Investigation of the connection between triglyceride-glucose (TyG) index and the risk of acute kidney injury in septic patients - a retrospective analysis utilizing the MIMIC-IV database.

The TyG index serves as a valuable tool for evaluating insulin resistance. An elevated TyG has shown a strong association with the occurrence of acute kidney injury (AKI). Nevertheless, existing literature does not address the relationship between the TyG index and acute kidney injury in patients with sepsis.

Prevalence and influencing factors of the dyadic psychological stress among patients with lung cancer and their family caregivers: a cross-sectional study.

Background: A lung cancer diagnosis has a huge impact on the psychological well-being of both patients and family caregivers. However, the current psychological stress status among dyads remains unclear. We aimed to determine the prevalence of anxiety and depression and identify the factors that influence patients with lung cancer and their caregivers.

Panoramic Nailfold Flow Velocity Measurement Method Based on Enhanced Plasma Gap Information.

Nailfold microcirculation examination is crucial for the early differential diagnosis of diseases and indicating their severity. In particular, panoramic nailfold flow velocity measurements can provide direct quantitative indicators for the study of vascular diseases and technical support to assess vascular health. Previously, nailfold imaging equipment was limited by a small field of view.

Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis.

Immune checkpoint inhibitors (ICIs) have significant therapeutic effects but can also cause fatal lung injury. However, the lack of mouse animal models of ICI-related lung injury (ICI-LI) has limited the in-depth exploration of its pathogenesis. In clinical practice, underlying lung diseases increase the risk of lung injury.

Association between pre-stroke frailty and post-discharge destination in acute stroke among Chinese older adults.

Aims: To investigate the association between pre-stroke frailty and discharge destination in hospitalized older adults in China.

Methods: We conducted this prospective cohort study in a tertiary care hospital in China. We enrolled patients aged 60 years and older admitted to the hospital for acute stroke from January 2022 to May 2022.

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.

The anti-PD-1 mAb may be further considered along with PGD2 or active molecules that can promote PGD2 synthesis to enhance the anti-tumor immune response.

High prevalence and plasmidome diversity of -positive enterococci in a Shenzhen community, China.

Background: The emergence of , which can confer resistance to phenicols and oxazolidinones in spp., poses a growing public health threat.

Methods: 102 -positive enterococci (OPEs) including various species were isolated from feces of 719 healthy volunteers in a Shenzhen community, China.

Single-cell RNA sequencing reveals the changes of the pulmonary immune environment in rat after L. treatment.

Image 1.

Corrigendum to "Patient tissue-derived FGFR4-variant and wild-type colorectal cancer organoid development and anticancer drug sensitivity testing" [Heliyon Vol 10, Iss 10, May 2024, Article e30985].

[This corrects the article DOI: 10.1016/j.heliyon.

Neuroimaging signatures and a deep learning modeling for early diagnosing and predicting non-pharmacological therapy success for subclinical depression comorbid sleep disorders in college students.

Objective: College students with subclinical depression often experience sleep disturbances and are at high risk of developing major depressive disorder without early intervention. Clinical guidelines recommend non-pharmacotherapy as the primary option for subclinical depression with comorbid sleep disorders (sDSDs). However, the neuroimaging mechanisms and therapeutic responses associated with these treatments are poorly understood.

Case report: Durable response from tegafur/gimeracil/oteracil (S-1) combined with fruquintinib and sintilimab as a third-line treatment for MSS metastatic colorectal cancer with a BRAF V600E mutation.

Patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC) who fail first- and second-line treatments face significant challenges in third-line therapy, where monotherapies often yield poor outcomes and limited survival benefits. The prognosis is particularly poor for mCRC with the unique molecular subtype of BRAF V600E mutation. This report describes sustained benefits from a third-line treatment regimen (SFS) combining tegafur/gimeracil/oteracil (S-1), fruquintinib, and sintilimab in a patient with BRAF V600E-mutated MSS mCRC.

Cost-effectiveness of camrelizumab plus rivoceranib versus sorafenib as first-line treatment of unresectable hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality globally. Recent advancements in targeted therapies have improved outcomes for advanced HCC, yet therapeutic options remain limited. The CARES-310 trial demonstrated that camrelizumab plus rivoceranib significantly improves survival compared to sorafenib for advanced HCC.

