Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice: the underlying mechanism.

Simple regulation of c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) pathways is not enough to trigger cell apoptosis. However, activation of the stress activated pathway (JNK/p38 MAPK) together with inhibition of the growth factor activated extracellular signal-regulated kinase (ERK) pathway can promote cell apoptosis. We hypothesized that inhibition of the JNK or p38 pro-apoptotic pathway and activating the ERK pathway could be the mechanism of anti-apoptosis following cerebral ischemia/reperfusion injury.

[Effects of dujieqing oral liquid on the promoter methylation of the MGMT gene in middle-and-late stage tumor patients receiving chemotherapy].

Objective: To observe the effects of Dujieqing Oral Liquid (DJQ) on the promoter methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene in the plasma DNA samples from middle-and-late stage tumor patients receiving chemotherapy.

Methods: Recruited 60 patients were randomly assigned to the treatment group (treated by conventional chemotherapy combined DJQ, 20 mL each time, three times daily) and the control group (treated by chemotherapy alone), 30 in each group. The therapeutic course was 8 weeks.

[Treatment of thirty primary hypothyroidism patients by fuzheng fujia mixture ].

Objective: To observe the clinical efficacy of treating primary hypothyroidism by Fuzheng Fujia Mixture (FFM) with formula composing principles of warming and tonifying Pi and Shen, and eliminating blood stasis and removing turbid substances.

Methods: Totally 60 patients with primary hypothyroidism were randomly assigned to the treated group and the control group, 30 in each group. All were treated by Levothyroxine Sodium Tablet (LST) as routines.

[Study on the pharmacognosy identification and UV identification of Basella rubra].

Objective: To provide reference for identification and development of Basella rubra.

Methods: Microscopic identification and UV spectrometry methods were used.

Results: Obvious characteristics were found in the tissue structures of the roots, stems and leaves .

[Study on the regional features of Chinese medicine etiology and pathogenesis of AIDS].

Objective: To analyze the differences in the Chinese medicine (CM) etiology and pathogenesis of AIDS.

Methods: A cross-sectional investigation study of AIDS patients and non-infected people was carried out in Henan, Guangdong and Xinjiang provinces respectively by questionnaire of clinical epidemiology and analyzed with frequencies of symptoms and signs combined with syndrome factors. The distribution differences of syndrome factors in the 3 provinces were compared.

[The establishment and evaluation of the model rats of blood stasis and heat accumulation syndrome].

Objective: To establish a rat model of blood stasis and heat accumulation syndrome in accordance with the Chinese medicine (CM) theoretic features.

Methods: Thirty male SD rats were randomly divided into the normal group, the model group, and the danshen root group, 10 in each. Rats in the danshen root group were given danshen decoction at 13.

[Clinical study on Baihua Xianglian detoxification recipe combined with adefovir dipivoxil in treating HBeAg positive chronic hepatitis].

Objective: To observe the effects on patients with HBeAg positive chronic hepatitis B by Baihua Xianglian Detoxification Recipe (BXDR) combined adefovir dipivoxil (AD), and to assess its clinical efficacy.

Methods: A multi-center randomized clinical trial was performed, and 240 patients with HBeAg positive chronic hepatitis B (CHB) were randomly assigned to the experimental group and the control group. Patients in the experimental group were given AD 10 mg, once daily, while BXDR was additionally given those in the control group, twice daily.

Management of hepatic encephalopathy by traditional chinese medicine.

In spite of the impressive progress in the investigation of hepatic encephalopathy (HE), the complex mechanisms underlying the onset and deterioration of HE are still not fully understood. Currently, none of the existing theories provide conclusive explanations on the symptoms that link liver dysfunction to nervous system disorders and clinical manifestations. This paper summarized the diagnostic and therapeutic approaches used for HE in modern medicine and traditional Chinese medicine and provided future perspective in HE therapies from the viewpoint of holistic and personalized Chinese medicine.

[Determination of three chemical constituents in zhuang medicine Blumea megacephala (Randeria) by HPLC].

Objective: To develop an HPLC method for content determination of protocatechuic acid, chlorogenic acid and caffeic acid in Zhuang medicine Blumea megacephala (Randeria), and explore the content variation of the 3 components of the herbs harvesting in different months, and provide the scientific basis of reasonable application.

Method: The determination was carried out on a Shimadzu VP-ODS column (4.6 mm x 250 mm, 5 microm) eluted with acetonitrile and water containing 0.

Study on the correlation between synaptic reconstruction and astrocyte after ischemia and the influence of electroacupuncture on rats.

Objective: To observe the effects of electroacupuncture (EA) on the structure parameters of synapse and reactive changes of astrocyte in the marginal zone of focal cerebral ischemia in rats at different time zones so as to further explore its underlying mechanisms in the treatment of cerebral ischemia.

Methods: Ninety male Wistar rats were randomly assigned to sham-operation, model, and EA groups, with 30 animals in each group. Each group was subdivided into 1 h, as well as 1, 3, 7, and 21 days post-operation groups, with 6 animals assigned to each time point subgroup.

[Clinical study on modified sanmiao powder in treating chronic uric acid nephropathy].

Objective: To investigate the clinical efficacy of modified Sanmiao Powder (SMP) in treating chronic uric acid nephropathy (CUAN).

Methods: Ninety-four patients with CUAN were equally randomized to the treated group and the control group. Conventional treatment was given to all patients and the treated group was administered with SMP additionally for 12 weeks.

