Bistable Soft Shells for Programmable Mechanical Logic.

Mechanical computing promises to integrate semiconductor-based digital logic in several applications, but it needs straightforward programmable devices for changing computing rules in situ. A methodology based on strain-governed, bistable soft shells that process digital information by interchanging their internal/external surfaces is proposed. This bistable behavior, explained via model-based design, safeguards robustness by working only once for each input pulse.

Molecular insights into the activation mechanism of GPR156 in maintaining auditory function.

The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through G. Here, we firstly demonstrate that GPR156 with high constitutive activity is essential for maintaining auditory function, and further reveal the structural basis of the sustained role of GPR156. We present the cryo-EM structures of human apo GPR156 and the GPR156-G complex, unveiling a small extracellular region formed by extracellular loop 2 (ECL2) and the N-terminus.

Innovative dual-benefit recycling and sustainable management of municipal solid waste incineration fly ash via ultra-high performance concrete.

Millions of tons of municipal solid waste incineration fly ash are generated worldwide each year. Currently, landfilling is the primary disposal method, consuming vast land resources and posing significant risks of soil and groundwater contamination due to the high concentration of hazardous heavy metals. Thus, this study investigated the potential of recycling hazardous municipal solid waste incineration fly ash into non-hazardous ultra-high performance concrete for sustainable development.

Single-Walled ZnSe Nanotubes for High-Performance Photodetectors: A Computational Prediction.

Low-dimensional nanomaterials show great potential for developing semiconducting materials due to their distinct electronic, optical, and mechanical properties. In this study, we constructed various one-dimensional ZnSe nanotubes and investigated their transport and photoresponse properties by using the density functional theory (DFT) and non-equilibrium Green's function (NEGF) method. Under bias regulation, one-dimensional tetragonal ZnSe nanotube curled along the diagonal can reach a current of 111.

Organocatalytic Stereodivergent Dearomatization and -Acylation of 2-Amino-3-subsituted Indoles.

Organocatalytic chemo- and enantioselective reactions of 2-amino-3-subsituted indoles have been achieved for the first time. Via asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates, organocatalytic enantioselective dearomatization of 2-amino-3-subsituted indoles afforded an array of enantioenriched 3,3-disubstituted indolin-2-imines bearing a quaternary carbon stereocenter in 34-79% yields with 61-91% ee. With BocO as reaction partner, the organocatalytic enantioselective -acylation of 2-amino-3-subsituted indoles was established to furnish C-N axially chiral products in 22-98% yields with 73-92% ee.

Ruthenium-Catalyzed α-Regioselective Hydroboration of Allenes.

Hydroboration of allenes is powerful and atom-economic approach to the synthesis of organoboranes, such as the highly versatile allylboranes. However, regarding regiocontrol, existing methods uniformly deliver the boron functionality to the less hindered β- or γ-position, but not the α-position. The latter is particularly challenging for allenes with substantial steric difference between the two terminals and lacking electronic bias (e.

Synthetic Study toward Daphnimacropodines.

Daphnimacropodines A-C are members of a small but structurally distinct subfamily of alkaloids. Their congested polycyclic skeletons, and two vicinal quaternary stereocenters, present significant synthetic challenges. This paper describes two stereoselective approaches to constructing the tricyclic core structures of daphnimacropodines, achieved through a straightforward Rh-catalyzed [4 + 3] cycloaddition using simple building blocks.

A Record-High Cryogenic Magnetocaloric Effect Discovered in EuCl Compound.

Adiabatic demagnetization refrigeration (ADR) based on the magnetocaloric effect (MCE) is a promising technique to achieve cryogenic temperature. However, magnetic entropy change (Δ), the driving force of ADR, remains far below theoretical -Δ = ln(2 + 1)/ for most magnetic refrigerants. Here, we report giant MCE in orthorhombic EuCl, where a ferromagnetic ground state with excellent single-ion behavior of Eu and free spins has been demonstrated by combining calculations with Brillouin function analysis and magnetic measurements.

In-Plane Adaptive Heteroepitaxy of 2D Cesium Bismuth Halides with Engineered Bandgaps on c-Sapphire.

