Integration of Metabolomics and Transcriptomics to Reveal the Antitumor Mechanism of Polysaccharide-Based Nanocarriers in Enhancing Photodynamic Immunotherapy in Colorectal Cancer.

: The mechanism of polysaccharide-based nanocarriers in enhancing photodynamic immunotherapy in colorectal cancer (CRC) remains poorly understood. : The effects of TPA-3BCP-loaded cholesteryl hemisuccinate- polysaccharide nanoparticles (DOP@3BCP NPs) and their potential molecular mechanism of action in a tumor-bearing mouse model of CRC were investigated using non-targeted metabolomics and transcriptomics. Meanwhile, a histopathological analysis (H&E staining, Ki67 staining, and TUNEL assay) and a qRT-PCR analysis revealed the antitumor effects of DOP@3BCP NPs with and without light activation.

Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis.

Psoriasis is a chronic, recurrent and inflammatory skin disease. Although conventional immunosuppressants can ameliorate psoriatic symptoms, it tends to relapse over time. Previous studies have shown that exosomes from both immune and non-immune cells participate in psoriatic immunopathology.

Peptide Aptamer-Paclitaxel Conjugates for Tumor Targeted Therapy.

: Traditional paclitaxel therapy often results in significant side effects due to its non-specific targeting of cancer cells. Peptide aptamer-paclitaxel conjugates present a promising alternative by covalently attaching paclitaxel to a versatile peptide aptamer via a linker. Compared to antibody-paclitaxel conjugates, peptide aptamer-paclitaxel conjugates offer several advantages, including a smaller size, lower immunogenicity, improved tissue penetration, and easier engineering.

Brussels Chicory Enhances Exhaustive Aerobic Exercise Performance and Post-Exercise Recovery, Possibly Through Promotion of Lactate Oxidation: A Pilot Randomized, Single-Blind, Placebo-Controlled, Two-Way Crossover Study.

Background: Brussels chicory affluent in phenolic acids could inhibit atherosclerosis; however, its effects on exercise performance and post-exercise recovery are unknown. We hypothesized that Brussels chicory could enhance exhaustive aerobic exercise performance and post-exercise recovery by promoting lactate oxidation.

Methods: This is a single-blind, randomized, placebo-controlled two-way cross-over trial involving 32 untrained college students (men 18) who consumed either Brussels chicory juice (100 g of Brussels chicory containing ~130 mg phenolic acids and 180 mL fresh milk) or placebo (180 mL fresh milk) for 7 days with a 2-week washout period.

Effects of Protein Intake on Cognitive Function in Chinese Older Adults: A 10-Year Follow-Up Study.

Background: As the global population ages, there is an increasing prevalence of mild cognitive impairment and dementia. Protecting and preserving cognitive function in older adults has become a critical public health concern.

Methods: This study utilized data from four phases of the Chinese Longitudinal Healthy Longevity Survey conducted from 2008 to 2018, encompassing a total of 2454 participants.

Neonatal Circulating Amino Acids and Lipid Metabolites Mediate the Association of Maternal Gestational Diabetes Mellitus with Offspring Neurodevelopment at 1 Year.

: We aimed to identify neonatal circulating metabolic alterations associated with maternal gestational diabetes mellitus (GDM) and to explore whether these altered metabolites could mediate the association of GDM with offspring neurodevelopment. Additionally, we investigated whether neonatal circulating metabolites could improve the prediction of offspring neurodevelopmental disorders over traditional risk factors. : The retrospective cohort study enrolled 1228 mother-child dyads in South China.

Associations of the Intake of Individual and Multiple Flavonoids with Metabolic Dysfunction Associated Steatotic Liver Disease in the United States.

Background: Evidence regarding the individual and combined impact of dietary flavonoids on the risk of metabolic dysfunction associated with steatotic liver disease (MASLD) remains scarce. Our objective is to evaluate the association between individual and multiple dietary flavonoids with MASLD in adults.

Methods: Data sets were obtained from the National Health and Nutrition Examination Survey (NHANES), 2017-2018.

Characterization of Self-Cured Silicone Oils for Encapsulation of Ultraviolet-C Light-Emitting Diodes.

