Utilizing machine learning techniques to identify severe sleep disturbances in Chinese adolescents: an analysis of lifestyle, physical activity, and psychological factors.

Background: Adolescents often experience difficulties with sleep quality. The existing literature on predicting severe sleep disturbance is limited, primarily due to the absence of reliable tools.

Methods: This study analyzed 1966 university students.

Bioinformatics study of the potential therapeutic effects of ginsenoside Rf in reversing nonalcoholic fatty liver disease.

Objective: Ginsenoside Rf, a tetracyclic triterpenoid only present in Panax ginseng, has been proven to relieve lipid metabolism and inflammatory reactions, which can be a potential treatment for nonalcoholic fatty liver disease (NAFLD). Therefore, this study aimed to reveal the underlying mechanisms of ginsenoside Rf in the treatment of early-stage NAFLD (NAFL) by using a bioinformatics method and biological experiments.

Methods: Target genes associated with NAFL were screened from the Gene Expression Omnibus (GEO) database, a database repository of high-throughput gene expression data and hybridization arrays, chips, and microarrays.

Exercise Ameliorates Insulin Resistance of Type 2 Diabetes through Motivating Short-Chain Fatty Acid-Mediated Skeletal Muscle Cell Autophagy.

: Exercise can ameliorate type II diabetes mellitus (T2DM) by regulating intestinal flora metabolites. However, the detailed mechanism needs to be further explored. : A T2DM model using mice was established by feeding them a high-fat diet and giving them subsequent streptozocin injections.

Adropin regulates hepatic glucose production via PP2A/AMPK pathway in insulin-resistant hepatocytes.

Adropin as a secretory peptide has shown a protective role on the disorders of glucose and lipid metabolism. However, the role and mechanism of this peptide on the hepatic glucose production has remained unclear. Adropin knockout (KO) mice were generated to explore its effects on the enhanced hepatic glucose production in obesity.

Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity.

Adropin, a secretory signal peptide, has shown beneficial effects on improving glucose homeostasis and dyslipidemia. However, whether this peptide affects nonalcoholic steatohepatitis (NASH) has remained unclear. In this study, the serum adropin levels, liver injury and oxidative stress were measured in diet-induced NASH mice.

Epigenetic regulation of L-type voltage-gated Ca channels in mesenteric arteries of aging hypertensive rats.

Accumulating evidence has shown that epigenetic regulation is involved in hypertension and aging. L-type voltage-gated Ca channels (LTCCs), the dominant channels in vascular myocytes, greatly contribute to arteriole contraction and blood pressure (BP) control. We investigated the dynamic changes and epigenetic regulation of LTCC in the mesenteric arteries of aging hypertensive rats.

The influence of gait speed on the stability of walking among the elderly.

Walking speed is a basic factor to consider when walking exercises are prescribed as part of a training programme. Although associations between walking speed, step length and falling risk have been identified, the relationship between spontaneous walking pattern and falling risk remains unclear. The present study, therefore, examined the stability of spontaneous walking at normal, fast and slow speed among elderly (67.

Autonomic Recovery Is Delayed in Chinese Compared with Caucasian following Treadmill Exercise.

Unlabelled: Caucasian populations have a higher prevalence of cardiovascular disease (CVD) when compared with their Chinese counterparts and CVD is associated with autonomic function. It is unknown whether autonomic function during exercise recovery differs between Caucasians and Chinese. The present study investigated autonomic recovery following an acute bout of treadmill exercise in healthy Caucasians and Chinese.

[Chinese medicine formula 1 regulating immunity and anti-oxidation experiments in mice].

Objective: To observe the effect of immunoregulation and anti-oxidation of Zhongyaofangji NO1 (ZYFJ).

Methods: 1. SPF BALB/C mice were randomly divided into control group (distilled water), positive control group (Broken Spore), ZYFJ low dose group (0.

Screening method based on walking plantar impulse for detecting musculoskeletal senescence and injury.

No consensus has been reached on how musculoskeletal system injuries or aging can be explained by a walking plantar impulse. We standardize the plantar impulse by defining a principal axis of plantar impulse. Based upon this standardized plantar impulse, two indexes are presented: plantar pressure record time series and plantar-impulse distribution along the principal axis of plantar impulse.

Arterial stiffness response to exercise in persons with and without Down syndrome.

This study compared arterial stiffness and wave reflection at rest and following maximal exercise between individuals with and without Down syndrome (DS), and the influence of body mass index (BMI), peak oxygen uptake (VO2 peak) on changes in arterial stiffness. Twelve people with DS (26.6 ± 2.

Bone surface mapping method.

Bone shape is an important factor to determine the bone's structural function. For the asymmetrically shaped and anisotropically distributed bone in vivo, a surface mapping method is proposed on the bases of its geometric transformation invariance and its uniqueness of the principal axes of inertia. Using spiral CT scanning, we can make precise measurements to bone in vivo.

Effects of exercise training on red blood cell production: implications for anemia.

Exercise training can increase total Hb and red cell mass, which enhances oxygen-carrying capacity. The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. Anemia is one of the most common medical conditions in chronic disease.

Optimal principle of bone structure.

Bone modeling and remodeling is an optimization process where no agreement has been reached regarding a unified theory or model. We measured 384 pieces of bone in vivo by 64-slice CT and discovered that the bone's center of mass approximately superposes its centroid of shape. This phenomenon indicates that the optimization process of non-homogeneous materials such as bone follows the same law of superposition of center of mass and centroid of shape as that of homogeneous materials.

Natural gaits of the non-pathological flat foot and high-arched foot.

There has been a controversy as to whether or not the non-pathological flat foot and high-arched foot have an effect on human walking activities. The 3D foot scanning system was employed to obtain static footprints from subjects adopting a half-weight-bearing stance. Based upon their footprints, the subjects were divided into two groups: the flat-footed and the high-arched.

Effects of resistance training on biomarkers of bone formation and association with red blood cell variables.

We previously showed that resistance training significantly increased the red blood cell count (RBC) and hematocrit (Hct) and decreased the mean cell hemoglobin concentration (MCHC) in physically inactive men. Since the enhanced hematopoiesis may result, at least partly, from bone metabolism, the purpose of this study was to further investigate the effect of resistance training on serum bone-specific alkaline phosphatase activity (B-ALP), a biomarker of bone formation, and focus on the relationship between the change in B-ALP from baseline to 20-week follow-up and the corresponding changes in RBC, Hct and MCHC. Seventy-four men aged 20-45 years were randomly assigned to training and control groups.

Effects of strength training on work capacity and parasympathetic heart rate modulation during exercise in physically inactive men.

This study was designed to assess the effects of strength training on work capacity and parasympathetic heart rate modulation during exercise in physically inactive men. Seventy-four men aged 20-45 were randomly assigned to training (n=52) and control (n=22) groups. Training groups underwent 10-weeks of progressive strength training.

[Effects of long-term physical training on age-related changes of energy transformation of mice heart mitochondria].

Aim And Methods: To observe effects of long-term physical training (running wheel) on the age-related changes of energy transformation of mice heart mitochondria.

Results: RCR and ADP/O decreased with age in the presence of a-ketoglutaric acid, especially in the late of age, which indicated that oxidative phosphorylation coupling decreased in the aging process.

Conclusion: Adaptive changes of mitochondria were brought by long-term physical training which might delay the age-related decline of mitochondrial function.