Optimizing knee joint imaging: A comparative study of 7T MRI sequences.

Purpose: To reduce long scan durations and improve patient comfort while maintaining image quality by assessing varying 7 T MRI sequences to optimize knee joint imaging.

Materials And Methods: In this prospective study, healthy participants underwent knee joint scans using 7 T proton density fat-saturated (PD-FS), 3-dimensional double-echo steady-state (3D-DESS), and susceptibility-weighted imaging (SWI) sequences. We evaluated the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of cartilage, meniscus, ligaments, synovial fluid, and adipose tissue and the imaging quality of cartilage, meniscus, and ligaments.

Anti photoaging mechanism of a novel recombinant human fibronectin peptide (rhFNP) derived from the extracellular matrix.

Photoaging is a major cause of skin ageing. Ultraviolet radiation is a key factor in this process, as it can increase the expression of inflammatory factors, promote an inflammatory response, and disrupt the balance between extracellular matrix (ECM) synthesis and degradation, resulting in impaired skin barrier function and increased skin sensitivity. Therefore, anti-inflammation and ECM remodelling are important directions in skin anti-aging research.

Comprehensive understanding of a rare disease: Cardiac metastatic tumor, a double-center 10-year case review.

Background: Cardiac metastatic tumors (CMTs) are rare yet pose significant medical concerns. Clinical studies on CMT are limited, particularly those involving multicenter data analysis.

Aim: To systematically analyze the etiology, sources, classification, treatment, and prognosis of CMT.

Effect of tandem autologous stem cell transplantation on survival in pediatric patients with high-risk solid tumors in South China.

Background: Despite advances in treatment, the prognosis for patients with high-risk pediatric solid tumors remains dismal. Tandem autologous stem cell transplantation (ASCT) offers promise for improving outcomes in these patients. This study aimed to examine the efficacy and prognostic factors of tandem ASCT in pediatric patients with high-risk solid tumors.

Rapid and Accurate Diagnosis of Urinary Tract Infections Using Targeted Next-Generation Sequencing: A Multicenter Comparative Study with Metagenomic Sequencing and Traditional Culture Methods.

Background: Urinary tract infections (UTIs) rank among the most prevalent bacterial infections globally. Traditional urine culture methods have significant limitations in detection time and sensitivity, prompting the need to evaluate targeted next-generation sequencing (tNGS) as a potential diagnostic tool.

Methods: The study included a discovery cohort of 400 suspected UTI patients (202 analyzed) and a validation cohort of 200 patients (110 analyzed).

Multi-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example.

Background: Shi Zheng (SZ, syndrome of dampness) is a major syndrome type in traditional Chinese Medicine (TCM), the ambiguity of its pathomechanism and the lack of blood diagnostic indicators have limited the understanding of the development of SZ.

Purpose: To explore the pathological mechanism of SZ and establish a symptom-centered diagnosis and treatment model.

Methods: We recruited 250 participants, including healthy individuals and patients diagnosed with SZ.

Global Incidence of Maternal Sepsis: A Systematic Review and Meta-analysis.

Objective: This study investigates the global incidence of maternal sepsis, a life-threatening condition and major cause of maternal mortality. Through a systematic review and meta-analysis, we aim to provide a more precise estimation of its incidence, identify regional variations, and examine associated risk factors to inform improved prevention and management strategies.

Methods: This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Poncirin ameliorates alcoholic liver injury by regulating lipid metabolism and inflammatory response in a PPARα dependent manner.

Background: Poncirin (PO) is a citrus flavonoid with various of functional effect including cardiac ischemia-reperfusion injury, colitis, cancer, et al. Considering the role of PO in improving inflammation and lipid metabolism, it may have potential therapeutic effects on alcoholic liver injury (ALI), but there are currently no relevant reports.

Purpose: Current study aimed to explore the protective effect of PO on preventing ALI.

Deciphering immune predictors of immunotherapy response: A multiomics approach at the pan-cancer level.

Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, yet many patients fail to respond. Employing single-cell multiomics, we unveil T cell dynamics influencing ICB response across 480 pan-cancer and 27 normal tissue samples. We identify four immunotherapy response-associated T cells (IRATs) linked to responsiveness or resistance and analyze their pseudotemporal patterns, regulatory mechanisms, and T cell receptor clonal expansion profiles specific to each response.

Knockdown of FKBP12.6 may Cause Bladder Dysfunction in Mice by Affecting IP3R/TRPM4 Function.

Background: FKBP12.6 is a crucial calcium regulatory molecule involved in the regulation of bladder excitatory contraction. This study employed FKBP12.

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer.

Understanding the prognosis of cancer patients is crucial for enabling precise diagnosis and treatment by clinical practitioners. Multimodal fusion models based on artificial intelligence (AI) offer a comprehensive depiction of the tumor heterogeneity landscape, facilitating more accurate predictions of cancer patient prognosis. However, in the real-world, the lack of complete multimodal data from patients often hinders the practical clinical utility of such models.

