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Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1.
Neuropharmacology
December 2024
Guangxi University of Traditional Chinese Medicine Affiliated Fangchenggang Hospital, Fangchenggang, China. Electronic address:
Article Synopsis
- Neuropathic pain (NP) is complex and involves factors like SOCS1 alterations that affect neural damage and inflammation, with new research highlighting the role of m6A methylation in this process.
- This study focuses on the interaction between METTL3 and SOCS1 in female rats with NP, revealing that downregulation of both contributes to inflammation and levels of pro-inflammatory cytokines.
- Further findings suggest that while restoring METTL3 can alleviate NP symptoms, SOCS1 is essential for these therapeutic effects, indicating that the METTL3/SOCS1 pathway could be targeted for new NP treatments.