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[Correlation between dissolution in vitro and absorption in vivo of chuanping sustained release tablets].
Zhongguo Zhong Yao Za Zhi
October 2013
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China.
Objective: To investigate the correlation between dissolution in vitro and absorption in vivo of Chuanping sustained release tablets.
Method: The ephedrine, pseudoephedrine were chosen as marker components, dissolution in vitro of Chuanping sustained release tablets in the different pH were tested by the rotating basket method and HPLC; urine drug levels were determined by HPLC and absorption fractions were calculated according to Wagner-Nelson's formula and deconvolution technique.
Result: The linear regressive equation between the absorption percentage in vivo F and accumulative release percentage in vitro of Chuanping sustained release tablets was established as F(ephedrine) = 1.