The effectiveness of ultraviolet-C light-emitting diodes (UVC LEDs) is currently limited by the lack of suitable encapsulation materials, restricting their use in sterilization, communication, and in vivo cancer tumor inhibition. This study evaluates various silicone oils for UVC LED encapsulation. A material aging experiment was conducted on CF1040 (octamethylcyclotetrasiloxane), HF2020 (methyl hydro polysiloxanes), and MF2020-1000 (polydimethylsiloxane) under UVC radiation for 1000 h.

Mechanisms of Copper-Induced Autophagy and Links with Human Diseases.

As a structural and catalytic cofactor, copper is involved in many biological pathways and is required for the biochemistry of all living organisms. However, excess intracellular copper can induce cell death due to its potential to catalyze the generation of reactive oxygen species, thus copper homeostasis is strictly regulated. And the deficiency or accumulation of intracellular copper is connected with various pathological conditions.

Structural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of Abel.

Background: Abel () is widely cultivated and serves as an important source of edible oil. Yet, during oil production, pruned branches generate significant waste and contribute to environmental pollution.

Objectives: In this work, we obtain a natural polysaccharide from the branches of and optimize its extraction using Box-Behnken design (BBD), which is a statistical method commonly used in response surface methodology.

Geometry-Based Synchrosqueezing S-Transform with Shifted Instantaneous Frequency Estimator Applied to Gearbox Fault Diagnosis.

This paper introduces a novel geometry-based synchrosqueezing S-transform (GSSST) for advanced gearbox fault diagnosis, designed to enhance diagnostic precision in both planetary and parallel gearboxes. Traditional time-frequency analysis (TFA) methods, such as the Synchrosqueezing S-transform (SSST), often face challenges in accurately representing fault-related features when significant mode closely spaced components are present. The proposed GSSST method overcomes these limitations by implementing an intuitive geometric reassignment framework, which reassigns time-frequency (TF) coefficients to maximize energy concentration, thereby allowing fault components to be distinctly isolated even under challenging conditions.

Energy-Efficient Route Planning Method for Ships Based on Level Set.

To reduce the fuel consumption of ships' oceanic voyages, this study incorporates the influence of ocean currents into the traditional level set algorithm and proposes a route planning algorithm capable of identifying energy-efficient routes in complex and variable sea conditions. The approach introduces the influence factor of ocean current to optimize routing in dynamically changing marie environments. First, models for the energy consumption of ships and flow fields are established.

An Ultra-Wide Range D-Shaped Fiber SPR Sensor with a Nanostructure of Gold-MoS and Sodium for the Simultaneous Measurement of Refractive Index and Temperature.

Refractive index (RI) and temperature (T) are both critical environmental parameters for environmental monitoring, food production, and medical testing. The paper develops a D-shaped photonic crystal fiber (PCF) sensor to measure RI and T simultaneously. Its cross-sectional structure encompasses a hexagonal-hole lattice, with one hole selectively filled with toluene for temperature sensing.

Enhanced Interfacial Contact and Lithium-Ion Transport in Ionic Liquid Polymer Electrolyte via In-Situ Electrolyte-Cathode Integration.

Solid polymer electrolytes (SPEs) have attracted much attention due to their excellent flexibility, strong interfacial adhesion, and good processibility. However, the poor interfacial contact between the separate solid polymer electrolytes and electrodes leads to large interfacial impedance and, thus, hinders Li transport. In this work, an ionic liquid-modified comb-like crosslinked network composite solid-state electrolyte with an integrated electrolyte/cathode structure is prepared by in situ ultraviolet (UV) photopolymerization.

Characterization and Analysis of 2-(2-Phenylethyl)chromone Derivatives and Sesquiterpenoids from Agarwood of Four "Qi-Nan" Clones () with Different Induction Times.

In recent years, some new "Qi-Nan" clones of with the characteristics of easy induction and high-quality agarwood have been obtained, through the cultivation and propagation of grafted seedlings. These clones are used for the intensive production of high-quality agarwood. The speed of resin formation and yield are crucial for the development of the agarwood industry.

A Study on the Mechanism of Cellulose Nanocrystals to Enhance the Stability of Hydrophobic Phthalocyanine Green in Water and the Functional Characteristics of Colour Pastes.

Cellulose nanocrystals (CNCs) prepared by sulfuric acid hydrolysis were added to phthalocyanine green colour pastes with a surfactant to improve stability. The particle size, zeta potential, absorbance, and microstructure of the colour pastes were analyzed and characterized. The mechanism of CNCs to enhance the stability of hydrophobic phthalocyanine green in water was investigated.

