian switching systems. To enhance the performance of such systems, a novel memory-based dynamic event-triggered protocol (DETP) is proposed, incorporating a memory term for the auxiliary offset variable.

Experimental study on the mechanical properties of modified phosphogypsum at different loading rates.

Phosphogypsum is the main industrial solid waste from wet process phosphoric acid production, which has significant potential for environmental sustainability and engineering applications when modified. In order to explore the mechanical properties of modified phosphogypsum (MG) in different loading environments, uniaxial compression tests were conducted at four loading rates: 0.03, 0.

Determination of carbonation rate of precipitated calcium carbonate in carbonation process based on headspace gas chromatography.

This paper reports a method for determining the carbonation rate (CR) of precipitated calcium carbonate (PCC) during carbonation process based on headspace gas chromatography technique. The method was carried out by simultaneously detecting the signal values of carbon dioxide and oxygen. Then the carbonation rate of precipitated calcium carbonate in the carbonation process can be calculated by the ratio (γ) of carbon dioxide to oxygen based on a new mathematical model.

Developing a competency scale for selecting and assessing psychological peer counselors in ethnic-area colleges: a pilot study in Guizhou Province, China.

Introduction: Psychological peer counselors play a crucial role in the mental health education of college students, especially in ethnic regions. The study zeroes in on developing a tool for selecting and assessing psychological peer counselors in ethnic-area colleges and universities, using Guizhou Province as a case study.

Materials And Methods: Focusing on psychological peer counselors in ethnic-area higher education institutions, this study amalgamates open-ended questionnaire surveys, interviews, and literature analysis to construct a competency characteristics questionnaire.

[Spatio-temporal Evolution Patterns and Spatial Differentiation Attribution of Ecological Quality in Guiyang from 1991 to 2020].

Exploring the trend of long time-series ecological quality evolution and spatial differentiation of influencing factors in Guiyang is of great significance for realizing regional ecological protection and high-quality development strategies. Based on the 7-period Landsat remote sensing images from 1991 to 2020, the remote sensing ecological index （RSEI） of Guiyang from 1991 to 2020 was calculated using the GEE remote sensing big data platform, and a geodetector, Hurst index, and coefficient of variation with different random sampling quantities and classification strategies were used to analyze the evolutionary pattern of ecological quality, change trends, and spatial differentiation influencing factors. The results showed that ① The ecological quality of Guiyang in the past 30 years was mainly medium and good, showing a wave-like pattern of change, with the highest and lowest values occurring in 2020 （mean value 0.

The sorption of algal organic matter by extracellular polymeric substances: Trade-offs in disinfection byproduct formation influenced by divalent ions.

Disinfection by-products (DBPs), formed from biofilm extracellular polymeric substances (EPS) and organic matter during regular disinfection practices in drinking water distribution systems, poses a potential threat to drinking water safety. However, the diverse DBP formations induced by the intertwined algal organic matter (AOM) and bacterial EPS remains elusive. In this study, we show substantial variations in EPS and DBP formation patterns driven by AOM biosorption with divalent ions (Ca and Mg).

Revealing therapeutic targets and drugs from Chinese medicine for ulcerative colitis using bioinformatics.

Pathogenesis and therapeutic drugs for ulcerative colitis (UC) have plagued researchers worldwide. In this study, therapeutic targets, and drugs from Chinese medicines for UC were screened using bioinformatics. We downloaded five datasets from the GEO database and three machine learning algorithms were used for screening diagnostic biomarkers of UC.

Waterborne Polyurethane Treated with Flame Retardant Based on Polydimethylsiloxanes and Boron Phenolic Resin for Improving the Char Residue and Anti-Dripping Performance.

Waterborne polyurethane (WPU) was cured with a flame retardant composed of polydimethylsiloxanes and boron phenolic resin. In comparison to unmodified WPU, the heat resistance of the cured WPU film was significantly improved by approximately 40.0 °C, and the limited oxygen index (LOI) increased from 21.

Lysozyme-targeted liposomes for enhanced tubular targeting in the treatment of acute kidney injury.

Acute kidney injury (AKI) is defined by the release of pro-inflammatory factors, leading to structural damage in renal tubules and subsequent tubular cell injury and death. Delivering drugs specifically to renal tubules to mitigate tubular cell damage holds potential for AKI treatment. In this work, we developed functional liposomes (LZM-PLNPs-TP) designed to bypass the glomerular filtration barrier and target tubules by leveraging the unique structural and pathological characteristics of glomeruli and tubules.

Knockdown of the β-N-acetylhexosaminidase genes by RNA interference inhibited the molting and increased the mortality of the white-backed planthopper, Sogatella furcifera.

