Factors associated with the relapse in Ponseti treated congenital clubfoot.

Objectives: We retrospectively investigated the clinical materials to seek the factors that lead to relapse after using the Ponseti method.

Methods: We retrospectively reviewed all children with congenital clubfoot treated with the Ponseti method in our hospital from June 2008 to June 2013. The data included the following factors: age, gender, initial Pinari score, number of casts, number of feet (unilateral or bilateral), age at the first casting, age of mother, tenotomy, walking age, and compliance with using bracing.

Identification of hub prognosis-associated oxidative stress genes in skin cutaneous melanoma using integrated bioinformatic analysis.

Objective: Oxidative stress (OS) significantly correlates with cancer progression. However, targeting OS has not been considered as a therapeutic strategy in skin cutaneous melanoma (SKCM) due to a lack of systematical studies on validated biomarkers. The work presented here aimed to identify hub prognosis-associated OS genes in SKCM and generated an effective predictive model.

Levels of economic growth and cross-province spread of the COVID-19 in China.

Background: After the first COVID-19 case detected on 8 December 2019 in Wuhan, the Provincial Capital of Hubei, the epidemic quickly spread throughout the whole country of China. Low developmental levels are often associated with infectious disease epidemic, this study attempted to test this notion with COVID-19 data.

Methods: Data by province from 8 December 2019 to 16 February 2020 were analysed using regression method.

Anti-cancer targets of formononetin and molecular mechanisms in osteosarcoma: Findings of bioinformatic and experimental assays.

In current study, a bioinformatic-based network pharmacology was used to identify the osteosarcoma (OGS)-pathological targets and formononetin (FN)-treated targets before the main core predictive biotargets were screened. In addition, all core targets were selected through a number of bioinformatic databases, followed by identification of predominant biological processes and signalling pathways of FN anti-OGS. Further, top three core targets of FN anti-OGS were determined as oestrogen receptor 1 (ESR1), tumour protein p53 (TP53), receptor tyrosine-protein kinase erbB-2 (ERBB2) respectively.

In vitro and in vivo studies of antiosteosarcoma activities of formononetin.

Osteogenic sarcoma (OGS) is a primary bone cancer, characterized by aggressive neoplasm from mesenchymal oncogenesis. However, the clinical therapeutic regimen against OGS is limited. Therefore, potential medication warrants to be further developed.

Minimally invasive versus open transforaminal lumbar fusion: a systematic review of complications.

Purpose: The aim of this study is to compare mTLIF vs. oTLIF with regard to peri-operative complications, operative time, estimated blood loss, fluoroscopic time, and the length of hospital stay.

Methods: The PubMed and EMBASE databases were searched for relevant articles reporting patients undergoing TLIF, and a comparison between mTILF and oTLIF was performed.