183 results match your criteria: "Guangdong No.2 Provincial People's Hospital[Affiliation]"
J Endod
August 2015
Department of Operative Dentistry and Endodontics, Guanghua School and Hospital of Stomatology, Institute of Stomatological Research, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:
Introduction: The relationship between Enterococcus faecalis and pulpal or periradicular diseases has been studied for many years; however, whether E. faecalis is correlated with persistent intraradicular infections (teeth after failed endodontic treatments) compared with primary intraradicular infections remains controversial. The objective of this systematic review was to compare the prevalence of E.
View Article and Find Full Text PDFOncotarget
June 2015
George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA.
Testicular nuclear receptor 4 (TR4), a member of the nuclear receptor superfamily, may play important roles to modulate the metabolic diseases and prostate tumorigenesis. Here we found TR4 could increase prostate cancer (PCa) cell invasion. Mechanism dissection revealed that TR4 might increase PCa cell invasion via decreasing the miR-373-3p expression that resulted in the activation of the TGFβR2/p-Smad3 signals.
View Article and Find Full Text PDFAnn Noninvasive Electrocardiol
January 2016
Department of Cardiology, First Affiliated Hospital of Jinan University, Guangzhou, China.
Aims: Research related to type 2 diabetes mellitus (DM) and parameters of electrocardiography (ECG) was limited. Patients with and without DM (NDM) were randomly enrolled in a study to exploit the influence of DM on planar QRS and T vectors derived from the Virtual Holter process.
Methods: A total of 216 (NDM) and 127 DM patients were consecutively and randomly recruited.
Anal Chem
June 2015
§Department of Laboratory Medicine, Guangdong No. 2 Provincial People's Hospital, Guangzhou 510317, People's Republic of China.
Lowering the detection limit is critical to the design of bioassays required for medical diagnostics, environmental monitoring, and food safety regulations. The current sensitivity of standard color-based analyte detection limits the further use of enzyme-linked immunosorbent assays (ELISAs) in research and clinical diagnoses. Here, we demonstrate a novel method that uses the Raman signal as the signal-generating system of an ELISA and combines surface-enhanced Raman scattering (SERS) with silver nanoparticles aggregation for ultrasensitive analyte detection.
View Article and Find Full Text PDFPLoS One
April 2016
Department of Medical Imaging Center, Nanfang Hospital, Southern Medial University, Guangzhou, PR China.
Background: Little is known about connectivity within the default mode network (DMN) in heroin-dependent individuals (HDIs). In the current study, diffusion-tensor imaging (DTI) and resting-state functional MRI (rs-fMRI) were combined to investigate both structural and functional connectivity within the DMN in HDIs.
Methods: Fourteen HDIs and 14 controls participated in the study.
Mol Cancer Ther
June 2015
George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York. Sex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan.
The testicular nuclear receptor 4 (TR4) is a member of the nuclear receptor superfamily that mediates various biologic functions with key impacts on metabolic disorders and tumor progression. Here, we demonstrate that TR4 may play a positive role in prostate cancer CD133(+) stem/progenitor (S/P) cell invasion. Targeting TR4 with lentiviral silencing RNA significantly suppressed prostate cancer CD133(+) S/P cell invasion both in vitro and in vivo.
View Article and Find Full Text PDFPLoS One
March 2016
Medical Imaging Centre, Nanfang Hospital, Southern Medial University, Guangzhou, People's Republic of China.
Background And Purpose: Increasing evidence suggests that cirrhosis may affect the connectivity among different brain regions in patients before overt hepatic encephalopathy (OHE) occurs. However, there has been no study investigating the structural reorganization of these altered connections at the network level. The primary focus of this study was to investigate the abnormal topological organization of the structural network in patients with hepatitis B virus-related cirrhosis (HBV-RC) without OHE using structural MRI.
View Article and Find Full Text PDFPLoS One
February 2016
Department of Medical Imaging Center, Nanfang Hospital, Southern Medial University, Guangzhou, PR China.
Purpose: This study aimed to investigate the topological organization of intrinsic functional brain networks in patients with end-stage renal disease (ESRD).
Materials And Methods: Resting-state functional MRI data were collected from 22 patients with ESRD (16 men, 18-61 years) and 29 age- and gender-matched healthy controls (HCs, 19 men, 32-61 years). Whole-brain functional networks were obtained by calculating the interregional correlation of low-frequency fluctuations in spontaneous brain activity among 1,024 parcels that cover the entire cerebrum.
Addict Biol
May 2016
Centre for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Healthy and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, China.
Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-dependent individuals (HDIs). Diffusion tensor imaging (DTI) offers a comprehensive technique to map the whole brain WM connectivity in vivo.