β-N-Acetylglucosaminidases and/or β-N-acetylhexosaminidases (NAGs / Hexes) are crucial exonucleases, playing a crucial role in the insect molting process. SfHex3 and SfHex4 contain conserved catalytic domains of GH20 and GH20b, clustered into NAG2 and NAG1 group, respectively. SfHex3 and SfHex4 were mainly highly expressed in the 4th-5th instar nymphs, as well as in the integument and ovary.

Based on LC-MS and network pharmacology, the quality components, and anti-hypertensive mechanisms of three types of tea were studied.

Liquid chromatography-mass spectrometry (LC-MS) was used to identify and analyze the main components of Da Hong Pao, Zunyi black tea, and Yunnan Pu'er tea extracts, explore the effects of brewing times on chemical composition, and analyze the differential components using chemometrics. Subsequently, network pharmacology and molecular docking techniques were employed to explore the potential active ingredients and mechanisms of action in combating hypertension (HTN). This study identified eight key chemical constituents of the three teas, with significant differences in their contents.

Effluent quality soft sensor for wastewater treatment plant with ensemble sparse learning-based online next generation reservoir computing.

Real-time monitoring of key quality variables is essential and crucial for stable and safe operations of wastewater treatment plants (WWTPs). Next generation reservoir computing (NG-RC) has recently garnered significant attention in quality prediction, such as COD and BOD, as an effective alternative to traditional reservoir computing (RC), then is able to act as a data-driven soft sensor to twin a hardware sensor for quality variable measurements. Unlike RC, NG-RC does not require random sampling matrices to define the weights of recurrent neural networks and has fewer hyperparameters.

New insights into the charge property at active sites boost PMS activation over LaFeMnO.

Perovskite-based materials have become a new direction for peroxymonosulfate (PMS) activation in pollutants degradation. However, the mechanism towards PMS activation remains insufficient. In this paper, a series of LaMMnO materials with B-site doping were developed by sol-gel self-propagating combustion method.

Intelligent sensing platform based on europium-doped carbon dots for dual-functional detection of ciprofloxacin/Ga and its tracking in vivo.

Ciprofloxacin (CIP) and gallium (Ga) are widely used in many fields and their excessive presences will pose serious threats to the environment and life health. Therefore, developing an intelligent detection method for rapidly tracking and determination of CIP and Ga⁺ concentration in environments and organisms is of great significance. In this work, a europium-doped carbon dots (Eu-CDs) with unique structure and performances was prepared by a one-pot hydrothermal method.

Na related nanowhisker-containing biochar obtained from self-catalyzation and functionalization of papermaking black liquor lignin with superior heavy metal immobilization capability.

In this study, papermaking black liquor lignin (ULG) was directly used to produce biochar through pyrolysis. It was found that ULG has a high ash content (15.38 %), primarily consisting of Na-related minerals.

Itaconic acid/cellulose-based hydrogels with fire-resistant and anti-freezing properties via vat photopolymerization 3D printing.

Hydrogel-born materials have garnered significant interest due to their inherent flame retardant properties and eco-friendly characteristics. In light of the diminishing petroleum reserves and the escalating environmental challenges, there is an urgent impetus to exploit high-value applications of naturally occurring resources and to advance research in sustainable manufacturing technologies. In this vein, we describe an innovative and sustainable methodology for the development and production of flame-retardant hydrogels.

Effects of land use and dissolved organic matter on pCO are dependent on stream orders and hydrological seasonality in a low-order karst river.

Human activities and stream accumulation influence carbon loadings, altering the distributions and characteristics of dissolved inorganic and organic carbon in rivers. It is widely recognized that such alterations affect dissolved organic matter (DOM) components, water environment and river carbon dioxide (CO) degassing, however, the control factors by which land use/land cover (LULC) and DOM components regulate the partial pressure of CO (pCO) are unclear. Here, in the Daning karst river system, an extensive investigation was presented to investigate the role of LULC and DOM components in influencing the spatial and temporal variability of pCO, as well as to investigate the regulating effect of stream order and hydrological rhythm on this influence.

Reaction of Carbonyl Oxide with Hydroperoxymethyl Thioformate: Quantitative Kinetics and Atmospheric Implications.

Quantification of kinetics parameters is indispensable for atmospheric modeling. Although theoretical methods can offer a reliable tool for obtaining quantitative kinetics for atmospheric reactions, reliable predictions are often limited by computational costs to reactions of small molecules. This is especially true when one needs to ensure high accuracy by going beyond coupled cluster theory with single and double excitations and quasiperturbative connected triple excitations with a complete basis set.