Injectable celastrol-loading emulsion hydrogel for immunotherapy of low-immunogenic cancer.

Immunotherapy, exemplified by immune checkpoint blockade (ICB), has been extensively employed in antitumor treatments. Nevertheless, its efficacy in addressing low-immunogenic tumors has not yielded satisfactory results, primarily due to the depletion and inadequate infiltration of effector T cells within the tumor microenvironment (TME). Here, we construct an injectable water-in-oil emulsion hydrogel to load clinically used Celastrol (Gel@Cel), which addresses the limitations of Cel's hydrophobicity.

Evaluation of geological hazard susceptibility based on the multi-kernel density information method.

The increasing occurrence of geological hazards along roadway infrastructures presents a significant concern. Evaluating geological hazard susceptibility along roads is a critical aspect of geological disaster emergency response and rescue efforts. Accurate evaluation outcomes are essential as they play a crucial role in mitigating potential financial losses.

The temporal-insula type of temporal plus epilepsy patients with different postoperative seizure outcomes have different cerebral blood flow patterns.

Purpose: This study retrospectively analyzed preoperative arterial spin labeling (ASL) perfusion MRI data of patients with the temporal-insula type of temporal plus epilepsy (TI-TPE). We aimed to investigate the differences in presurgical cerebral blood flow (CBF) changes in TI-TPE patients with different surgical outcomes.

Method: A total of 48 TI-TPE patients confirmed by SEEG were meticulously reviewed for this study.

Reliability Analysis of Complex PCB Assemblies Under Temperature Cycling and Random Vibration.

This paper examined the reliability of complex PCB assemblies under random vibration and temperature cycling, which are two primary causes of assembly failure. A combination of finite element simulation and environmental testing was employed to investigate the effects of different reinforcement methods and solder joint morphology on assembly reliability. The linear accumulation of damage was utilized to predict assembly failure, and the predicted failure damage was compared with the damage extracted post-testing to validate the simulation analysis.

Long non-coding RNA-MIR181A1HG acts as an oncogene and contributes to invasion and metastasis in gastric cancer.

Dysregulation of long non-coding RNAs (lncRNA) plays an essential role in cancer development and progression. However, their functions and mechanisms of action in gastric cancer (GC) remain largely unknown. Gene expression in GC was evaluated using quantitative real-time PCR, western blotting, immunofluorescence, immunohistochemistry, and RNA in situ hybridization.

Artificial intelligence-based model to predict recurrence after local excision in T1 rectal cancer.

Background: According to current guideline, patients with resected specimens showing high-risk features are recommended additional surgery after local excision (LE) of T1 colorectal cancer, despite the low incidence of recurrence. However, surgical resection in patients with low rectal cancer (RC) is challenging and may compromise anal function, leading to a low quality of life. To reduce unnecessary surgical resection in these patients, we used artificial intelligence (AI) to develop and validate a prediction model for the risk of recurrence after LE.

Working mechanisms for enhanced interface stability and electrochemical properties in dual-salt polymer electrolyte with in-situ electrolyte-cathode integration.

Solid polymer electrolytes (SPEs) have attracted much attention due to their excellent flexibility, strong interfacial adhesion and good processibility. However, the incompatibility at the electrode/electrolyte interface often results in increased impedance and rapid capacity attenuation. In this work, dual-salt composite solid electrolytes (CSEs) with an integrated electrolyte/cathode structure are prepared by in-situ ultraviolet (UV) photopolymerization.

Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment interacting with protein phosphatase 2A.

The catalytic activity of 3-mercaptopyruvate (3MP) sulfurtransferase (MPST) converts 3MP to hydrogen sulfide (HS). However, the regulatory mechanisms governing MPST and its impact on the brain remain largely unexplored. Our study reveals the neuroprotective role of endothelial MPST-generated HS, regulated by protein phosphatase 2A (PP2A).

Contrasting diversity patterns between microeukaryotic and prokaryotic communities in cold-seep sediments.

Cold seeps are hotspots of biodiversity. However, the quantification of the microbial diversity, particularly that of microeukaryotes, remains scarce and little is known about the active groups. In this study we investigated the diversity and activity of prokaryotes and microeukaryotes in the Haima cold seep sediments in the northern South China Sea using both DNA (whole community) and RNA (active community) signatures.

Integrative Analysis of scRNA-Seq and Bulk RNA-Seq Identifies Plasma Cell Related Genes and Constructs a Prognostic Model for Hepatocellular Carcinoma.

Purpose: The complexity and heterogeneity of the tumor immune microenvironment (TIME) are linked to the development and poor prognosis of hepatocellular carcinoma (HCC). However, the cell type within the TIME that is most closely associated with HCC development remains unclear. Herein, we aimed to identify cell clusters that significantly contribute to HCC development and their underlying mechanisms.