View Article and Find Full Text PDFSci Rep
March 2015
1] State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China [2] Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Previous work from our laboratory demonstrated the existence of miRNAs in human follicular fluid. In the current study, we have sought to identify miRNAs that might affect oocyte/embryo quality in patients undergoing intracytoplasmic sperm injection and to investigate their roles in in vitro fertilization outcomes in mouse oocytes. 53 samples were classified as Group 1 (high quality) if the day-3 embryos had seven and more cells or as Group 2 (low quality) if the embryos had six and fewer cells.
View Article and Find Full Text PDFBiosens Bioelectron
July 2015
Department of Bioengineering, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou 510632, PR China. Electronic address:
Ultrasensitive and quantitative detection using simple and low-cost assays is critical in clinical diagnostics. In this report, we developed a triangular silver nanoprism (AgNPRs) etching-based plasmonic biosensor for the detection of cancer biomarkers. The triangular AgNPRs-based plasmonic biosensor is an enzyme-linked immunosorbent assay combined with the enzyme-mediated surface plasmon resonance (SPR) of triangular AgNPRs.
View Article and Find Full Text PDFClin Neurophysiol
November 2015
Centre for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China. Electronic address:
Objective: To date, no study has examined the effect of hyperbaric oxygen (HBO) on the cognitive performance and spontaneous brain activity in healthy adults using resting-state functional magnetic resonance imaging (rsfMRI). Our aim was to reveal the neural mechanism underlying the change in cognitive performance caused by increased oxygen.
Methods: In this study, we acquired fMRI data from 20 healthy young adults and used placebo-controlled (PBO) rsfMRI to identify the effect of HBO on the cognitive measures and the regional homogeneity (ReHo) in healthy adults.
Biosci Rep
March 2015
*Department of Hepatic Surgery, the Third Affiliated hospital, Sun Yat-san University, Guangzhou 510630, China.
Activatable cell-penetrating peptides (aCPPs) allow non-viral, low cytotoxic and selective delivery of compounds into target cells for cancer therapy. In tumour cells, up-regulation of human telomerase reverse transcriptase (hTERT) frequently occurs and is being considered as a target in cancer diagnosis and treatment. siRNA sequence that target hTERT mRNA can silence the gene and reduce hTERT protein expression to reduce cell proliferation and inhibit cell growth.
View Article and Find Full Text PDFJ Orthop Res
September 2015
Department of Orthopedics, Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510665, China.
The roles of different immune cell populations and cytokines in bone metabolism have been extensively investigated. However, the influence of whole immune organ removal on osteopathology remains unknown. In the current study, we investigated the effects of splenectomy on bone metabolism and microarchitecture in rats with or without concurrent ovariectomy.
View Article and Find Full Text PDFActa Radiol
January 2016
Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
Background: Cavernous hemangiomas (CHs) of the adrenal gland are extremely rare. To date, only a few studies of adrenal CH imaging have been reported.
Purpose: To analyze the computed tomography (CT) imaging findings of adrenal CHs.
Bone
May 2015
Department of Prosthodontics Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, PR China. Electronic address:
Mechanical stimulation plays an important role in bone cell metabolic activity. However, bone cells lose their mechanosensitivity upon continuous mechanical stimulation (desensitization) and they can recover the sensitivity with insertion of appropriate rest period into the mechanical loading profiles. The concrete molecular mechanism behind the regulation of cell mechanosensitivity still remains unclear.
View Article and Find Full Text PDFJ Microbiol Methods
February 2015
Department of Laboratory Medicine, Guangdong No.2 Provincial People's Hospital, Guangzhou 510317, PR China. Electronic address:
A reliable, simple and rapid diagnostic method that can be helpful in pulmonary tuberculosis diagnosis is urgently needed. Loop-mediated Isothermal Amplification (LAMP) allows DNA to be amplified rapidly at a constant temperature. In this study, real-time fluorescence LAMP was evaluated to rapidly detect Mycobacterium tuberculosis in sputum and was compared to the performance of real-time fluorescence quantitative PCR (Q-PCR).
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2015
Department of Laboratory Medicine, Guangdong No. 2 Provincial People's Hospital, Guangzhou 510317, PR China.
MicroRNA-196b (miR-196b) is frequently amplified and aberrantly overexpressed in acute leukemias. To investigate the role of miR-196b in acute leukemias, it has been observed that forced expression of this miRNA increases proliferation and inhibits apoptosis in human cell lines. More importantly, we show that this miRNA can significantly increase the colony-forming capacity of mouse normal bone marrow progenitor cells alone, as well as partially blocking the cells from differentiation.
