7 results match your criteria: "Guangzhou Psychiatry Hospital[Affiliation]"

Literatures have suggested that not only genetic but also environmental factors, interactively accounted for susceptibility of obsessive-compulsive disorder (OCD). DNA methylation may regulate expression of genes as the heritable epigenetic modification. The examination for genome-wide DNA methylation was performed on blood samples from 65 patients with OCD, as well as 96 healthy control subjects.

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Cortical asymmetries in unaffected siblings of patients with obsessive-compulsive disorder.

Psychiatry Res

December 2015

Centre for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China; Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea. Electronic address:

Obsessive-compulsive disorder (OCD) is considered to be associated with atypical brain asymmetry. However, no study has examined the asymmetry in OCD from the perspective of cortical morphometry. This study is aimed to describe the characteristics of cortical asymmetry in OCD patients, and to investigate whether these features exist in their unaffected siblings - a vital step in identifying putative endophenotypes for OCD.

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The nature of prospective memory deficit in patients with obsessive-compulsive disorder.

Psychiatry Res

December 2015

Neuropsychology and Applied Cognitive Neuroscience, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Electronic address:

We comprehensively examined prospective memory (PM) performance in patients with obsessive-compulsive disorder (OCD), and explored the cognitive and psychopathological correlates of PM in this clinical population. Fifty-eight OCD patients and 58 healthy controls were assessed with computer-based PM tasks and related neurocognitive functions, and the participants also reported frequency of PM failures and compulsive behaviours in daily life. OCD patients had intact activity-based PM performance but had lower accuracy in time-based PM and longer reaction time to event-based PM cues compared to healthy controls.

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Psychometric properties of the Chinese version of the Obsessive Beliefs Questionnaire-44 (OBQ-44).

BMC Psychiatry

August 2015

Centre for Studies of Psychological Application, School of Psychology, South China Normal University, 55 Zhongshang Road, Guangzhou, 510630, China.

Background: The Obsessive Beliefs Questionnaire-44 (OBQ-44) is originally developed by the Obsessive Compulsive Cognitions Working Group and has been translated into several languages. This paper is aimed to investigate the psychometric properties of the Chinese version of the Obsessive Beliefs Questionnaire-44 (OBQ-44) in both clinical and non-clinical samples.

Methods: Five hundred and sixty-nine undergraduate volunteers and sixty-six OCD patients were included in the study.

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Structural and diffusion property alterations in unaffected siblings of patients with obsessive-compulsive disorder.

PLoS One

December 2014

Department of Radiology and BRIC, University of North Carolina at Chapel Hill, North Carolina, United States of America ; Department of Brain and Cognitive Engineering, Korea University, Korea.

Disrupted white matter integrity and abnormal cortical thickness are widely reported in the pathophysiology of obsessive-compulsive disorder (OCD). However, the relationship between alterations in white matter connectivity and cortical thickness in OCD is unclear. In addition, the heritability of this relationship is poorly understood.

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Default network connectivity as a vulnerability marker for obsessive compulsive disorder.

Psychol Med

May 2014

Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China.

Background: Aberrant functional connectivity within the default network is generally assumed to be involved in the pathophysiology of obsessive compulsive disorder (OCD); however, the genetic risk of default network connectivity in OCD remains largely unknown.

Method: Here, we systematically investigated default network connectivity in 15 OCD patients, 15 paired unaffected siblings and 28 healthy controls. We sought to examine the profiles of default network connectivity in OCD patients and their siblings, exploring the correlation between abnormal default network connectivity and genetic risk for this population.

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Aim: To investigate the possible association of the CYP2D6 gene C100T polymorphism and the CYP1A2 gene C163A polymorphism with tardive dyskinesia (TD) in Chinese patients with schizophrenia.

Methods: The recruited schizophrenic patients were assessed with the Abnormal Involuntary Movement Scale (AIMS), and divided into groups with TD (n=91) and without TD (n=91) according to the AIMS score. Polymorphisms of the CYP2D6 and CYP1A2 genes were determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).

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