[Research on public education of traditional Chinese medicine in Guangxi during the period of New Gui Faction].

Through the research of the establishment, development, cause, feature, effectiveness, and influence of public education of traditional Chinese Medicine (TCM) in Guangxi during the period of New Gui Faction, it is shown that many measures were adopted by the New Gui Faction to strongly support and develop TCM in Guangxi. In order to raise the social status of TCM and ensure its involvement in the prevention and treatment of diseases, the government of New Gui Faction developed TCM under the schedule of Government Medical Development and the system of Pubic Healthy Care. Meanwhile, the government organized TCM schools and trained more clinical TCM talents.

[Study on the anticancer effects of extracts from roots of Livistona chinensis in vitro].

Objective: To observe the effects of extracts from root of Livistona chinensis on the growth inhibition in seven carcinoma cell lines.

Methods: The growth inhibition was analyzed by MTT, cell colony and cell growth curve measuremen technique in the stomach carcinoma SGC7901, Lymphocytic leukemia L1210, Lymphoid neoplasm P388D1, tumor of cervix uteri Hela, hepar carcinoma hele 7404, melanoma B16 and mouse neuroblastomax rat glioma hybrid NG108-15 cells lines.

Results: The growth of all tumor cells were inhibited by ethyl acetate of alcohol extract from roots of Livistona chinensis.

[Effects of resolving phlegm method on fibrinolytic status in non-alcoholic steatohepatitis patients of phlegm and blood-stasis syndrome].

Objective: To observe the effect of resolving phlegm method (RPM) on fibrinolytic status in non-alcoholic steatohepatitis (NASH) patients of phlegm blood-stasis (PBS) syndrome type.

Methods: Sixty-two patients were randomly assigned to 2 groups, namely the treated group (n = 34) treated with Chinese herbs for resolving phlegm and dampness, smoothing liver and gallbladder, promoting blood circulation and removing blood stasis (composition: Indigo Naturalis 10 g, Alumen 3 g, Semen Cassiae 15 g, Fructus Crataegi 15 g, vinegar prepared Radix Bupleuri 10 g, Radix Curcumae 10 g, Radix Salviae Miltiorrhizae 12 g, Herba Lycopi 12 g, talc 12 g and Radix Glycyrrhizae 2 g), one dose twice per day orally, and the control group (n = 28) with ursodeoxycholic acid tablet (UAT) 150 mg three times per day. The treatment course for both groups was 12 weeks.

[Pharmacognostical identification of Vernonia patula (Dry) Merr].

Objective: To identify Vernonia patula (Dry) Merry.

Methods: Characteristic study, microscopic identification and UV spectrometry method were carried out.

Results: Obvious characteristics were found in the tissue structures of the roots, stems and leaves.

[Effects of Anxin Granules on blood lipid and ultrastructure of aorta in rabbits with dyslipidemia].

Objective: To study the effects of Anxin Granules on dyslipidemia in rabbits caused by high fat plus high cholesterol diet.

Methods: Thirty-two healthy New Zealand male white rabbits were randomly divided into 4 groups: normal control group, untreated group, Zhibituo Tablet-treated group and Anxin Granule-treated group. Rabbits in the normal control group were fed with regular chow, while rabbits in the other three groups were fed with high fat plus high cholesterol diet.

[Chlorogenic acid content comparison of different processed products of Ilex hainanensis Merr].

Objective: To control different processed products of Ilex hainanensis Merr quality.

Methods: Using HPLC to determine chlorogenic acid of Ilex hainanensis Merr. Measure wavelength is 327 nm.

[Morphological and microscopical identification of Murraya kwangsiensis].

Objective: To identify medical plant Murraya kwangsiensis by its tissue characters.

Method: Morphological characters and microstructure of this plant were described and illustrated.

Result: Oil cell, fiber cell and calcium oxalate prism were found in its tissue.

[Regulation on the immunological effect of mogrosides in mice].

Objective: To investigate the cellular immunological effect of mogrosides in mice.

Methods: Mogrosides was administered to normal or CTX-induced immunosuppressive mice, and their macrophage function and T lymphocyte proliferation were detected.

Results: Mogrosides could promote phagocytosis and T lymphocyte proliferation significantly in the CTX-induced immunosuppressive mice, but not in the normal mice.

[Influence of cervical curvature change on the nerve root and vertebral artery of patients with cervical spondylosis and clinical observation of manipulation treatment].

Objective: To observe the influence of the change of cervical curvature on the nerve root and the vertebral artery of the patients with cervical spondylosis and the curative effect of therapeutic manipulations.

Methods: Sixty cases of cervical spondylosis with the change of cervical curvature, 60 cases of cervical spondylosis without the change of cervical curvature and 60 normal people were chosen. They were clinically observed and the cervical spondylosis was treated by manipulations and the data was processed according to the principle of statistics.

Acupuncture treatment of chronic superficial gastritis by the eight methods of intelligent turtle.

With the clinical manifestations and the point electric conduction volume as the indexes, the authors observed the immediate effects of the acupuncture treatment on chronic superficial gastritis with the points selected according to the date and time set by Ling Gui Ba Fa ([symbol: see text] Eight Methods of Intelligent Turtle), which was compared with the effects in the control group treated with the points selected according to syndrome-differentiation. A higher symptom improvement rate (P < 0.01) and a higher channel's balance-inverting rate were noticed in the former (P < 0.