4 results match your criteria: "Guangzhou Medical University Affiliated Guangzhou Women and Children's Medical Center[Affiliation]"
Novel multi-allelic variants, two BBS2 and one PKD1 variant, of renal ciliopathies: A case report and literature review.
Eur J Med Genet
June 2023
Guangzhou Medical University Affiliated Guangzhou Women and Children's Medical Center, Guangzhou, China. Electronic address:
Background: Bardet-Biedl syndrome (BBS) and autosomal dominant polycystic kidney disease (ADPKD) are renal ciliopathies. BBS has 22 pathogenic genes, and ADPKD is mainly caused by PKD1 and PKD2 variants. Cases with tri-allelic variants of BBS and PKD1 are rare.
View Article and Find Full Text PDFTissue Transglutaminase Impairs HTR-8/SVneo Trophoblast Cell Invasion via the PI3K/AKT Signaling Pathway.
Gynecol Obstet Invest
August 2021
Department of Obstetrics, Guangzhou Medical University Affiliated Guangzhou Women and Children's Medical Center, Guangzhou, China.
Article Synopsis
- The study investigates the role of tissue transglutaminase (tTG) in trophoblast invasion and its potential link to preeclampsia (PE) by exploring how tTG affects the expression of matrix metalloproteinases (MMP)-2 and MMP-9.
- Results show that increasing tTG levels decreased cell proliferation and invasion, while promoting apoptosis in trophoblast cells, and altered PI3K/AKT signaling pathways.
- The findings suggest that tTG may regulate trophoblast invasiveness and offer a new therapeutic target for managing preeclampsia.
CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia.
Cell Physiol Biochem
August 2018
Department of Clinical Laboratory, Guangzhou Medical University Affiliated Guangzhou Women and Children's Medical Center, Guangzhou, China.
Background/aims: Circular RNAs (circRNAs) are transcribed prevalently in the genome; however, their potential roles in multiple cardiovascular diseases, particularly preeclampsia (PE), are not yet well understood. This study investigated the expression profiles of circRNAs and explored circRNA-mediated pregnancy-associated plasma protein A (PAPP-A) expression as a potential biomarker for PE before 20 weeks of pregnancy.
Methods: A nested case-control two-phase screening/validation study was performed in pregnant women before 20 weeks of gestation (before clinical diagnosis) at Guangzhou Women and Children's Medical Center from 2012 to 2015.
Validation of aspartate aminotransferase to platelet ratio for diagnosis of liver fibrosis and prediction of postoperative prognosis in infants with biliary atresia.
World J Gastroenterol
May 2015
Li-Yuan Yang, Xiao-Fang Peng, Shu-Yin Pang, Kan-Kan Gao, Hai-Ying Liu, Clinical Laboratory, Guangzhou Medical University Affiliated Guangzhou Women and Children's Medical Center, Guangzhou 510120, Guangdong Province, China.
Aim: To validate the value of aspartate aminotransferase to platelet ratio index (APRI) in assessment of liver fibrosis and prediction of postoperative prognosis of biliary atresia (BA) infants from Mainland China.
Methods: Medical records of 153 BA infants who were hospitalized from January 2010 to June 2013 were reviewed. The efficacy of APRI for diagnosis of liver fibrosis was assessed using the receiver operator characteristic (ROC) curve compared to the pathological Metavir fibrosis score of the liver wedge specimens of 91 BA infants.