Rotavirus vaccine effectiveness stratified by national-level characteristics: an introduction to the 24-country MNSSTER-V Project, 2007-2023.

Background: Rotavirus vaccines are moderately protective against illness in high mortality settings compared with low mortality settings. Vaccine effectiveness (VE) evaluations may clarify our understanding of these disparities, but estimates among key subpopulations and against rare outcomes are not available in many analyses due to sample size. We combined 25 datasets from test-negative design case-control evaluations in 24 countries that enrolled children with medically-attended diarrhea, laboratory-confirmed rotavirus stool testing, and documented vaccination status.

[Analysis of the institutional capabilities of the Guatemalan Ministry of Health: democratic constraint, defunding, reforms, and model of care].

Guatemala is one of the Latin American countries with the greatest inequalities in access to health services, especially in primary health care. Multiple reforms have been proposed to solve accessibility problems but did not achieve the expected success, either for being isolated experiments or due to their interrupted implementation. Other associated factors are yet unknown, given the absence of a consolidated evaluation over time.

Factors associated with loneliness in Latin-American family care partners during the COVID-19 pandemic.

Background: COVID-19-related restrictions led to an increase in overall loneliness and social isolation. Before the pandemic, care partners reported higher levels of loneliness and higher loneliness prevalence compared to non-care partners. Because of the spread and severity of the infections, and the access to support spread, we expect a different impact of the COVID-19 pandemic on LATAM care partners.

A rare complication of infantile hemangioma: Kasabach-Merritt phenomenon.

Infantile hemangiomas are the most common type of vascular tumors, affecting ~5% of infants within the first weeks of life. In rare instances, these tumors can lead to Kasabach-Merritt phenomenon (KMP), a life-threatening consumptive coagulopathy characterized by thrombocytopenia, microangiopathic hemolytic anemia, and hypofibrinogenemia. In the present case, a 20-month-old patient is diagnosed with KMP.

Understanding pathophysiology in fragile X syndrome: a comprehensive review.

Fragile X syndrome (FXS) is the leading hereditary cause of intellectual disability and the most commonly associated genetic cause of autism. Historically, research into its pathophysiology has focused predominantly on neurons; however, emerging evidence suggests involvement of additional cell types and systems. The objective of this study was to review and synthesize current evidence regarding the pathophysiology of Fragile X syndrome.

How studies on zoonotic risks in wildlife implement the one health approach - A systematic review.

Background: The recent COVID-19 pandemic and the emergence of infectious diseases at the human-animal interface highlight the global challenge of mitigating zoonotic risks. The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, urging for holistic and interdisciplinary strategies in disease prevention. Despite growing interest, the attention to wildlife in pandemic prevention remains limited.

Correction: Strategies to Overcome Erroneous Outcomes in Reverse Transcription-Polymerase Chain Reaction (RT-PCR) Testing: Insights From the COVID-19 Pandemic.

[This corrects the article DOI: 10.7759/cureus.72954.

Micronutrient deficiencies according to sociodemographic factors and nutritional status among Panamanian children aged six to 59 months in 2019: a cross-sectional population-based study.

Background: Micronutrient deficiencies have serious lifelong consequences. This study aimed to estimate the prevalence of anaemia, iron deficiency anaemia, iron deficiency, and vitamin A deficiency, according to sociodemographic factors and nutritional status among Panamanian children aged six to 59 months in 2019.

Methods: We used data from the National Health Survey of Panama (ENSPA), a population-based, cross-sectional study, with a nationally representative subsample to evaluate haemoglobin, C-reactive protein (CRP), ferritin, and retinol levels among children aged six to 59 months.

Community-Based Participatory Research to Promote Health Equity Among Sexual and Gender Minorities in the US South: Research Laureate Address.

Sexual and gender minorities (SGM), including lesbian, gay, bisexual, transgender, and queer (LGBTQ+), communities, continue to face profound health disparities in the United States and globally. Although the terms SGM and LGBTQ+ are used as umbrella terms, the populations they describe are highly diverse. Currently, SGM persons are increasingly open and visible in the United States and many other parts of the world, and a modest body of knowledge on the health and well-being of some SGM subgroups currently exists.

Evaluating Foodborne Cyclosporiasis Using Foodborne Diseases Active Surveillance Network and Foodborne Disease Outbreak Surveillance System Data, 2015-2019.

Cyclosporiasis has been a nationally notifiable disease in the United States since 1999, and cases have increased in recent years. We evaluated characteristics of U.S.