The heteroepitaxy of 2D materials with engineered bandgaps are crucial to broaden the spectral response for their integrated optoelectronic devices. However, it is a challenge to achieve the high-oriented epitaxy and integration of multicomponent 2D materials with varying lattice constants on the same substrate due to the limitation of lattice matching. Here, in-plane adaptive heteroepitaxy of a series of high-oriented 2D cesium bismuth halide (CsBiX X = I, Br, Cl) single crystals with varying lattice constants from 8.

An effective and open source interactive 3D medical image segmentation solution.

3D medical image segmentation is a key step in numerous clinical applications. Even though many automatic segmentation solutions have been proposed, it is arguably that medical image segmentation is more of a preference than a reference as inter- and intra-variability are widely observed in final segmentation output. Therefore, designing a user oriented and open-source solution for interactive annotation is of great value for the community.

Advancing EGFR mutation subtypes prediction in NSCLC by combining 3D pretrained ConvNeXt, radiomics, and clinical features.

Purpose: The aim of this study was to develop a novel approach for predicting the expression status of Epidermal Growth Factor Receptor (EGFR) and its subtypes in patients with Non-Small Cell Lung Cancer (NSCLC) using a Three-Dimensional Convolutional Neural Network (3D-CNN) ConvNeXt, radiomics features and clinical features.

Materials And Methods: A total of 732 NSCLC patients with available CT imaging and EGFR expression data were included in this retrospective study. The region of interest (ROI) was manually segmented, and clinicopathological features were collected.

Intracranial aneurysm instability prediction model based on 4D-Flow MRI and HR-MRI.

This study aims to develop a reliable predictive model for assessing intracranial aneurysm (IA) instability by utilizing four-dimensional flow magnetic resonance imaging (4D-Flow MRI) and high-resolution MRI (HR-MRI). Initially, we curated a prospective dataset, dubbed the primary cohort, by aggregating patient data that was consecutively enrolled across two centers from November 2018 to November 2021. Unstable aneurysms were defined as those with symptoms, morphological change or ruptured during follow-up periods.

Tailoring tetrahedral and pair-correlation entropies of glass-forming liquids for energy storage applications at ultralow temperatures.

Aqueous solution experiences either crystallization or vitrification as being cooled, yet the mechanism of this bifurcation is confused. Since the glass-transition temperature T is much lower than the melting temperature, we herein propose an entropy-driven glass-forming liquid (EDGFL) as an attractive concept to develop anti-freezing electrolytes. The T is delicately modulated via regulating local structural orders to avoid the energy-driven ice crystallization and enter an entropy-driven glass transition, which can be theoretically explained by the competitive effect between tetrahedral entropy of water and pair correlation entropy related to ions.

Mild defluorinative -acrylation of amines with (trifluoromethyl)alkenes: synthesis of α-arylacrylamides.

A practical and efficient method for the -acrylation of amines with (trifluoromethyl)alkenes is achieved the cleavage of three C(sp)-F bonds, affording a diverse range of useful tertiary and secondary α-arylacrylamides in high yields. This protocol features mild conditions, is transition-metal free, operationally simple, gram-scalable, and compatible with valuable functional groups, and has a broad substrate scope. Mechanistic studies indicate that exchange of an oxygen atom happens between HO and NaOH, and that the oxygen atom is incorporated into the α-arylacrylamides the -defluorooxylation of the (trifluoromethyl)alkene.

Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles.

Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, both and . Most of the review literature employs meta-analysis methods to explore the association between dairy intake and breast cancer risk.

A CRISPR-Cas12a-mediated dual-mode luminescence and colorimetric nucleic acid biosensing platform based on upconversion nanozyme.

In this study, a CRISPR-Cas12a-mediated dual-mode upconversion luminescence/colorimetric nucleic acid biosensing platform is developed based on UCNP@SiO/CeO (UNSC) nanozyme. Here, UNSC is conjugated with single-stranded DNA (ssDNA) probes used as both peroxidase-like nanozyme and upconversion luminescence donors. When no target nucleic acid is present, ssDNA-conjugated UNSC attaches on magnetic graphene oxide (MGO) via pi-pi stacking force, resulting in upconversion luminescence quenching (OFF) and no color change after magnetic removal of nanozymes attached on the MGO.