View Article and Find Full Text PDFInt J Infect Dis
February 2015
Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong, China. Electronic address:
Objectives: The aim of this study was to screen the non-invasive indexes correlated with liver fibrosis and establish a scoring system for the diagnosis of liver fibrosis in hepatitis B patients.
Methods: Data of 34 non-invasive indexes were collected for 208 hepatitis B patients. Correlation analysis and stepwise discriminant analysis was used to screen out indexes useful for the diagnosis of liver fibrosis.
Clin Neurophysiol
June 2015
Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China. Electronic address:
Objective: We aimed to provide additional evidence that brain functional alterations induced by IBS are not limited to local changes but also express at a level of functional integration within related brain regions involved in processing of visceral afferent information and somatic pain.
Methods: With fMRI data acquired from 21 IBS and healthy control (HC) subjects. We investigated the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) to reveal the changes of the brain spontaneous activity and the interaction among different related regions.
Eur Rev Med Pharmacol Sci
October 2014
Department of Orthopedics, Guangdong No. 2 Provincial People's Hospital, Guangzhou, China.
Objective: Traditional percutaneous laser disc decompression (PLDD) eliminates nucleus pulposus in the center of lumbar discs. Targeted PLDD is an alternative technique that involves elimination and decompression of the target area located 5-8 mm in the front of the herniated disc. We aimed to compare the efficacy of targeted PLDD with traditional PLDD in the treatment of lumbar disc herniation and evaluate the usefulness of guidance by puncture-radiating pain on clinical outcomes of PLDD.
View Article and Find Full Text PDFStroke
December 2014
From the Neuroradiology Division, Department of Radiology, Stanford University, CA (M.W.); Department of Neurology (N.K.H., K.S., H.J.F.), Departments of Biostatistics and Epidemiology (N.K.H.), Department of Radiology (A.J.B.), and Department of Pediatrics (A.J.B., H.J.F), University of California at San Francisco; Department of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada (G.A.d.); Departments of Neurology and Epidemiology, Columbia University College of Physicians and Surgeons and Mailman School of Public Health, New York, NY (M.S.V.E.); Department of Neurology, Military General Hospital of Beijing PLA, Beijing, China (G.Z.); Department of Radiology, University of Virginia, Charlottesville, VA (C.L.-S.); Department of Neurology, Guangdong No. 2 Provincial People's Hospital, Guangzhou, China (Q.H.); Departments of Pediatrics and Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas (M.M.D.); Department of Pediatrics, University of Colorado, Denver (T.J.B.); Center for Pediatric Neurology, Neurological Institute, Cleveland Clinic, OH (N.R.F.); and Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Children's Hospital of Philadelphia (R.N.I.).
Background And Purpose: Although arteriopathies are the most common cause of childhood arterial ischemic stroke, and the strongest predictor of recurrent stroke, they are difficult to diagnose. We studied the role of clinical data and follow-up imaging in diagnosing cerebral and cervical arteriopathy in children with arterial ischemic stroke.
Methods: Vascular effects of infection in pediatric stroke, an international prospective study, enrolled 355 cases of arterial ischemic stroke (age, 29 days to 18 years) at 39 centers.
Sci Rep
November 2014
1] Academy of Orthopedics, Guangdong Province, Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510665, China [2] State Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Science, Southern Medical University, Guangzhou, 510515, China.
Citric acid-based polymer/hydroxyapatite composites (CABP-HAs) are a novel class of biomimetic composites that have recently attracted significant attention in tissue engineering. The objective of this study was to compare the efficacy of using two different CABP-HAs, poly (1,8-octanediol citrate)-click-HA (POC-Click-HA) and crosslinked urethane-doped polyester-HA (CUPE-HA) as an alternative to autologous tissue grafts in the repair of skeletal defects. CABP-HA disc-shaped scaffolds (65 wt.
View Article and Find Full Text PDFHum Reprod
December 2014
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
J Biol Chem
November 2014
From the Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, the Key Laboratory of Functional Molecules from Marine Microorganisms, Sun Yat-sen University, Department of Education of Guangdong Province, Guangzhou 510080, China
Human plasminogen kringle 5 (K5) is known to display its potent anti-angiogenesis effect through inducing endothelial cell (EC) apoptosis, and the voltage-dependent anion channel 1 (VDAC1) has been identified as a receptor of K5. However, the exact role and underlying mechanisms of VDAC1 in K5-induced EC apoptosis remain elusive. In the current study, we showed that K5 increased the protein level of VDAC1, which initiated the mitochondrial apoptosis pathway of ECs.
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