Evaluation of Educational Activity with Guatemalan Birth Attendants About Helping Babies Breathe.

Guatemala's Infant Mortality Rate was 20th highest in the world at 18 deaths per 1,000 live births in 2022. Part of the problem is lay midwives (LMs) who attend most births at home lack training in helping babies breathe (HBB). LMs transfer babies struggling to breathe to firefighters (FF).

Gray foxes (Urocyon cinereoargenteus) as natural definitive hosts of Paragonimus mexicanus.

Paragonimus mexicanus is a trematode that causes pulmonary and extrapulmonary infections in humans, characterized by chest pain, dyspnea, fever, and weight loss. The detection of Paragonimus spp. is primarily achieved through the microscopic observation of eggs in feces, sputum, and pleural fluid.

Predictive factors of long-term visual outcomes after primary Descemet's membrane endothelial keratoplasty (DMEK): retrospective study.

Purpose: To determine predictive factors of higher levels of best-corrected visual acuity (BCVA) in the long-term after primary Descemet's membrane endothelial keratoplasty (DMEK).

Methods: Retrospective, single-surgeon case series of 129 successful primary DMEK eyes without graft failure and with a minimum postoperative follow-up of 12 months. Mixed effect model for repeated measurements (MMRM) analysis was performed to determine recipient, donor, surgical and postoperative factors associated with BCVA ≤ 0.

Ambitions and realities: Are Global Fund investments designed to achieve resilient and sustainable systems for health? Findings from the Global Fund Prospective Country Evaluation.

Strengthening resilient and sustainable systems for health (RSSH) is central to the Global Fund's strategy, however questions persist about the Global Fund's role in the health systems strengthening space, and the extent to which investments are designed to achieve strengthening objectives, or just fill in gaps in the system. This paper reports on findings from the Prospective Country Evaluations (PCE), a multi-country multi-year evaluation of Global Fund support. We adapted a framework from Chee et al.

Mother-child collaboration in an Indigenous community: Changing and enduring across generations.

Changes in family life related to globalization may include reduction in the collaborativeness observed in many Indigenous American communities. The present study examined longitudinal changes and continuities in collaboration in a Guatemalan Maya community experiencing rapid globalization. Fluid collaboration was widespread 3 decades ago among triads of mothers and 1- to 6-year-olds in 24 Mayan families exploring novel objects during home visits (Dayton et al.

Exploring the acceptability of a decision aid for rural women with a history of prior cesarean birth regarding subsequent mode of birth in Coatepeque, Guatemala.

Background: Decisions regarding mode of delivery in the context of a prior cesarean birth is complicated because both trial of labor after cesarean and elective repeat cesarean birth have risks and benefits.

Purpose: The objective of this study was to understand the perspective of women and obstetricians in Coatepeque, Guatemala, to guide the development of a decision aid about mode of birth for women with a history of prior cesarean.

Methods: We conducted in-depth semi-structured interviews with obstetricians at Coatepeque Hospital and women at the Center for Human Development in the southwest Trifinio region of Guatemala in February 2020.

Mental Health Risk and Protection Among First-Generation Latinx Immigrant Youth: A Latent Profile Analysis.

First-generation Latinx immigrant youth from the Northern Triangle (NT; El Salvador, Guatemala, and Honduras) face unique risks for experiencing stressors across the phases of migration, which could exacerbate their mental health. This study aimed to (a) identify and characterize unique latent profile groups based on response patterns to immigrant minority stress and psychosocial protective factor items and (b) examine the associations of latent profile membership with depression and anxiety symptoms among NT immigrant youth, controlling for study covariates (i.e.

Assisted reproductive technologies in Latin America: the Latin American Registry, 2021.

Research Question: What are the trends and impact of new technologies on the effectiveness and safety of assisted reproductive technology (ART) performed in Latin America during 2021?

Design: This was a retrospective collection of cycle-based multinational data obtained from ART procedures performed by 204 accredited institutions in 16 countries.

Results: In total 127,351initiated cycles resulted in 20,032 deliveries and 22,708 births. ART utilization showed great variability, from 623.

[Clinical characterization of patients with complete fetal atrioventricular block].

The following article seeks to describe the clinical characterization of patients with congenital complete atrioventricular block. Information was collected from different sources, among which is the presentation of the pathology and its impact on the fetus, and the main basis was look for an association between the use of medications and its prognosis. Within the treatment to be used in patients with fetal atrioventricular block, the use of steroids, beta-adrenergic stimulators, plasma, etc.