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Bioactive substances inhibiting COX-2 and cancer cells isolated from the fibrous roots of (Lour.) Harms.

RSC Adv

January 2023

The State Key Laboratory of Functions and Applications of Medicinal Plants the Department of Pharmaceutic Preparation of Chinse Medicine, The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability, School of Pharmaceutical Sciences, Guizhou Medical University Guiyang 550025 China

has been used as a traditional folk medicine for centuries to treat rheumatism, skin diseases, and diabetes by the people of Southeast Asia. However, the bioactive constituents inhibiting COX-2 and cancer cells (HepG2, Caco-2, HeLa) remain unclear. In this study one new (14) along with twenty-four known compounds (1-13, 15-25) were isolated from the fibrous roots of by chromatographic methods, and identified by NMR, and Gaussian and CD calculation.

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