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Role of C5a and C5aR in doxorubicin-induced cardiomyocyte senescence.
Exp Ther Med
October 2021
Department of Outpatients, Shenzhen Traditional Chinese Medicine Hospital, Guangdong Shenzhen Health Management Center, Shenzhen, Guangdong 518033, P.R. China.
Doxorubicin (DOX) is an efficacious antineoplastic drug; however, its use is limited due to its cardiotoxicity. Cardiomyocyte senescence is considered to be a key factor in the development of DOX-related cardiomyopathy. Complement component 5a (C5a) and the C5a receptor (C5aR) have been reported to play a key role in the process of cellular senescence.
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