A Photocontrolled Molecular Rotor Based on Azobenzene-Strapped Mixed (Phthalocyaninato)(Porphyrinato) Rare Earth Triple-Decker.

Effectively regulating the rotary motions of molecular rotors through external stimuli poses a tremendous challenge. Herein, a new type of molecular rotor based on azobenzene-strapped mixed (phthalocyaninato)(porphyrinato) rare earth triple-decker complex is reported. Electronic absorption and H NMR spectra manifested the reversible isomerization of the rotor between the configuration and the configuration.

MCF-DTI: Multi-Scale Convolutional Local-Global Feature Fusion for Drug-Target Interaction Prediction.

Predicting drug-target interactions (DTIs) is a crucial step in the development of new drugs and drug repurposing. In this paper, we propose a novel drug-target prediction model called MCF-DTI. The model utilizes the SMILES representation of drugs and the sequence features of targets, employing a multi-scale convolutional neural network (MSCNN) with parallel shared-weight modules to extract features from the drug side.

Redefining the Tea Green Leafhopper: Matsuda (Hemiptera: Cicadellidae) as a Vital Asset in Premium Tea Production.

This review explores the evolving role of the tea green leafhopper, , in the tea industry, transitioning from a recognized pest to a significant enhancer of tea quality. Recent research highlights how its feeding behavior stimulates the production of desirable secondary metabolites, thereby improving the flavor profiles and market value of premium teas, particularly varieties like Taiwan's "Oriental Beauty". As consumer demand for unique and artisanal teas rises, the economic benefits associated with are becoming increasingly evident, prompting farmers to adopt sustainable agricultural practices that often involve reduced pesticide use.

Investigations on Beekeeping and Breeding of in China.

The worldwide value of the honey bee as an agricultural animal is increasingly being recognized. Not only does the honey bee directly produce useful agricultural products, but also large portions of crops are dependent on the pollination activities of honey bees. (), the native honey bee of China, is widely distributed in the country.

Current Characteristics of REBCO Tapes in 6-Slot TSTC-CICC Under Bending Conditions.

Embedding stacked HTS tapes into twisted slots is one design approach for constructing fusion conductors. This paper adopts a Cable-in-Conduit Conductor (CICC) structure, utilizing commercially REBCO coated conductors. The cable framework is made of copper and features six helically twisted slots filled with 2G HTS tapes.

Enhanced Control Efficacy of Different Insecticides Mixed with Mineral Oil Against Asian Citrus Psyllid, Kuwayama, Under Varying Climates.

Asian citrus psyllid (ACP), (Hemiptera: Liviidae), is one of the most devastating pests in citrus orchards due to its role in transmitting Huanglongbing (HLB). Currently, chemical control remains the most effective strategy for ACP management. Mineral oils are commonly used as insecticides or adjuvants in integrated pest management (IPM) practices.

Subacute PM2.5 Exposure Induces Hepatic Insulin Resistance Through Inflammation and Oxidative Stress.

Epidemiological studies prove that type II diabetes, characterized by insulin resistance (IR), may be caused by fine particulate matter 2.5 (PM2.5).

Cellular Signaling of Amino Acid Metabolism in Prostate Cancer.

Prostate cancer is one of the most common malignancies affecting men worldwide and a leading cause of cancer-related mortality, necessitating a deeper understanding of its underlying biochemical pathways. Similar to other cancer types, prostate cancer is also characterised by aberrantly activated metabolic pathways that support tumour development, such as amino acid metabolism, which is involved in modulating key physiological and pathological cellular processes during the progression of this disease. The metabolism of several amino acids, such as glutamine and methionine, crucial for tumorigenesis, is dysregulated and commonly discussed in prostate cancer.

Toxicology Effects of Cadmium in : Accumulation, Oxidative Stress, Microbial Community, and Transcriptome Analysis.

Cadmium (Cd) pollution poses an important problem, but limited information is available about the toxicology effects of Cd on freshwater invertebrates. We investigated the accumulation, oxidative stress, microbial community changes, and transcriptomic alterations in apple snails ) under Cd stress. The snails were exposed to the 10 μg/L Cd solution for 16 days, followed by a 16-day elimination period.