2,275 results match your criteria: "Guangdong Provincial Hospital of Chinese Medicine[Affiliation]"

Screening for viruses in lung adenocarcinoma in China.

Chin Med J Pulm Crit Care Med

September 2024

Department of Respiratory Medicine, Graduate School of Medicine, Osaka Metropolitan University, Chemotherapy Center, Osaka City University Hospital, Osaka 558-8585, Japan.

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Objective: This study aims to explore the correlation between patients with Hashimoto's thyroiditis and food intolerance.

Methods: A total of 172 subjects who visited Guangdong Provincial Hospital of Traditional Chinese Medicine between January 2020 and March 2023 were selected and tested for 90 food-specific IgG antibodies. The study group composed 85 individuals diagnosed with Hashimoto's thyroiditis, while the control group consisted of 87 healthy individuals.

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Genomic Correlation, Shared Loci, and Causal Relationship Between Bullous Pemphigoid and Atopic Dermatitis: A Large-Scale Genome-Wide Cross-Trait Analysis.

Mol Genet Genomic Med

October 2024

Guangdong Academy of Traditional Chinese Medicine, Research Team of Bio-Molecular and System Biology of Chinese Medicine, Guangzhou, China.

Article Synopsis
  • Bullous pemphigoid (BP) and atopic dermatitis (AD) are connected, but more research is needed to understand their co-morbidities.* -
  • Analysis using data from large genetic studies found a significant genetic correlation between BP and AD, along with shared loci and genes.* -
  • The results suggest that BP may increase the risk of developing AD, providing crucial insights for dermatologists in patient management.*
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  • - The study investigates how tumor-associated macrophages (TAMs) and their secretion of CXCL1 contribute to autophagy-mediated chemoresistance in breast cancer, which leads to poor treatment outcomes.
  • - It was discovered that blocking CXCL1 increases the sensitivity of breast cancer cells to chemotherapy by inhibiting autophagy, primarily through a mechanism involving IGF1R and its signaling pathways.
  • - The findings link CXCL1 with enhanced autophagy and identify a novel signaling pathway (IGF1R/STAT3/HMGB1) that plays a significant role in cancer progression and patient prognosis, emphasizing the importance of targeting CXCL1 for better treatment strategies.
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Luteolin alleviates airway remodeling in asthma by inhibiting the epithelial-mesenchymal transition via β-catenin regulation.

Phytomedicine

December 2024

State Key Laboratory of Traditional Chinese Medicine Syndrome/Department of Respiratory Disease, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China; State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, China. Electronic address:

Article Synopsis
  • Asthma is a long-term inflammatory condition that causes changes in the airways, and researchers are investigating how epithelial-mesenchymal transition (EMT) contributes to these changes in asthma patients, particularly focusing on the effects of flavonoids like Luteolin (Lut).
  • The study aims to determine whether Lut can inhibit airway remodeling in asthma and explore the role of β-catenin in this process through both laboratory (cell and animal) experiments.
  • Various methods, including cell migration assays, gene expression analysis, and the evaluation of inflammatory cells in mice, were used to assess Lut’s effects on EMT and to understand its regulatory influence on β-catenin signaling in asthma.
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  • - Colorectal cancer (CRC) is a serious disease that can be detected early using colonoscopy, but identifying polyps visually can be challenging due to varying lighting conditions.
  • - The article introduces a new technique called Enhanced Scattering Wavelet Convolutional Neural Network (ESWCNN) which combines CNN and Scattering Wavelet Transform to improve the accuracy of polyp classification.
  • - ESWCNN achieved impressive results with 96.4% accuracy in classifying three types of polyps and 94.8% accuracy in a two-class scenario, showing it outperforms traditional CNN models in identifying different polyp types.
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  • Ulcerative colitis is a chronic inflammatory bowel disease marked by inflammation and ulcers in the colon, and the HLJD herbal formulation is traditionally used in its treatment, though its mechanisms are not fully understood.
  • The study involved inducing chronic colitis in mice with a substance called DSS, followed by administering HLJD in varying doses to assess its effects on the disease over eight weeks, while monitoring various health indicators and gut microbiome composition.
  • Results indicated that HLJD effectively reduced colitis symptoms by lowering inflammation through a specific receptor pathway and also altered the gut microbiota, highlighting the interplay between inflammation, macrophage activity, and microbial balance in treating the condition.
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Mechanism of macrophages in gout: Recent progress and perspective.

