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Urinary Cytokeratin 20 as a Biomarker for AKI-CKD Transition among Patients with Acute Decompensated Heart Failure and Acute Kidney Injury.

J Am Soc Nephrol

October 2024

Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Province Institute of Nephrology, Guangdong Province Key Laboratory of Renal Failure Research, Guangzhou, China.

Article Synopsis
  • * In a cohort of hospitalized patients, high levels of CK20 at the time of AKI diagnosis significantly increased the risk of both AKI-CKD progression and all-cause death within 90 days, outperforming other biomarkers.
  • * The findings suggest that incorporating urinary CK20 measurements can enhance the accuracy of predicting adverse outcomes in AKI patients, indicating its potential utility in clinical practice.
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