Enhancing smart healthcare networks: Integrating attribute-based encryption for optimization and anti-corruption mechanisms.

This study investigates the feasibility and effectiveness of integrating Attribute-Based Encryption (ABE) into smart healthcare networks, with a particular focus on its role in enhancing anti-corruption mechanisms. The study provides a comprehensive analysis of current vulnerabilities in these networks, identifying potential data security risks. An anti-corruption mechanism is designed to ensure data integrity and reliability.

Amplified impacts of human activities: Non-linear responses of riverine microbial communities to distribution of land use.

Rapid global urbanization poses considerable ecological risks to freshwater systems, notably leading to substantial reductions in microbial communities. To assess the impacts of human activities on these communities, we applied the high-throughput amplicon DNA sequencing to examine spatial variations in riverine microbial communities within an urbanized watershed. Coupled with the Geographical Detector Model, the effects of the land use were identified across the watershed.

Efficient separation and extraction of copper ions from electroplating wastewater by capacitive deionization using chalcopyrite (CuFeS) electrode.

As a hot issue, the scientific and effective separation and extraction of heavy metal ions from complex industrial effluent deserves wide investigation. Copper is an important valuable heavy metal in industrial wastewater. Selective extraction of copper ion (Cu) from effluent not only alleviates the shortage of resources, but also has economic and social benefits.

The structure of meaning in schizophrenia: A study of spontaneous speech in Chinese.

Narrative speech production requires the retrieval of concepts to refer to entities, which need to be referenceable more than once for any form of narrative coherence to arise. Such coherence has long been observed to be affected in schizophrenia spectrum disorders (SSD), yet the underlying mechanisms have been a longstanding puzzle, with existing evidence predominantly derived from Indo-European languages. Here we analyzed two picture descriptions from 22 native Mandarin Chinese speakers with SSD and 15 healthy controls.

Berberine restrains non-small cell lung cancer cell growth, invasion and glycolysis via inactivating the SPC25/NUF2 pathway.

Berberine (BBR) has been proved to inhibit the malignant progression of non-small cell lung cancer (NSCLC), but the underlying molecular mechanism still needs to be further revealed. NSCLC cells (A549 and H1299) were treated with BBR. CCK8 assay, colony formation assay, flow cytometry, TUNEL staining and transwell assay were used to examine cell proliferation, apoptosis and invasion.

Evaluation of the low energy cyclotron production of the gamma emitters Cd and Cd.

Cd (T = 6.5 h) and Cd (T = 461.9 d) are promising non-standard gamma-emitting radionuclides with significant potential for SPECT use.

Disrupting EDEM3-induced M2-like macrophage trafficking by glucose restriction overcomes resistance to PD-1/PD-L1 blockade.

Background: Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer-associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need for new treatment strategies.

Methods: Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T cell coculture, crystal violetstaining, ELISA, metabonomic and clinical tumour samples were conducted to assess the role of EDEM3 in immune escape and itsmolecular mechanisms.

SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation.

Sorting nexins (SNXs) as the key regulators of sorting cargo proteins are involved in diverse diseases. SNXs can form the specific reverse vesicle transport complex (SNXs-retromer) with vacuolar protein sortings (VPSs) to sort and modulate recovery and degradation of cargo proteins. Our previous study has shown that SNX3-retromer promotes both STAT3 activation and nuclear translocation in cardiomyocytes, suggesting that SNX3 might be a critical regulator in the heart.

Risk of myocardial infarction and Osteoporosis: Insights from the 2015-2018 NHANES and Mendelian randomization Studies.

Background: There are some common pathophysiological risk factors between myocardial infarction and osteoporosis, and the exact relationship between the two is not yet clear. Our study aims to provide evidence on the relationship between myocardial infarction and osteoporosis through the analysis of data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization (MR) analysis from 2015 to 2018.

Methods: A two-sample MR study using summary statistics from genome-wide association studies (GWAS) was conducted to determine the causal relationship between myocardial infarction and osteoporosis.

Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p.

Background: Qingre Huoxue Decoction (QRHX) is a classical Chinese herbal prescription widely used in clinical practice for the treatment of atherosclerosis (AS). Our previous study demonstrated its efficacy in stabilizing plaque and improving prognosis, as well as its ability to regulate macrophage polarization. This study aimed to further investigate the effects of QRHX on AS and explore the underlying mechanisms.