Heliyon

October 2024

The Department of Rheumatism, The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangdong Second Hospital of Traditional Chinese Medicine, Guangzhou, 510000, PR China.

Article Synopsis
  • - Gout is an inflammatory disorder caused by the buildup of monosodium urate crystals, which triggers immune response from various cells, particularly neutrophils and macrophages.
  • - Macrophages play a critical role in both the onset and management of gout inflammation, with different subtypes showing varying effects on disease progression.
  • - Targeting the polarization of macrophages for better regulation, instead of just reducing inflammation, could improve treatments for acute gout and offer new understandings of immune functions in this condition.
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Dynamic changes in Beclin-1, LC3B, and p62 in aldose reductase-knockout mice at different time points after ischemic stroke.

Heliyon

October 2024

State Key Laboratory of Traditional Chinese Medicine Syndrome/Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, China.

Article Synopsis
  • * A study using a mouse model of transient middle cerebral artery occlusion (tMCAO) observed changes in neurological function and brain damage due to ischemia-reperfusion injury, with significant alterations in autophagy-related proteins over time.
  • * The findings showed that specific proteins related to autophagy and inflammation had varied expression levels at different time points after the stroke, highlighting a dynamic response in AR mice that could inform future research on treatment strategies.
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Article Synopsis
  • Digoxin is a cardiac medication with a narrow therapeutic range, making accurate blood concentration monitoring crucial for effective treatment.
  • The report outlines an optimized reference measurement procedure (RMP) using ID-LC-MS/MS for more accurate digoxin measurement, showing strong precision and a broad detection range.
  • The study highlights the need for standardization in clinical systems due to significant variability in results, proposing the optimized RMP as a reliable reference for improving measurement accuracy in laboratories.*
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Introduction: When young children experience recurrent respiratory infections, caregivers face the challenge of preventing new episodes whilst maintaining close rapport with their children. Pediatric massage, such as pediatric Tuina, entails soft massage of the skin, administered by trained providers. This non-pharmaceutical measure is used to prevent new respiratory infections in China.

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Vanillic acid is widely used in the food industry and exhibits an excellent neuroprotective effect. Nevertheless, the mechanisms underlying them are largely unexplored, especially the interactions between the neuroprotection effects of vanillic acid and inflammation-immunity-metabolism. A cell metabolomics-based mathematics algorithm was reported to interpret the potential mechanism of vanillic acid on corticosterone-induced PC12 cells by regulating immune and metabolic dysregulation.

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Role of epicardial adipose tissue in cardiac remodeling.

Diabetes Res Clin Pract

November 2024

Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China; Guangdong Provincial Key Laboratory of TCM Emergency Research, Guangzhou 510120, Guangdong, China. Electronic address:

Epicardial adipose tissue, or epicardial fat, is a type of visceral fat located between the heart and the pericardium. Due to its anatomical proximity to the heart, EAT plays a significant role in both cardiac physiology and pathologies, including cardiac remodeling and cardiovascular diseases (CVD). However, our understanding of how EAT pathology is influenced by risk factors such as obesity and type 2 diabetes mellitus and how altered EAT can drive cardiac remodeling and CVD, remains limited.

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acFibroMASH Index for the Diagnosis of Fibrotic MASH and Prediction of Liver-related Events: An International Multicenter Study.

