2 results match your criteria: "Guizhou Higher Education Mega Center[Affiliation]"
Significance of serum lncRNA XIST in chronic obstructive pulmonary disease and its progression to pulmonary heart disease.
BMC Pulm Med
October 2024
Center of Clinical Laboratory, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Article Synopsis
- - This study investigated the role of lncRNA XIST in chronic obstructive pulmonary disease (COPD) and chronic pulmonary heart disease (CPHD), identifying it as a potential biomarker for screening and prognosis.
- - A total of 127 COPD patients were compared to 76 healthy individuals, revealing that XIST levels were significantly higher in COPD patients, especially those with acute exacerbations and CPHD.
- - The findings suggest that elevated XIST levels correlate with greater pulmonary complications and can indicate a poor 3-year prognosis for COPD patients, particularly those also suffering from CPHD.
Anti-Inflammatory Effects of Shenfu Injection against Acute Lung Injury through Inhibiting HMGB1-NF-B Pathway in a Rat Model of Endotoxin Shock.
Evid Based Complement Alternat Med
November 2019
School of Basic Medical Sciences, Guizhou University of Chinese Medicine, Dongqingnan Road, Guizhou Higher Education Mega Center, Huaxi District, Guiyang, Guizhou 550025, China.
Shenfu injection (SFI), a Chinese herbal medicine with substances extracted from and , is widely used as an anti-inflammatory reagent to treat endotoxin shock in China. However, the mechanism of SFI in endotoxin shock remains to be illuminated. High mobility group box 1 (HMGB1), a vital inflammatory factor in the late stage of endotoxin shock, may stimulate multiple signalling cascades, including B (NF-B), a nuclear transcription factor, as well as tumour necrosis factor (TNF)- and interleukin (IL)-1, among others in the overexpression of downstream proinflammatory cytokines.
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