Clin Gastroenterol Hepatol

October 2024

MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, Zhejiang, China. Electronic address:

Article Synopsis
  • Scientists studied a health problem called MASH, which affects people's livers, and worked on two tests to help doctors tell if someone has it.
  • They looked at data from over 3,000 people to make sure their first test, called acMASH, worked well, and then created a new test called acFibroMASH to find more severe cases.
  • The new acFibroMASH test was better at predicting who might have future liver problems compared to another test, showing it's a useful tool for doctors to keep patients healthy.
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Article Synopsis
  • The study investigates how traditional Chinese medicine's concept of deficiency constitution relates to anemia, specifically examining gut microbiome differences in individuals with this constitution.
  • Deficient constitution individuals exhibited lower hemoglobin levels and distinct gut microbiome profiles, including increased Firmicutes and decreased Bacteroidetes, plus higher microbial diversity.
  • The research suggests that changes in the gut microbiome are linked to worse health outcomes and a higher risk of anemia, potentially due to impacts on intestinal barriers and immune function mediated by short-chain fatty acids and bile acids.
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Objective: This study aimed to assess and visually depict the clinical evidence landscape of traditional Chinese exercises and identify any research gaps and future research needs.

Methods: We comprehensively searched seven Chinese and English databases to identify randomized controlled trials (RCTs) and systematic reviews (SRs) evaluating the effects of traditional Chinese exercises from their inception until May 2023. The quality of evidence was assessed via the GRADE approach, and the research topics, intervention effects, and strength of evidence were graphically displayed.

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Psychometric Validation of the Dampness Syndrome Scale of Chinese Medicine for People in China.

Patient Prefer Adherence

September 2024

State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.

Background: Dampness syndrome is a basic syndrome of many major and chronic diseases. Early screening and identification of dampness syndrome are important. The Dampness Syndrome Scale of Chinese Medicine (DSSCM) was developed to measure the occurrence and severity of dampness syndrome.

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Moutan cortex has demonstrated antitumor properties attributed to its bioactive compound Paeoniflorigenone (PA). Nevertheless, there is limited research on the efficacy of PA in the prevention and treatment of hepatocellular carcinoma (HCC). We aimed to investigate the potential pharmacological mechanisms of PA in the treatment of Aflatoxin B1 (AFB1)-induced hepatocarcinogenesis using network pharmacology and bioinformatics analysis approaches.

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Objective: Insulin resistance (IR) is a well-established major risk factor for type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerotic cardiovascular disease. Previous studies have shown an association between increased serum albumin (ALB) levels and the risk of IR. However, there is a lack of studies simultaneously evaluating the association of total protein (TP), ALB, and globulin (GLB) with IR.

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Article Synopsis
  • - Vunakizumab, an anti-interleukin-17A antibody, is being tested for its effectiveness in treating moderate-to-severe plaque psoriasis in a phase 3 trial involving 690 participants.
  • - The trial found that those receiving vunakizumab showed significantly better improvement in psoriasis severity scores at week 12 compared to the placebo group, with maintained efficacy through week 52.
  • - While the treatment showed good results and tolerability, the study was limited to Chinese subjects and didn't include an active comparator for broader context. !*
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Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant side effect of some chemotherapeutic agents. Effective treatment is limited.

Objectives: This single patient case details gua sha as an intervention to reduce CIPN.

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Introduction: Mobile phone-based interventions show promise for smoking cessation but often face low engagement. This study assessed the feasibility and preliminary effectiveness of a 2-phase, multi-component mobile phone-based smoking cessation intervention for patients with chronic diseases.

Methods: This Sequential Multiple Assignment Randomized Trial (SMART) recruited smokers with chronic diseases from hospitals in Zhuhai, China.

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Objectives: Serum cystatin C (CysC) is a reliable and ideal endogenous marker for accurately assessing early changes in glomerular filtration rate (GFR), surpassing the limitations of creatinine-based estimated GFR. To improve the precision of GFR calculation, the development of strategies for accurately measuring serum CysC is crucial.

Methods: In this study, the full-length CysC pure product and fully recombinant N-labeled CysC internal standard were subjected to protein cleavage.

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